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2024 Journal Article Dual therapy with corticosteroid ablates the beneficial effect of DP2 antagonism in chronic experimental asthmaUllah, Md Ashik, Rittchen, Sonja, Li, Jia, Curren, Bodie F., Namubiru, Patricia, Ahmed, Tufael, Howard, Daniel R., Rahman, Muhammed Mahfuzur, Sikder, Md Al Amin, Rashid, Ridwan B., Collinson, Natasha, Lor, Mary, Smythe, Mark L. and Phipps, Simon (2024). Dual therapy with corticosteroid ablates the beneficial effect of DP2 antagonism in chronic experimental asthma. Nature Communications, 15 (1) 10253, 1-13. doi: 10.1038/s41467-024-54670-8 |
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2024 Journal Article Prostaglandins in the inflamed central nervous system: potential therapeutic targetsSheremeta, Chynna-Loren, Yarlagadda, Sai, Smythe, Mark L. and Noakes, Peter G. (2024). Prostaglandins in the inflamed central nervous system: potential therapeutic targets. Current Drug Targets, 25 (13), 885-908. doi: 10.2174/0113894501323980240815113851 |
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2024 Journal Article Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarctionRedd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2024). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal, 45 (17), 1571-1574. doi: 10.1093/eurheartj/ehad793 |
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2021 Journal Article Hematopoietic prostaglandin D synthase inhibitor PK007 decreases muscle necrosis in DMD mdx model miceYarlagadda, Sai, Kulis, Christina, Noakes, Peter G. and Smythe, Mark L. (2021). Hematopoietic prostaglandin D synthase inhibitor PK007 decreases muscle necrosis in DMD mdx model mice. Life, 11 (9) 994, 994. doi: 10.3390/life11090994 |
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2020 Conference Publication Hepcidin peptidomimetics - oral efficacy in pre-clinical disease model of iron overloadTaranath, Roopa, Bourne, Gregory, Zhang, Jie, Frederick, Brian, Tran, Tran T., Bhandari, Ashok, Vengalam, Jayanthi, McMahon, Jaimee, Huie, Keith, Ledet, Grace A., Zhao, Li, Tovera, James, Lee, Larry, Yang, Bo, Dion, Celino, Yuan, Lucy, Zemede, Genet, Nguyen, Michelle, Masjedizadeh, Mohammad, Cheng, Xiaoli, Mattheakis, Larry, Liu, David and Smythe, Mark L. (2020). Hepcidin peptidomimetics - oral efficacy in pre-clinical disease model of iron overload. 62nd Annual Meeting of the American Society of Hematology (ASH), Virtual, 5-8 December 2020. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2020-141720 |
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2018 Journal Article PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ productionWerder, Rhiannon B., Lynch, Jason P., Simpson, Jennifer C., Zhang, Vivian, Hodge, Nick H., Poh, Matthew, Forbes-Blom, Elizabeth, Kulis, Christina, Smythe, Mark L., Upham, John W., Spann, Kirsten, Everard, Mark L. and Phipps, Simon (2018). PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production. Science Translational Medicine, 10 (440) eaao0052, eaao0052. doi: 10.1126/scitranslmed.aao0052 |
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2017 Conference Publication Hepcidin Mimetic Ptg-300 for Treatment of Ineffective Erythropoiesis and Iron OverloadBourne, Gregory, Zhao, Li, Bhandari, Ashok, Frederick, Brian, McMahon, Jaimee, Tran, Vinh, Zhang, Jenny, Stephenson, Adam, Tovera, James, Bai, Lu, Annamalai, Thamil, Patel, Dinesh, Smythe, Mark and Liu, David (2017). Hepcidin Mimetic Ptg-300 for Treatment of Ineffective Erythropoiesis and Iron Overload. Seventh Congress of the International BioIron Society (IBIS)Biennial World Meeting (BioIron 2017), Los Angeles, CA, United States, 7 - 11 May 2017. Hoboken, NJ United States: Wiley. |
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2016 Journal Article Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23Barkan, David T., Cheng, Xiao-Li, Celino, Herodion, Tran, Tran T., Bhandari, Ashok, Craik, Charles S., Sali, Andrej and Smythe, Mark L. (2016). Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23. BMC Bioinformatics, 17 (481) 481, 481. doi: 10.1186/s12859-016-1350-9 |
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2016 Conference Publication Novel hepcidin mimeticsBourne, Greg, Smythe, Mark, Frederick, Brian, Scott, Sonya, Vink, Simone, Fog, Jacob Ulrik, Tofteng-Shelton, Pernille and Madala, Praveen (2016). Novel hepcidin mimetics. 6th Meeting of the International BioIron Society, Hangzhou, China, 6-10 September 2015. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/ajh.24277 |
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2015 Journal Article Discovery and characterization of a potent interleukin-6 binding peptide with neutralizing activity in vivoRanganath, Sheila, Bhandari, Ashok, Avitahl-Curtis, Nicole, McMahon, Jaimee, Wachtel, Derek, Zhang, Jenny, Leitheiser, Christopher, Bernier, Sylvie G., Liu, Guang, Tran, Tran T., Celino, Herodion, Tobin, Jenny, Jung, Joon, Zhao, Hong, Glen, Katie E., Graul, Chris, Griffin, Aliesha, Schairer, Wayne C., Higgins, Carolyn, Reza, Tammi L., Mowe, Eva, Rivers, Sam, Scott, Sonya, Monreal, Alex, Shea, Courtney, Bourne, Greg, Coons, Casey, Smith, Adaline, Tang, Kim ... Carlson, Kenneth E. (2015). Discovery and characterization of a potent interleukin-6 binding peptide with neutralizing activity in vivo. PLoS One, 10 (11) e0141330, 1-19. doi: 10.1371/journal.pone.0141330 |
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2013 Conference Publication Replacement of peptide amide bond by amide nitroxide to enhance precision of distance distributions by DEER EPRMarshall, Garland R., Kulis, Christina, Bourne, Gregory T., Hindson, Christopher M., Hanson, Graeme R. and Smythe, Mark L. (2013). Replacement of peptide amide bond by amide nitroxide to enhance precision of distance distributions by DEER EPR. 23rd American Peptide Symposium, Waikoloa, HI, United States, 22-27 June 2013. Hoboken, NJ, United States: John Wiley & Sons. |
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2011 Journal Article Conformational searching using a population-based incremental learning algorithmLong, Stephen M., Tran, Tran T., Adams, Peter, Darwen, Paul and Smythe, M. L. (2011). Conformational searching using a population-based incremental learning algorithm. Journal of Computational Chemistry, 32 (8), 1541-1549. doi: 10.1002/jcc.21732 |
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2011 Journal Article Sigma-class glutathione transferasesFlanagan, Jack U. and Smythe, Mark L. (2011). Sigma-class glutathione transferases. Drug Metabolism Reviews, 43 (2), 194-214. doi: 10.3109/03602532.2011.560157 |
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2010 Journal Article Defining scaffold geometries for interacting with proteins: Geometrical classification of secondary structure linking regionsTran, Tran T., Kulis, Christina, Long, Steven M., Bryant, Darryn, Adams, Peter and Smythe, Mark L. (2010). Defining scaffold geometries for interacting with proteins: Geometrical classification of secondary structure linking regions. Journal of Computer-Aided Molecular Design, 24 (11), 917-934. doi: 10.1007/s10822-010-9384-y |
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2010 Journal Article Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D-2 synthasesChrist, Angelika N., Labzin, Larisa, Bourne, Gregory T., Fukunishi, Hirotada, Weber, Jane E., Sweet, Matthew J., Smythe, Mark L. and Flanagan, Jack U. (2010). Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D-2 synthases. Journal of Medicinal Chemistry, 53 (15), 5536-5548. doi: 10.1021/jm100194a |
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2010 Journal Article Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D-2 synthaseWeber, Jane E., Oakley, Aaron J., Christ, Angelika N., Hayes, John D., Hall, Rhonda, Hume, David A., Board, Philip G., Smythe, Mark L. and Flanagan, Jack U. (2010). Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D-2 synthase. European Journal of Medicinal Chemistry, 45 (2), 447-454. doi: 10.1016/j.ejmech.2009.10.025 |
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2010 Conference Publication Design, synthesis and evaluation of inhibitors targeting the SHP-1 catalytic domainKulis, C., Bourne, G., Kellie, S. and Smythe, M. (2010). Design, synthesis and evaluation of inhibitors targeting the SHP-1 catalytic domain. EPS 2010: The 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.1303 |
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2008 Journal Article Library of biphenyl privileged substructures using a safety-catch linker approachSeverinsen, Rune, Bourne, Gregory T., Tran, Tran T., Ankersen, Michael, Begtrup, Mikael and Smythe, Mark L. (2008). Library of biphenyl privileged substructures using a safety-catch linker approach. Journal of Combinatorial Chemistry, 10 (4), 557-566. doi: 10.1021/cc800006g |
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2008 Journal Article Cyclic tetrapeptides via the ring contraction strategy: Chemical techniques useful for their identificationHorton, D. A., Bourne, G. T., Coughlan, J., Kaiser, S. M., Jacobs, C. M., Jones, A., Ruhmann, A., Turner, J. Y. and Smythe, M. L. (2008). Cyclic tetrapeptides via the ring contraction strategy: Chemical techniques useful for their identification. Organic & Biomolecular Chemistry, 6 (8), 1386-1395. doi: 10.1039/b800464a |
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2006 Journal Article A gradient descent algorithm for minimizing amino acid coupling reactions when synthesizing cyclic-peptide librariesDarwen, PJ, Tran, TT, Bourne, GT, Nielson, JL and Smythe, ML (2006). A gradient descent algorithm for minimizing amino acid coupling reactions when synthesizing cyclic-peptide libraries. Combinatorial Chemistry & High Throughput Screening, 9 (7), 559-563. doi: 10.2174/138620706777935333 |
