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2025 Journal Article Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparumWebster, Rebecca, Oyong, Damian A., Llewellyn, Stacey, Abd-Rahman, Azrin N., Potter, Adam J., Mukhiya, Reena, Sahai, Nischal, Leelasena, Indika, Ujvary, Eniko, Mathison, Sue, Andrew, Dean W., Bukali, Luzia, de Labastida Rivera, Fabian, Engel, Jessica, Soon, Megan S. F., Frame, Teija, Hamelink, Julianne, Nalubega, Mayimuna, Dooley, Nicholas L., Loughland, Jessica R., Nguyen, Tran, Rosenberg-Hasson, Yael, Maysel-Auslender, Sofia, Sigal, Natalia, Foygel, Kira, Gower, Jeremy, Peters, Jenny, Woo, Ria, Amante, Fiona ... Boyle, Michelle J. (2025). Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparum. Science Translational Medicine, 17 (826) eaea2531, 1-15. doi: 10.1126/scitranslmed.aea2531 |
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2025 Journal Article Data standards for single‐cell RNA‐sequencing of paediatric cancerXu, Xiaohan, Saxon, John, Soon, Megan Sioe Fei, Lee, Colin Y. C. and Tuong, Zewen Kelvin (2025). Data standards for single‐cell RNA‐sequencing of paediatric cancer. Clinical & Translational Immunology, 14 (5) e70033, e70033-5. doi: 10.1002/cti2.70033 |
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2024 Journal Article CD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasitesLee, Hyun Jae, Moreira, Marcela L., Li, Shihan, Asatsuma, Takahiro, Williams, Cameron G., Skinner, Oliver P., Asad, Saba, Bramhall, Michael, Jiang, Zhe, Liu, Zihan, Kerr, Ashlyn S., Engel, Jessica A., Soon, Megan S. F., Straube, Jasmin, Barrera, Irving, Murray, Evan, Chen, Fei, Nideffer, Jason, Jagannathan, Prasanna and Haque, Ashraful (2024). CD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasites. Nature Communications, 15 (1) 5497, 1-18. doi: 10.1038/s41467-024-49879-6 |
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2024 Journal Article Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4+ T cells (vol 43, 114317, 2024)Williams, Cameron G., Moreira, Marcela L., Asatsuma, Takahiro, Lee, Hyun Jae, Li, Shihan, Burn, Thomas N., Barrera, Irving, Murray, Evan, Soon, Megan S. F., Engel, Jessica A., Khoury, David S., Le, Shirley, Wanrooy, Brooke J., Schienstock, Dominick, Alexandre, Yannick O., Skinner, Oliver P., Joseph, Rainon, Beattie, Lynette, Mueller, Scott N., Chen, Fei and Haque, Ashraful (2024). Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4+ T cells (vol 43, 114317, 2024). Cell Reports, 43 (9) 114754. doi: 10.1016/j.celrep.2024.114754 |
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2024 Journal Article Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4+T cellsWilliams, Cameron G., Moreira, Marcela L., Asatsuma, Takahiro, Lee, Hyun Jae, Li, Shihan, Barrera, Irving, Murray, Evan, Soon, Megan S. F., Engel, Jessica A., Khoury, David S., Le, Shirley, Wanrooy, Brooke J., Schienstock, Dominick, Alexandre, Yannick O., Skinner, Oliver P., Joseph, Rainon, Beattie, Lynette, Mueller, Scott N., Chen, Fei and Haque, Ashraful (2024). Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4+T cells. Cell Reports, 43 (6) 114317, 1-28. doi: 10.1016/j.celrep.2024.114317 |
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2024 Journal Article Single-cell immune repertoire analysisIrac, Sergio E., Soon, Megan Sioe Fei, Borcherding, Nicholas and Tuong, Zewen Kelvin (2024). Single-cell immune repertoire analysis. Nature Methods, 21 (5), 777-792. doi: 10.1038/s41592-024-02243-4 |
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2024 Journal Article Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammationNg, Susanna S., De Labastida Rivera, Fabian, Yan, Juming, Corvino, Dillon, Das, Indrajit, Zhang, Ping, Kuns, Rachel, Chauhan, Shashi Bhushan, Hou, Jiajie, Li, Xian-Yang, Frame, Teija C. M., McEnroe, Benjamin A., Moore, Eilish, Na, Jinrui, Engel, Jessica A., Soon, Megan S. F., Singh, Bhawana, Kueh, Andrew J., Herold, Marco J., Montes de Oca, Marcela, Singh, Siddharth Sankar, Bunn, Patrick T., Aguilera, Amy Roman, Casey, Mika, Braun, Matthias, Ghazanfari, Nazanin, Wani, Shivangi, Wang, Yulin, Amante, Fiona H. ... Engwerda, Christian R. (2024). Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nature Immunology, 25 (4), 716-716. doi: 10.1038/s41590-024-01770-8 |
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2023 Journal Article Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsetsDooley, Nicholas L., Chabikwa, Tinashe G., Pava, Zuleima, Loughland, Jessica R., Hamelink, Julianne, Berry, Kiana, Andrew, Dean, Soon, Megan S. F., SheelaNair, Arya, Piera, Kim A., William, Timothy, Barber, Bridget E., Grigg, Matthew J., Engwerda, Christian R., Lopez, J. Alejandro, Anstey, Nicholas M. and Boyle, Michelle J. (2023). Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets. Nature Communications, 14 (1) 7387, 1-22. doi: 10.1038/s41467-023-43181-7 |
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2023 Journal Article Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasitesLansink, Lianne I. M., Skinner, Oliver P., Engel, Jessica A., Lee, Hyun Jae, Soon, Megan S. F., Williams, Cameron G., SheelaNair, Arya, Pernold, Clara P. S., Laohamonthonkul, Pawat, Akter, Jasmin, Stoll, Thomas, Hill, Michelle M., Talman, Arthur M., Russell, Andrew, Lawniczak, Mara, Jia, Xiaoxiao, Chua, Brendon, Anderson, Dovile, Creek, Darren J., Davenport, Miles P., Khoury, David S. and Haque, Ashraful (2023). Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites. mBio, 14 (4). doi: 10.1128/mbio.01129-23 |
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2020 Journal Article The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammationNg, Susanna S., De Labastida Rivera, Fabian, Yan, Juming, Corvino, Dillon, Das, Indrajit, Zhang, Ping, Kuns, Rachel, Chauhan, Shashi Bhushan, Hou, Jiajie, Li, Xian-Yang, Frame, Teija C. M., McEnroe, Benjamin A., Moore, Eilish, Na, Jinrui, Engel, Jessica A., Soon, Megan S. F., Singh, Bhawana, Kueh, Andrew J., Herold, Marco J., Montes de Oca, Marcela, Singh, Siddharth Sankar, Bunn, Patrick T., Aguilera, Amy Roman, Casey, Mika, Braun, Matthias, Ghazanfari, Nazanin, Wani, Shivangi, Wang, Yulin, Amante, Fiona H. ... Engwerda, Christian R. (2020). The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nature Immunology, 21 (10), 1205-1218. doi: 10.1038/s41590-020-0758-6 |
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2020 Journal Article Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memorySoon, Megan S. F., Lee, Hyun Jae, Engel, Jessica A., Straube, Jasmin, Thomas, Bryce S., Pernold, Clara P. S., Clarke, Lachlan S., Laohamonthonkul, Pawat, Haldar, Rohit N., Williams, Cameron G., Lansink, Lianne I. M., Moreira, Marcela L., Bramhall, Michael, Koufariotis, Lambros T., Wood, Scott, Chen, Xi, James, Kylie R., Lönnberg, Tapio, Lane, Steven W., Belz, Gabrielle T., Engwerda, Christian R., Khoury, David S., Davenport, Miles P., Svensson, Valentine, Teichmann, Sarah A. and Haque, Ashraful (2020). Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory. Nature Immunology, 21 (12), 1597-1610. doi: 10.1038/s41590-020-0800-8 |
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2019 Journal Article NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsionLam, Pui Yeng, Kobayashi, Takumi, Soon, Megan, Zeng, Bijun, Dolcetti, Riccardo, Leggatt, Graham, Thomas, Ranjeny and Mattarollo, Stephen R. (2019). NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion. Cancer Immunology Research, 7 (6), 952-962. doi: 10.1158/2326-6066.cir-18-0650 |
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2019 Journal Article Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cellsAkter, Jasmin, Khoury, David S., Aogo, Rosemary, Lansink, Lianne I. M., SheelaNair, Arya, Thomas, Bryce S., Laohamonthonkul, Pawat, Pernold, Clara P. S., Dixon, Matthew W. A., Soon, Megan S. F., Fogg, Lily G., Engel, Jessica A., Elliott, Trish, Sebina, Ismail, James, Kylie R., Cromer, Deborah, Davenport, Miles P. and Haque, Ashraful (2019). Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells. PLoS Pathogens, 15 (2) e1007599, e1007599. doi: 10.1371/journal.ppat.1007599 |
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2018 Journal Article Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in miceAogo, Rosemary A., Khoury, David S., Cromer, Deborah, Elliott, Trish, Akter, Jasmin, Fogg, Lily G., Nair, Arya Sheela, Liligeto, Urijah N., Soon, Megan S. F., Thomas, Bryce S., Pernold, Clara P. S., Romanczuk, Aleksandra S., Laohamonthonkul, Pawat, Haque, Ashraful and Davenport, Miles P. (2018). Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in mice. International Journal for Parasitology, 48 (12), 903-913. doi: 10.1016/j.ijpara.2018.05.010 |
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2018 Journal Article Therapeutic vaccination with 4–1BB co-stimulation eradicates mouse acute myeloid leukemiaKerage, Daniel, Soon, Megan S. F., Doff, Brianna L., Kobayashi, Takumi, Nissen, Michael D., Lam, Pui Yeng, Leggatt, Graham R. and Mattarollo, Stephen R. (2018). Therapeutic vaccination with 4–1BB co-stimulation eradicates mouse acute myeloid leukemia. OncoImmunology, 7 (10) e1486952, 1-10. doi: 10.1080/2162402x.2018.1486952 |
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2018 Journal Article Recent insights into CD4 Th cell differentiation in malariaSoon, Megan S F and Haque, Ashraful (2018). Recent insights into CD4 Th cell differentiation in malaria. Journal of Immunology, 200 (6), 1965-1975. doi: 10.4049/jimmunol.1701316 |
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2018 Journal Article IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infectionJames, Kylie R., Soon, Megan S. F., Sebina, Ismail, Fernandez-Ruiz, Daniel, Davey, Gayle, Liligeto, Urijah N., Nair, Arya Sheela, Fogg, Lily G., Edwards, Chelsea L., Best, Shannon E., Lansink, Lianne I. M., Schroder, Kate, Wilson, Jane A. C., Austin, Rebecca, Suhrbier, Andreas, Lane, Steven W., Hill, Geoffrey R., Engwerda, Christian R., Heath, William R. and Haque, Ashraful (2018). IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection. Journal of Immunology, 200 (4), 1443-1456. doi: 10.4049/jimmunol.1700782 |
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2018 Journal Article B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activityMcKee, Sara J., Tuong, Zewen K., Kobayashi, Takumi, Doff, Brianna L., Soon, Megan S. F ., Nissen, Michael, Lam, Pui Yeng, Keane, Colm, Vari, Frank, Moi, Davide, Mazzieri, Roberta, Leggatt, Graham, Gandhi, Maher K. and Mattarollo, Stephen R. (2018). B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity. OncoImmunology, 7 (2) e1393599, e1393599. doi: 10.1080/2162402X.2017.1393599 |
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2017 Journal Article Development of a novel CD4+ TCR transgenic line that reveals a dominant role for CD8+ dendritic cells and CD40 signaling in the generation of helper and CTL responses to blood-stage malariaFernandez-Ruiz, Daniel, Lau, Lei Shong, Ghazanfari, Nazanin, Jones, Claerwen M., Ng, Wei Yi, Davey, Gayle M., Berthold, Dorothee, Holz, Lauren, Kato, Yu, Enders, Matthias H., Bayarsaikhan, Ganchimeg, Hendriks, Sanne H., Lansink, Lianne I. M., Engel, Jessica A., Soon, Megan S. F., James, Kylie R., Cozijnsen, Anton, Mollard, Vanessa, Uboldi, Alessandro D., Tonkin, Christopher J., de Koning-Ward, Tania F., Gilson, Paul R., Kaisho, Tsuneyasu, Haque, Ashraful, Crabb, Brendan S., Carbone, Francis R., McFadden, Geoffrey I. and Heath, William R. (2017). Development of a novel CD4+ TCR transgenic line that reveals a dominant role for CD8+ dendritic cells and CD40 signaling in the generation of helper and CTL responses to blood-stage malaria. The Journal of Immunology, 199 (12), 4165-4179. doi: 10.4049/jimmunol.1700186 |
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2017 Journal Article Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivoKhoury, David S., Cromer, Deborah, Elliott, Trish, Soon, Megan S. F., Thomas, Bryce S., James, Kylie R., Best, Shannon E., Aogo, Rosemary A., Engel, Jessica A., Gartlan, Kate H., Akter, Jasmin, Sebina, Ismail, Haque, Ashraful and Davenport, Miles P. (2017). Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo. International Journal for Parasitology, 47 (14), 913-922. doi: 10.1016/j.ijpara.2017.05.009 |
