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2025

Journal Article

A contemporary narrative review of sodium homeostasis mechanisms, dysnatraemia, and the clinical relevance in adult critical illness

Raman, Vignesh, Ramanan, Mahesh, Edwards, Felicity and Laupland, Kevin B. (2025). A contemporary narrative review of sodium homeostasis mechanisms, dysnatraemia, and the clinical relevance in adult critical illness. Journal of Clinical Medicine, 14 (19) 6914, 1-14. doi: 10.3390/jcm14196914

A contemporary narrative review of sodium homeostasis mechanisms, dysnatraemia, and the clinical relevance in adult critical illness

2025

Journal Article

The dawn of target trials in Intensive Care: time to move beyond association is not causation. Authors’ reply

Blank, Sebastiaan Paul, Blank, Ruth Miriam, Laupland, Kevin B., White, Kyle C. and Ramanan, Mahesh (2025). The dawn of target trials in Intensive Care: time to move beyond association is not causation. Authors’ reply. Intensive Care Medicine, 51 (9), 1734-1735. doi: 10.1007/s00134-025-08018-5

The dawn of target trials in Intensive Care: time to move beyond association is not causation. Authors’ reply

2025

Journal Article

Sodium bicarbonate in critical illness: targeted or too broad? Author’s reply

Blank, Ruth Miriam, Blank, Sebastiaan Paul, Laupland, Kevin B., White, Kyle C. and Ramanan, Mahesh (2025). Sodium bicarbonate in critical illness: targeted or too broad? Author’s reply. Intensive Care Medicine, 51 (10), 1-2. doi: 10.1007/s00134-025-08091-w

Sodium bicarbonate in critical illness: targeted or too broad? Author’s reply

2025

Journal Article

Sodium bicarbonate administration for metabolic acidosis in the intensive care unit: a target trial emulation

Blank, Sebastiaan Paul, Blank, Ruth Miriam, Laupland, Kevin B., Tabah, Alexis, Gill, Denzil, Kumar, Aashish, White, Kyle, Attokaran, Antony, Luke, Stephen, Whebell, Stephen, Garrett, Peter, McCullough, James, McIlroy, Philippa, Ramanan, Mahesh, Keogh, Sam, Tyack, Zephanie, Gatton, Michelle, Nash, Ben, Blank, Sebastiaan, Dash, Sananta, Senthuran, Siva, Smart, Christopher, Taylor, Jennifer, Paasilahti, Anni, Reoch, Josephine, Poggenpoel, Jaco, Attokaran, Antony G., Anderson, Cameron, Lutshaba, Langa ... on behalf of the Queensland Critical Care Research Network (QCCRN) (2025). Sodium bicarbonate administration for metabolic acidosis in the intensive care unit: a target trial emulation. Intensive Care Medicine, 51 (6), 1078-1086. doi: 10.1007/s00134-025-07979-x

Sodium bicarbonate administration for metabolic acidosis in the intensive care unit: a target trial emulation

2025

Journal Article

The impact of critical illness on the outcomes of cardiac surgery in patients with acute infective endocarditis

Matebele, Mbakise P., Vemuri, Kanthi R., Sedgwick, John F., Marshall, Lachlan, Horvath, Robert, Obonyo, Nchafatso G. and Ramanan, Mahesh (2025). The impact of critical illness on the outcomes of cardiac surgery in patients with acute infective endocarditis. Hearts, 6 (2) 15, 1-14. doi: 10.3390/hearts6020015

The impact of critical illness on the outcomes of cardiac surgery in patients with acute infective endocarditis

2025

Journal Article

A randomised, controlled, feasibility trial comparing vasopressors infused via peripheral cannula versus central venous access for critically ill adults: the VIPCA trial

Ramanan, Mahesh, Apte, Yogesh, Watts, Stacey, Holland, Thomas, Hatt, April, Craswell, Alison, Lin, Frances, Tabah, Alexis, Ware, Robert S., Byrnes, Joshua, Anstey, Christopher and Keijzers, Gerben (2025). A randomised, controlled, feasibility trial comparing vasopressors infused via peripheral cannula versus central venous access for critically ill adults: the VIPCA trial. Critical Care and Resuscitation, 27 (2) 100106, 1-8. doi: 10.1016/j.ccrj.2025.100106

A randomised, controlled, feasibility trial comparing vasopressors infused via peripheral cannula versus central venous access for critically ill adults: the VIPCA trial

2025

Journal Article

Prevalence and characteristics of metaraminol usage in a large intensive care patient cohort. A multicentre, retrospective, observational study

Zimsen, Tarren, Quick, Lachlan, White, Gentry, Costa-Pinto, Rahul, Whebell, Stephen, Meyer, Jason, McCullough, James, Shekar, Kiran, Laupland, Kevin B., Ramanan, Mahesh, Blank, Sebastiaan, Tabah, Alexis, Luke, Stephen, Garrett, Peter, Attokaran, Antony G., Kumar, Aashish and White, Kyle C. (2025). Prevalence and characteristics of metaraminol usage in a large intensive care patient cohort. A multicentre, retrospective, observational study. Critical Care and Resuscitation, 27 (2) 100112, 100112. doi: 10.1016/j.ccrj.2025.100112

Prevalence and characteristics of metaraminol usage in a large intensive care patient cohort. A multicentre, retrospective, observational study

2025

Journal Article

Impact of frailty on outcomes after cardiac surgery

Ahuja, Abhilasha, Baker, Thomas and Ramanan, Mahesh (2025). Impact of frailty on outcomes after cardiac surgery. Journal of Thoracic and Cardiovascular Surgery, 169 (6), 1787-1794.e9. doi: 10.1016/j.jtcvs.2024.05.025

Impact of frailty on outcomes after cardiac surgery

2025

Journal Article

Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage: Protocol for an international, phase 3, randomised, placebo-controlled, multicentre trial

Cohen, Jeremy, Delaney, Anthony, Udy, Andrew, Andersen, Christopher, Anderson, Craig S., Bellapart, Judith, Burrell, Louise M., Devaux, Anthony, Evans, David M., Fitzgerald, Emily, Garside, Tessa, Hammond, Naomi, Hardie, Miranda, Jeffree, Rosalind L., Knowles, Serena, Lassig-Smith, Melissa, Li, Qiang, Nethathe, Gladness, Rajbhandari, Dorrilyn, Ramanan, Mahesh, Talbot, Philip, Taylor, Colman, Wright, Jason, Young, Morag J., Young, Paul J. and Venkatesh, Balasubramanian (2025). Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage: Protocol for an international, phase 3, randomised, placebo-controlled, multicentre trial. Critical Care and Resuscitation, 27 (2) 100116, 1-7. doi: 10.1016/j.ccrj.2025.100116

Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage: Protocol for an international, phase 3, randomised, placebo-controlled, multicentre trial

2025

Journal Article

Predicting a strongly positive fluid balance in critically ill patients with acute kidney injury: a multicentre, international study

White, Kyle C., Bellomo, Rinaldo, Laupland, Kevin B., Gatton, Michelle L., Ostermann, Marlies, McIlroy, Philipa, Luke, Stephen, Garrett, Peter, Tabah, Alexis, Whebell, Stephen, Marella, Prashanti, McCullough, James, Shekar, Kiran, Attokaran, Antony G., Kumar, Aashish, Meyer, Jason, Sanderson, Barnaby, Serpa-Neto, Ary, Ramanan, Mahesh, Marella, Prashanti, Young, Patrick, McIlroy, Phillipa, Nash, Ben, McCullough, James, Denny, Kerina J., Tallott, Mandy, Marshall, Andrea, Moore, David, White, Hayden ... on behalf of the Queensland Critical Care Research Network (QCCRN) (2025). Predicting a strongly positive fluid balance in critically ill patients with acute kidney injury: a multicentre, international study. Journal of Critical Care, 87 155016, 1-9. doi: 10.1016/j.jcrc.2025.155016

Predicting a strongly positive fluid balance in critically ill patients with acute kidney injury: a multicentre, international study

2025

Journal Article

Respiratory syncytial virus infection in adult and paediatric patients admitted to intensive care in Australia: a nation-wide comparison with COVID-19

Tang, Yaodong, Zhao, Peinan, Cheng, Allen C., Ibrahim, Aaliya, Hassall, Jenna, Litton, Edward, Andersen, Christopher R., Liang, Cindy, Milford, Elissa M., Rose, Morgan, Plummer, Mark, Kong, Jing, Johnson, Kerry, Bihari, Shailesh, Chaba, Anis, Begum, Husna, Cruz, Sherene Magana, Ng, Sze, Trapani, Tony, Campbell, Lewis, Ramanan, Mahesh, McAllister, Richard, Chumbes, Jenipher, Erickson, Simon, Kol, Mark, Cheung, Winston, Udy, Andrew A. and Burrell, Aidan (2025). Respiratory syncytial virus infection in adult and paediatric patients admitted to intensive care in Australia: a nation-wide comparison with COVID-19. Critical Care and Resuscitation, 27 (2) 100113, 1-7. doi: 10.1016/j.ccrj.2025.100113

Respiratory syncytial virus infection in adult and paediatric patients admitted to intensive care in Australia: a nation-wide comparison with COVID-19

2025

Journal Article

Higher versus lower mean arterial blood pressure after cardiac arrest and resuscitation (MAP‐CARE): A protocol for a randomized clinical trial

Niemelä, V. H., Reinikainen, M., Nielsen, N., Bass, F., Young, P., Lilja, G., Dankiewicz, J., Hammond, N., Hästbacka, J., Levin, H., Moseby‐Knappe, M., Saxena, M., Tiainen, M., Ceric, A., Holgersson, J., Kamp, C. B., Tirkkonen, J., Oksanen, T., Kaakinen, T., Bendel, S., Düring, J., Lybeck, A., Johnsson, J., Unden, J., Lundin, A., Kåhlin, J., Grip, J., Lotman, E., Romundstad, L. ... Skrifvars, M. B. (2025). Higher versus lower mean arterial blood pressure after cardiac arrest and resuscitation (MAP‐CARE): A protocol for a randomized clinical trial. Acta Anaesthesiologica Scandinavica, 69 (6) e70040, 1-11. doi: 10.1111/aas.70040

Higher versus lower mean arterial blood pressure after cardiac arrest and resuscitation (MAP‐CARE): A protocol for a randomized clinical trial

2025

Journal Article

Effect of early adjunctive vasopressin initiation for septic shock patients: a target trial emulation

White, Kyle C., Costa-Pinto, Rahul, Blank, Sebastiaan, Whebell, Stephen, Quick, Lachlan, Luke, Stephen, Attokaran, Antony G., Garrett, Peter, Ramanan, Mahesh, Tabah, Alexis, Shekar, Kiran, Laupland, Kevin B., Kumar, Aashish, McCullough, James, Udy, Andrew, Eastwood, Glenn, Bellomo, Rinaldo, Chaba, Anis, the Queensland Critical Care Research Network (QCCRN), Ramanan, Mahesh, Marella, Prashanti, Young, Patrick, McIlroy, Phillipa, Nash, Ben, McCullough, James, Denny, Kerina J., Tallott, Mandy, Marshall, Andrea, Moore, David ... Keogh, Sam (2025). Effect of early adjunctive vasopressin initiation for septic shock patients: a target trial emulation. Critical Care, 29 (1) 188, 1-10. doi: 10.1186/s13054-025-05401-y

Effect of early adjunctive vasopressin initiation for septic shock patients: a target trial emulation

2025

Journal Article

Tracking outcomes post intensive care: findings of a longitudinal observational study

Flaws, Dylan, Tronstad, Oystein, Fraser, John F., Lavana, Jayshree, Laupland, Kevin B., Ramanan, Mahesh, Tabah, Alexis and Patterson, Sue (2025). Tracking outcomes post intensive care: findings of a longitudinal observational study. Australian Critical Care, 38 (3) 101164, 1-8. doi: 10.1016/j.aucc.2024.101164

Tracking outcomes post intensive care: findings of a longitudinal observational study

2025

Journal Article

Continuous deep sedation versus minimal sedation after cardiac arrest and resuscitation (SED-CARE): A protocol for a randomized clinical trial

Ceric, A., Dankiewicz, J., Hästbacka, J., Young, P., Niemelä, V. H., Bass, F., Skrifvars, M. B., Hammond, N., Saxena, M., Levin, H., Lilja, G., Moseby-Knappe, M., Tiainen, M., Reinikainen, M., Holgersson, J., Kamp, C. B., Wise, M. P., McGuigan, P. J., White, J., Sweet, K., Keeble, T. R., Glover, G., Hopkins, P., Remmington, C., Cole, J. M., Gorgoraptis, N., Pogson, D. G., Jackson, P., Düring, J. ... Nielsen, N. (2025). Continuous deep sedation versus minimal sedation after cardiac arrest and resuscitation (SED-CARE): A protocol for a randomized clinical trial. Acta Anaesthesiologica Scandinavica, 69 (5) e70022, 1-13. doi: 10.1111/aas.70022

Continuous deep sedation versus minimal sedation after cardiac arrest and resuscitation (SED-CARE): A protocol for a randomized clinical trial

2025

Journal Article

Fever management with or without a temperature control device after out‐of‐hospital cardiac arrest and resuscitation (TEMP‐CARE): A study protocol for a randomized clinical trial

Holgersson, Johan, Niemelä, V., Skrifvars, M. B., Kamp‐Jorgensen, C., Saxena, M., Young, P., Bass, F., Dankiewicz, J., Hammond, N., Hästbacka, J., Levin, H., Lilja, G., Moseby‐Knappe, M., Tiainen, M., Reinikainen, M., Ceric, A., Düring, J., Lybeck, A., Rodriguez‐Santos, D., Johnsson, J., Unden, J., Lundin, A., Kåhlin, J., Grip, J., Rosell, J., Lotman, E. M., Navarra, L., Crichton, B., Knight, D. ... Nielsen, N. (2025). Fever management with or without a temperature control device after out‐of‐hospital cardiac arrest and resuscitation (TEMP‐CARE): A study protocol for a randomized clinical trial. Acta Anaesthesiologica Scandinavica, 69 (5) e70034, 1-12. doi: 10.1111/aas.70034

Fever management with or without a temperature control device after out‐of‐hospital cardiac arrest and resuscitation (TEMP‐CARE): A study protocol for a randomized clinical trial

2025

Journal Article

Research priorities for diabetic ketoacidosis: an evidence and gap mapping review

Sieben, Nicolas and Ramanan, Mahesh (2025). Research priorities for diabetic ketoacidosis: an evidence and gap mapping review. Medical Sciences, 13 (2) 53, 53-2. doi: 10.3390/medsci13020053

Research priorities for diabetic ketoacidosis: an evidence and gap mapping review

2025

Journal Article

Frailty and long-term survival in patients with critical illness after nonhome discharge: A retrospective cohort study

Mehta, Hardik, Ling, Ryan Ruiyang, Ramanan, Mahesh, Bartlett, Catherine, Grewal, Jatinder, Gupta, Kshityj, Reynolds, James, Kumar, Aashish, Marella, Prashanti, Pilcher, David, Shah, Nilesh, Shekar, Kiran and Subramaniam, Ashwin (2025). Frailty and long-term survival in patients with critical illness after nonhome discharge: A retrospective cohort study. Critical Care Medicine, 53 (7), e1402-e1415. doi: 10.1097/ccm.0000000000006684

Frailty and long-term survival in patients with critical illness after nonhome discharge: A retrospective cohort study

2025

Journal Article

Waiting to be discharged from intensive care units: Key factors shaping patient and family experiences

Chen, Yingyan, Peet, Jacqueline, Murray, Lauren, Ramanan, Mahesh, Jacobs, Kylie, Brailsford, Jane, Osmond, Amelia, Kajevu, Moreblessing, Garrett, Peter, Tabah, Alexis, Mock, Carol and Lin, Frances Fengzhi (2025). Waiting to be discharged from intensive care units: Key factors shaping patient and family experiences. Intensive and Critical Care Nursing, 87 103961, 1-7. doi: 10.1016/j.iccn.2025.103961

Waiting to be discharged from intensive care units: Key factors shaping patient and family experiences

2025

Journal Article

In-hospital mortality in patients admitted to Australian intensive care units with COVID-19 between 2020 and 2024

Donnan, Matthew T., Zhao, Peinan, Cheng, Allen C., Ibrahim, Aaliya, Palermo, Annamaria, Reddi, Benjamin, Reynolds, Claire, French, Craig, Litton, Edward, Rotherham, Hannah, Begum, Husna, Cooper, Jamie, Dumbrell, Jodi, Campbell, Lewis, Plummer, Mark, Ramanan, Mahesh, Alliegro, Patricia, McAllister, Richard E., Erickson, Simon, Priyadarshini, Shweta, Ng, Sze, Broadley, Tessa, Trapani, Tony, Papanikolaou, Vicki, Cheung, Winston, Udy, Andrew A. and Burrell, Aidan (2025). In-hospital mortality in patients admitted to Australian intensive care units with COVID-19 between 2020 and 2024. Critical Care and Resuscitation, 27 (1) 100094, 100094. doi: 10.1016/j.ccrj.2024.11.003

In-hospital mortality in patients admitted to Australian intensive care units with COVID-19 between 2020 and 2024