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2025

Journal Article

Innate immune sensors and cell death—frontiers coordinating homeostasis, immunity, and inflammation in skin

Soe, Ye Mon, Sim, Seen Ling and Kumari, Snehlata (2025). Innate immune sensors and cell death—frontiers coordinating homeostasis, immunity, and inflammation in skin. Viruses, 17 (2) 241. doi: 10.3390/v17020241

Innate immune sensors and cell death—frontiers coordinating homeostasis, immunity, and inflammation in skin

2024

Journal Article

Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium

Zhao, Jilai, Sormani, Laura, Jacquelin, Sebastien, Li, Haiming, Styke, Cassandra, Zhou, Chenhao, Beesley, Jonathan, Oon, Linus, Kaur, Simranpreet, Sim, Seen-Ling, Wong, Ho Yi, Dight, James, Hashemi, Ghazaleh, Shafiee, Abbas, Roy, Edwige, Patel, Jatin and Khosrotehrani, Kiarash (2024). Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium. Angiogenesis, 27 (3), 1-16. doi: 10.1007/s10456-024-09927-7

Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium

2023

Other Outputs

Deciphering the influence of macrophages on endothelial progenitors

Sim, Seen Ling (2023). Deciphering the influence of macrophages on endothelial progenitors. PhD Thesis, Frazer Institute, The University of Queensland. doi: 10.14264/3483871

Deciphering the influence of macrophages on endothelial progenitors

2023

Conference Publication

1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling

Sim, S., Kaur, S., Styke, C., Millard, S., Blumenthal, A., Pettit, A. and Khosrotehrani, K. (2023). 1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling. 1st International Societies for Investigative Dermatology Meeting, Tokyo, Japan, 10 - 13 May 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2023.03.1528

1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling

2023

Conference Publication

PDGFRA-expressing endovascular progenitors contribute to differentiated endothelium of aorta and wounds

Styke, C., Kaur, S., Sim, S., Zhao, J., Shafiee, A., Zhou, C., Wong, H. and Khosrotehrani, K. (2023). PDGFRA-expressing endovascular progenitors contribute to differentiated endothelium of aorta and wounds. 1st International Societies for Investigative Dermatology Meeting, Tokyo, Japan, 10 - 13 May 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2023.03.1476

PDGFRA-expressing endovascular progenitors contribute to differentiated endothelium of aorta and wounds

2022

Journal Article

Macrophages in skin wounds: functions and therapeutic potential

Sim, Seen Ling, Kumari, Snehlata, Kaur, Simranpreet and Khosrotehrani, Kiarash (2022). Macrophages in skin wounds: functions and therapeutic potential. Biomolecules, 12 (11) 1659, 1-31. doi: 10.3390/biom12111659

Macrophages in skin wounds: functions and therapeutic potential

2022

Journal Article

Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration

Sim, Seen Ling, Blumenthal, Antje, Kaur, Simranpreet and Khosrotehrani, Kiarash (2022). Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration. Frontiers in Endocrinology, 13 957833, 957833. doi: 10.3389/fendo.2022.957833

Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration

2022

Journal Article

High-yield isolation of pure fetal endothelial colony forming cells and mesenchymal stem cells from the human full-term placenta

Nano, Rachel, Sim, Seen Ling, Shafiee, Abbas, Khosrotehrani, Kiarash and Patel, Jatin (2022). High-yield isolation of pure fetal endothelial colony forming cells and mesenchymal stem cells from the human full-term placenta. STAR Protocols, 3 (2) 101354, 101354. doi: 10.1016/j.xpro.2022.101354

High-yield isolation of pure fetal endothelial colony forming cells and mesenchymal stem cells from the human full-term placenta

2021

Journal Article

Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn

Chand, Kirat K., Patel, Jatin, Bjorkman, S. T., Sim, Seen-Ling, Miller, Stephanie M., Teo, Elliot, Jones, Lara, Sun, Jane, Colditz, Paul B., Khosrotehrani, Kiarash and Wixey, Julie A. (2021). Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn. npj Regenerative Medicine, 6 (1) 75, 75. doi: 10.1038/s41536-021-00185-5

Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn

2021

Journal Article

Subtype specific analyses reveal infiltrative basal cell carcinoma are highly interactive with their environment

Villani, Rehan, Murigneux, Valentine, Alexis, Josue, Sim, Seen-Ling, Wagels, Michael, Saunders, Nicholas, Soyer, H. Peter, Parmentier, Laurent, Nikolaev, Sergey, Fink, J. Lynn, Roy, Edwige and Khosrotehrani, Kiarash (2021). Subtype specific analyses reveal infiltrative basal cell carcinoma are highly interactive with their environment. The Journal of Investigative Dermatology, 141 (10), 2380-2390. doi: 10.1016/j.jid.2021.02.760

Subtype specific analyses reveal infiltrative basal cell carcinoma are highly interactive with their environment

2021

Journal Article

Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors

Zhao, Jilai, Patel, Jatin, Kaur, Simranpreet, Sim, Seen-Ling, Wong, Ho Yi, Styke, Cassandra, Hogan, Isabella, Kahler, Sam, Hamilton, Hamish, Wadlow, Racheal, Dight, James, Hashemi, Ghazaleh, Sormani, Laura, Roy, Edwige, Yoder, Mervin C., Francois, Mathias and Khosrotehrani, Kiarash (2021). Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors. Nature Communications, 12 (1) 2564, 1-17. doi: 10.1038/s41467-021-22717-9

Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors

2020

Journal Article

Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal Progenitors

Roy, Edwige, Wong, Ho Yi, Villani, Rehan, Rouille, Thomas, Salik, Basit, Sim, Seen Ling, Murigneux, Valentine, Stark, Mitchell S., Fink, J. Lynn, Soyer, H. Peter, Walker, Graeme, Lyons, J. Guy, Saunders, Nicholas and Khosrotehrani, Kiarash (2020). Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal Progenitors. Cell Reports, 31 (9) 107702, 107702. doi: 10.1016/j.celrep.2020.107702

Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal Progenitors

2020

Journal Article

Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progression

Villani, Rehan, Sim, Seen Ling, Roy, Edwige, Wainwright, Brandon, Francois, Mathias and Khosrotehrani, Kiarash (2020). Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progression. Journal of Dermatological Science, 98 (3), 179-185. doi: 10.1016/j.jdermsci.2020.04.006

Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progression

2019

Journal Article

Single-cell transcriptional profiling of aortic endothelium identifies a hierarchy from endovascular progenitors to differentiated cells

Lukowski, Samuel W., Patel, Jatin, Andersen, Stacey B., Sim, Seen-Ling, Wong, Ho Yi, Tay, Joshua, Winkler, Ingrid, Powell, Joseph E. and Khosrotehrani, Kiarash (2019). Single-cell transcriptional profiling of aortic endothelium identifies a hierarchy from endovascular progenitors to differentiated cells. Cell Reports, 27 (9), 2748-2758. doi: 10.1016/j.celrep.2019.04.102

Single-cell transcriptional profiling of aortic endothelium identifies a hierarchy from endovascular progenitors to differentiated cells

2019

Journal Article

Abstract 576: Immunosuppression Agent Cyclosporine Reduces Self-Renewal and Vessel Regeneration Potentiation of Human Endothelial Colony Forming Cells

Sim, Seen-Ling, Alexis, Josue, Shafiee, Abbas, Khosrotehrani, Kiarash and Patel, Jatin (2019). Abstract 576: Immunosuppression Agent Cyclosporine Reduces Self-Renewal and Vessel Regeneration Potentiation of Human Endothelial Colony Forming Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 39 (Suppl_1). doi: 10.1161/atvb.39.suppl_1.576

Abstract 576: Immunosuppression Agent Cyclosporine Reduces Self-Renewal and Vessel Regeneration Potentiation of Human Endothelial Colony Forming Cells

2019

Journal Article

Endovascular progenitors infiltrate melanomas and differentiate towards a variety of vascular beds promoting tumor metastasis

Donovan, Prudence, Patel, Jatin, Dight, James, Wong, Ho Yi, Sim, Seen-Ling, Murigneux, Valentine, Francois, Mathias and Khosrotehrani, Kiarash (2019). Endovascular progenitors infiltrate melanomas and differentiate towards a variety of vascular beds promoting tumor metastasis. Nature Communications, 10 (1) 18, 18. doi: 10.1038/s41467-018-07961-w

Endovascular progenitors infiltrate melanomas and differentiate towards a variety of vascular beds promoting tumor metastasis

2019

Conference Publication

Cancer associated fibroblast profiling reveals endothelin signalling as a novel mediator of niche to tumour cross-talk in Basal Cell Carcinoma

Villani, R., Roy, E., Murigneux, V., Sim, S., Malapitan, C., Galbraith, J., Kapadia, S., Fink, L. and Khosrotehrani, K. (2019). Cancer associated fibroblast profiling reveals endothelin signalling as a novel mediator of niche to tumour cross-talk in Basal Cell Carcinoma. 49th Annual Meeting of the European Society for Dermatological Research (ESDR), Bordeaux, France, 18-21 September 2019. New York, NY United States: Elsevier. doi: 10.1016/j.jid.2019.07.507

Cancer associated fibroblast profiling reveals endothelin signalling as a novel mediator of niche to tumour cross-talk in Basal Cell Carcinoma

2019

Conference Publication

Changing endothelial cell fate in wound healing through modulation of Sox9 to reduce scarring

Patel, J., Hamilton, H., Kahler, S., Sim, S., Wong, H. and Khosrotehrani, K. (2019). Changing endothelial cell fate in wound healing through modulation of Sox9 to reduce scarring. 49th Annual Meeting of the European Society for Dermatological Research (ESDR), Bordeaux, France, 18-21 September, 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2019.07.628

Changing endothelial cell fate in wound healing through modulation of Sox9 to reduce scarring

2018

Journal Article

Immunosuppression agent cyclosporine reduces self-renewal and vessel regeneration potentiation of human endothelial colony forming cells: deleterious effect of cyclosporine on ECFC

Sim, Seen-Ling, Alexis, Josue, Roy, Edwige, Shafiee, Abbas, Khosrotehrani, Kiarash and Patel, Jatin (2018). Immunosuppression agent cyclosporine reduces self-renewal and vessel regeneration potentiation of human endothelial colony forming cells: deleterious effect of cyclosporine on ECFC. STEM CELLS Translational Medicine, 8 (2), 162-168. doi: 10.1002/sctm.18-0103

Immunosuppression agent cyclosporine reduces self-renewal and vessel regeneration potentiation of human endothelial colony forming cells: deleterious effect of cyclosporine on ECFC

2016

Conference Publication

Basal cell carcinoma development is promoted by ablation of the dermal papilla mesenchymal niche

Villani, R., Sim, S. L., Greaney, J., Wainwright, B. and Khosrotehrani, K. (2016). Basal cell carcinoma development is promoted by ablation of the dermal papilla mesenchymal niche. Asia-Pacific Combined Dermatology Research Conference 2016, Noosa, QLD, Australia, 25–28 August 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12584

Basal cell carcinoma development is promoted by ablation of the dermal papilla mesenchymal niche