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2023 Journal Article Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancerRamsay, Robert G., Whitehall, Vicki and Flood, Michael P. (2023). Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancer. Growth Factors, 41 (4), 179-191. doi: 10.1080/08977194.2023.2227274 |
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2023 Journal Article The therapeutic landscape for KRAS-Mutated colorectal cancersTria, Simon Manuel, Burge, Matthew E. and Whitehall, Vicki L. J. (2023). The therapeutic landscape for KRAS-Mutated colorectal cancers. Cancers, 15 (8) 2375, 2375. doi: 10.3390/cancers15082375 |
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2023 Journal Article The efficacy of using patient-derived organoids to predict treatment response in colorectal cancerSu, Chang, Olsen, Kelly A., Bond, Catherine E. and Whitehall, Vicki L. J. (2023). The efficacy of using patient-derived organoids to predict treatment response in colorectal cancer. Cancers, 15 (3) 805, 1-16. doi: 10.3390/cancers15030805 |
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2022 Conference Publication Proof of principle that loss of mismatch repair protein reduces tumor burden in mouse model of gastric cancerHuber, Anne, Dijkstra, Christine, Whitehall, Vicki, Ernst, Matthias and Eissmann, Moritz (2022). Proof of principle that loss of mismatch repair protein reduces tumor burden in mouse model of gastric cancer. AACR Special Conference: Tumor Immunology and Immunotherapy, Boston, MA United States, 21-24 October 2022. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/2326-6074.tumimm22-a49 |
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2022 Journal Article Comparative analysis of Illumina Mouse Methylation BeadChip and reduced-representation bisulfite sequencing for routine DNA methylation analysisFennell, Lochlan J., Hartel, Gunter, McKeone, Diane M., Bond, Catherine E., Kane, Alexandra, Leggett, Barbara A., Patch, Ann-Marie and Whitehall, Vicki L.J. (2022). Comparative analysis of Illumina Mouse Methylation BeadChip and reduced-representation bisulfite sequencing for routine DNA methylation analysis. Cell Reports Methods, 2 (11) 100323, 1-14. doi: 10.1016/j.crmeth.2022.100323 |
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2022 Journal Article Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progressionLuk, Ian Y., Jenkins, Laura J., Schoffer, Kael L., Ng, Irvin, Tse, Janson W. T., Mouradov, Dmitri, Kaczmarczyk, Stanislaw, Nightingale, Rebecca, Burrows, Allan D., Anderson, Robin L., Arango, Diego, Dopeso, Higinio, Croft, Larry, Richardson, Mark F., Sieber, Oliver M., Liao, Yang, Mooi, Jennifer K., Vukelic, Natalia, Reehorst, Camilla M., Afshar-Sterle, Shoukat, Whitehall, Vicki L. J., Fennell, Lochlan, Abud, Helen E., Tebbutt, Niall C., Phillips, Wayne A., Williams, David S., Shi, Wei, Mielke, Lisa A., Ernst, Matthias ... Mariadason, John M. (2022). Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression. Cell Death and Differentiation, 29 (11), 2288-2302. doi: 10.1038/s41418-022-01016-w |
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2021 Journal Article Global methylome scores correlate with histological subtypes of colorectal carcinoma and show different associations with common clinical and molecular featuresTurpín‐sevilla, María Del Carmen, Pérez‐sanz, Fernando, García‐solano, José, Sebastián‐león, Patricia, Trujillo‐santos, Javier, Carbonell, Pablo, Estrada, Eduardo, Tuomisto, Anne, Herruzo, Irene, Fennell, Lochlan J., Mäkinen, Markus J., Rodríguez‐braun, Edith, Whitehall, Vicki L. J., Conesa, Ana and Conesa‐zamora, Pablo (2021). Global methylome scores correlate with histological subtypes of colorectal carcinoma and show different associations with common clinical and molecular features. Cancers, 13 (20) 5165, 5165. doi: 10.3390/cancers13205165 |
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2021 Conference Publication Preclinical study of aspirin and regorafenib combination therapy for colorectal cancerSu, C., Bond, C., Fennell, L., Kerr, G., Jarde, T., Micati, D., Engel, R., Chan, W. H., Hlavca, S., Archer, S., Mcmurrick, P., Hammerlindl, H., Lim, F., Salik, B., Mckeone, D., Hartel, G., Leggett, B., Schaider, H., Abud, H., Boyle, G., Burge, M. and Whitehall, V. (2021). Preclinical study of aspirin and regorafenib combination therapy for colorectal cancer. GESA AGW 2021, Online, 4 - 12 September 2021. HOBOKEN: WILEY. |
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2021 Journal Article Braf mutation induces rapid neoplastic transformation in the aged and aberrantly methylated intestinal epitheliumFennell, Lochlan, Kane, Alexandra, Liu, Cheng, McKeone, Diane, Hartel, Gunter, Su, Chang, Bond, Catherine, Bettington, Mark, Leggett, Barbara and Whitehall, Vicki (2021). Braf mutation induces rapid neoplastic transformation in the aged and aberrantly methylated intestinal epithelium. Gut, 71 (6) 322166, 1127-1140. doi: 10.1136/gutjnl-2020-322166 |
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2021 Journal Article Association of Fusobacterium nucleatum with specific T-cell subsets in the colorectal carcinoma microenvironmentBorowsky, Jennifer, Haruki, Koichiro, Lau, Mai Chan, Costa, Andressa Dias, Vayrynen, Juha P., Ugai, Tomotaka, Arima, Kota, Da Silva, Annacarolina, Felt, Kristen D., Zhao, Melissa, Gurjao, Carino, Twombly, Tyler S., Fujiyoshi, Kenji, Vayrynen, Sara A., Hamada, Tsuyoshi, Mima, Kosuke, Bullman, Susan, Harrison, Tabitha A., Phipps, Amanda I., Peters, Ulrike, Ng, Kimmie, Meyerhardt, Jeffrey A., Song, Mingyang, Giovannucci, Edward L., Wu, Kana, Zhang, Xuehong, Freeman, Gordon J., Huttenhower, Curtis, Garrett, Wendy S. ... Ogino, Shuji (2021). Association of Fusobacterium nucleatum with specific T-cell subsets in the colorectal carcinoma microenvironment. Clinical Cancer Research, 27 (10), 2816-2826. doi: 10.1158/1078-0432.CCR-20-4009 |
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2021 Journal Article Aspirin reduces the incidence of metastasis in a pre-clinical study of Braf mutant serrated colorectal neoplasiaKane, Alexandra M., Liu, Cheng, Fennell, Lochlan J., McKeone, Diane M., Bond, Catherine E., Pollock, Pamela M., Young, Graeme, Leggett, Barbara A. and Whitehall, Vicki L. J. (2021). Aspirin reduces the incidence of metastasis in a pre-clinical study of Braf mutant serrated colorectal neoplasia. British Journal of Cancer, 124 (11), 1820-1827. doi: 10.1038/s41416-021-01339-4 |
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2021 Journal Article Curcumin chemoprevention reduces the incidence of Braf mutant colorectal cancer in a preclinical studyKane, Alexandra M., Liu, Cheng, Akhter, Dewan T., McKeone, Diane M., Bell, Craig A., Thurecht, Kristofer J., Leggett, Barbara A. and Whitehall, Vicki L. J. (2021). Curcumin chemoprevention reduces the incidence of Braf mutant colorectal cancer in a preclinical study. Digestive Diseases and Sciences, 66 (12), 4326-4332. doi: 10.1007/s10620-020-06752-y |
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2020 Journal Article PET imaging quantifying Ga-PSMA-11 uptake in metastatic colorectal cancerCuda, Tahleesa J., Riddell, Andrew D., Liu, Cheng, Whitehall, Vicki L., Borowsky, Jennifer, Wyld, David K., Burge, Matthew E., Ahern, Elizabeth, Griffin, Alison, Lyons, Nicholas J. R., Rose, Stephen E., Clark, David A., Stevenson, Andrew R. L., Hooper, John D., Puttick, Simon and Thomas, Paul A. (2020). PET imaging quantifying Ga-PSMA-11 uptake in metastatic colorectal cancer. The Journal of Nuclear Medicine, 61 (11), 1576-1579. doi: 10.2967/jnumed.119.233312 |
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2020 Journal Article Trends in epidemiology, treatment and molecular testing of metastatic colorectal cancer in a real‐world multi‐institution cohort studyKuchel, Anna, Ahern, Elizabeth, Collins, Stephanie, Whitehall, Vicki, Okano, Satomi, Pelecanos, Anita, Wyld, David, Eastgate, Melissa and Burge, Matthew (2020). Trends in epidemiology, treatment and molecular testing of metastatic colorectal cancer in a real‐world multi‐institution cohort study. Asia-Pacific Journal of Clinical Oncology, 17 (1) ajco.13420, 84-93. doi: 10.1111/ajco.13420 |
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2020 Journal Article APC mutation marks an aggressive subtype of BRAF mutant colorectal cancersFennell, Lochlan J., Kane, Alexandra, Liu, Cheng, McKeone, Diane, Fernando, Winnie, Su, Chang, Bond, Catherine, Jamieson, Saara, Dumenil, Troy, Patch, Ann-Marie, Kazakoff, Stephen H., Pearson, John V., Waddell, Nicola, Leggett, Barbara and Whitehall, Vicki L. J (2020). APC mutation marks an aggressive subtype of BRAF mutant colorectal cancers. Cancers, 12 (5) 1171, 1-26. doi: 10.3390/cancers12051171 |
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2020 Journal Article Traditional serrated adenoma-like lesions in patients with inflammatory bowel disease:Miller, Gregory C., Liu, Cheng, Bettington, Mark L., Leggett, Barbara, Whitehall, Vicki L.J. and Rosty, Christophe (2020). Traditional serrated adenoma-like lesions in patients with inflammatory bowel disease:. Human Pathology, 97, 19-28. doi: 10.1016/j.humpath.2019.12.005 |
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2020 Journal Article Alterations in signaling pathways that accompany spontaneous transition to malignancy in a mouse model of BRAF mutant microsatellite stable colorectal cancerKane, Alexandra M., Fennell, Lochlan J., Liu, Cheng, Borowsky, Jennifer, McKeone, Diane M., Bond, Catherine E., Kazakoff, Stephen, Patch, Ann-Marie, Koufariotis, Lambros T., Pearson, John, Waddell, Nicola, Leggett, Barbara A. and Whitehall, Vicki L.J. (2020). Alterations in signaling pathways that accompany spontaneous transition to malignancy in a mouse model of BRAF mutant microsatellite stable colorectal cancer. Neoplasia, 22 (2), 120-128. doi: 10.1016/j.neo.2019.12.002 |
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2019 Conference Publication Aspirin reduces the incidence of metastatic Braf mutant colorectal cancer in a preclinical trialKane, A., Mckeone, D., Liu, C., Borowsky, J., Leggett, B. and Whitehall, V. (2019). Aspirin reduces the incidence of metastatic Braf mutant colorectal cancer in a preclinical trial. HOBOKEN: WILEY. |
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2019 Conference Publication Intestinal epigenetic age and risk of sessile serrated adenoma progression to cancerFennell, L., Kane, A., Mckeone, D., Bond, C., Leggett, B. and Whitehall, V. (2019). Intestinal epigenetic age and risk of sessile serrated adenoma progression to cancer. HOBOKEN: WILEY. |
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2019 Journal Article BRAF V600E immunohistochemistry demonstrates that some sessile serrated lesions with adenomatous dysplasia may represent collision lesionsBettington, Mark, Liu, Cheng, Gill, Anthony, Walker, Neal, Leggett, Barbara, Whitehall, Vicki and Rosty, Christophe (2019). BRAF V600E immunohistochemistry demonstrates that some sessile serrated lesions with adenomatous dysplasia may represent collision lesions. Histopathology, 75 (1), 81-87. doi: 10.1111/his.13851 |
