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2025

Journal Article

A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection

Yeap, Hui Wen, Goh, Ghin Ray, Rosli, Safwah Nasuha, Pung, Hai Shin, Giogha, Cristina, Eng, Vik Ven, Pearson, Jaclyn S., Hartland, Elizabeth L. and Chen, Kaiwen W. (2025). A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection. The EMBO Journal, 44 (9), 2424-2445. doi: 10.1038/s44318-025-00412-5

A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection

2023

Journal Article

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

Garnish, Sarah E., Martin, Katherine R., Kauppi, Maria, Jackson, Victoria E., Ambrose, Rebecca, Eng, Vik Ven, Chiou, Shene, Meng, Yanxiang, Frank, Daniel, Crutchfield, Emma C. Tovey, Patel, Komal M., Jacobsen, Annette V., Atkin-Smith, Georgia K., Di Rago, Ladina, Doerflinger, Marcel, Horne, Christopher R., Hall, Cathrine, Young, Samuel N., Cook, Matthew, Athanasopoulos, Vicki, Vinuesa, Carola G., Lawlor, Kate E., Wicks, Ian P., Ebert, Gregor, Ng, Ashley P., Slade, Charlotte A., Pearson, Jaclyn S., Samson, Andre L., Silke, John ... Hildebrand, Joanne M. (2023). A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation. Nature Communications, 14 (1) 6046, 1-17. doi: 10.1038/s41467-023-41724-6

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

2022

Journal Article

Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death

Frank, Daniel, Garnish, Sarah E., Sandow, Jarrod J., Weir, Ashley, Liu, Lin, Clayer, Elise, Meza, Lizeth, Rashidi, Maryam, Cobbold, Simon A., Scutts, Simon R., Doerflinger, Marcel, Anderton, Holly, Lawlor, Kate E., Lalaoui, Najoua, Kueh, Andrew J., Eng, Vik Ven, Ambrose, Rebecca L., Herold, Marco J., Samson, Andre L., Feltham, Rebecca, Murphy, James M., Ebert, Gregor, Pearson, Jaclyn S. and Vince, James E. (2022). Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death. iScience, 25 (7) 104632, 1-29. doi: 10.1016/j.isci.2022.104632

Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death

2021

Journal Article

In vivo studies on Citrobacter rodentium and host cell death pathways

Eng, Vik Ven and Pearson, Jaclyn S. (2021). In vivo studies on Citrobacter rodentium and host cell death pathways. Current Opinion in Microbiology, 64, 60-67. doi: 10.1016/j.mib.2021.09.005

In vivo studies on Citrobacter rodentium and host cell death pathways

2021

Journal Article

An acetate‐yielding diet imprints an immune and anti‐microbial programme against enteric infection

Yap, Yu Anne, McLeod, Keiran H., McKenzie, Craig I., Gavin, Patrick G., Davalos‐Salas, Mercedes, Richards, James L., Moore, Robert J., Lockett, Trevor J., Clarke, Julie M., Eng, Vik Ven, Pearson, Jaclyn S., Hamilton‐Williams, Emma E., Mackay, Charles R. and Mariño, Eliana (2021). An acetate‐yielding diet imprints an immune and anti‐microbial programme against enteric infection. Clinical and Translational Immunology, 10 (1) e1233, e1233. doi: 10.1002/cti2.1233

An acetate‐yielding diet imprints an immune and anti‐microbial programme against enteric infection

2021

Journal Article

The diverse roles of RIP kinases in host-pathogen interactions

Eng, Vik Ven, Wemyss, Madeleine A. and Pearson, Jaclyn S. (2021). The diverse roles of RIP kinases in host-pathogen interactions. Seminars in Cell and Developmental Biology, 109, 125-143. doi: 10.1016/j.semcdb.2020.08.005

The diverse roles of RIP kinases in host-pathogen interactions