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2025 Journal Article Intradermal immunization with Plasmodium berghei late-arresting genetically attenuated sporozoites induces PD-L1 expression on regulatory macrophages and dendritic cellsvan Schuijlenburg, Roos, Naar, Chanel M., de Bes-Roeleveld, Helena M., Chevalley-Maurel, Séverine, Zigó, Lili A., Houlder, Emma L., Lambooij, Joost M., Baalbergen, Els, Roestenberg, Meta and Franke-Fayard, Blandine (2025). Intradermal immunization with Plasmodium berghei late-arresting genetically attenuated sporozoites induces PD-L1 expression on regulatory macrophages and dendritic cells. Scientific Reports, 15 (1) 43673, 1-15. doi: 10.1038/s41598-025-27588-4 |
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2025 Journal Article A Trojan horse: Chemical boosting of Plasmodium falciparum whole sporozoite vaccine immunogenicityNaar, Chanel Milène, van Schuijlenburg, Roos, van Meerbeek, Maarten, Almeida, Luís, van Leeuwen, Fijs W.B. and Roestenberg, Meta (2025). A Trojan horse: Chemical boosting of Plasmodium falciparum whole sporozoite vaccine immunogenicity. Biomedicine and Pharmacotherapy, 192 118666, 1-11. doi: 10.1016/j.biopha.2025.118666 |
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2025 Journal Article Early activation of lung CD8+ T cells after immunization with live plasmodium berghei malaria sporozoitesVan Schuijlenburg, Roos, Naar, Chanel, Van der Wees, Stefanie, Chevalley-Maurel, Severine, Duszenko, Nikolas, De Bes-Roeleveld, Laura, Iliopoulou, Eva, Houlder, Emma, Geurten, Fiona, Baalbergen, Els, Roestenberg, Meta and Franke-Fayard, Blandine (2025). Early activation of lung CD8+ T cells after immunization with live plasmodium berghei malaria sporozoites. Pathogens and Immunity, 10 (2), 46-68. doi: 10.20411/pai.v10i2.794 |
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2025 Journal Article Single immunization with genetically attenuated Pf∆mei2 (GA2) parasites by mosquito bite in controlled human malaria infection: a placebo-controlled randomized trialRoozen, Geert V. T., van Schuijlenburg, Roos, Hensen, Annefleur D. O., Koopman, Jan Pieter R., Lamers, Olivia A. C., Geurten, Fiona J. A., Sijtsma, Jeroen C., Baalbergen, Els, Janse, Jacqueline J., Chevalley-Maurel, Séverine, Naar, Chanel M., Bezemer, Sascha, Kroeze, Hans, van de Stadt, Huybert J. F., de Visser, Bram, Meij, Pauline, Tihaya, Mara S., Colstrup, Emil, Iliopoulou, Eva, de Bes-Roeleveld, Helena M., Wessels, Els, van der Stoep, M. Y. Eileen C., Janse, Chris J., Murugan, Rajagopal, Franke-Fayard, Blandine M. D. and Roestenberg, Meta (2025). Single immunization with genetically attenuated Pf∆mei2 (GA2) parasites by mosquito bite in controlled human malaria infection: a placebo-controlled randomized trial. Nature Medicine, 31 (1), 218-222. doi: 10.1038/s41591-024-03347-2 |
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2024 Journal Article Ageing of Plasmodium falciparum malaria sporozoites alters their motility, infectivity and reduces immune activation in vitrovan Schuijlenburg, Roos, Azargoshasb, Samaneh, de Korne, Clarize M, Sijtsma, Jeroen C, Bezemer, Sascha, van der Ham, Alwin J, Baalbergen, Els, Geurten, Fiona, de Bes-Roeleveld, Laura M, Chevalley-Maurel, Severine C, van Oosterom, Matthias N, van Leeuwen, Fijs W B, Franke-Fayard, Blandine and Roestenberg, Meta (2024). Ageing of Plasmodium falciparum malaria sporozoites alters their motility, infectivity and reduces immune activation in vitro. Malaria Journal, 23 (1) 111, 1-14. doi: 10.1186/s12936-024-04946-7 |
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2023 Journal Article Protective efficacy of short-term infection with Necator americanus hookworm larvae in healthy volunteers in the Netherlands: a single-centre, placebo-controlled, randomised, controlled, phase 1 trialHoogerwerf, Marie-Astrid, Janse, Jacqueline J., Kuiper, Vincent P., van Schuijlenburg, Roos, Kruize, Yvonne C. M., Sijtsma, Jeroen C., Nosoh, Beckley A., Koopman, Jan-Pieter R, Verbeek-Menken, Petra H, Westra, Inge M, Meij, Pauline, Brienen, Eric A. T., Visser, Leo G., van Lieshout, Lisette, Jochems, Simon P., Yazdanbakhsh, Maria and Roestenberg, Meta (2023). Protective efficacy of short-term infection with Necator americanus hookworm larvae in healthy volunteers in the Netherlands: a single-centre, placebo-controlled, randomised, controlled, phase 1 trial. The Lancet: Microbe, 4 (12), e1024-e1034. doi: 10.1016/S2666-5247(23)00218-5 |
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2023 Journal Article Causal chemoprophylactic activity of cabamiquine against Plasmodium falciparum in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the Netherlandsvan der Plas, Johan L., Kuiper, Vincent P., Bagchus, Wilhelmina M., Bödding, Matthias, Yalkinoglu, Özkan, Tappert, Aliona, Seitzinger, Andrea, Spangenberg, Thomas, Bezuidenhout, Deon, Wilkins, Justin, Oeuvray, Claude, Dhingra, Satish K., Thathy, Vandana, Fidock, David A., Smidt, Lisanne C. A., Roozen, Geert V. T., Koopman, Jan Pieter R., Lamers, Olivia A. C., Sijtsma, Jeroen, van Schuijlenburg, Roos, Wessels, Els, Meij, Pauline, Kamerling, Ingrid M. C., Roestenberg, Meta and Khandelwal, Akash (2023). Causal chemoprophylactic activity of cabamiquine against Plasmodium falciparum in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the Netherlands. The Lancet. Infectious diseases, 23 (10), 1164-1174. doi: 10.1016/S1473-3099(23)00212-8 |
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2023 Journal Article Chemically augmented malaria sporozoites display an altered immunogenic profileDuszenko, Nikolas, van Schuijlenburg, Roos, Chevalley-Maurel, Severine, van Willigen, Danny M., de Bes-Roeleveld, Laura, van der Wees, Stefanie, Naar, Chanel, Baalbergen, Els, Heieis, Graham, Bunschoten, Anton, Velders, Aldrik H., Franke-Fayard, Blandine, van Leeuwen, Fijs W. B. and Roestenberg, Meta (2023). Chemically augmented malaria sporozoites display an altered immunogenic profile. Frontiers in Immunology, 14 1204606, 1-14. doi: 10.3389/fimmu.2023.1204606 |
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2022 Journal Article Sporozoite motility as a quantitative readout for anti-CSP antibody inhibitionde Korne, C M, van Schuijlenburg, R, Sijtsma, J C, de Bes, H M, Baalbergen, E, Azargoshasb, S, van Oosterom, M N, McCall, M B B, van Leeuwen, F W B and Roestenberg, M (2022). Sporozoite motility as a quantitative readout for anti-CSP antibody inhibition. Scientific Reports, 12 (1) 17194, 1-11. doi: 10.1038/s41598-022-22154-8 |
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2021 Journal Article Latent CMV infection is associated with lower influenza virus-specific memory t-cell frequencies, but not with an impaired t-cell response to acute influenza virus infectionvan den Berg, Sara P H, Lanfermeijer, Josien, Jacobi, Ronald H J, Hendriks, Marion, Vos, Martijn, van Schuijlenburg, Roos, Nanlohy, Nening M, Borghans, José A M, van Beek, Josine, van Baarle, Debbie and de Wit, Jelle (2021). Latent CMV infection is associated with lower influenza virus-specific memory t-cell frequencies, but not with an impaired t-cell response to acute influenza virus infection. Frontiers in Immunology, 12 663664, 1-15. doi: 10.3389/fimmu.2021.663664 |
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2021 Journal Article A randomized controlled trial to investigate safety and variability of egg excretion after repeated controlled human hookworm infectionHoogerwerf, Marie-Astrid, Koopman, Jan Pieter R., Janse, Jacqueline J., Langenberg, Marijke C. C., van Schuijlenburg, Roos, Kruize, Yvonne C. M., Brienen, Eric A. T., Manurung, Mikhael D., Verbeek-Menken, Petra, van der Beek, Martha T., Westra, Inge M., Meij, Pauline, Visser, Leo G., van Lieshout, Lisette, de Vlas, Sake J., Yazdanbakhsh, Maria, Coffeng, Luc E. and Roestenberg, Meta (2021). A randomized controlled trial to investigate safety and variability of egg excretion after repeated controlled human hookworm infection. The Journal of Infectious Diseases, 223 (5), 905-913. doi: 10.1093/infdis/jiaa414 |
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2020 Journal Article Generation of a genetically modified chimeric Plasmodium falciparum parasite expressing Plasmodium vivax circumsporozoite protein for malaria vaccine DevelopmentMiyazaki, Yukiko, Marin-Mogollon, Catherin, Imai, Takashi, Mendes, António M, van der Laak, Rianne, Sturm, Angelika, Geurten, Fiona J A, Miyazaki, Shinya, Chevalley-Maurel, Severine, Ramesar, Jai, Kolli, Surendra K, Kroeze, Hans, van Schuijlenburg, Roos, Salman, Ahmed M, Wilder, Brandon K, Reyes-Sandoval, Arturo, Dechering, Koen J, Prudêncio, Miguel, Janse, Chris J, Khan, Shahid M and Franke-Fayard, Blandine (2020). Generation of a genetically modified chimeric Plasmodium falciparum parasite expressing Plasmodium vivax circumsporozoite protein for malaria vaccine Development. Frontiers in Cellular and Infection Microbiology, 10 591046, 1-14. doi: 10.3389/fcimb.2020.591046 |
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2020 Journal Article Plasmodium sporozoites induce regulatory macrophagesWinkel, Béatrice M F, Pelgrom, Leonard R, van Schuijlenburg, Roos, Baalbergen, Els, Ganesh, Munisha S, Gerritsma, Heleen, de Korne, Clarize M, Duszenko, Nikolas, Langenberg, Marijke C C, Chevalley-Maurel, Séverine C, Smits, Hermelijn H, de Jong, Esther C, Everts, Bart, Franke-Fayard, Blandine and Roestenberg, Meta (2020). Plasmodium sporozoites induce regulatory macrophages. PLoS Pathogens, 16 (9) e1008799, 1-24. doi: 10.1371/journal.ppat.1008799 |
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2020 Journal Article A supramolecular platform technology for bacterial cell surface modificationDuszenko, Nikolas, van Willigen, Danny M., Welling, Mick M, de Korne, Clarize M., van Schuijlenburg, Roos, Winkel, Beatrice M. F., van Leeuwen, Fijs W. B. and Roestenberg, Meta (2020). A supramolecular platform technology for bacterial cell surface modification. ACS Infectious Diseases, 6 (7), 1734-1744. doi: 10.1021/acsinfecdis.9b00523 |
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2020 Journal Article Antigen-based diagnosis of Schistosoma infection in travellers: a prospective studyCasacuberta-Partal, Miriam, Janse, Jacqueline J, van Schuijlenburg, Roos, de Vries, Jutte J C, Erkens, Marianne A A, Suijk, Kitty, van Aalst, Mariëlle, Maas, Jaap J, Grobusch, Martin P, van Genderen, Perry J J, de Dood, Claudia, Corstjens, Paul L A M, van Dam, Govert J, van Lieshout, Lisette and Roestenberg, Meta (2020). Antigen-based diagnosis of Schistosoma infection in travellers: a prospective study. Journal of Travel Medicine, 27 (4) taaa055, 1-9. doi: 10.1093/jtm/taaa055 |
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2020 Journal Article A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnosticsLangenberg, Marijke C. C., Hoogerwerf, Marie-Astrid, Koopman, Jan Pieter R., Janse, Jacqueline J., Kos-van Oosterhoud, Janneke, Feijt, Carola, Jochems, Simon P., de Dood, Claudia J., van Schuijlenburg, Roos, Ozir-Fazalalikhan, Arifa, Manurung, Mikhael D., Sartono, Erliyani, van der Beek, Martha T., Winkel, Béatrice M. F., Verbeek-Menken, Petra H., Stam, Koen A., van Leeuwen, Fijs W. B., Meij, Pauline, van Diepen, Angela, van Lieshout, Lisette, van Dam, Govert J., Corstjens, Paul L. A. M., Hokke, Cornelis H., Yazdanbakhsh, Maria, Visser, Leo G. and Roestenberg, Meta (2020). A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics. Nature Medicine, 26 (3), 326-332. doi: 10.1038/s41591-020-0759-x |
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2019 Journal Article Katayama syndrome without Schistosoma mansoni eggsLangenberg, Marijke C. C., Hoogerwerf, Marie-Astrid, Janse, Jacqueline J., van Lieshout, Lisette, Corstjens, Paul L. A. M., Roestenberg, Meta, CoHSI clinical trial team and van Schuijlenburg, Roos (2019). Katayama syndrome without Schistosoma mansoni eggs. Annals of Internal Medicine, 170 (10), 732-733. doi: 10.7326/L18-0438 |
