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2026 Journal Article Drug screen and machine learning predict neuroprotective agents in a preclinical human model of childhood dementiaGreenberg, Zarina, McDonald, Ella, Noreña Puerta, Alejandra, De Silva, Manam Inushi, Christensen, Cade, Adams, Robert, Tran, Jenne, Mazzachi, Paris, Loskarn, Sebastian, Mubarokah, Siti N., Winner, Leanne, Neavin, Drew, Maack, Megan, Elvidge, Kristina L., Melton, Lisa, Hutchinson, Mark R., Hemsley, Kim M., Smith, Nicholas and Bardy, Cedric (2026). Drug screen and machine learning predict neuroprotective agents in a preclinical human model of childhood dementia. Nature Communications. doi: 10.1038/s41467-026-76837-1 |
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2026 Journal Article Stochasticity in response to rostrocaudal and mediolateral determinants influences inaccurate specification within kidney organoidsWilson, Sean B., Vanslambrouck, Jessica M., Er, Pei Xuan, Xie, Mian, Baric, Hannah, Vidal Pitarch, Berta, Agafonova, Alisa, Arora, Himanshi, Muskovic, Walter, Neavin, Drew, Murphy, Angela, Trusina, Ala, Howden, Sara E., Zylberberg, Allara K., Lawlor, Kynan T., Powell, Joseph E. and Little, Melissa H. (2026). Stochasticity in response to rostrocaudal and mediolateral determinants influences inaccurate specification within kidney organoids. Genome Biology. doi: 10.1186/s13059-026-04221-9 |
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2026 Journal Article Primary sclerosing cholangitis displays distinct colonic mucosa topography yet a shared mast cell state with ulcerative colitisTearle, Jacqueline LE, Sviriaeva, Ekaterina, Zhang, Fan, Jackson, Katherine JL, Kaye, Joshua, Tavakoli, Paris, Koentgen, Sabrina, Warren, Joanna, Liang, Raymond R., Malhotra, Pratibha, Williams, Cameron, Haque, Ashraful, Arzivian, Arteen, Sudhakar, Kavitha K., Neavin, Drew, Tedla, Nicodemus, Kim, Andrew, Haifer, Craig, King, Hamish W., Hold, Georgina L., Ghaly, Simon and James, Kylie R. (2026). Primary sclerosing cholangitis displays distinct colonic mucosa topography yet a shared mast cell state with ulcerative colitis. Nature Communications. doi: 10.1038/s41467-026-75231-1 |
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2026 Journal Article Classification of indeterminate and off-target cell types within human kidney organoid differentiationWilson, Sean B., Vanslambrouck, Jessica M., Murphy, Angela, Neavin, Drew R., Powell, Joseph E., Howden, Sara E. and Little, Melissa H. (2026). Classification of indeterminate and off-target cell types within human kidney organoid differentiation. iScience, 29 (6) 115752, 115752-6. doi: 10.1016/j.isci.2026.115752 |
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2025 Journal Article A novel paradigm for single-cell annotation in stem cell researchAtkeson, Trevor, Wilson, Sean B., Ruiz-Morales, Elias R., Little, Melissa H., Vento-Tormo, Roser, Neavin, Drew and Powell, Joseph E. (2025). A novel paradigm for single-cell annotation in stem cell research. Stem Cell Reports, 20 (12) 102707, 1-20. doi: 10.1016/j.stemcr.2025.102707 |
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2025 Journal Article Optimized summary-statistic-based single-cell eQTL meta-analysisKorshevniuk, Maryna, Westra, Harm-Jan, Oelen, Roy, van der Wijst, Monique G. P., Franke, Lude, Bonder, Marc Jan, Bonder, Marc Jan, Powell, Joseph E., Melé, Marta, Mahfouz, Ahmed, Hemberg, Martin, Ye, Jimmie, Yazar, Seyhan, Trynka, Gosia, Shin, Jay W., Shahin, Tala, Rajagopalan, Deepa, Park, Woong-Yang, Stegle, Oliver, Okada, Yukinori, Nawijn, Martijn C., Moody, Jonathan, Manikanda, Vinu, Idaghdour, Youssef, Hon, Chung-Chau, van der Harst, Pim, Groot, Hilde E., Gordon, M. Grace, Dieng, Mame M. ... Alquicira-Hernández, José (sc-eQTLGen Consortium group member) (2025). Optimized summary-statistic-based single-cell eQTL meta-analysis. Scientific Reports, 15 (1) 28407, 1. doi: 10.1038/s41598-025-08808-3 |
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2025 Journal Article Protein translation dysregulation and immune cell evasion mediated by IFN and immunoproteasome downregulation define metastatic clones in HPV-related cancer of the oropharynxChin, Venessa T., Muskovic, Walter, McCloy, Rachael A., Neavin, Drew R., Alquicira-Hernandez, Jose, Arora, Himanshi, Senabouth, Anne, Sudhakar, Kavitha Krishna, Keith, Patricia, Spenceley, Eleanor, Kaczorowski, Dominik, Floros, Peter, Leavers, Brett, Crawford, Julia A., Gallagher, Richard and Powell, Joseph E. (2025). Protein translation dysregulation and immune cell evasion mediated by IFN and immunoproteasome downregulation define metastatic clones in HPV-related cancer of the oropharynx. BMC Medicine, 23 (1) 559, 1-20. doi: 10.1186/s12916-025-04392-5 |
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2025 Conference Publication A polygenic risk score to predict immunotherapy toxicity: A pilot single-cell RNA sequencing studyLim, J.W.Y., Keith, P., McCloy, R., Neavin, D., Spenceley, E., Xu, A., Krishna Sudhakar, K., Bowen, B., Suan, D., Mehta, A., Joshua, A.M., Chin, V. and Powell, J. (2025). A polygenic risk score to predict immunotherapy toxicity: A pilot single-cell RNA sequencing study. ESMO Congress 2025, Berlin, Germany, 17-21 October 2025. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2025.08.640 |
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2024 Conference Publication Predicting immunotherapy toxicity through single-cell sequencing of peripheral immune cells: A pilot studyLim, Jennifer Wen Ying, Chin, Venessa T., Keith, Patricia, McCloy, Rachael, Neavin, Drew, Xue, Angli, Kaczorowski, Dominik, Spenceley, Ellie, Arora, Himanshi, Joshua, Anthony M. and Powell, Joseph (2024). Predicting immunotherapy toxicity through single-cell sequencing of peripheral immune cells: A pilot study. 2024 ASCO Annual Meeting, 31 May - 4 June 2024, Chicago, Ill, United States. Alexandria, VA, United States: American Society of Clinical Oncology. doi: 10.1200/jco.2024.42.16_suppl.e14538 |
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2024 Journal Article Integrating population genetics, stem cell biology and cellular genomics to study complex human diseasesFarbehi, Nona, Neavin, Drew R., Cuomo, Anna S. E., Studer, Lorenz, MacArthur, Daniel G. and Powell, Joseph E. (2024). Integrating population genetics, stem cell biology and cellular genomics to study complex human diseases. Nature Genetics, 56 (5), 758-766. doi: 10.1038/s41588-024-01731-9 |
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2024 Journal Article Demuxafy: improvement in droplet assignment by integrating multiple single-cell demultiplexing and doublet detection methodsNeavin, Drew, Senabouth, Anne, Arora, Himanshi, Lee, Jimmy Tsz Hang, Ripoll-Cladellas, Aida, sc-eQTLGen Consortium, Franke, Lude, Prabhakar, Shyam, Ye, Chun Jimmie, McCarthy, Davis J., Melé, Marta, Hemberg, Martin and Powell, Joseph E. (2024). Demuxafy: improvement in droplet assignment by integrating multiple single-cell demultiplexing and doublet detection methods. Genome Biology, 25 (1) 94, 1-24. doi: 10.1186/s13059-024-03224-8 |
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2024 Journal Article Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s diseaseWang, Qian, Wang, Minghui, Choi, Insup, Sarrafha, Lily, Liang, Marianna, Ho, Lap, Farrell, Kurt, Beaumont, Kristin G., Sebra, Robert, De Sanctis, Claudia, Crary, John F., Ahfeldt, Tim, Blanchard, Joel, Neavin, Drew, Powell, Joseph, Davis, David A., Sun, Xiaoyan, Zhang, Bin and Yue, Zhenyu (2024). Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s disease. Science Advances, 10 (2) eadi8287, 1-18. doi: 10.1126/sciadv.adi8287 |
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2023 Journal Article Novel human pluripotent stem cell-derived hypothalamus organoids demonstrate cellular diversitySarrafha, Lily, Neavin, Drew R., Parfitt, Gustavo M., Kruglikov, Ilya A., Whitney, Kristen, Reyes, Ricardo, Coccia, Elena, Kareva, Tatyana, Goldman, Camille, Tipon, Regine, Croft, Gist, Crary, John F., Powell, Joseph E., Blanchard, Joel and Ahfeldt, Tim (2023). Novel human pluripotent stem cell-derived hypothalamus organoids demonstrate cellular diversity. iScience, 26 (9) 107525, 1-26. doi: 10.1016/j.isci.2023.107525 |
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2023 Journal Article A village in a dish model system for population-scale hiPSC studiesNeavin, Drew R., Steinmann, Angela M., Farbehi, Nona, Chiu, Han Sheng, Daniszewski, Maciej S., Arora, Himanshi, Bermudez, Yasmin, Moutinho, Cátia, Chan, Chia-Ling, Bax, Monique, Tyebally, Mubarika, Gnanasambandapillai, Vikkitharan, Lam, Chuan E., Nguyen, Uyen, Hernández, Damián, Lidgerwood, Grace E., Graham, Robert M., Hewitt, Alex W., Pébay, Alice, Palpant, Nathan J. and Powell, Joseph E. (2023). A village in a dish model system for population-scale hiPSC studies. Nature Communications, 14 (1) 3240, 1-12. doi: 10.1038/s41467-023-38704-1 |
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2023 Journal Article Pitfalls and opportunities for applying latent variables in single-cell eQTL analysesXue, Angli, Yazar, Seyhan, Neavin, Drew and Powell, Joseph E. (2023). Pitfalls and opportunities for applying latent variables in single-cell eQTL analyses. Genome Biology, 24 (1) 33, 1-11. doi: 10.1186/s13059-023-02873-5 |
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2022 Journal Article Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degenerationSenabouth, Anne, Daniszewski, Maciej, Lidgerwood, Grace E., Liang, Helena H., Hernández, Damián, Mirzaei, Mehdi, Keenan, Stacey N., Zhang, Ran, Han, Xikun, Neavin, Drew, Rooney, Louise, Lopez Sanchez, Maria Isabel G., Gulluyan, Lerna, Paulo, Joao A., Clarke, Linda, Kearns, Lisa S., Gnanasambandapillai, Vikkitharan, Chan, Chia-Ling, Nguyen, Uyen, Steinmann, Angela M., McCloy, Rachael A., Farbehi, Nona, Gupta, Vivek K., Mackey, David A., Bylsma, Guy, Verma, Nitin, MacGregor, Stuart, Watt, Matthew J., Guymer, Robyn H. ... Pébay, Alice (2022). Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration. Nature Communications, 13 (1) 4233, 4233-1. doi: 10.1038/s41467-022-31707-4 |
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2022 Journal Article Shared genetic susceptibility between trigger finger and carpal tunnel syndrome: a genome-wide association studyPatel, Benjamin, Kleeman, Sam O, Neavin, Drew, Powell, Joseph, Baskozos, Georgios, Ng, Michael, Ahmed, Waheed-Ul-Rahman, Bennett, David L, Schmid, Annina B, Furniss, Dominic and Wiberg, Akira (2022). Shared genetic susceptibility between trigger finger and carpal tunnel syndrome: a genome-wide association study. The Lancet Rheumatology, 4 (8), e556-e565. doi: 10.1016/S2665-9913(22)00180-1 |
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2021 Journal Article ERICH3: vesicular association and antidepressant treatment responseLiu, Duan, Zhuang, Yongxian, Zhang, Lingxin, Gao, Huanyao, Neavin, Drew, Carrillo-Roa, Tania, Wang, Yani, Yu, Jia, Qin, Sisi, Kim, Daniel C., Liu, Erica, Nguyen, Thanh Thanh Le, Biernacka, Joanna M., Kaddurah-Daouk, Rima, Dunlop, Boadie W., Craighead, W. Edward, Mayberg, Helen S., Binder, Elisabeth B., Frye, Mark A., Wang, Liewei and Weinshilboum, Richard M. (2021). ERICH3: vesicular association and antidepressant treatment response. Molecular Psychiatry, 26 (6), 2415-2428. doi: 10.1038/s41380-020-00940-y |
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2021 Journal Article Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cellsNeavin, Drew, Nguyen, Quan, Daniszewski, Maciej S., Liang, Helena H., Chiu, Han Sheng, Wee, Yong Kiat, Senabouth, Anne, Lukowski, Samuel W., Crombie, Duncan E., Lidgerwood, Grace E., Hernández, Damián, Vickers, James C., Cook, Anthony L., Palpant, Nathan J., Pébay, Alice, Hewitt, Alex W. and Powell, Joseph E. (2021). Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells. Genome Biology, 22 (1) 76, 1-19. doi: 10.1186/s13059-021-02293-3 |
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2021 Journal Article Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depressionMahmoudianDehkordi, Siamak, Ahmed, Ahmed T., Bhattacharyya, Sudeepa, Han, Xianlin, Baillie, Rebecca A., Arnold, Matthias, Skime, Michelle K., John-Williams, Lisa St., Moseley, M. Arthur, Thompson, J. Will, Louie, Gregory, Riva-Posse, Patricio, Craighead, W. Edward, McDonald, William, Krishnan, Ranga, Rush, A. John, Frye, Mark A., Dunlop, Boadie W., Weinshilboum, Richard M., Kaddurah-Daouk, Rima, Kaddurah-Daouk, Rima, Rush, John, Tenenbaum, Jessica, Moseley, Arthur, Thompson, Will, Louie, Gregory, Blach, Colette, Mahmoudiandehkhordi, Siamak, Baillie, Rebecca ... Krishnan, Ranga (2021). Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression. Translational Psychiatry, 11 (1) 153, 1-14. doi: 10.1038/s41398-020-01097-6 |
