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2026 Journal Article Implementing the design cues of dissociation dynamics and transmetalation in gallium( iii ) complexes to promote the anti-proliferative activity of ligands targeting intracellular iron( ii ) traffickingDharmasivam, Mahendiran, Faiz, Sadia, Kaya, Busra, Wijesinghe, Tharushi P., Suleymanoglu, Mediha, Azad, Mahan Gholam, Richardson, Vera, Zahoor, Ameer Fawad, Kalinowski, Danuta, Lewis, William, Bernhardt, Paul V., Anjum, Rukhsana and Richardson, Des R. (2026). Implementing the design cues of dissociation dynamics and transmetalation in gallium( iii ) complexes to promote the anti-proliferative activity of ligands targeting intracellular iron( ii ) trafficking. Chemical Science, 17 (13), 6546-6563. doi: 10.1039/d5sc06084b |
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2026 Journal Article Leading artificial intelligence-driven drug discovery platforms: 2025 landscape and global outlookDharmasivam, Mahendiran, Maya, Busra, Akinware, Adedoyin, Azad, Mahan Gholam and Richardson, Des R. (2026). Leading artificial intelligence-driven drug discovery platforms: 2025 landscape and global outlook. Pharmacological Reviews, 78 (1) 100102, 1-28. doi: 10.1016/j.pharmr.2025.100102 |
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2025 Journal Article Artificial intelligence-assisted drug discovery in 2025: Faster, but is it better? The robots are coming, look out!Dharmasivam, Mahendiran, Azad, Mahan Gholam, Richardson, Vera, Kaya, Busra and Richardson, Des R. (2025). Artificial intelligence-assisted drug discovery in 2025: Faster, but is it better? The robots are coming, look out!. Pharmacological Reviews, 78 (1) 100103, 100103. doi: 10.1016/j.pharmr.2025.100103 |
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2025 Journal Article Thiosemicarbazones down-regulate N-Myc expression in neuroblastoma cells via transcriptional and post-translational mechanismsDeng, Zhao, Azad, Mahan Gholam and Richardson, Des R. (2025). Thiosemicarbazones down-regulate N-Myc expression in neuroblastoma cells via transcriptional and post-translational mechanisms. Pharmacological Research, 221 107967, 1-27. doi: 10.1016/j.phrs.2025.107967 |
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2025 Journal Article Metal-based antibody, nanobody, and peptide conjugates: potential for breast cancer therapyKaya, Busra, Laurencia, Devina, Ayoub, Maseeha Farha, Azad, Mahan Gholam, Dharmasivam, Mahendiran and Richardson, Des R. (2025). Metal-based antibody, nanobody, and peptide conjugates: potential for breast cancer therapy. Pharmacological Reviews, 77 (6) 100087, 1-37. doi: 10.1016/j.pharmr.2025.100087 |
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2025 Journal Article NDRG1 and its family members: more than just metastasis suppressor proteins and targets of thiosemicarbazonesAzad, Mahan Gholam, Russell, Tiffany M., Gu, Xuanling, Zhao, Xiao, Richardson, Vera, Wijesinghe, Tharushi P., Babu, Golap, Guo, Xinnong, Kaya, Busra, Dharmasivam, Mahendiran, Deng, Zhao and Richardson, Des R. (2025). NDRG1 and its family members: more than just metastasis suppressor proteins and targets of thiosemicarbazones. Journal of Biological Chemistry, 301 (7) 110230, 1-30. doi: 10.1016/j.jbc.2025.110230 |
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2025 Journal Article Advantages of novel anti-cancer selenosemicarbazones: preferential reactivity of their Fe(III), Cu(II), and Zn(II) complexes with key physiological reductants/ligands versus isosteric thiosemicarbazonesDharmasivam, Mahendiran, Zhang, Stanley, Zhao, Xiao, Richardson, Vera, Wijesinghe, Tharushi P., Suleymanoglu, Mediha, Gholam Azad, Mahan, Bernhardt, Paul V., Kaya, Busra and Richardson, Des R. (2025). Advantages of novel anti-cancer selenosemicarbazones: preferential reactivity of their Fe(III), Cu(II), and Zn(II) complexes with key physiological reductants/ligands versus isosteric thiosemicarbazones. Journal of Medicinal Chemistry, 68 (9), 9594-9622. doi: 10.1021/acs.jmedchem.5c00374 |
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2025 Conference Publication Mechanisms of the Multi-Modal Inhibition of c-Cbl by the Metastasis Suppressor, N-myc Downstream-Regulated Gene-1 (NDRG1)Azad, Mahan Gholam and Richardson, Des (2025). Mechanisms of the Multi-Modal Inhibition of c-Cbl by the Metastasis Suppressor, N-myc Downstream-Regulated Gene-1 (NDRG1). AMSTERDAM: ELSEVIER. doi: 10.1016/j.jpet.2024.100558 |
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2024 Journal Article Innovative N-acridine thiosemicarbazones and their Zn(II) complexes transmetallate with Cu(II): redox activity and suppression of detrimental oxy-myoglobin oxidationKaya, Busra, Smith, Henry, Chen, Yanbing, Azad, Mahan Gholam, Russell, Tiffany M., Richardson, Vera, Dharmasivam, Mahendiran and Richardson, Des R. (2024). Innovative N-acridine thiosemicarbazones and their Zn(II) complexes transmetallate with Cu(II): redox activity and suppression of detrimental oxy-myoglobin oxidation. Inorganic Chemistry, 63 (43), 20840-20858. doi: 10.1021/acs.inorgchem.4c03642 |
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2024 Journal Article Isosteric replacement of sulfur to selenium in a thiosemicarbazone: promotion of Zn(II) complex dissociation and transmetalation to augment anticancer efficacyKaya, Busra, Gholam Azad, Mahan, Suleymanoglu, Mediha, Harmer, Jeffrey R., Wijesinghe, Tharushi P., Richardson, Vera, Zhao, Xiao, Bernhardt, Paul V., Dharmasivam, Mahendiran and Richardson, Des R. (2024). Isosteric replacement of sulfur to selenium in a thiosemicarbazone: promotion of Zn(II) complex dissociation and transmetalation to augment anticancer efficacy. Journal of Medicinal Chemistry, 67 (14), 12155-12183. doi: 10.1021/acs.jmedchem.4c00884 |
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2024 Journal Article Multi-modal mechanisms of the metastasis suppressor, NDRG1: Inhibition of WNT/β-catenin signaling by stabilization of protein kinase CαGholam Azad, Mahan, Hussaini, Mohammed, Russell, Tiffany M., Richardson, Vera, Kaya, Busra, Dharmasivam, Mahendiran and Richardson, Des R. (2024). Multi-modal mechanisms of the metastasis suppressor, NDRG1: Inhibition of WNT/β-catenin signaling by stabilization of protein kinase Cα. Journal of Biological Chemistry, 300 (7) 107417, 1-22. doi: 10.1016/j.jbc.2024.107417 |
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2024 Journal Article Correction to “Steric blockade of oxy-myoglobin oxidation by thiosemicarbazones: structure–activity relationships of the novel PPP4pT series’’Wijesinghe, Tharushi P., Kaya, Busra, Gonzálvez, Miguel A., Harmer, Jeffrey R., Gholam Azad, Mahan, Bernhardt, Paul V., Dharmasivam, Mahendiran and Richardson, Des R. (2024). Correction to “Steric blockade of oxy-myoglobin oxidation by thiosemicarbazones: structure–activity relationships of the novel PPP4pT series’’. Journal of Medicinal Chemistry, 67 (8), 6893-6893. doi: 10.1021/acs.jmedchem.4c00714 |
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2024 Journal Article Differential transmetallation of complexes of the anti-cancer thiosemicarbazone, Dp4e4mT: effects on anti-proliferative efficacy, redox activity, oxy-myoglobin and oxy-hemoglobin oxidationDharmasivam, Mahendiran, Kaya, Busra, Wijesinghe, Tharushi P., Richardson, Vera, Harmer, Jeffrey R., Gonzalvez, Miguel A., Lewis, William, Azad, Mahan Gholam, Bernhardt, Paul V. and Richardson, Des R. (2024). Differential transmetallation of complexes of the anti-cancer thiosemicarbazone, Dp4e4mT: effects on anti-proliferative efficacy, redox activity, oxy-myoglobin and oxy-hemoglobin oxidation. Chemical Science, 15 (3), 974-990. doi: 10.1039/d3sc05723b |
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2024 Journal Article Targeting lysosomes by design: novel N-acridine thiosemicarbazones that enable direct detection of intracellular drug localization and overcome P-glycoprotein (Pgp)-mediated resistanceKaya, Busra, Smith, Henry, Chen, Yanbing, Azad, Mahan Gholam, M. Russell, Tiffany, Richardson, Vera, Bernhardt, Paul V., Dharmasivam, Mahendiran and Richardson, Des R. (2024). Targeting lysosomes by design: novel N-acridine thiosemicarbazones that enable direct detection of intracellular drug localization and overcome P-glycoprotein (Pgp)-mediated resistance. Chemical Science, 15 (37), 15109-15124. doi: 10.1039/d4sc04339a |
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2023 Journal Article Steric blockade of oxy-myoglobin oxidation by thiosemicarbazones: structure–activity relationships of the novel PPP4pT seriesWijesinghe, Tharushi P., Kaya, Busra, Gonzálvez, Miguel A., Harmer, Jeffrey R., Gholam Azad, Mahan, Bernhardt, Paul V., Dharmasivam, Mahendiran and Richardson, Des R. (2023). Steric blockade of oxy-myoglobin oxidation by thiosemicarbazones: structure–activity relationships of the novel PPP4pT series. Journal of Medicinal Chemistry, 66 (22), 15453-15476. doi: 10.1021/acs.jmedchem.3c01612 |
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2023 Journal Article Innovative thiosemicarbazones that induce multi-modal mechanisms to down-regulate estrogen-, progesterone-, androgen- and prolactin-receptors in breast cancerShehadeh-Tout, Faten, Milioli, Heloisa H., Roslan, Suraya, Jansson, Patric J., Dharmasivam, Mahendiran, Graham, Dinny, Anderson, Robin, Wijesinghe, Tharushi, Azad, Mahan Gholam, Richardson, Des R. and Kovacevic, Zaklina (2023). Innovative thiosemicarbazones that induce multi-modal mechanisms to down-regulate estrogen-, progesterone-, androgen- and prolactin-receptors in breast cancer. Pharmacological Research, 193 106806, 1-21. doi: 10.1016/j.phrs.2023.106806 |
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2023 Journal Article Designing tailored thiosemicarbazones with bespoke properties: the styrene moiety imparts potent activity, inhibits heme center oxidation, and results in a novel “Stealth Zinc(II) Complex”Dharmasivam, Mahendiran, Kaya, Busra, Wijesinghe, Tharushi, Gholam Azad, Mahan, Gonzálvez, Miguel A., Hussaini, Mohammad, Chekmarev, Jason, Bernhardt, Paul V. and Richardson, Des R. (2023). Designing tailored thiosemicarbazones with bespoke properties: the styrene moiety imparts potent activity, inhibits heme center oxidation, and results in a novel “Stealth Zinc(II) Complex”. Journal of Medicinal Chemistry, 66 (2), 1426-1453. doi: 10.1021/acs.jmedchem.2c01600 |
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2022 Journal Article The thiosemicarbazone, DpC, broadly synergizes with multiple anti-cancer therapeutics and demonstrates temperature- and energy-dependent uptake by tumor cellsDharmasivam, Mahendiran, Azad, Mahan Gholam, Afroz, Rizwana, Richardson, Vera, Jansson, Patric J. and Richardson, Des R. (2022). The thiosemicarbazone, DpC, broadly synergizes with multiple anti-cancer therapeutics and demonstrates temperature- and energy-dependent uptake by tumor cells. Biochimica et Biophysica Acta - General Subjects, 1866 (8) 130152, 1-10. doi: 10.1016/j.bbagen.2022.130152 |
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2022 Journal Article Thiosemicarbazones reprogram pancreatic cancer bidirectional oncogenic signaling between cancer cells and stellate cells to suppress desmoplasiaRichardson, D. R., Azad, M Gholam, Afroz, R., Richardson, V. and Dharmasivam, M. (2022). Thiosemicarbazones reprogram pancreatic cancer bidirectional oncogenic signaling between cancer cells and stellate cells to suppress desmoplasia. Future Medicinal Chemistry, 14 (13), 1005-1017. doi: 10.4155/fmc-2022-0050 |
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2021 Journal Article The relationship of glutathione-s-transferase and multi-drug resistance-related protein 1 in nitric oxide (No) transport and storageRussell, Tiffany M., Azad, Mahan Gholam and Richardson, Des R. (2021). The relationship of glutathione-s-transferase and multi-drug resistance-related protein 1 in nitric oxide (No) transport and storage. Molecules, 26 (19) 5784, 1-27. doi: 10.3390/molecules26195784 |
