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2026 Journal Article Impact of process parameters on IgG glycosylation in CHO systems: a comprehensive quantitative analysisBravo-Venegas, Javier, Rodriguez-Siza, Jose, Vergara, Mauricio, Torres, Mauro, Dickson, Alan, Toledo, Jorge R., Molina, Maria Carmen, Hermoso, Marcela A., Berrios, Julio and Altamirano, Claudia (2026). Impact of process parameters on IgG glycosylation in CHO systems: a comprehensive quantitative analysis. Mabs, 18 (1) 2643039, 1-23. doi: 10.1080/19420862.2026.2643039 |
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2026 Journal Article Reconstruction of arginine deiminase pathway sustains a higher-energy state in mammalian cellsTorres, Mauro, Reaney, Matthew, Meeson, Kate, Kalsi, Devika, Pybus, Leon P and Dickson, Alan J (2026). Reconstruction of arginine deiminase pathway sustains a higher-energy state in mammalian cells. Metabolic Engineering, 95, 63-76. doi: 10.1016/j.ymben.2026.02.004 |
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2025 Journal Article Deciphering molecular drivers of lactate metabolic shift in mammalian cell culturesTorres, Mauro, Hawke, Ellie, Hoare, Robyn, Scholey, Rachel, Pybus, Leon P., Young, Alison, Hayes, Andrew and Dickson, Alan J. (2025). Deciphering molecular drivers of lactate metabolic shift in mammalian cell cultures. Metabolic Engineering, 88, 25-39. doi: 10.1016/j.ymben.2024.12.001 |
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2024 Journal Article A multiscale hybrid modelling methodology for cell cultures enabled by enzyme-constrained dynamic metabolic flux analysis under uncertaintyPennington, Oliver, Espinel Ríos, Sebastián, Sebastian, Mauro Torres, Dickson, Alan and Zhang, Dongda (2024). A multiscale hybrid modelling methodology for cell cultures enabled by enzyme-constrained dynamic metabolic flux analysis under uncertainty. Metabolic Engineering, 86, 274-287. doi: 10.1016/j.ymben.2024.10.013 |
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2024 Conference Publication Dynamic multiscale hybrid modelling of a CHO cell system for recombinant protein productionPennington, Oliver, Rios, Sebastian Espinel, Sebastian, Mauro Torres, Dickson, Alan and Zhang, Dongda (2024). Dynamic multiscale hybrid modelling of a CHO cell system for recombinant protein production. 12th IFAC Symposium on Advanced Control of Chemical Processes (ADCHEM), Toronto, Canada, 14-17 July 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.ifacol.2024.08.326 |
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2024 Journal Article Engineering mammalian cell growth dynamics for biomanufacturingTorres, Mauro, Mcconnaughie, Dewi, Akhtar, Samia, Gaffney, Claire E., Fievet, Bruno, Ingham, Catherine, Stockdale, Mark and Dickson, Alan J. (2024). Engineering mammalian cell growth dynamics for biomanufacturing. Metabolic Engineering, 82, 89-99. doi: 10.1016/j.ymben.2024.01.006 |
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2023 Journal Article Long term culture promotes changes to growth, gene expression, and metabolism in CHO cells that are independent of production stabilityTorres, Mauro, Betts, Zeynep, Scholey, Rachel, Elvin, Mark, Place, Svetlana, Hayes, Andrew and Dickson, Alan J. (2023). Long term culture promotes changes to growth, gene expression, and metabolism in CHO cells that are independent of production stability. Biotechnology and Bioengineering, 120 (9), 2389-2402. doi: 10.1002/bit.28399 |
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2023 Journal Article Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombinant EPO productionLatorre, Yesenia, Torres, Mauro, Vergara, Mauricio, Berrios, Julio, Sampayo, Maria Molina, Goedecke, Natasha, Wirth, Dagmar, Hauser, Hansjoerg, Dickson, Alan J. and Altamirano, Claudia (2023). Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombinant EPO production. Scientific Reports, 13 (1) 1482. doi: 10.1038/s41598-023-28622-z |
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2022 Journal Article Enhanced recombinant protein production in CHO cell continuous cultures under growth-inhibiting conditions is associated with an arrested cell cycle in G1/G0 phaseAvello, Veronica, Torres, Mauro, Vergara, Mauricio, Berrios, Julio, Valdez-Cruz, Norma A., Acevedo, Cristian, Sampayo, Maria Molina, Dickson, Alan J. and Altamirano, Claudia (2022). Enhanced recombinant protein production in CHO cell continuous cultures under growth-inhibiting conditions is associated with an arrested cell cycle in G1/G0 phase. PLoS One, 17 (11) e0277620, e0277620. doi: 10.1371/journal.pone.0277620 |
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2022 Journal Article The secretory pathway - the key for unlocking the potential of Chinese hamster ovary cell factories for manufacturing therapeutic proteinsTorres, Mauro, Hussain, Hirra and Dickson, Alan J. (2022). The secretory pathway - the key for unlocking the potential of Chinese hamster ovary cell factories for manufacturing therapeutic proteins. Critical Reviews in Biotechnology, 43 (4), 628-645. doi: 10.1080/07388551.2022.2047004 |
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2022 Journal Article Combined gene and environmental engineering offers a synergetic strategy to enhance r-protein production in Chinese hamster ovary cellsTorres, Mauro and Dickson, Alan J. (2022). Combined gene and environmental engineering offers a synergetic strategy to enhance r-protein production in Chinese hamster ovary cells. Biotechnology and Bioengineering, 119 (2), 550-565. doi: 10.1002/bit.28000 |
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2022 Journal Article Reprogramming of Chinese hamster ovary cells towards enhanced protein secretionTorres, Mauro and Dickson, Alan J. (2022). Reprogramming of Chinese hamster ovary cells towards enhanced protein secretion. Metabolic Engineering, 69, 249-261. doi: 10.1016/j.ymben.2021.12.004 |
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2021 Journal Article Overexpression of transcription factor BLIMP1/prdm1 leads to growth inhibition and enhanced secretory capacity in Chinese hamster ovary cellsTorres, Mauro and Dickson, Alan J. (2021). Overexpression of transcription factor BLIMP1/prdm1 leads to growth inhibition and enhanced secretory capacity in Chinese hamster ovary cells. Metabolic Engineering, 67, 237-249. doi: 10.1016/j.ymben.2021.07.004 |
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2021 Journal Article Temperature down-shift modifies expression of UPR-/ERAD-related genes and enhances production of a chimeric fusion protein in CHO cellsTorres, Mauro, Akhtar, Sarnia, McKenzie, Edward A. and Dicksons, Alan (2021). Temperature down-shift modifies expression of UPR-/ERAD-related genes and enhances production of a chimeric fusion protein in CHO cells. Biotechnology Journal, 16 (2) 2000081. doi: 10.1002/biot.202000081 |
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2021 Book Chapter An omic’s data-driven approach towards engineering mammalian cell factories and bioprocesses for biopharmaceutical productionTorres, Mauro, Ortuzar, Veronica, Dickson, Alan J. and Hussain, Hirra (2021). An omic’s data-driven approach towards engineering mammalian cell factories and bioprocesses for biopharmaceutical production. Cell culture engineering and technology. (pp. 93-128) edited by Ralf Pörtner. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-030-79871-0_4 |
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2020 Journal Article Metabolic profiling of Chinese hamster ovary cell cultures at different working volumes and agitation speeds using spin tube reactorsTorres, Mauro, Elvin, Mark, Betts, Zeynep, Place, Svetlana, Gaffney, Claire and Dickson, Alan J. (2020). Metabolic profiling of Chinese hamster ovary cell cultures at different working volumes and agitation speeds using spin tube reactors. Biotechnology Progress, 37 (2) e3099, e3099. doi: 10.1002/btpr.3099 |
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2019 Journal Article Metabolic flux analysis during galactose and lactate co-consumption reveals enhanced energy metabolism in continuous CHO cell culturesTorres, Mauro, Berrios, Julio, Rigual, Yandi, Latorre, Yesenia, Vergara, Mauricio, Dickson, Alan J. and Altamirano, Claudia (2019). Metabolic flux analysis during galactose and lactate co-consumption reveals enhanced energy metabolism in continuous CHO cell cultures. Chemical Engineering Science, 205, 201-211. doi: 10.1016/j.ces.2019.04.049 |
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2018 Journal Article Process and metabolic engineering perspectives of lactate production in mammalian cell culturesTorres, Mauro, Altamirano, Claudia and Dickson, Alan J. (2018). Process and metabolic engineering perspectives of lactate production in mammalian cell cultures. Current Opinion in Chemical Engineering, 22, 184-190. doi: 10.1016/j.coche.2018.10.004 |
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2018 Journal Article High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cellsVergara, Mauricio, Torres, Mauro, Mueller, Andrea, Avello, Veronica, Acevedo, Cristian, Berrios, Julio, Reyes, Juan G., Valdez-Cruz, Norma A. and Altamirano, Claudia (2018). High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells. PLoS One, 13 (8) e0202098, e0202098. doi: 10.1371/journal.pone.0202098 |
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2018 Journal Article Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cellsTorres, Mauro, Zuniga, Roberto, Gutierrez, Matias, Vergara, Mauricio, Collazo, Norberto, Reyes, Juan, Berrios, Julio, Carlos Aguillon, Juan, Carmen Molina, Maria and Altamirano, Claudia (2018). Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells. PLoS One, 13 (3) e0194510, e0194510. doi: 10.1371/journal.pone.0194510 |
