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2024 Journal Article Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cellsHolley, Caroline L., Monteleone, Mercedes, Fisch, Daniel, Libert, Alexandre E. S., Ju, Robert J., Choi, Joon H., Condon, Nicholas D., Emming, Stefan, Crawford, Joanna, Lawrence, Grace M. E. P., Coombs, Jared R., Lefevre, James G., Bajracharya, Rinie, Lahoud, Mireille H., Yap, Alpha S., Hamilton, Nicholas, Stehbens, Samantha J., Kagan, Jonathan C., Ariotti, Nicholas, Burgener, Sabrina S. and Schroder, Kate (2024). Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells. Nature Immunology, 26 (1) eaas8995, 1-35. doi: 10.1038/s41590-024-02024-3 |
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2024 Journal Article Cardiolipin Inhibits the Noncanonical Inflammasome by Preventing LPS Binding to Caspase 4/11 to Mitigate Endotoxemia in VivoPizzuto, Malvina, Monteleone, Mercedes, Burgener, Sabrina Sofia, Began, Jakub, Kurera, Melan, Chia, Jing Rong, Frampton, Emmanuelle, Crawford, Joanna, Oliveira, Monalisa, Kenney, Kirsten M., Coombs, Jared R., Yamamoto, Masahiro, Man, Si Ming, Broz, Petr, Pelegrin, Pablo and Schroder, Kate (2024). Cardiolipin Inhibits the Noncanonical Inflammasome by Preventing LPS Binding to Caspase 4/11 to Mitigate Endotoxemia in Vivo. BioRxiv. doi: 10.1101/2024.10.14.618051 |
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2024 Journal Article The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axisHolley, Caroline L., Emming, Stefan, Monteleone, Mercedes M., Mellacheruvu, Manasa, Kenney, Kirsten M., Lawrence, Grace M.E.P., Coombs, Jared R., Burgener, Sabrina S. and Schroder, Kate (2024). The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis. Cell Chemical Biology, 31 (5), 962-972.e4. doi: 10.1016/j.chembiol.2024.04.012 |
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2024 Journal Article Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophagesThygesen, Sara J., Burgener, Sabrina S., Mudai, Prerna, Monteleone, Mercedes, Boucher, Dave, Sagulenko, Vitaliya, Schroder, Kate and Stacey, Katryn J. (2024). Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages. European Journal of Immunology, 54 (5) 2350515, e2350515. doi: 10.1002/eji.202350515 |
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2024 Journal Article Pyroptotic corpses are flagged by filopodia to alert dendritic cellsMonteleone, Mercedes and Schroder, Kate (2024). Pyroptotic corpses are flagged by filopodia to alert dendritic cells. Nature Immunology, 26 (1), 11-12. doi: 10.1038/s41590-024-02025-2 |
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2023 Book Chapter Quantifying Cell Death Induced by the NLRC4 InflammasomeEmming, Stefan, Monteleone, Mercedes M., Kambara, Hiroto, Starchenko, Alina, Alley, Jennifer, Nolan, Michael A., Li, Wei, Kilty, Iain and Schroder, Kate (2023). Quantifying Cell Death Induced by the NLRC4 Inflammasome. NLR Proteins: Methods and Protocols. (pp. 199-210) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-3350-2_13 |
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2022 Book Chapter Measuring non-canonical inflammasome activation in neutrophilsMonteleone, Mercedes and Boucher, Dave (2022). Measuring non-canonical inflammasome activation in neutrophils. The inflammasome: methods and protocols. (pp. 29-37) edited by Ali A. Abdul-Sater. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-2144-8_3 |
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2021 Journal Article Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infectionRichter, Johanna, Monteleone, Mercedes M, Cork, Amanda J., Barnett, Timothy C., Nizet, Victor, Brouwer, Stephan, Schroder, Kate and Walker, Mark J. (2021). Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection. Immunology and Cell Biology, 99 (10), 1-13. doi: 10.1111/imcb.12499 |
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2021 Journal Article Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β releaseStarobova, Hana, Monteleone, Mercedes, Adolphe, Christelle, Batoon, Lena, Sandrock, Cheyenne J., Tay, Bryan, Deuis, Jennifer R., Smith, Alexandra V., Mueller, Alexander, Nadar, Evelyn Israel, Lawrence, Grace Pamo, Mayor, Amanda, Tolson, Elissa, Levesque, Jean-Pierre, Pettit, Allison R., Wainwright, Brandon J., Schroder, Kate and Vetter, Irina (2021). Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. Journal of Experimental Medicine, 218 (5) e20201452. doi: 10.1084/jem.20201452 |
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2019 Journal Article Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolismSerafini, Agnese, Tan, Lendl, Horswell, Stuart, Howell, Steven, Greenwood, Daniel J., Hunt, Deborah M., Phan, Minh-Duy, Schembri, Mark, Monteleone, Mercedes, Montague, Christine R., Britton, Warwick, Garza-Garcia, Acely, Snijders, Ambrosius P., VanderVen, Brian, Gutierrez, Maximiliano G., West, Nicholas P. and de Carvalho, Luiz Pedro S. (2019). Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism. Molecular Microbiology, 112 (4) mmi.14362, 1284-1307. doi: 10.1111/mmi.14362 |
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2019 Journal Article The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responsesBierschenk, Damien, Monteleone, Mercedes, Moghaddas, Fiona, Baker, Paul J., Masters, Seth L., Boucher, Dave and Schroder, Kate (2019). The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses. Journal of Leukocyte Biology, 105 (2), 401-410. doi: 10.1002/JLB.MA0318-112RR |
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2018 Journal Article Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular trapsChen, Kaiwen W., Monteleone, Mercedes, Boucher, Dave, Sollberger, Gabriel, Ramnath, Divya, Condon, Nicholas D., von Pein, Jessica B., Broz, Petr, Sweet, Matthew J. and Schroder, Kate (2018). Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps. Science Immunology, 3 (26) eaar6676, eaar6676. doi: 10.1126/sciimmunol.aar6676 |
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2018 Journal Article Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretionMonteleone, Mercedes, Stanley, Amanda C., Chen, Kaiwen W., Brown, Darren L., Bezbradica, Jelena S., von Pein, Jessica B., Holley, Caroline L., Boucher, Dave, Shakespear, Melanie R., Kapetanovic, Ronan, Rolfes, Verena, Sweet, Matthew J., Stow, Jennifer L. and Schroder, Kate (2018). Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion. Cell Reports, 24 (6), 1425-1433. doi: 10.1016/j.celrep.2018.07.027 |
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2018 Journal Article Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activityBoucher, Dave, Monteleone, Mercedes, Coll, Rebecca C., Chen, Kaiwen W., Ross, Connie M., Teo, Jessica L., Gomez, Guillermo A., Holley, Caroline L., Bierschenk, Damien, Stacey, Katryn J., Yap, Alpha S., Bezbradica, Jelena S. and Schroder, Kate (2018). Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. The Journal of Experimental Medicine, 215 (3), 827-840. doi: 10.1084/jem.20172222 |
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2016 Journal Article Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophagesKapetanovic, Ronan, Bokil, Nilesh J., Achard, Maud E. S., Ong, Cheryl-lynn Y, Peters, Kate M., Stocks, Claudia J., Phan, Minh-Duy, Monteleone, Mercedes, Schroder, Kate, Irvine, Katharine M., Saunders, Bernadette M., Walker, Mark J., Stacey, Katryn J., McEwan, Alastair G., Schembri, Mark A. and Sweet, Matthew J. (2016). Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal, 30 (5), 1901-1912. doi: 10.1096/fj.201500061 |
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2015 Journal Article NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5Baker, Paul J., Boucher, Dave, Bierschenk, Damien, Tebartz, Christina, Whitney, Paul G., D'Silva, Damian B, Tanzer, Marco J., Monteleone, Mercedes, Robertson, Avril A.B., Cooper, Matthew A., Alvarez-Diaz, Silvia, Herold, Marco J., Bedoui, Sammy, Schroder, Kate and Masters, Seth L. (2015). NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology, 45 (10), 2918-2926. doi: 10.1002/eji.201545655 |
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2015 Journal Article Mechanisms of unconventional secretion of IL-1 family cytokinesMonteleone, Mercedes, Stow, Jennifer L. and Schroder, Kate (2015). Mechanisms of unconventional secretion of IL-1 family cytokines. Cytokine, 74 (2), 213-218. doi: 10.1016/j.cyto.2015.03.022 |
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2014 Journal Article Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killingLy, Diane, Taylor, Jude M., Tsatsaronis, James A., Monteleone, Mercedes M., Skora, Amanda S., Donald, Cortny A., Maddocks, Tracy, Nizet, Victor, West, Nicholas P., Ranson, Marie, Walker, Mark J., McArthur, Jason D. and Sanderson-Smith, Martina L. (2014). Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing. Journal of Innate Immunity, 6 (2), 240-250. doi: 10.1159/000353754 |
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2013 Journal Article A genetic strategy to identify targets for the development of drugs that prevent bacterial persistenceKim, Jee-Hyun, O'Brien, Kathryn M., Sharma, Ritu, Boshoff, Helena I. M., Rehren, German, Chakraborty, Sumit, Wallach, Joshua B., Monteleone, Mercedes, Wilson, Daniel J., Aldrich, Courtney C., Barry, Clifton E., III, Rhee, Kyu Y., Ehrt, Sabine and Schnappinger, Dirk (2013). A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence. Proceedings of the National Academy of Sciences of the United States of America, 110 (47), 19095-19100. doi: 10.1073/pnas.1315860110 |
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2007 Journal Article In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in miceGandotra, Sheetal, Schnappinger, Dirk, Monteleone, Mercedes, Hillen, Wolfgang and Ehrt, Sabine (2007). In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. Nature Medicine, 13 (12), 1515-1520. doi: 10.1038/nm1683 |
