Overview
Availability
- Dr Saroja Weeratunga is:
- Available for supervision
Qualifications
- Doctor of Philosophy, University of Kansas
Research interests
-
Membrane trafficking
My research is focused on understanding the molecular mechanisms in membrane trafficking by analysing protein-protein interactions using crystallography and other biological and physical techniques.
Works
Search Professor Saroja Weeratunga’s works on UQ eSpace
2024
Journal Article
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4
Nguyen-Dien, Giang Thanh, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Kozul, Keri-Lyn, Ooi, Soo Siang, Eldershaw, Denaye N, Weeratunga, Saroja, Liu, Meihan, Jones, Mathew JK, Millard, S Sean, Ng, Dominic CH, Pagano, Michele, Bonfim-Melo, Alexis, Schneider, Tobias, Komander, David, Lazarou, Michael, Collins, Brett M and Pagan, Julia K (2024). PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4. EMBO Reports, 25 (8), 3324-3347. doi: 10.1038/s44319-024-00181-y
2024
Journal Article
Interrogation and validation of the interactome of neuronal Munc18-interacting Mint proteins with AlphaFold2
Weeratunga, Saroja, Gormal, Rachel S., Liu, Meihan, Eldershaw, Denaye, Livingstone, Emma K., Malapaka, Anusha, Wallis, Tristan P., Bademosi, Adekunle T., Jiang, Anmin, Healy, Michael D., Meunier, Frederic A. and Collins, Brett M. (2024). Interrogation and validation of the interactome of neuronal Munc18-interacting Mint proteins with AlphaFold2. Journal of Biological Chemistry, 300 (1) 105541, 105541. doi: 10.1016/j.jbc.2023.105541
2023
Conference Publication
Discovery and structural characterization of novel nanobodies targeting the Cavin1 complex essential for forming caveola membrane vesicles
Gao, Ya, Tillu, Vikas A., Wu, Yeping, Rae, James, Hall, Thomas E., Chen, Kai-En, Weeratunga, Saroja, Guo, Qian, Parton, Robert G. and Collins, Brett M. (2023). Discovery and structural characterization of novel nanobodies targeting the Cavin1 complex essential for forming caveola membrane vesicles. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323086825
2022
Journal Article
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1
Simonetti, Boris, Daly, James L., Simón-Gracia, Lorena, Klein, Katja, Weeratunga, Saroja, Antón-Plágaro, Carlos, Tobi, Allan, Hodgson, Lorna, Lewis, Philip A., Heesom, Kate J., Shoemark, Deborah K., Davidson, Andrew D., Collins, Brett M., Teesalu, Tambet, Yamauchi, Yohei and Cullen, Peter J. (2022). ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1. Proceedings of the National Academy of Sciences, 119 (25) e2201980119, 1-11. doi: 10.1073/pnas.2201980119
2022
Journal Article
Structural predictions of the SNX-RGS proteins suggest they belong to a new class of lipid transfer proteins
Paul, Blessy, Weeratunga, Saroja, Tillu, Vikas A., Hariri, Hanaa, Henne, W. Mike and Collins, Brett M. (2022). Structural predictions of the SNX-RGS proteins suggest they belong to a new class of lipid transfer proteins. Frontiers in Cell and Developmental Biology, 10 826688, 826688. doi: 10.3389/fcell.2022.826688
2021
Journal Article
Community-wide experimental evaluation of the PROSS stability-design method
Peleg, Yoav, Vincentelli, Renaud, Collins, Brett M., Chen, Kai-En, Livingstone, Emma K., Weeratunga, Saroja, Leneva, Natalya, Guo, Qian, Remans, Kim, Perez, Kathryn, Bjerga, Gro E K, Larsen, Øivind, Vaněk, Ondřej, Skořepa, Ondřej, Jacquemin, Sophie, Poterszman, Arnaud, Kjær, Svend, Christodoulou, Evangelos, Albeck, Shira, Dym, Orly, Ainbinder, Elena, Unger, Tamar, Schuetz, Anja, Matthes, Susann, Bader, Michael, de Marco, Ario, Storici, Paola, Semrau, Marta S., Stolt-Bergner, Peggy ... Fleishman, Sarel J. (2021). Community-wide experimental evaluation of the PROSS stability-design method. Journal of Molecular Biology, 433 (13) 166964, 166964. doi: 10.1016/j.jmb.2021.166964
2021
Journal Article
A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release
Li, Lei, Liu, Haowen, Krout, Mia, Richmond, Janet E., Wang, Yu, Bai, Jihong, Weeratunga, Saroja, Collins, Brett M., Ventimiglia, Donovan, Yu, Yi, Xia, Jingyao, Tang, Jing, Liu, Jie and Hu, Zhitao (2021). A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release. Journal of Cell Biology, 220 (4) e202008121, 1-24. doi: 10.1083/jcb.202008121
2020
Journal Article
Recognising the signals for endosomal trafficking
Weeratunga, Saroja, Paul, Blessy and Collins, Brett M. (2020). Recognising the signals for endosomal trafficking. Current Opinion in Cell Biology, 65, 17-27. doi: 10.1016/j.ceb.2020.02.005
2020
Journal Article
Caveolae control contractile tension for epithelia to eliminate tumor cells
Teo, Jessica L., Gomez, Guillermo A., Weeratunga, Saroja, Davies, Elizabeth M., Noordstra, Ivar, Budnar, Srikanth, Katsuno-Kambe, Hiroko, McGrath, Meagan J., Verma, Suzie, Tomatis, Vanesa, Acharya, Bipul R., Balasubramaniam, Lakshmi, Templin, Rachel M., McMahon, Kerrie-Ann, Lee, Yoke Seng, Ju, Robert J., Stebhens, Samantha J., Ladoux, Benoit, Mitchell, Christina A., Collins, Brett M., Parton, Robert G. and Yap, Alpha S. (2020). Caveolae control contractile tension for epithelia to eliminate tumor cells. Developmental Cell, 54 (1), 75-91.e7. doi: 10.1016/j.devcel.2020.05.002
2019
Journal Article
Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins
Simonetti, Boris, Paul, Blessy, Chaudhari, Karina, Weeratunga, Saroja, Steinberg, Florian, Gorla, Madhavi, Heesom, Kate J., Bashaw, Greg J., Collins, Brett M. and Cullen, Peter J. (2019). Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins. Nature Cell Biology, 21 (10), 1219-1233. doi: 10.1038/s41556-019-0393-3
2019
Journal Article
VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming
Kasula, Ravikiran, Blum, Ailisa, Salla-Martret, Merce, Chai, Ye Jin, Jiang, Anmin, Wallis, Tristan P., Gormal, Rachel S., Brouillet, Julie Z., Padmanabhan, Pranesh, Weeratunga, Saroja K., Livingstone, Emma K., Mollazade, Mahdie, Joensuu, Merja, Martínez-Mármol, Ramón, Collins, Brett M. and Meunier, Frederic (2019). VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming. SSRN Electronic Journal. doi: 10.2139/ssrn.3362260
2018
Conference Publication
Characterisation of protein complexes essential to cellular trafficking
Livingstone, Emma, Whitten, Andrew, Weeratunga, Saroja, Martin, Jennifer and Collins, Brett (2018). Characterisation of protein complexes essential to cellular trafficking. 32nd Annual Symposium of the Protein Society, Boston, MA, 9-12 July 2018 . Hoboken, NJ, United States: Wiley-Blackwell.
2012
Journal Article
Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms
Weeratunga, Saroja K., Osman, Asiah, Hu, Nien-Jen, Wang, Conan K., Mason, Lyndel, Svard, Staffan, Hope, Greg, Jones, Malcolm K. and Hofmann, Andreas (2012). Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms. Journal of Molecular Biology, 423 (2), 169-181. doi: 10.1016/j.jmb.2012.06.041
2012
Journal Article
SDAR: a practical tool for graphical analysis of two-dimensional data
Weeratunga, Saroja, Hu, Nien-Jen, Simon, Anne and Hofmann, Andreas (2012). SDAR: a practical tool for graphical analysis of two-dimensional data. BMC Bioinformatics, 13 (1) 201. doi: 10.1186/1471-2105-13-201
2012
Journal Article
SBAL: A practical tool to generate and edit structure-based amino acid sequence alignments
Wang, Conan K., Broder, Ursula, Weeratunga, Saroja K., Gasser, Robin B., Loukas, Alex and Hofmann, Andreas (2012). SBAL: A practical tool to generate and edit structure-based amino acid sequence alignments. Bioinformatics, 28 (7) bts035, 1026-1027. doi: 10.1093/bioinformatics/bts035
2011
Journal Article
DMAN: a java tool for analysis of multi-well differential scanning fluorimetry experiments
Wang, Conan K., Weeratunga, Saroja K., Pacheco, Chris M. and Hofmann, Andreas (2011). DMAN: a java tool for analysis of multi-well differential scanning fluorimetry experiments. Bioinformatics, 28 (3) btr664, 439-440. doi: 10.1093/bioinformatics/btr664
2011
Journal Article
Two distinct ferritin-like molecules in pseudomonas aeruginosa: the product of the bfrA gene is a bacterial ferritin (FtnA) and not a bacterioferritin (Bfr)
Yao, Huili, Jepkorir, Grace, Lovell, Scott, Nama, Pavithra V., Weeratunga, Saroja, Battaile, Kevin P. and Rivera, Mario (2011). Two distinct ferritin-like molecules in pseudomonas aeruginosa: the product of the bfrA gene is a bacterial ferritin (FtnA) and not a bacterioferritin (Bfr). Biochemistry, 50 (23), 5236-5248. doi: 10.1021/bi2004119
2011
Conference Publication
Protein interactions in the utilization of bacterioferritin iron
Rivera, Mario, Weeratunga, Saroja and Lovell, Scott (2011). Protein interactions in the utilization of bacterioferritin iron. 241st ACS National Meeting & Exposition, Anaheim, CA, United States, 27-31 March 2011.
2010
Journal Article
Structural studies of bacterioferritin B from Pseudomonas aeruginosa suggest a gating mechanism for iron uptake via the ferroxidase center
Weeratunga, Saroja K., Lovell, Scott, Yao, Huili, Battaile, Kevin P., Fischer, Christopher J., Gee, Casey E. and Rivera, Mario (2010). Structural studies of bacterioferritin B from Pseudomonas aeruginosa suggest a gating mechanism for iron uptake via the ferroxidase center. Biochemistry, 49 (6), 1160-1175. doi: 10.1021/bi9015204
2009
Journal Article
Binding of Pseudomonas aeruginosa apobacterioferritin-associated ferredoxin to bacterioferritin B promotes heme mediation of electron delivery and mobilization of core mineral iron
Weeratunga, Saroja K., Gee, Casey E., Lovell, Scott, Zeng, Yuhong, Woodin, Carrie L. and Rivera, Mario (2009). Binding of Pseudomonas aeruginosa apobacterioferritin-associated ferredoxin to bacterioferritin B promotes heme mediation of electron delivery and mobilization of core mineral iron. Biochemistry, 48 (31), 7420-7431. doi: 10.1021/bi900561a
Supervision
Availability
- Dr Saroja Weeratunga is:
- Available for supervision
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