Dr

Tim Hill

Email: 
Phone: 
+61 7 334 62987

Availability

Dr Tim Hill is:
Available for supervision

Fields of research

Medicinal and biomolecular chemistry Organic chemistry Pharmacology and pharmaceutical sciences

Qualifications

  • Doctor of Philosophy, University of Newcastle

Search Professor Tim Hill’s works on UQ eSpace

57 works between 2002 and 2024
All (57) Journal Article (54) Book Chapter (1) Conference Publication (2)

41 - 57 of 57 works

2010

Journal Article

Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice

Harrison, Rosemary S., Ruiz-Gomez, Gloria, Hill, Timothy A., Chow, Shiao Y., Shepherd, Nicholas E., Lohman, Rink-Jan, Abbenante, Giovanni, Hoang, Huy N. and Fairlie, David P. (2010). Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice. Journal of Medicinal Chemistry, 53 (23), 8400-8408. doi: 10.1021/jm101139f

Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice

2010

Journal Article

The antiplasmodial activity of norcantharidin analogs

Bajsa, Joanna, McCluskey, Adam, Gordon, Christopher P., Stewart, Scott G., Hill, Timothy A., Sahu, Rajnish, Duke, Stephen O. and Tekwani, Babu L. (2010). The antiplasmodial activity of norcantharidin analogs. Bioorganic and Medicinal Chemistry Letters, 20 (22), 6688-6695. doi: 10.1016/j.bmcl.2010.09.004

The antiplasmodial activity of norcantharidin analogs

2010

Journal Article

Update 1 of: Beta-strand mimetics

Loughlin, Wendy A., Tyndall, Joel D. A., Glenn, Matthew P., Hill, Timothy A. and Fairlie, David P. (2010). Update 1 of: Beta-strand mimetics. Chemical Reviews, 110 (6), 1-38. doi: 10.1021/cr900395y

Update 1 of: Beta-strand mimetics

2010

Journal Article

Update 1 of: beta-strand mimetics

Loughlin, Wendy A., Tyndall, Joel D. A., Glenn, Matthew P., Hill, Timothy A. and Fairlie, David P. (2010). Update 1 of: beta-strand mimetics. Chemical Reviews, 110 (6), PR32-PR69. doi: 10.1021/cr040648k

Update 1 of: beta-strand mimetics

2010

Journal Article

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

Harrison, Rosemary S., Shepherd, Nicholas E., Hoang, Huy N., Ruiz-Goméz, Gloria, Hill, Timothy A., Driver, Russell W., Desai, Vishal S., Young, Paul R., Abbenante, Giovanni and Fairlie, David P. (2010). Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency. Proceedings of the National Academy of Sciences of the United States of America, 107 (26), 11686-11691. doi: 10.1073/pnas.1002498107

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

2010

Journal Article

Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis

Hill, Timothy A., Mariana, Anna, Gordon, Christopher P., Odell, Luke R., Robertson, Mark J., McGeachie, Andrew B., Chau, Ngoc, Daniel, James A., Gorgani, Nick N., Robinson, Phillip J. and McCluskey, Adam (2010). Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. Journal of Medicinal Chemistry, 53 (10), 4094-4102. doi: 10.1021/jm100119c

Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis

2009

Journal Article

Inhibition of dynamin mediated endocytosis by the Dynoles - synthesis and functional activity of a family of indoles

Hill, Timothy A., Gordon, Christopher P., McGeachie, Andrew B., Venn-Brown, Barbara, Odell, Luke R., Chau, Ngoc, Quan, Annie, Mariana, Anna, Sakoff, Jennette A., Chircop (nee Fabbro), Megan, Robinson, Phillip J. and McCluskey, Adam (2009). Inhibition of dynamin mediated endocytosis by the Dynoles - synthesis and functional activity of a family of indoles. Journal of Medicinal Chemistry, 52 (12), 3762-3773. doi: 10.1021/jm900036m

Inhibition of dynamin mediated endocytosis by the Dynoles - synthesis and functional activity of a family of indoles

2008

Journal Article

Norcantharidin analogues: Synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition

Hill, Timothy A., Stewart, Scott G., Gordon, Christopher P., Ackland, Stephen P., Gilbert, Jayne, Sauer, Benjamin, Sakoff, Jennette A. and McCluskey, Adam (2008). Norcantharidin analogues: Synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition. ChemMedChem, 3 (12), 1878-1892. doi: 10.1002/cmdc.200800192

Norcantharidin analogues: Synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition

2007

Journal Article

Synthesis and biological evaluation of norcantharidin analogues: Towards PP1 selectivity

Stewart, Scott G., Hill, Timothy A., Gilbert, Jayne, Ackland, Stephen P., Sakoff, Jennette A. and McCluskey, Adam (2007). Synthesis and biological evaluation of norcantharidin analogues: Towards PP1 selectivity. Bioorganic & Medicinal Chemistry, 15 (23), 7301-7310. doi: 10.1016/j.bmc.2007.08.028

Synthesis and biological evaluation of norcantharidin analogues: Towards PP1 selectivity

2007

Journal Article

Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation

Hill, Timothy A., Stewart, Scott G., Ackland, Stephen P., Gilbert, Jayne, Sauer, Benjamin, Sakoff, Jennette and McCluskey, Adam (2007). Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation. Bioorganic & Medicinal Chemistry, 15 (18), 6126-6134. doi: 10.1016/j.bmc.2007.06.034

Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation

2007

Journal Article

Heterocyclic substituted cantharidin and norcantharidin analogues—synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity

Hill, Timothy A., Stewart, Scott G., Sauer, Benjamin, Gilbert, Jayne, Ackland, Stephen P., Sakoff, Jennette A. and McCluskey, Adam (2007). Heterocyclic substituted cantharidin and norcantharidin analogues—synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity. Bioorganic & Medicinal Chemistry Letters, 17 (12), 3392-3397. doi: 10.1016/j.bmcl.2007.03.093

Heterocyclic substituted cantharidin and norcantharidin analogues—synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity

2005

Journal Article

Small molecule inhibitors of dynamin I GTPase activity: Development of dimeric tyrphostins

Hill, Timothy, Odell, Luke R., Edwards, Jennifer K., Graham, Mark E., McGeachie, Andrew B., Rusak, Jenny, Quan, Annie, Abagyan, Ruben, Scott, Janet L., Robinson, Phillip J. and McCluskey, Adam (2005). Small molecule inhibitors of dynamin I GTPase activity: Development of dimeric tyrphostins. Journal of Medicinal Chemistry, 48 (24), 7781-7788. doi: 10.1021/jm040208l

Small molecule inhibitors of dynamin I GTPase activity: Development of dimeric tyrphostins

2005

Journal Article

BiCl3-mediated opening of epoxides, a facile route to chlorohydrins or amino alcohols: One reagent, two paths

McCluskey, Adam, Leitch, Sarah K., Garner, James, Caden, Christine E., Hill, Timothy A., Odell, Luke R. and Stewart, Scott G. (2005). BiCl3-mediated opening of epoxides, a facile route to chlorohydrins or amino alcohols: One reagent, two paths. Tetrahedron Letters, 46 (47), 8229-8232. doi: 10.1016/j.tetlet.2005.09.088

BiCl3-mediated opening of epoxides, a facile route to chlorohydrins or amino alcohols: One reagent, two paths

2005

Journal Article

Parallel solution-phase synthesis of targeted tyrphostin libraries with anticancer activity

Hill, Timothy A., Sakoff, Jennette A., Robinson, Phillip J. and McCluskey, Adam (2005). Parallel solution-phase synthesis of targeted tyrphostin libraries with anticancer activity. Australian Journal of Chemistry, 58 (2), 94-103. doi: 10.1071/CH04143

Parallel solution-phase synthesis of targeted tyrphostin libraries with anticancer activity

2004

Journal Article

Identification of aminopyrimidine regioisomers via line broadening effects in 1H and 13C NMR spectroscopy

Garner, James, Hill, Tim, Odell, Luke, Keller, Paul, Morgan, Jody and McCluskey, Adam (2004). Identification of aminopyrimidine regioisomers via line broadening effects in 1H and 13C NMR spectroscopy. Australian Journal of Chemistry, 57 (11), 1079-1083. doi: 10.1071/CH03316

Identification of aminopyrimidine regioisomers via line broadening effects in 1H and 13C NMR spectroscopy

2004

Journal Article

Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity

Hill, Timothy A., Odell, Luke R., Quan, Annie, Abagyan, Ruben, Ferguson, Gemma, Robinson, Phillip J. and McCluskey, Adam (2004). Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. Bioorganic & Medicinal Chemistry Letters, 14 (12), 3275-3278. doi: 10.1016/j.bmcl.2004.03.096

Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity

2002

Journal Article

Green chemistry approaches to the Knoevenagel condensation: Comparison of ethanol, water and solvent free (dry grind) approaches

McCluskey, A, Robinson, PJ, Hill, T, Scott, JL and Edwards, JK (2002). Green chemistry approaches to the Knoevenagel condensation: Comparison of ethanol, water and solvent free (dry grind) approaches. Tetrahedron Letters, 43 (17), 3117-3120. doi: 10.1016/S0040-4039(02)00480-X

Green chemistry approaches to the Knoevenagel condensation: Comparison of ethanol, water and solvent free (dry grind) approaches

Past funding

  • 2014
    Continuous-Flow Hydrogenation Reactor (H-Cube Pro)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Peptide Drug Synthesis and Purification Unit
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Towards Novel Therapeutics for Type II Diabetes
    UQ Early Career Researcher
    Open grant

Availability

Dr Tim Hill is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

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