Overview
Availability
- Dr Charles Bell is:
- Available for supervision
Works
Search Professor Charles Bell’s works on UQ eSpace
2024
Journal Article
Chromatin-based memory as a self-stabilizing influence on cell identity
Bell, Charles C., Faulkner, Geoffrey J. and Gilan, Omer (2024). Chromatin-based memory as a self-stabilizing influence on cell identity. Genome Biology, 25 (1) 320. doi: 10.1186/s13059-024-03461-x
2024
Conference Publication
Transient Menin Inhibition Is Sufficient to Induce Irreversible Polycomb-Mediated Silencing and Potent Anti-Proliferative Effects in MLL-Rearranged AML
Neville, Daniel, Ferguson, Daniel, Heikamp, Emily, Bell, Charles, Armstrong, Scott A. and Gilan, Omer (2024). Transient Menin Inhibition Is Sufficient to Induce Irreversible Polycomb-Mediated Silencing and Potent Anti-Proliferative Effects in MLL-Rearranged AML. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-206624
2024
Journal Article
Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architecture
Lou, Jieqiong, Deng, Qiji, Zhang, Xiaomeng, Bell, Charles C, Das, Andrew B, Bediaga, Naiara G, Zlatic, Courtney O, Johanson, Timothy M, Allan, Rhys S, Griffin, Michael D W, Paradkar, PrasadN, Harvey, Kieran F, Dawson, Mark A and Hinde, Elizabeth (2024). Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architecture. Nucleic Acids Research, 52 (18), 10918-10933. doi: 10.1093/nar/gkae720
2024
Journal Article
LINE-1 retrotransposons contribute to mouse PV interneuron development
Bodea, Gabriela O., Botto, Juan M., Ferreiro, Maria E., Sanchez-Luque, Francisco J., de los Rios Barreda, Jose, Rasmussen, Jay, Rahman, Muhammed A., Fenlon, Laura R., Jansz, Natasha, Gubert, Carolina, Gerdes, Patricia, Bodea, Liviu-Gabriel, Ajjikuttira, Prabha, Da Costa Guevara, Darwin J., Cumner, Linda, Bell, Charles C., Kozulin, Peter, Billon, Victor, Morell, Santiago, Kempen, Marie-Jeanne H. C., Love, Chloe J., Saha, Karabi, Palmer, Lucy M., Ewing, Adam D., Jhaveri, Dhanisha J., Richardson, Sandra R., Hannan, Anthony J. and Faulkner, Geoffrey J. (2024). LINE-1 retrotransposons contribute to mouse PV interneuron development. Nature Neuroscience, 27 (7), 1-34. doi: 10.1038/s41593-024-01650-2
2024
Journal Article
Comparative cofactor screens show the influence of transactivation domains and core promoters on the mechanisms of transcription
Bell, Charles C., Balic, Jesse J., Talarmain, Laure, Gillespie, Andrea, Scolamiero, Laura, Lam, Enid Y. N., Ang, Ching-Seng, Faulkner, Geoffrey J., Gilan, Omer and Dawson, Mark A. (2024). Comparative cofactor screens show the influence of transactivation domains and core promoters on the mechanisms of transcription. Nature Genetics, 56 (6), 1181-1192. doi: 10.1038/s41588-024-01749-z
2023
Journal Article
CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia
Gilan, Omer, Talarmain, Laure, Bell, Charles C., Neville, Daniel, Knezevic, Kathy, Ferguson, Daniel T., Boudes, Marion, Chan, Yih-Chih, Davidovich, Chen, Lam, Enid Y. N. and Dawson, Mark A. (2023). CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia. Nature Structural and Molecular Biology, 30 (10), 1592-1606. doi: 10.1038/s41594-023-01087-4
2023
Journal Article
Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
Sparbier, Christina E., Gillespie, Andrea, Gomez, Juliana, Kumari, Nishi, Motazedian, Ali, Chan, Kah Lok, Bell, Charles C., Gilan, Omer, Chan, Yih-Chih, Popp, Sarah, Gough, Daniel J., Eckersley-Maslin, Melanie A., Dawson, Sarah-Jane, Lehner, Paul J., Sutherland, Kate D., Ernst, Patricia, McGeehan, Gerard M., Lam, Enid Y. N., Burr, Marian L. and Dawson, Mark A. (2023). Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes. Nature Cell Biology, 25 (2), 258-272. doi: 10.1038/s41556-022-01056-x
2021
Journal Article
CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity
Watt, April C., Cejas, Paloma, DeCristo, Molly J., Metzger-Filho, Otto, Lam, Enid Y. N., Qiu, Xintao, BrinJones, Haley, Kesten, Nikolas, Coulson, Rhiannon, Font-Tello, Alba, Lim, Klothilda, Vadhi, Raga, Daniels, Veerle W., Montero, Joan, Taing, Len, Meyer, Clifford A., Gilan, Omer, Bell, Charles C., Korthauer, Keegan D., Giambartolomei, Claudia, Pasaniuc, Bogdan, Seo, Ji-Heui, Freedman, Matthew L., Ma, Cynthia, Ellis, Matthew J., Krop, Ian, Winer, Eric, Letai, Anthony, Brown, Myles ... Goel, Shom (2021). CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity. Nature Cancer, 2 (1), 34-48. doi: 10.1038/s43018-020-00135-y
2020
Journal Article
An Erg-driven transcriptional program controls B cell lymphopoiesis
Ng, Ashley P., Coughlan, Hannah D., Hediyeh-zadeh, Soroor, Behrens, Kira, Johanson, Timothy M., Low, Michael Sze Yuan, Bell, Charles C., Gilan, Omer, Chan, Yih-Chih, Kueh, Andrew J., Boudier, Thomas, Feltham, Rebecca, Gabrielyan, Anna, DiRago, Ladina, Hyland, Craig D., Ierino, Helen, Mifsud, Sandra, Viney, Elizabeth, Willson, Tracy, Dawson, Mark A., Allan, Rhys S., Herold, Marco J., Rogers, Kelly, Tarlinton, David M., Smyth, Gordon K., Davis, Melissa J., Nutt, Stephen L. and Alexander, Warren S. (2020). An Erg-driven transcriptional program controls B cell lymphopoiesis. Nature Communications, 11 (1) 3013, 1-14. doi: 10.1038/s41467-020-16828-y
2020
Journal Article
Principles and mechanisms of non-genetic resistance in cancer
Bell, Charles C. and Gilan, Omer (2020). Principles and mechanisms of non-genetic resistance in cancer. British Journal of Cancer, 122 (4), 465-472. doi: 10.1038/s41416-019-0648-6
2019
Journal Article
Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
Bell, Charles C., Fennell, Katie A., Chan, Yih-Chih, Rambow, Florian, Yeung, Miriam M., Vassiliadis, Dane, Lara, Luis, Yeh, Paul, Martelotto, Luciano G., Rogiers, Aljosja, Kremer, Brandon E., Barbash, Olena, Mohammad, Helai P., Johanson, Timothy M., Burr, Marian L., Dhar, Arindam, Karpinich, Natalie, Tian, Luyi, Tyler, Dean S., MacPherson, Laura, Shi, Junwei, Pinnawala, Nathan, Yew Fong, Chun, Papenfuss, Anthony T., Grimmond, Sean M., Dawson, Sarah-Jane, Allan, Rhys S., Kruger, Ryan G., Vakoc, Christopher R. ... Dawson, Mark A. (2019). Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia. Nature Communications, 10 (1) 2723, 2723-10. doi: 10.1038/s41467-019-10652-9
2019
Journal Article
An evolutionarily conserved function of polycomb silences the MHC Class I antigen presentation pathway and enables immune evasion in cancer
Burr, Marian L., Sparbier, Christina E., Chan, Kah Lok, Chan, Yih-Chih, Kersbergen, Ariena, Lam, Enid Y.N., Azidis-Yates, Elizabeth, Vassiliadis, Dane, Bell, Charles C., Gilan, Omer, Jackson, Susan, Tan, Lavinia, Wong, Stephen Q., Hollizeck, Sebastian, Michalak, Ewa M., Siddle, Hannah V., McCabe, Michael T., Prinjha, Rab K., Guerra, Glen R., Solomon, Benjamin J., Sandhu, Shahneen, Dawson, Sarah-Jane, Beavis, Paul A., Tothill, Richard W., Cullinane, Carleen, Lehner, Paul J., Sutherland, Kate D. and Dawson, Mark A. (2019). An evolutionarily conserved function of polycomb silences the MHC Class I antigen presentation pathway and enables immune evasion in cancer. Cancer Cell, 36 (4), 385-401.e8. doi: 10.1016/j.ccell.2019.08.008
2019
Journal Article
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia
McKenzie, Mark D., Ghisi, Margherita, Oxley, Ethan P., Ngo, Steven, Cimmino, L., Esnault, Cécile, Liu, Ruijie, Salmon, Jessica M., Bell, Charles C., Ahmed, Nouraiz, Erlichster, Michael, Witkowski, Matthew T., Liu, Grace J., Chopin, Michael, Dakic, Aleksandar, Simankowicz, Emilia, Pomilio, Giovanna, Vu, Tina, Krsmanovic, P., Su, S., Tian, Luyi, Baldwin, Tracey M., Zalcenstein, Daniela A., DiRago, Ladina, Wang, Shu, Metcalf, Donald, Johnstone, Ricky W., Croker, B. A., Lancaster, Graeme I. ... Dickins, Ross A. (2019). Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia. Cell Stem Cell, 25 (2), 258-272.e9. doi: 10.1016/j.stem.2019.07.001
2019
Journal Article
Epigenetic therapies in acute myeloid leukemia: Where to from here?
Fennell, Katie A., Bell, Charles C. and Dawson, Mark A. (2019). Epigenetic therapies in acute myeloid leukemia: Where to from here?. Blood, 134 (22), 1891-1901. doi: 10.1182/blood.2019003262
2019
Journal Article
Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma
Agarwal, Rishu, Chan, Yih-Chih, Tam, Constantine S., Hunter, Tane, Vassiliadis, Dane, Teh, Charis E., Thijssen, Rachel, Yeh, Paul, Wong, Stephen Q., Ftouni, Sarah, Lam, Enid Y. N., Anderson, Mary Ann, Pott, Christiane, Gilan, Omer, Bell, Charles C., Knezevic, Kathy, Blombery, Piers, Rayeroux, Kathleen, Zordan, Adrian, Li, Jason, Huang, David C. S., Wall, Meaghan, Seymour, John F., Gray, Daniel H. D., Roberts, Andrew W., Dawson, Mark A. and Dawson, Sarah-Jane (2019). Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma. Nature Medicine, 25 (1), 119-129. doi: 10.1038/s41591-018-0243-z
2018
Journal Article
TFIID and MYB Share a Therapeutic Handshake in AML
Bell, Charles C. and Dawson, Mark A. (2018). TFIID and MYB Share a Therapeutic Handshake in AML. Cancer Cell, 33 (1), 1-3. doi: 10.1016/j.ccell.2017.12.008
2017
Journal Article
CMTM6 maintains the expression of PD-L1 and regulates anti-Tumour immunity
Burr, Marian L., Sparbier, Christina E., Chan, Yih-Chih, Williamson, James C., Woods, Katherine, Beavis, Paul A., Lam, Enid Y. N., Henderson, Melissa A., Bell, Charles C., Stolzenburg, Sabine, Gilan, Omer, Bloor, Stuart, Noori, Tahereh, Morgens, David W., Bassik, Michael C., Neeson, Paul J., Behren, Andreas, Darcy, Phillip K., Dawson, Sarah-Jane, Voskoboinik, Ilia, Trapani, Joseph A., Cebon, Jonathan, Lehner, Paul J. and Dawson, Mark A. (2017). CMTM6 maintains the expression of PD-L1 and regulates anti-Tumour immunity. Nature, 549 (7670), 101-105. doi: 10.1038/nature23643
2017
Journal Article
Direct targets of pStat5 signalling in erythropoiesis
Gillinder, Kevin R., Tuckey, Hugh, Bell, Charles C., Magor, Graham W., Huang, Stephen, Ilsley, Melissa D. and Perkins, Andrew C. (2017). Direct targets of pStat5 signalling in erythropoiesis. PLoS One, 12 (7) e0180922, e0180922. doi: 10.1371/journal.pone.0180922
2017
Journal Article
Click chemistry enables preclinical evaluation of targeted epigenetic therapies
Tyler, Dean S., Vappiani, Johanna, Cañeque, Tatiana, Lam, Enid Y. N., Ward, Aoife, Gilan, Omer, Chan, Yih-Chih, Hienzsch, Antje, Rutkowska, Anna, Werner, Thilo, Wagner, Anne J., Lugo, Dave, Gregory, Richard, Molina, Cesar Ramirez, Garton, Neil, Wellaway, Christopher R., Jackson, Susan, Macpherson, Laura, Figueiredo, Margarida, Stolzenburg, Sabine, Bell, Charles C., House, Colin, Dawson, Sarah-Jane, Hawkins, Edwin D., Drewes, Gerard, Prinjha, Rab K., Rodriguez, Raphaël, Grandi, Paola and Dawson, Mark A. (2017). Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science, 356 (6345), 1397-1401. doi: 10.1126/science.aal2066
2016
Journal Article
The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation
Bell, Charles C., Amaral, Paulo P., Kalsbeek, Anton, Magor, Graham W., Gillinder, Kevin R., Tangermann, Pierre, di Lisio, Lorena, Cheetham, Seth W., Gruhl, Franziska, Frith, Jessica, Tallack, Michael R., Ru, Ke-Lin, Crawford, Joanna, Mattick, John S., Dinger, Marcel E. and Perkins, Andrew C. (2016). The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation. Scientific Reports, 6 (1) 26657, 26657. doi: 10.1038/srep26657
Supervision
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- Dr Charles Bell is:
- Available for supervision
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