The rules of engagement between transcription factors and cofactors (2025-2027)

Regulation of which genes are switched on and off is of fundamental importance to biology. This process is coordinated by proteins called transcription factors, which directly read the genetic code, and the proteins they recruit called cofactors. This application aims to establish predictive rules of engagement between transcription factors and cofactors, which will address a major gap in our understanding of how the genetic code is interpreted by the cell. Expected outcomes include improved models and tools for predicting and manipulating cell behaviour, which will provide significant benefits for commercial, industrial and biotechnological applications that require control over the behaviour of biological organisms.