Overview
Background
Dr Ismail Sebina is a Research Fellow at the Frazer Institute-The University of Queensland, under the mentorship of Prof. Gabrielle Belz. He holds a PhD in immunology from The University of Queensland (awarded in 2017) and a Master’s degree in the Immunology of Infectious Diseases from the London School of Hygiene and Tropical Medicine (LSHTM; UK). He has contributed to discovery and translational immunological research in several laboratories across the USA, the UK, Uganda, and Australia, implementing studies in both preclinical mouse models and humans. He completed six years of rigorous postdoctoral training in immunology at the University of Washington (USA) and QIMR Berghofer Medical Research institute (QIMR Berghofer; Australia). He has demonstrated a strong record of publications in high-impact journals such as Immunity, Science Immunology, JCI and PNAS. He has regularly presented his findings at national and international conferences (e.g. Keystone Symposium and ASI), furthering my engagement with the scientific community. Dr. Sebina's primary research focus revolves around uncovering the mechanisms that underpin natural and vaccine-induced immunity to infections. With a passion for improving maternal, newborn, and child health, he also explores novel immunological strategies that have the potential to revolutionize healthcare practices in this area.
Availability
- Dr Ismail Sebina is:
- Available for supervision
Qualifications
- Bachelor (Honours) of Biomedical Science, Makerere University
- Masters (Extended) of Immunology, London School of Hygiene and Tropical Medicine
- Doctor of Philosophy of Immunology, The University of Queensland
Research interests
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Infection and Immunity
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Vaccine Immunology
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Immunology of Infectious Diseases
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Maternal-Newborn Immunity
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Humoral immunity
Works
Search Professor Ismail Sebina’s works on UQ eSpace
2024
Journal Article
Pre-pregnancy obesity is associated with an altered maternal metabolome and reduced Flt3L expression in preterm birth
Sebina, Ismail, Bidgood, Charles, Stalley, Felicity, Hartel, Gunter, Stark, Terra, Callaway, Leonie, Amoako, Akwasi, Lehner, Christoph, Dekker Nitert, Marloes and Phipps, Simon (2024). Pre-pregnancy obesity is associated with an altered maternal metabolome and reduced Flt3L expression in preterm birth. Scientific Reports, 14 (1) 30027, 1-12. doi: 10.1038/s41598-024-81194-4
2024
Journal Article
CXCR3<sup>+</sup> effector regulatory T cells associate with disease tolerance during lower respiratory pneumovirus infection
Sebina, Ismail, Ngo, Sylvia, Rashid, Ridwan B., Alorro, Mariah, Namubiru, Patricia, Howard, Daniel, Ahmed, Tufael and Phipps, Simon (2024). CXCR3+ effector regulatory T cells associate with disease tolerance during lower respiratory pneumovirus infection. Immunology, 172 (3), 500-515. doi: 10.1111/imm.13790
2024
Journal Article
Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures
Stylianou, Nataly, Sebina, Ismail, Matigian, Nicholas, Monkman, James, Doehler, Hadeel, Röhl, Joan, Allenby, Mark, Nam, Andy, Pan, Liuliu, Rockstroh, Anja, Sadeghirad, Habib, Chung, Kimberly, Sobanski, Thais, O'Byrne, Ken, Almeida, Ana Clara Simoes Florido, Rebutini, Patricia Zadorosnei, Machado‐Souza, Cleber, Stonoga, Emanuele Therezinha Schueda, Warkiani, Majid E, Salomon, Carlos, Short, Kirsty, McClements, Lana, de Noronha, Lucia, Huang, Ruby, Belz, Gabrielle T, Souza‐Fonseca‐Guimaraes, Fernando, Clifton, Vicki and Kulasinghe, Arutha (2024). Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures. Clinical and Translational Immunology, 13 (2) e1488, e1488. doi: 10.1002/cti2.1488
2023
Journal Article
Research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends
Agravat, Priyesh, Loucaides, Eva M., Kumar, Meghan Bruce, Howells, Anna, García, Alexandra Molina, Sebina, Ismail, Balanza, Núria, Fitchett, Elizabeth J. A. and Lawn, Joy E. (2023). Research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends. The Lancet Global Health, 11 (11), e1794-e1804. doi: 10.1016/s2214-109x(23)00379-0
2023
Journal Article
IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma
Curren, Bodie, Ahmed, Tufael, Howard, Daniel R., Ashik Ullah, Md., Sebina, Ismail, Rashid, Ridwan B., Al Amin Sikder, Md., Namubiru, Patricia, Bissell, Alec, Ngo, Sylvia, Jackson, David J, Toussaint, Marie, Edwards, Michael R., Johnston, Sebastian L, McSorley, Henry J. and Phipps, Simon (2023). IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma. Mucosal Immunology, 16 (5), 671-684. doi: 10.1016/j.mucimm.2023.07.002
2023
Conference Publication
Research funding for newborn health and stillbirths: systematic analyses of levels and trends (2011–2020) with implications for impact
Agravat, Priyesh, Loucaides, Eva M., Kumar, Meghan, Howells, Anna, García, Alexandra Molina, Sebina, Ismail, Balanza, Nuria, Fitchett, Elizabeth J.A. and Lawn, Joy (2023). Research funding for newborn health and stillbirths: systematic analyses of levels and trends (2011–2020) with implications for impact. Royal College of Paediatrics and Child Health, RCPCH Conference 2023, Glasgow, United Kingdom, 23–25 May 2023. London, United Kingdom: BMJ Group. doi: 10.1136/archdischild-2023-rcpch.497
2023
Journal Article
Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection
Sikder, Md. Al Amin, Rashid, Ridwan B., Ahmed, Tufael, Sebina, Ismail, Howard, Daniel R., Ullah, Md. Ashik, Rahman, Muhammed Mahfuzur, Lynch, Jason P., Curren, Bodie, Werder, Rhiannon B., Simpson, Jennifer, Bissell, Alec, Morrison, Mark, Walpole, Carina, Radford, Kristen J., Kumar, Vinod, Woodruff, Trent M., Ying, Tan Hui, Ali, Ayesha, Kaiko, Gerard E., Upham, John W., Hoelzle, Robert D., Cuív, Páraic Ó., Holt, Patrick G., Dennis, Paul G. and Phipps, Simon (2023). Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection. Immunity, 56 (5), 1098-1114.e10. doi: 10.1016/j.immuni.2023.03.002
2022
Journal Article
IFN-λ diminishes the severity of viral bronchiolitis in neonatal mice by limiting NADPH oxidase–induced PAD4-independent NETosis
Sebina, Ismail, Rashid, Ridwan B., Sikder, Md. Al Amin, Rahman, Muhammed Mahfuzur, Ahmed, Tufael, Radford-Smith, Daniel E., Kotenko, Sergei V., Hill, Geoffrey R., Bald, Tobias and Phipps, Simon (2022). IFN-λ diminishes the severity of viral bronchiolitis in neonatal mice by limiting NADPH oxidase–induced PAD4-independent NETosis. The Journal of Immunology, 208 (12), 2806-2816. doi: 10.4049/jimmunol.2100876
2022
Journal Article
Synergism and antagonism of bacterial-viral coinfection in the upper respiratory tract
Manna, Sam, McAuley, Julie, Jacobson, Jonathan, Nguyen, Cattram D., Ullah, Md Ashik, Sebina, Ismail, Williamson, Victoria, Mulholland, E. Kim, Wijburg, Odilia, Phipps, Simon and Satzke, Catherine (2022). Synergism and antagonism of bacterial-viral coinfection in the upper respiratory tract. mSphere, 7 (1) e00984-21. doi: 10.1128/msphere.00984-21
2022
Journal Article
Targeting the P2Y13 receptor suppresses IL-33 and HMGB1 release and ameliorates experimental asthma
Werder, Rhiannon B., Ullah, Md Ashik, Rahman, Muhammed Mahfuzur, Simpson, Jennifer, Lynch, Jason P., Collinson, Natasha, Rittchen, Sonja, Rashid, Ridwan B., Sikder, Md Al Amin, Handoko, Herlina Y., Curren, Bodie F., Sebina, Ismail, Hartel, Gunter, Bissell, Alec, Ngo, Sylvia, Yarlagadda, Tejasri, Hasnain, Sumaira Z., Lu, Wenying, Sohal, Sukhwinder S., Martin, Megan, Bowler, Simon, Burr, Lucy D., Martinez, Laurent O., Robaye, Bernard, Spann, Kirsten, Ferreira, Manuel A. R. and Phipps, Simon (2022). Targeting the P2Y13 receptor suppresses IL-33 and HMGB1 release and ameliorates experimental asthma. American Journal of Respiratory and Critical Care Medicine, 205 (3), 300-312. doi: 10.1164/rccm.202009-3686oc
2020
Journal Article
Mycobacterium tuberculosis infection is associated with increased B cell responses to unrelated pathogens
Kimuda, Simon G., Andia-Biraro, Irene, Sebina, Ismail, Egesa, Moses, Nalwoga, Angela, Smith, Steven G., Bagaya, Bernard S., Levin, Jonathan, Elliott, Alison M., Raynes, John G. and Cose, Stephen (2020). Mycobacterium tuberculosis infection is associated with increased B cell responses to unrelated pathogens. Scientific Reports, 10 (1) 14324, 14324. doi: 10.1038/s41598-020-71044-4
2020
Journal Article
The contribution of neutrophils to the pathogenesis of RSV bronchiolitis
Sebina, Ismail and Phipps, Simon (2020). The contribution of neutrophils to the pathogenesis of RSV bronchiolitis. Viruses, 12 (8) 808, 808. doi: 10.3390/v12080808
2020
Journal Article
Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma
Lynch, Jason P., Werder, Rhiannon B., Curren, Bodie F., Sikder, Md. Al Amin, Ullah, Ashik, Sebina, Ismail, Rashid, Ridwan B., Zhang, Vivian, Upham, John W., Hill, Geoff R., Steptoe, Raymond J. and Phipps, Simon (2020). Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma. Mucosal Immunology, 13 (4), 652-664. doi: 10.1038/s41385-020-0268-8
2020
Journal Article
PAG1 limits allergen-induced type 2 inflammation in the murine lung
Ullah, Md Ashik, Vicente, Cristina T., Collinson, Natasha, Curren, Bodie, Sikder, Md Al Amin, Sebina, Ismail, Simpson, Jennifer, Varelias, Antiopi, Lindquist, Jonathan A., Ferreira, Manuel A. R. and Phipps, Simon (2020). PAG1 limits allergen-induced type 2 inflammation in the murine lung. Allergy, 75 (2) all.13991, 336-345. doi: 10.1111/all.13991
2019
Journal Article
Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells
Akter, Jasmin, Khoury, David S., Aogo, Rosemary, Lansink, Lianne I. M., SheelaNair, Arya, Thomas, Bryce S., Laohamonthonkul, Pawat, Pernold, Clara P. S., Dixon, Matthew W. A., Soon, Megan S. F., Fogg, Lily G., Engel, Jessica A., Elliott, Trish, Sebina, Ismail, James, Kylie R., Cromer, Deborah, Davenport, Miles P. and Haque, Ashraful (2019). Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells. PLoS Pathogens, 15 (2) e1007599, e1007599. doi: 10.1371/journal.ppat.1007599
2018
Journal Article
Determinants of gammaherpesvirus shedding in saliva among Ugandan children and their mothers
Newton, Robert, Labo, Nazzarena, Wakeham, Katie, Marshall, Vickie, Roshan, Romin, Nalwoga, Angela, Sebina, Ismail, Muhangi, Lawrence, Webb, Emily L., Miley, Wendell, Rochford, Rosemary, Elliott, Alison M. and Whitby, Denise (2018). Determinants of gammaherpesvirus shedding in saliva among Ugandan children and their mothers. Journal of Infectious Diseases, 218 (6), 892-900. doi: 10.1093/infdis/jiy262
2018
Journal Article
Effects of type I interferons in malaria
Sebina, Ismail and Haque, Ashraful (2018). Effects of type I interferons in malaria. Immunology, 155 (2), 176-185. doi: 10.1111/imm.12971
2018
Journal Article
Humoral immune responses to infection: common mechanisms and unique strategies to combat pathogen immune evasion tactics
Sebina, Ismail and Pepper, Marion (2018). Humoral immune responses to infection: common mechanisms and unique strategies to combat pathogen immune evasion tactics. Current Opinion in Immunology, 51, 46-54. doi: 10.1016/j.coi.2018.02.001
2018
Journal Article
IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection
James, Kylie R., Soon, Megan S. F., Sebina, Ismail, Fernandez-Ruiz, Daniel, Davey, Gayle, Liligeto, Urijah N., Nair, Arya Sheela, Fogg, Lily G., Edwards, Chelsea L., Best, Shannon E., Lansink, Lianne I. M., Schroder, Kate, Wilson, Jane A. C., Austin, Rebecca, Suhrbier, Andreas, Lane, Steven W., Hill, Geoffrey R., Engwerda, Christian R., Heath, William R. and Haque, Ashraful (2018). IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection. Journal of Immunology, 200 (4), 1443-1456. doi: 10.4049/jimmunol.1700782
2017
Journal Article
Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo
Khoury, David S., Cromer, Deborah, Elliott, Trish, Soon, Megan S. F., Thomas, Bryce S., James, Kylie R., Best, Shannon E., Aogo, Rosemary A., Engel, Jessica A., Gartlan, Kate H., Akter, Jasmin, Sebina, Ismail, Haque, Ashraful and Davenport, Miles P. (2017). Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo. International Journal for Parasitology, 47 (14), 913-922. doi: 10.1016/j.ijpara.2017.05.009
Supervision
Availability
- Dr Ismail Sebina is:
- Available for supervision
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Supervision history
Completed supervision
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2021
Doctor Philosophy
New Pathogenic Mechanisms of Virus Associated Onset and Exacerbations of Asthma
Associate Advisor
Media
Enquiries
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