Overview
Background
Harrison is a medicinal chemist with a research focus on bioactive peptides as therapeutics and molecular tools. He completed his Honours and PhD at UQ in the School of Chemistry and Molecular Biosciences where he developed synthetic peptide-based vaccine candidates against a range of targets including Group A Streptococcus and small molecule substances of abuse in the laboratory of Professor Istvan Toth. He is now a postdoctoral research fellow in the Muttenthaler group at IMB where he is involved in several programs of peptide-based drug discovery and pharmacological probe development.
Availability
- Dr Harrison Madge is:
- Available for supervision
Qualifications
- Doctor of Philosophy of Medicinal and Biomolecular Chemistry, The University of Queensland
Works
Search Professor Harrison Madge’s works on UQ eSpace
2025
Journal Article
A synthetic cyclic peptide for promoting antigen presentation and immune activation
Zhang, Jiahui, Madge, Harrison Y. R., Mahmoud, Asmaa, Lu, Lantian, Wang, Wanyi, Huang, Wenbin, Koirala, Prashamsa, Gonzalez Cruz, Jazmina L., Kong, Wei Yang, Bashiri, Sahra, Shalash, Ahmed O., Hussein, Waleed M., Khalil, Zeinab G., Wells, James W., Toth, Istvan and Stephenson, Rachel J. (2025). A synthetic cyclic peptide for promoting antigen presentation and immune activation. NPJ Vaccines, 10 (1) 9, 9-1. doi: 10.1038/s41541-024-01050-4
2024
Book Chapter
Recent trends in peptide drug discovery and development
Madge, H. Y. R. and Muttenthaler, M. (2024). Recent trends in peptide drug discovery and development. Sustainability in tides chemistry. (pp. 23-49) edited by Alessandra Tolomelli, Lucia Ferrazzano and Walter Cabri. London, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781837674541-00023
2024
Conference Publication
Synthetic anti-cocaine nano-vaccine successfully prevents cocaine-induced hyperlocomotion
Madge, Harrison, Alexander, Suzy, Azuar, Armira, Zhang, Jiahui, Koirala, Prashamsa, Burne, Thomas, Toth, Istvan and Stephenson, Rachel (2024). Synthetic anti-cocaine nano-vaccine successfully prevents cocaine-induced hyperlocomotion. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons.
2024
Journal Article
Cyclic Peptide Conjugate Vaccines and Physically Mixed Cyclic Peptide Vaccines for Subcutaneous Immunization
Huang, Wenbin, Madge, Harrison Y. R., Toth, Istvan and Stephenson, Rachel J. (2024). Cyclic Peptide Conjugate Vaccines and Physically Mixed Cyclic Peptide Vaccines for Subcutaneous Immunization. Methods in Molecular Biology, 2821, 111-127. doi: 10.1007/978-1-0716-3914-6_9
2023
Journal Article
Synthetic anti-cocaine nanoaccine successfully prevents cocaine-induced hyperlocomotion
Madge, Harrison Y. R., Alexander, Suzy, Azuar, Armira, Zhang, Jiahui, Koirala, Prashamsa, Burne, Thomas H., Toth, Istvan and Stephenson, Rachel J. (2023). Synthetic anti-cocaine nanoaccine successfully prevents cocaine-induced hyperlocomotion. Journal of Medicinal Chemistry, 66 (17), 12407-12419. doi: 10.1021/acs.jmedchem.3c00889
2022
Other Outputs
Development of vaccine delivery systems for peptide antigens and small molecule haptens
Madge, Harrison (2022). Development of vaccine delivery systems for peptide antigens and small molecule haptens. PhD Thesis, School of Chemistry and Molecular Biosciences, The University of Queensland. doi: 10.14264/9869022
2022
Journal Article
Poly(hydrophobic amino acids) and liposomes for delivery of vaccine against Group A Streptococcus
Azuar, Armira, Madge, Harrison Y. R., Boer, Jennifer C., Gonzalez Cruz, Jazmina L., Wang, Jingwen, Khalil, Zeinab G., Deceneux, Cyril, Goodchild, Georgia, Yang, Jieru, Koirala, Prashamsa, Hussein, Waleed M., Capon, Robert J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2022). Poly(hydrophobic amino acids) and liposomes for delivery of vaccine against Group A Streptococcus. Vaccines, 10 (8) 1212, 1-14. doi: 10.3390/vaccines10081212
2022
Journal Article
Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems
Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander A., Hussein, Waleed M., Chappell, Keith J., Watterson, Daniel, Young, Paul R., Skwarczynski, Mariusz and Toth, Istvan (2022). Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems. Pharmaceutics, 14 (4) 856, 856. doi: 10.3390/pharmaceutics14040856
2022
Journal Article
Structure-activity relationship of lipid, cyclic peptide and antigen rearrangement of physically mixed vaccines
Huang, Wenbin, Madge, Harrison Y. R., Zhang, Jiahui, Gilmartin, Lachlan, Hussein, Waleed M., Khalil, Zeinab G., Koirala, Prashamsa, Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2022). Structure-activity relationship of lipid, cyclic peptide and antigen rearrangement of physically mixed vaccines. International Journal of Pharmaceutics, 617 121614, 1-12. doi: 10.1016/j.ijpharm.2022.121614
2022
Journal Article
Physical mixture of a cyclic lipopeptide vaccine induced high titres of opsonic IgG antibodies against group A streptococcus
Madge, Harrison Y. R., Huang, Wenbin, Gilmartin, Lachlan, Rigau-Planella, Berta, Hussein, Waleed M., Khalil, Zeinab G., Koirala, Prashamsa, Santiago, Viviene S., Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2022). Physical mixture of a cyclic lipopeptide vaccine induced high titres of opsonic IgG antibodies against group A streptococcus. Biomaterials Science, 10 (1), 281-293. doi: 10.1039/d1bm01333e
2021
Journal Article
Detection and quantification of SARS-CoV-2 receptor binding domain neutralization by a sensitive competitive ELISA assay
Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander A., Watterson, Daniel, Young, Paul R., Toth, Istvan and Skwarczynski, Mariusz (2021). Detection and quantification of SARS-CoV-2 receptor binding domain neutralization by a sensitive competitive ELISA assay. Vaccines, 9 (12) 1493, 1-21. doi: 10.3390/vaccines9121493
2021
Other Outputs
Detection and Quantification of SARS-CoV-2 Receptor Binding Domain Neutralization by a Sensitive Competitive ELISA Assay
Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander, Watterson, Daniel, Young, Paul R., Toth, Istvan and Skwarczynski, Mariusz (2021). Detection and Quantification of SARS-CoV-2 Receptor Binding Domain Neutralization by a Sensitive Competitive ELISA Assay. doi: 10.21203/rs.3.pex-1559/v1
2021
Book Chapter
Nanocarrier-based vaccine delivery systems for synthetic peptide vaccines
Madge, Harrison Y.R., Stephenson, Rachel J. and Toth, Istvan (2021). Nanocarrier-based vaccine delivery systems for synthetic peptide vaccines. Handbook of nanotechnology applications: environment, energy, agriculture and medicine. (pp. 509-535) edited by Woei Jye Lau, Kajornsak Faungnawakij, Kuakoon Piyachomkwan and Uracha Rungsardthong Ruktanonchai. Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-821506-7.00020-x
2020
Journal Article
Structure–activity analysis of cyclic multicomponent lipopeptide self-adjuvanting vaccine candidates presenting Group A Streptococcus antigens
Madge, Harrison Y. R., Sharma, Hansa, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert John, Toth, Istvan and Stephenson, Rachel (2020). Structure–activity analysis of cyclic multicomponent lipopeptide self-adjuvanting vaccine candidates presenting Group A Streptococcus antigens. Journal of Medicinal Chemistry, 63 (10) acs.jmedchem.0c00203, 5387-5397. doi: 10.1021/acs.jmedchem.0c00203
Funding
Current funding
Supervision
Availability
- Dr Harrison Madge is:
- Available for supervision
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