Graham Lee

My research has had wide-ranging impacts on the eye health of the population (Citations 3721, h-index 30). My greatest contributions have been in the field of ocular surface squamous neoplasia. I was the first to define the appropriate terminology in my landmark study (Surv Ophthalmology, 1995;39:429-450), which now has 795 citations in the literature. Other works on this condition have made significant contributions to the body of knowledge including establishing an incidence rate (Arch Ophthalmol, 1992;10:525-527) with 191 citations, described ultraviolet light exposure as a major risk factor (Ophthalmology, 1994;2:360-364) with 220 citations, elucidated the higher incidence in older males and the high recurrence rates with surgical excision (Aust NZ J Ophthalmol 1997 25:269-276) with 143 citations and the successful use of topical chemotherapeutic agents rather than surgical excision to provide better resolution rates with less morbidity (Am J Ophthalmol 2006; 142:568-571 with 57 citations and Am J Ophthalmol 2014;15:287-293 with 62 citations).

I have made significant contributions in other fields of ophthalmology. My work on prognostic indicators for severe trauma to the eye resulting in open globe injury found larger wounds in rural settings were more likely to result in loss of the eye (Clin Exp Ophthalmol 2006 34:783-6) with 140 citations. A follow up quality of life survey, found patients coped best if every attempt was made to save their injured eye even if they subsequently lost the eye, compared to patients who had their eye removed at the time of injury (Ophthalmology 2006;113:1057). Acanthamoeba is a severe protozoal infection of the cornea that can result in blindness. In collaboration with colleagues from Moorfields Eye Hospital in London, I described a devastating variant of this condition involving the sclera of the eye and the role of immunosuppression treatment (Ophthalmology 2002;109:1178-1182) with 87 citations. My other current subspecialty interest is glaucoma - a chronic progressive loss of vision, most often due to high eye ocular pressure. A key factor in the management of the disease is measurement of this pressure, and I described the numerous factors including corneal thickness that influence the obtained values (Clin Exp Ophthalmol 2002;30;334-7). One of the most common chronic eye conditions affecting up to 15% of the population over 50 worldwide is dry eye syndrome. In the more severe form, it can lead to depression and be recalcitrant to the commercially available forms of lubrication. The use of serum eye drops is a novel treatment and can be a biologically active way to restore the health of the ocular surface and relieve symptoms (Clin Exp Ophthalmol 2008;36:119-122 - 93 citations).