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Comparing properties of innate immune proteins of bats and humans (ARC Discovery Project administered by UNSW) (2024-2027)

Abstract

Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the 'supra-immunity' of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms that regulate the signalosomes. The intended outcome is to answer the long-standing question of control of speed and amplitude of innate immune response at the molecular level. Both locally and internationally, this new approach should provide benefits across structural biology, molecular evolution and biotechnology.

Experts

Professor Bostjan Kobe

NHMRC Leadership Fellow
School of Chemistry and Molecular Biosciences
Faculty of Science
Affiliate Professor
Institute for Molecular Bioscience
Bostjan Kobe
Bostjan Kobe