Reversible patterning of surfaces for biomolecule immobilisation (2026-2029)
Abstract
Development of biomolecule capture and purification methodologies is the cornerstone for many disruptive advances in the field of biotech and pharma but advances are often hamstrung by only incremental improvements. This project aims to develop a unique methodology for selectively modulating the immobilisation of biomolecules on a designed polymer surface. Anticipated outcomes provide unique insight into factors dictating spatially-resolved patterning of biomolecules, and methodologies that improve control over immobilisation using wavelength-dependent stimulii and bioorthogonal chemistries. This could improve translation of advanced polymer materials, expanding capability/applications in biomolecule capture, interrogation and manipulation.
