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Scaling-up fermentation processes is not straightforward due to the emergence of concentration gradients at scale. For gas fermentation processes, with CO2, CO and CH4 and H2, scaling is even more challenging as high mass transfer rates need to be obtained. In his work, Lars is developing a framework to reliably scale-up gas fermentation processes, considering both mass transfer and concentration gradients. We aim to employ mechanistic models, combined with wet-lab data, to develop relationships and fluid dynamic (CFD) models to estimate the fermentation performance at industrial scale. He specialised in topics like bioreactor and bioprocess design, bioprocess scale-up/scale-down, mass transfer and transport phenomena, metabolic and kinetic modelling and simulation techniques.

I obtained a Diploma in Chemistry from the University of Bern in Switzerland in 1992. Upon receiving the award of an International Postgraduate Research Scholarship (IPRS) I joined The University of Queensland (UQ) in 1993 to carry out research towards a PhD in Biochemistry(supervisors: Assoc. Profs. Peter Nixon and Ron Duggleby). I graduated in 1997 and continued postdoctoral research at UQ under the guidance of Profs John de Jersey, Susan Hamilton and Graeme Hanson. During this period, I was awarded Fellowships from both the Wellcome Trust and UQ. In 2000 I spent several months in the Department of Chemistry at the University of Newcastle-upon-Tyne, England, collaborating with Prof. Geoff Sykes, and later that year I commenced a Senior Postdoctoral Fellowship in the Chemistry Department at Stanford University (advisor: Prof. Edward Solomon). In 2003 I was appointed to a Lectureship in (Bio)Physical Chemistry at UQ. In 2006 I was promoted to Senior Lecturer. Following the award of a UQ Foundation Research Excellence Award (in 2007) I was promoted to Associate Professor (in 2008), and between 2011 and 2013 I was also on a fractional professorial appointment (50%) at Maynooth University, Ireland. From 2013 to 2017 I held a Future Fellowship from the Australian Research Council, and during this period I was promoted to Full Professor at UQ (2015). I also hold affiliate professorships in the Sustainable Minerals Institute and the Australian Institute for Bioengineering and Nanotechnology, both located at UQ.

I have successfully focused my research on the investigation of enzyme-catalysed reactions, their optimisation for applications in biotechnology and the synthesis of small molecules that mimic their structure and catalytic function (i.e. biomimetics). I advanced understanding of the contribution of metals to enzyme-catalysed reactions and employed state-of-the-art technologies (e.g. cryo-EM, ancestral gene reconstruction) to develop enzyme inhibitors as leads for novel biocides (herbicides, fungicides, antibacterial compounds) and engineer enzymes with enhanced catalytic properties for industrial applications in the advanced manufacturing sector (i.e. cell-free enzyme cascades, next-gen fertilisers). My work into enzyme mechanisms, regulation and engineering received international acclaim evidenced by invitations to provide plenary and keynote lectures and review articles in prestigious journals. I have published over 250 peer-reviewed articles, including over 40 papers in the ACS staple (J. Am. Chem. Soc, ACS Catalysis, ACS Sus. Chem. Eng., Inorg. Chem, Chem. Rev., Acc. Chem. Rev.) as well as landmark studies in Nature, Nature Catalysis, Nature Communications and Proc. Natl. Acad. Sci. (USA). For my leadership in enzymology I was awarded a Future Fellowship by the Australian Research Council, a Foundation Research Excellence Award by UQ and, most recently, the prestigious role as Ambassador for the Technical University of Munich (TUM), an honour bestowed upon me also for my leading role in building an extensive network of collaborations between UQ and TUM in the areas of bioengineering and bioeconomy. The network has since evolved into the Global Bioeconomy Alliance.

Dr Xiangkang Zeng is currently an Honorary Research Fellow at the UQ Dow Centre, School of Chemical Engineering, The University of Queensland. He received his PhD in Chemical Engineering from Monash University in 2017. He subsequently undertook postdoctoral research at the Hong Kong University of Science and Technology and Monash University before joining UQ as an ARC DECRA Research Fellow (2022-2025) and UQ Amplify Lecturer (2025-2026).

Dr Zeng’s research focuses on functional materials and redox catalysis for energy and environmental applications, particularly electrocatalysis, photocatalysis, peroxide synthesis, CO₂ conversion, and energy storage. He has published more than 60 peer-reviewed papers in leading journals, including Advanced Materials, Advanced Energy Materials, Angewandte Chemie, ACS Catalysis, Applied Catalysis B, Water Research, and Green Chemistry. He also has extensive teaching experience in bioprocess engineering, process principles, thermodynamics, and research thesis supervision.