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2018 Journal Article Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in miceGordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A. and Woodruff, Trent M. (2018). Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10 (465) aah4066, eaah4066. doi: 10.1126/scitranslmed.aah4066 |
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2018 Journal Article Mitochondrial DNA synthesis fuels NLRP3 inflammasomeColl, Rebecca C., Holley, Caroline L. and Schroder, Kate (2018). Mitochondrial DNA synthesis fuels NLRP3 inflammasome. Cell Research, 28 (11), 1046-1047. doi: 10.1038/s41422-018-0093-8 |
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2018 Journal Article Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genesRamnath, Divya, Irvine, Katharine M., Lukowski, Samuel W., Horsfall, Leigh U., Loh, Zhixuan, Clouston, Andrew D., Patel, Preya J., Fagan, Kevin J., Iyer, Abishek, Lampe, Guy, Stow, Jennifer L., Schroder, Kate, Fairlie, David P., Powell, Joseph E., Powell, Elizabeth E. and Sweet, Matthew J. (2018). Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight, 3 (14) e120274. doi: 10.1172/jci.insight.120274 |
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2018 Journal Article Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborationsDeretic, Vojo, Prossnitz, Eric, Burge, Mark, Campen, Matthew J., Cannon, Judy, Liu, Ke Jian, Sklar, Larry A., Allers, Lee, Garcia, Sally Ann, Baehrecke, Eric H., Behrends, Christian, Cecconi, Francesco, Codogno, Patrice, Chen, Guang-Chao, Elazar, Zvulun, Eskelinen, Eeva-Liisa, Fourie, Bernard, Gozuacik, Devrim, Hong, Wanjin, Hotamisligi, Gokhan, Jäättelä, Marja, Jo, Eun-Kyeong, Johansen, Terje, Juhász, Gábor, Kimchi, Adi, Ktistakis, Nicholas, Kroemer, Guido, MIzushima, Noboru, Münz, Christian ... Klionsky, Daniel J. (2018). Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations. Autophagy, 14 (6) 15548627.2018.1465784, 925-929. doi: 10.1080/15548627.2018.1465784 |
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2018 Journal Article MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis micePerera, Agampodi Promoda, Fernando, Ruchira, Shinde, Tanvi, Gundamaraju, Rohit, Southam, Benjamin, Sohal, Sukhwinder Singh, Robertson, Avril A. B., Schroder, Kate, Kunde, Dale and Eri, Rajaraman (2018). MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice. Scientific Reports, 8 (1) 8618, 8618. doi: 10.1038/s41598-018-26775-w |
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2018 Journal Article Cutting edge: blockade of inhibitor of apoptosis proteins sensitizes neutrophils to TNF- but not lipopolysaccharide-mediated cell death and IL-1β secretionChen, Kaiwen W., Lawlor, Kate E., von Pein, Jessica B., Boucher, Dave, Gerlic, Motti, Croker, Ben A., Bezbradica, Jelena S., Vince, James E and Schroder, Kate (2018). Cutting edge: blockade of inhibitor of apoptosis proteins sensitizes neutrophils to TNF- but not lipopolysaccharide-mediated cell death and IL-1β secretion. Journal of Immunology, 200 (10), 3341-3346. doi: 10.4049/jimmunol.1701620 |
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2018 Journal Article IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infectionJames, Kylie R., Soon, Megan S. F., Sebina, Ismail, Fernandez-Ruiz, Daniel, Davey, Gayle, Liligeto, Urijah N., Nair, Arya Sheela, Fogg, Lily G., Edwards, Chelsea L., Best, Shannon E., Lansink, Lianne I. M., Schroder, Kate, Wilson, Jane A. C., Austin, Rebecca, Suhrbier, Andreas, Lane, Steven W., Hill, Geoffrey R., Engwerda, Christian R., Heath, William R. and Haque, Ashraful (2018). IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection. Journal of Immunology, 200 (4), 1443-1456. doi: 10.4049/jimmunol.1700782 |
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2018 Journal Article Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitisChen, Alice C. -H., Tran, Hai B., Xi, Yang, Yerkovich, Stephanie T., Baines, Katherine J., Pizzutto, Susan J., Carroll, Melanie, Robertson, Avril A. B., Cooper, Matthew A., Schroder, Kate, Simpson, Jodie L., Gibson, Peter G., Hodge, Greg, Masters, Ian B., Buntain, Helen M., Petsky, Helen L., Prime, Samantha J., Chang, Anne B., Hodge, Sandra and Upham, John W. (2018). Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis. ERJ Open Research, 4 (1) 00130-2017, 00130-2017. doi: 10.1183/23120541.00130-2017 |
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2017 Journal Article Mechanisms and Consequences of Inflammasome ActivationSchroder, Kate, Kanneganti, Thirumala-Devi, Shao, Feng and Broz, Petr (2017). Mechanisms and Consequences of Inflammasome Activation. Journal of Molecular Biology, 430 (2), 131-132. doi: 10.1016/j.jmb.2017.12.005 |
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2017 Journal Article Zebrafish earns its stripes for in vivo ASC speck dynamicsBezbradica, Jelena S. and Schroder, Kate (2017). Zebrafish earns its stripes for in vivo ASC speck dynamics. Journal of Cell Biology, 216 (9), 2615-2618. doi: 10.1083/jcb.201708002 |
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2017 Journal Article Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitorsHill, James R., Coll, Rebecca C., Sue, Nancy, Reid, Janet C., Dou, Jennifer, Holley, Caroline L., Pelingon, Ruby, Dickinson, Joshua B., Biden, Trevor J., Schroder, Kate, Cooper, Matthew A. and Robertson, Avril A. B. (2017). Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors. ChemMedChem, 12 (17), 1449-1457. doi: 10.1002/cmdc.201700270 |
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2017 Journal Article Correction: Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner (Proceedings of the National Academy of Sciences of the United States of America (2017) 114 (E961-E969) DOI: 10.1073/pnas.1613305114)Conos, Stephanie A., Chen, Kaiwen W., De Nardo, Dominic, Hara, Hideki, Whitehead, Lachlan, Núñez, Gabriel, Masters, Seth L., Murphy, James M., Schroder, Kate, Vaux, David L., Lawlor, Kate E., Lindqvist, Lisa M. and Vince, James E. (2017). Correction: Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner (Proceedings of the National Academy of Sciences of the United States of America (2017) 114 (E961-E969) DOI: 10.1073/pnas.1613305114). Proceedings of the National Academy of Sciences of the United States of America, 114 (28), E5762-E5763. doi: 10.1073/pnas.1710668114 |
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2017 Journal Article In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosisDuszyc, Kinga, Gomez, Guillermo A., Schroder, Kate, Sweet, Matthew J. and Yap, Alpha S. (2017). In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis. Tissue Barriers, 5 (4) e1345353, e1345353. doi: 10.1080/21688370.2017.1345353 |
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2017 Journal Article XIAP loss triggers RIPK3- and caspase-8-driven IL-1β activation and cell death as a consequence of TLR-MyD88-induced cIAP1-TRAF2 degradationLawlor, Kate E., Feltham, Rebecca, Yabal, Monica, Conos, Stephanie A., Chen, Kaiwen W., Ziehe, Stephanie, Grass, Carina, Zhan, Yifan, Nguyen, Tan A., Hall, Cathrine, Vince, Angelina J., Chatfield, Simon M., D'Silva, Damian B., Pang, Kenneth C., Schroder, Kate, Silke, John, Vaux, David L., Jost, Philipp J. and Vince, James E. (2017). XIAP loss triggers RIPK3- and caspase-8-driven IL-1β activation and cell death as a consequence of TLR-MyD88-induced cIAP1-TRAF2 degradation. Cell Reports, 20 (3), 668-682. doi: 10.1016/j.celrep.2017.06.073 |
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2017 Journal Article NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in miceMridha, Auvro R., Wree, Alexander, Robertson, Avril A. B., Yeh, Matthew M., Johnson, Casey D., Van Rooyen, Derrick M., Haczeyni, Fahrettin, Teoh, Narci C. -H., Savard, Christopher, Ioannou, George N., Masters, Seth L., Schroder, Kate, Cooper, Matthew A., Feldstein, Ariel E. and Farrell, Geoffrey C. (2017). NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. Journal of Hepatology, 66 (5), 1037-1046. doi: 10.1016/j.jhep.2017.01.022 |
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2017 Journal Article Active MLKL triggers the NLRP3 inflammasome in a cell intrinsic mannerConos, Stephanie A. , Chen, Kaiwen W. , De Nardo, Dominic , Hara, Hideki , Whitehead, Lachlan , Núñez, Gabriel , Masters, Seth L. , Murphy, James M. , Schroder, Kate , Vaux, David L. , Lawlor, Kate E. , Lindqvist, Lisa M. and Vince, James E. (2017). Active MLKL triggers the NLRP3 inflammasome in a cell intrinsic manner. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 114 (6), E961-E969. doi: 10.1073/pnas.1613305114 |
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2016 Journal Article Role of NLRP3 inflammasome in a model of acute burn-induced painDeuis, Jennifer R., Yin, Kathleen, Cooper, Matthew A., Schroder, Kate and Vetter, Irina (2016). Role of NLRP3 inflammasome in a model of acute burn-induced pain. Burns, 43 (2), 304-309. doi: 10.1016/j.burns.2016.09.001 |
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2016 Journal Article Salmonella-induced inflammasome activation in humansBierschenk, Damien, Boucher, Dave and Schroder, Kate (2016). Salmonella-induced inflammasome activation in humans. Molecular Immunology, 86, 38-43. doi: 10.1016/j.molimm.2016.11.009 |
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2016 Journal Article K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondriaGroß, Christina J., Mishra, Ritu, Schneider, Katharina S., Médard, Guillaume, Wettmarshausen, Jennifer, Dittlein, Daniela C., Shi, Hexin, Gorka, Oliver, Koenig, Paul-Albert, Fromm, Stephan, Magnani, Giovanni, Ćiković, Tamara, Hartjes, Lara, Smollich, Joachim, Robertson, Avril A. B., Cooper, Matthew A., Schmidt-Supprian, Marc, Schuster, Michael, Schroder, Kate, Broz, Petr, Traidl-Hoffmann, Claudia, Beutler, Bruce, Kuster, Bernhard, Ruland, Jürgen, Schneider, Sabine, Perocchi, Fabiana and Groß, Olaf (2016). K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria. Immunity, 45 (4), 761-773. doi: 10.1016/j.immuni.2016.08.010 |
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2016 Journal Article IL-1 contributes to the anti-cancer efficacy of ingenol mebutateLe, Thuy T., Skak, Kresten, Schroder, Kate, Schroder, Wayne A., Boyle, Glen M., Pierce, Carly J. and Suhrbier, Andreas (2016). IL-1 contributes to the anti-cancer efficacy of ingenol mebutate. PLoS One, 11 (4) e0153975, e0153975. doi: 10.1371/journal.pone.0153975 |
