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2024 Conference Publication In-silico application of structure prediction to peptide mechanism of actionTucker, Isaac, King, Glenn, Saez, Natalie, Deplazes, Evelyne, Rash, Lachlan, Cristofori-Armstrong, Ben and Budusan, Elena (2024). In-silico application of structure prediction to peptide mechanism of action. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons. |
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2024 Conference Publication Mending achy-breaky hearts: cyclic peptide TL01 is an enhancer of cardiac intracellular protein-protein interactions and promotes heart contractilityRojas-Azofeifa, Daniela, Passioura, Toby, McMillen, Timothy, Cheesman, Elisabeth, Saez, Natalie, Chow, Jonathan, Eagles, David, Norman, Alexander, Perry, Matthew, Molenar, Peter, Regnier, Michael, King, Glenn and Palpant, Nathan (2024). Mending achy-breaky hearts: cyclic peptide TL01 is an enhancer of cardiac intracellular protein-protein interactions and promotes heart contractility. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons. |
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2024 Journal Article Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarctionRedd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2024). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal, 45 (17), 1571-1574. doi: 10.1093/eurheartj/ehad793 |
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2024 Journal Article Hi1a improves sensorimotor deficit following endothelin-1-induced stroke in rats but does not improve functional outcomes following filament-induced stroke in miceKnezic, Adriana, Budusan, Elena, Saez, Natalie J., Broughton, Brad R. S., Rash, Lachlan D., King, Glenn F., Widdop, Robert E. and McCarthy, Claudia A. (2024). Hi1a improves sensorimotor deficit following endothelin-1-induced stroke in rats but does not improve functional outcomes following filament-induced stroke in mice. ACS Pharmacology and Translational Science, 7 (4), 1043-1054. doi: 10.1021/acsptsci.3c00328 |
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2023 Journal Article Acute inhibition of acid sensing ion channel 1a after spinal cord injury selectively affects excitatory synaptic transmission, but not intrinsic membrane properties, in deep dorsal horn interneuronsFoster, Victoria S., Saez, Natalie, King, Glenn F. and Rank, Michelle M. (2023). Acute inhibition of acid sensing ion channel 1a after spinal cord injury selectively affects excitatory synaptic transmission, but not intrinsic membrane properties, in deep dorsal horn interneurons. PLoS One, 18 (11 November) e0289053, 1-23. doi: 10.1371/journal.pone.0289053 |
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2023 Journal Article Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1aTran, Hue N. T., Budusan, Elena, Saez, Natalie J., Norman, Alexander, Tucker, Isaac J., King, Glenn F., Payne, Richard J., Rash, Lachlan D., Vetter, Irina and Schroeder, Christina I. (2023). Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a. Organic Letters, 25 (24), 4439-4444. doi: 10.1021/acs.orglett.3c01346 |
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2023 Journal Article Genetic or pharmacological ablation of acid-sensing ion channel 1a (ASIC1a) is not neuroprotective in a mouse model of spinal cord injuryFoster, Victoria, Saez, Natalie, Gillespie, Ellen, Jogia, Trisha, Reid, Chantelle, Maljevic, Snezana, Jung, Woncheol, Lao, Hong W., Ruitenberg, Marc Jan and King, Glen (2023). Genetic or pharmacological ablation of acid-sensing ion channel 1a (ASIC1a) is not neuroprotective in a mouse model of spinal cord injury. Journal of Neurotrauma, 41 (9-10), 1007-1019. doi: 10.1089/neu.2022.0295 |
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2022 Journal Article A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammalsEagles, David A., Saez, Natalie J., Krishnarjuna, Bankala, Bradford, Julia J., Chin, Yanni K.-Y., Starobova, Hana, Mueller, Alexander, Reichelt, Melissa E., Undheim, Eivind A. B., Norton, Raymond S., Thomas, Walter G., Vetter, Irina, King, Glenn F. and Robinson, Samuel D. (2022). A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals. Proceedings of the National Academy of Sciences, 119 (7) e2112630119. doi: 10.1073/pnas.2112630119 |
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2022 Journal Article Strategies for heterologous expression, synthesis, and purification of animal venom toxinsRivera-de-Torre, Esperanza, Rimbault, Charlotte, Jenkins, Timothy P., Sørensen, Christoffer V., Damsbo, Anna, Saez, Natalie J., Duhoo, Yoan, Hackney, Celeste Menuet, Ellgaard, Lars and Laustsen, Andreas H. (2022). Strategies for heterologous expression, synthesis, and purification of animal venom toxins. Frontiers in Bioengineering and Biotechnology, 9 811905, 811905. doi: 10.3389/fbioe.2021.811905 |
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2021 Journal Article Total synthesis of the spider-venom peptide Hi1aDuggan, Nisharnthi M., Saez, Natalie J., Clayton, Daniel, Budusan, Elena, Watson, Emma E., Tucker, Isaac J., Rash, Lachlan D., King, Glenn F. and Payne, Richard J. (2021). Total synthesis of the spider-venom peptide Hi1a. Organic Letters, 23 (21) acs.orglett.1c03112, 8375-8379. doi: 10.1021/acs.orglett.1c03112 |
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2021 Journal Article Therapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injuryRedd, Meredith A., Scheuer, Sarah E., Saez, Natalie J., Yoshikawa, Yusuke, Chiu, Han Sheng, Gao, Ling, Hicks, Mark, Villanueva, Jeanette E., Joshi, Yashutosh, Chow, Chun Yuen, Cuellar-Partida, Gabriel, Peart, Jason N., See Hoe, Louise E., Chen, Xiaoli, Sun, Yuliangzi, Suen, Jacky Y., Hatch, Robert J., Rollo, Ben, Xiao, Di, Alzubaidi, Mubarak A.H., Maljevic, Snezana, Quaife-Ryan, Gregory A., Hudson, James E., Porrello, Enzo R., White, Melanie Y., Cordwell, Stuart J., Fraser, John F., Petrou, Steven, Reichelt, Melissa E. ... Palpant, Nathan J. (2021). Therapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury. Circulation, 144 (12), 947-960. doi: 10.1161/circulationaha.121.054360 |
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2020 Journal Article A venomics approach coupled to high-throughput toxin production strategies identifies the first venom-derived melanocortin receptor agonistsReynaud, Steve, Ciolek, Justyna, Degueldre, Michel, Saez, Natalie J., Sequeira, Ana Filipa, Duhoo, Yoan, Brás, Joana L A, Meudal, Hervé, Cabo Díez, Miguel, Fernández Pedrosa, Victoria, Verdenaud, Marion, Boeri, Julia, Pereira Ramos, Oscar, Ducancel, Frédéric, Vanden Driessche, Margot, Fourmy, Rudy, Violette, Aude, Upert, Grégory, Mourier, Gilles, Beck-Sickinger, Annette G., Mörl, Karin, Landon, Céline, Fontes, Carlos M. G. A., Miñambres Herráiz, Rebeca, Rodríguez de la Vega, Ricardo C., Peigneur, Steve, Tytgat, Jan, Quinton, Loïc, De Pauw, Edwin ... Gilles, Nicolas (2020). A venomics approach coupled to high-throughput toxin production strategies identifies the first venom-derived melanocortin receptor agonists. Journal of Medicinal Chemistry, 63 (15), 8250-8264. doi: 10.1021/acs.jmedchem.0c00485 |
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2020 Conference Publication A spider-venom peptide for preventing ischemic injuries of the heart: application to heart transplant and myocardial infarctionRedd, M. A., Scheuer, S. E., Saez, N. J., Macdonald, P. S., Palpant, N. J. and King, G. F. (2020). A spider-venom peptide for preventing ischemic injuries of the heart: application to heart transplant and myocardial infarction. Venom Week, Gainesville, FL, United States, 4-7 March, 2020. Oxford, United Kingdom : Elsevier. |
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2019 Journal Article The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitroNixon, Samantha A., Saez, Natalie J., Herzig, Volker, King, Glenn F. and Kotze, Andrew C. (2019). The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro. Veterinary Parasitology, 270, 40-46. doi: 10.1016/j.vetpar.2019.05.008 |
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2019 Journal Article The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analoguesCristofori-Armstrong, Ben, Saez, Natalie J., Chassagnon, Irène R., King, Glenn F. and Rash, Lachlan D. (2019). The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues. Biochemical Pharmacology, 163, 381-390. doi: 10.1016/j.bcp.2019.03.004 |
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2019 Journal Article Versatile spider venom peptides and their medical and agricultural applicationsSaez, Natalie J. and Herzig, Volker (2019). Versatile spider venom peptides and their medical and agricultural applications. Toxicon, 158, 109-126. doi: 10.1016/j.toxicon.2018.11.298 |
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2019 Book Chapter High-throughput production of oxidized animal toxins in Escherichia coliDuhoo, Yoan, Sequeira, Ana Filipa, Saez, Natalie J, Turchetto, Jeremy, Ramond, Laurie, Peysson, Fanny, Brás, Joana L A, Gilles, Nicolas, Darbon, Hervé, Fontes, Carlos M G A and Vincentelli, Renaud (2019). High-throughput production of oxidized animal toxins in Escherichia coli. High-Throughput Protein Production and Purification. (pp. 165-190) edited by Renaud Vincentelli. New York, NY, United States: Humana. doi: 10.1007/978-1-4939-9624-7_7 |
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2018 Journal Article Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory painLee, Jia Yu Peppermint, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, King, Glenn F., Smith, Maree T. and Rash, Lachlan D. (2018). Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. British Journal of Pharmacology, 175 (12), 2204-2218. doi: 10.1111/bph.14089 |
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2017 Journal Article ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxinsPineda, Sandy S., Chaumeil, Pierre-Alain, Kunert, Anne, Kaas, Quentin, Thang, Mike W. C., Le, Lien, Nuhn, Michael, Herzig, Volker, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, Senff, Sebastian, Gorse, Dominique and King, Glenn F. (2017). ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins. Bioinformatics, 34 (6), 1074-1076. doi: 10.1093/bioinformatics/btx661 |
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2017 Journal Article Gene design, fusion technology and TEV cleavage conditions influence the purification of oxidized disulphide-rich venom peptides in Escherichia coliSequeira, Ana Filipa, Turchetto, Jeremy, Saez, Natalie J., Peysson, Fanny, Ramond, Laurie, Duhoo, Yoan, Blemont, Marilyne, Fernandes, Vânia O., Gama, Luís T., Ferreira, Luís M. A., Guerreiro, Catarina I. P. I., Gilles, Nicolas, Darbon, Hervé, Fontes, Carlos M. G. A. and Vincentelli, Renaud (2017). Gene design, fusion technology and TEV cleavage conditions influence the purification of oxidized disulphide-rich venom peptides in Escherichia coli. Microbial Cell Factories, 16 (1) 4, 4. doi: 10.1186/s12934-016-0618-0 |
