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2020 Journal Article Structure, function, and therapeutic potential of the trefoil factor family in the gastrointestinal tractBraga Emidio, Nayara, Brierley, Stuart M., Schroeder, Christina I. and Muttenthaler, Markus (2020). Structure, function, and therapeutic potential of the trefoil factor family in the gastrointestinal tract. ACS Pharmacology and Translational Science, 3 (4) acsptsci.0c00023, 583-597. doi: 10.1021/acsptsci.0c00023 |
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2020 Journal Article Neuropeptide signalling systems -an underexplored target for venom drug discoveryMendel, Helen C., Kaas, Quentin and Muttenthaler, Markus (2020). Neuropeptide signalling systems -an underexplored target for venom drug discovery. Biochemical Pharmacology, 181 114129, 114129. doi: 10.1016/j.bcp.2020.114129 |
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2020 Journal Article Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of actionBraga Emidio, Nayara, Baik, Hayeon, Lee, David, Stürmer, René, Heuer, Jörn, Elliott, Alysha G, Blaskovich, Mark A T, Haupenthal, Katharina, Tegtmeyer, Nicole, Hoffmann, Werner, Schroeder, Christina I and Muttenthaler, Markus (2020). Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical communications (Cambridge, England), 56 (51), 7049-7049. doi: 10.1039/d0cc90250k |
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2020 Journal Article The tumor suppressor TFF1 occurs in different forms and interacts with multiple partners in the human gastric mucus barrier: indications for diverse protective functionsHeuer, Jörn, Heuer, Franziska, Stürmer, René, Harder, Sönke, Schlüter, Hartmut, Braga Emidio, Nayara, Muttenthaler, Markus, Jechorek, Dörthe, Meyer, Frank and Hoffmann, Werner (2020). The tumor suppressor TFF1 occurs in different forms and interacts with multiple partners in the human gastric mucus barrier: indications for diverse protective functions. International Journal of Molecular Sciences, 21 (7) 2508, 2508. doi: 10.3390/ijms21072508 |
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2020 Journal Article Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of actionBraga Emidio, Nayara, Baik, Hayeon, Lee, David, Stürmer, René, Heuer, Jörn, Elliott, Alysha G., Blaskovich, Mark A. T., Haupenthal, Katharina, Tegtmeyer, Nicole, Hoffmann, Werner, Schroeder, Christina I. and Muttenthaler, Markus (2020). Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical Communications, 56 (47), 6420-6423. doi: 10.1039/d0cc02321c |
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2019 Journal Article I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptorDuerrauer, Leopold, Muratspahić, Edin, Gattringer, Jasmin, Keov, Peter, Mendel, Helen C., Pfleger, Kevin D. G., Muttenthaler, Markus and Gruber, Christian W. (2019). I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptor. Scientific Reports, 9 (1) 19295, 19295. doi: 10.1038/s41598-019-55675-w |
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2019 Journal Article Conotoxins: chemistry and biologyJin, Ai-Hua, Muttenthaler, Markus, Dutertre, Sebastien, Himaya, S.W.A., Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2019). Conotoxins: chemistry and biology. Chemical Reviews, 119 (21), 11510-11549. doi: 10.1021/acs.chemrev.9b00207 |
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2019 Journal Article Trefoil Factor Family: Unresolved Questions and Clinical PerspectivesBraga Emidio, Nayara, Hoffmann, Werner, Brierley, Stuart M. and Muttenthaler, Markus (2019). Trefoil Factor Family: Unresolved Questions and Clinical Perspectives. Trends in Biochemical Sciences, 44 (5), 387-390. doi: 10.1016/j.tibs.2019.01.004 |
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2019 Journal Article On-resin strategy to label α-Conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probeMuttenthaler, Markus, Nevin, Simon T., Inserra, Marco, Lewis, Richard J., Adams, David J. and Alewood, Paul F. (2019). On-resin strategy to label α-Conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe. Australian Journal of Chemistry, 73 (4), 327-333. doi: 10.1071/CH19456 |
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2018 Journal Article Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activityLiutkevičiūtė, Zita, Gil-Mansilla, Esther, Eder, Thomas, Casillas-Pérez, Barbara, Di Giglio, Maria Giulia, Muratspahić, Edin, Grebien, Florian, Rattei, Thomas, Muttenthaler, Markus, Cremer, Sylvia and Gruber, Christian W. (2018). Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity. The FASEB Journal, 32 (12), 6808-6821. doi: 10.1096/fj.201800443 |
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2018 Journal Article Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal PeptidesHerzig, Volker, de Araujo, Aline, Greenwood, Kathryn, Chin, Yanni, Windley, Monique, Chong, Youmie, Muttenthaler, Markus, Mobli, Mehdi, Audsley, Neil, Nicholson, Graham, Alewood, Paul and King, Glenn (2018). Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides. Biomedicines, 6 (3) 90, 90. doi: 10.3390/biomedicines6030090 |
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2018 Journal Article Contractility measurements of human uterine smooth muscle to aid drug developmentArrowsmith, Sarah, Keov, Peter, Muttenthaler, Markus and Gruber, Christian W. (2018). Contractility measurements of human uterine smooth muscle to aid drug development. Journal of Visualized Experiments, 2018 (131) e56639. doi: 10.3791/56639 |
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2017 Journal Article Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across speciesMuttenthaler, Markus, Andersson, Asa, Vetter, Irina, Menon, Rohit, Busnelli, Marta, Ragnarsson, Lotten, Bergmayr, Christian, Arrowsmith, Sarah, Deuis, Jennifer R., Chiu, Han Sheng, Palpant, Nathan J., O'Brien, Margaret, Smith, Terry J., Wray, Susan, Neumann, Inga D., Gruber, Christian W., Lewis, Richard J. and Alewood, Paul F. (2017). Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling, 10 (508) eaan3398, 1-13. doi: 10.1126/scisignal.aan3398 |
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2017 Journal Article Nanoparticle cellular uptake by dendritic wedge peptides: achieving single peptide facilitated deliveryBreger, Joyce C., Muttenthaler, Markus, Delehanty, James B., Thompson, Darren A., Oh, Eunkeu, Susumu, Kimihiro, Deschamps, Jeffrey R., Anderson, George P., Field, Lauren D., Walper, Scott A., Dawson, Philip E. and Medintz, Igor L. (2017). Nanoparticle cellular uptake by dendritic wedge peptides: achieving single peptide facilitated delivery. Nanoscale, 9 (29), 10447-10464. doi: 10.1039/c7nr03362a |
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2017 Journal Article Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responsesWan, Jingjing, Mobli, Mehdi, Brust, Andreas, Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Castro, Joel, Vetter, Irina, Huang, Johnny X., Nilsson, Mathias, Brierley, Stuart M., Cooper, Matthew A., Lewis, Richard J. and Alewood, Paul F. (2017). Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responses. Australian Journal of Chemistry, 70 (2), 162-171. doi: 10.1071/CH16407 |
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2017 Journal Article Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptideDi Giglio, Maria Giulia , Muttenthaler, Markus, Harpsoe, Kasper, Liutkeviciute, Zita, Keov, Peter, Eder, Thomas, Rattei, Thomas, Arrowsmith, Sarah, Wray, Susan, Marek, Ales, Elbert, Tomas, Alewood, Paul F. , Gloriam, David E. and Gruber, Christian W. (2017). Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. Scientific Reports, 7 (1) 41002, 41002. doi: 10.1038/srep41002 |
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2016 Journal Article Design and characterization of superpotent bivalent ligands targeting oxytocin receptor dimers via a channel-like structureBusnelli, Marta, Kleinau, Gunnar, Muttenthaler, Markus, Stoev, Stoytcho, Manning, Maurice, Bibic, Lucka, Howell, Lesley A., McCormick, Peter J., Di Lascio, Simona, Braida, Daniela, Sala, Mariaelvina, Rovati, G. Enrico, Bellini, Tommaso and Chini, Bice (2016). Design and characterization of superpotent bivalent ligands targeting oxytocin receptor dimers via a channel-like structure. Journal of Medicinal Chemistry, 59 (15), 7152-7166. doi: 10.1021/acs.jmedchem.6b00564 |
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2015 Journal Article Methods, setup and safe handling for anhydrous hydrogen fluoride cleavage in Boc solid-phase peptide synthesisMuttenthaler, Markus, Albericio, Fernando and Dawson, Philip E. (2015). Methods, setup and safe handling for anhydrous hydrogen fluoride cleavage in Boc solid-phase peptide synthesis. Nature Protocols, 10 (7), 1067-1083. doi: 10.1038/nprot.2015.061 |
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2015 Journal Article Lipid bilayer crossing-the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier shuttlesArranz-Gibert, Pol, Guixer, Bernat, Malakoutikhah, Morteza, Muttenthaler, Markus, Guzman, Fanny, Teixido, Meritxell and Giralt, Ernest (2015). Lipid bilayer crossing-the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier shuttles. Journal of the American Chemical Society, 137 (23), 7357-7364. doi: 10.1021/jacs.5b02050 |
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2014 Journal Article Discovery, synthesis, and structure: activity relationships of conotoxinsAkondi, Kalyana, Muttenthaler, Markus, Dutertre, Sébastien, Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2014). Discovery, synthesis, and structure: activity relationships of conotoxins. Chemical Reviews, Articles ASAP (11), 1-33. doi: 10.1021/cr400401e |
