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2026 Journal Article Review of the Pathology of Muscle in Amyotrophic Lateral SclerosisKatz, Matthew, Robertson, Thomas, Ngo, Shyuan T., Yarlagadda, Sai, Henderson, Robert D., McCombe, Pamela A. and Noakes, Peter G. (2026). Review of the Pathology of Muscle in Amyotrophic Lateral Sclerosis. International Journal of Molecular Sciences, 27 (6), 2802. doi: 10.3390/ijms27062802 |
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2026 Journal Article Treating age-related loss of muscle mass and function: Where should we be focusing?Ham, Daniel J., Fry, Christopher S., Ruparelia, Avnika Ashok, Ngo, Shyuan T. and Lamon, Severine (2026). Treating age-related loss of muscle mass and function: Where should we be focusing?. Journal of Physiology-London JP289838. doi: 10.1113/JP289838 |
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2026 Journal Article Blood Lactate as a Prognostic Biomarker for Survival and Weight Loss in Amyotrophic Lateral Sclerosis: An Exploratory–Validation StudyNakamura, Ryutaro, Steyn, Frederik J., Kobashi, Shuhei, Ogawa, Nobuhiro, Kitamura, Akihiro, Yamakawa, Isamu, Henderson, Robert D., Ngo, Shyuan T. and Urushitani, Makoto (2026). Blood Lactate as a Prognostic Biomarker for Survival and Weight Loss in Amyotrophic Lateral Sclerosis: An Exploratory–Validation Study. Annals of Neurology ana.78184. doi: 10.1002/ana.78184 |
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2026 Journal Article Systemic immune-metabolic interactions in patients with amyotrophic lateral sclerosis: correlations of plasma cytokines with metabolic statusHowe, Stephanie L., Holdom, Cory J., McCombe, Pamela A., Henderson, Robert D., Steyn, Frederik J. and Ngo, Shyuan T. (2026). Systemic immune-metabolic interactions in patients with amyotrophic lateral sclerosis: correlations of plasma cytokines with metabolic status. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 1-11. doi: 10.1080/21678421.2026.2627902 |
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2026 Journal Article Lower-limb biomechanics in motor neuron disease: a joint-level perspective of gait disruptionHoldom, Cory J., Williamson, James L., O’Reilly, Georgia, Henderson, Robert D., Neville, Sally, Ngo, Shyuan T., Dick, Taylor J. M. and Steyn, Frederik J. (2026). Lower-limb biomechanics in motor neuron disease: a joint-level perspective of gait disruption. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 27 (1-2), 44-54. doi: 10.1080/21678421.2025.2523945 |
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2025 Journal Article BLOC1S1 depletion via splice-switching oligonucleotides improves mitochondrial respiration and rescues ALS phenotypesHor, Jin-Hui, Ow, Jin Rong, Ng, Winanto, Ramasamy, Boominathan, Tabaglio, Tommaso, Lim, Kimberly Ngee Hui, Bin Muzakar, Muhammad Ikhsan, Lim, Valerie Jing Wen, Gurrampati, Rajasekhar Reddy, Rajarethinam, Ravisankar, Ngo, Shyuan T., Ramadass, Venkataramanan, Lakshmanan, Manikandan, Ling, Shuo-Chien, Wee, Keng Boon and Ng, Shi-Yan (2025). BLOC1S1 depletion via splice-switching oligonucleotides improves mitochondrial respiration and rescues ALS phenotypes. Molecular Therapy, 34 (3), 1672-1683. doi: 10.1016/j.ymthe.2025.12.026 |
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2025 Journal Article Examining the impact and role of lipid classes on the risk of amyotrophic lateral sclerosis (ALS) onset: a systematic review and GRADE analysis of the evidenceSewell-Green, Amber R., Kuiper, Merle, Holdom, Cory J., Beelen, Anita, Ngo, Shyuan T., Steyn, Frederik J. and Matthews-Rensch, Kylie L. (2025). Examining the impact and role of lipid classes on the risk of amyotrophic lateral sclerosis (ALS) onset: a systematic review and GRADE analysis of the evidence. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 1-13. doi: 10.1080/21678421.2025.2574685 |
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2025 Journal Article Long-term fixation impact on archived human nervous tissues for sequencing-based transcriptomicsHowe, Stephanie, McCann, Heather, Xiong, Zherui, Nguyen, Quan, Steyn, Frederik J., Ngo, Shyuan T. and Chang, Jeryn (2025). Long-term fixation impact on archived human nervous tissues for sequencing-based transcriptomics. Brain Communications, 7 (6) fcaf428, fcaf428. doi: 10.1093/braincomms/fcaf428 |
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2025 Journal Article Epigenetic profiles of tissue informative CpGs inform ALS disease status and progressionCaggiano, Christa, Morselli, Marco, Qian, Xiaoyu, Celona, Barbara, Thompson, Michael J., Wani, Shivangi, Tosevska, Anela, Taraszka, Kodi, Heuer, Galen, Ngo, Shyuan T., Steyn, Frederick J., Nestor, Peter J., Wallace, Leanne, Mccombe, Pamela, Heggie, Susan, Thorpe, Kathryn, Mcelligott, Caitlin, English, Gemyka, Henders, Anjali, Henderson, Robert, Lomen-Hoerth, Catherine, Wray, Naomi R., Mcrae, Allan F., Pellegrini, Matteo, Garton, Fleur C. and Zaitlen, Noah (2025). Epigenetic profiles of tissue informative CpGs inform ALS disease status and progression. Genome Medicine, 17 (1) 115, 1-20. doi: 10.1186/s13073-025-01542-5 |
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2025 Journal Article Segmentation of the human tongue musculature using MRI: Field guide and validation in motor neuron diseaseShaw, Thomas B., Ribeiro, Fernanda L., Zhu, Xiangyun, Aiken, Patrick, Bollmann, Saskia, Bollmann, Steffen, Chang, Jeryn, Chidley, Kali, Dempsey-Jones, Harriet, Eftekhari, Zeinab, Gillespie, Jennifer, Henderson, Robert D., Kiernan, Matthew C., Ktena, Ira, McCombe, Pamela A., Ngo, Shyuan T., Taubert, Shana T., Whelan, Brooke-Mai, Ye, Xincheng, Steyn, Frederik J., Tu, Sicong and Barth, Markus (2025). Segmentation of the human tongue musculature using MRI: Field guide and validation in motor neuron disease. Computers in Biology and Medicine, 196 (Part B) 110824, 1-13. doi: 10.1016/j.compbiomed.2025.110824 |
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2025 Journal Article Deciphering hypothalamic pathology in ALS: insights into non-motor symptoms and disease progressionChang, Jeryn, Teo, Annissa H., Shaw, Thomas B., Dupuis, Luc, Ngo, Shyuan T. and Steyn, Frederik J. (2025). Deciphering hypothalamic pathology in ALS: insights into non-motor symptoms and disease progression. eBioMedicine, 118 105845, 1-13. doi: 10.1016/j.ebiom.2025.105845 |
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2025 Journal Article Identification of passive wrist-worn accelerometry outcomes for improved disease monitoring and trial design in motor neuron diseaseHoldom, Cory J., Pilkar, Rakesh, Guo, Christine C., Eijk, Ruben P.A van, Sethi, Nadia, Henderson, Robert D., Ngo, Shyuan T. and Steyn, Frederik J. (2025). Identification of passive wrist-worn accelerometry outcomes for improved disease monitoring and trial design in motor neuron disease. eBioMedicine, 117 105779, 1-14. doi: 10.1016/j.ebiom.2025.105779 |
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2025 Journal Article Assessment of the “MND-Prism” smartphone application as a tool for self-managementNeville, Sally, Ziser, Laura, Henders, Anjali, Milne, Jane, Ngo, Shyuan T., Packer, Rebecca and Steyn, Frederik J. (2025). Assessment of the “MND-Prism” smartphone application as a tool for self-management. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 1-10. doi: 10.1080/21678421.2025.2511119 |
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2025 Journal Article Site-specific quantification of the in vivo UFMylome reveals myosin modification in ALSBlazev, Ronnie, Zee, Barry M., Peckham, Hayley, Ng, Yaan-Kit, Lewis, Christopher T. A., Zhang, Chengxin, McNamara, James W., Goodman, Craig A., Gregorevic, Paul, Ochala, Julien, Steyn, Frederik J., Ngo, Shyuan T., Stokes, Matthew P. and Parker, Benjamin L. (2025). Site-specific quantification of the in vivo UFMylome reveals myosin modification in ALS. Cell Reports Methods, 5 (5) 101048, 101048. doi: 10.1016/j.crmeth.2025.101048 |
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2025 Journal Article An annotated multi-site and multi-contrast magnetic resonance imaging dataset for the study of the human tongue musculatureRibeiro, Fernanda L., Zhu, Xiangyun, Ye, Xincheng, Tu, Sicong, Ngo, Shyuan T., Henderson, Robert D., Steyn, Frederik J., Kiernan, Matthew C., Barth, Markus, Bollmann, Steffen and Shaw, Thomas B. (2025). An annotated multi-site and multi-contrast magnetic resonance imaging dataset for the study of the human tongue musculature. Scientific Data, 12 (1) 790, 790. doi: 10.1038/s41597-025-05092-8 |
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2025 Journal Article An fMRI dataset for appetite neural correlates in people living with Motor Neuron DiseaseChang, Jeryn, Lv, JingLei, Guo, Christine C., Lucia, Diana, Bollmann, Saskia, Garner, Kelly, McCombe, Pamela A., Henderson, Robert D., Shaw, Thomas B., Steyn, Frederik J. and Ngo, Shyuan T. (2025). An fMRI dataset for appetite neural correlates in people living with Motor Neuron Disease. Scientific Data, 12 (1) 466, 1-8. doi: 10.1038/s41597-025-04828-w |
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2025 Journal Article Appetite loss in patients with motor neuron disease: impact on weight loss and neural correlates of visual food cuesChang, Jeryn, Shaw, Thomas B., McCombe, Pamela A., Henderson, Robert D., Lucia, Diana, Guo, Christine C., Lv, Jinglei, Garner, Kelly, Bollmann, Saskia, Ngo, Shyuan T. and Steyn, Frederik J. (2025). Appetite loss in patients with motor neuron disease: impact on weight loss and neural correlates of visual food cues. Brain Communications, 7 (2) fcaf111, 1-14. doi: 10.1093/braincomms/fcaf111 |
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2025 Journal Article Persistent high levels of perceived fatigue are not associated with hypermetabolism in patients with amyotrophic lateral sclerosisBuckett, Lauren E., Holdom, Cory J., Howe, Stephanie L., McCombe, Pamela A., Henderson, Robert D., Al-Chalabi, Ammar, Steyn, Frederik J. and Ngo, Shyuan T. (2025). Persistent high levels of perceived fatigue are not associated with hypermetabolism in patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 26 (5-6), 485-494. doi: 10.1080/21678421.2025.2471429 |
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2025 Journal Article An open-label phase 2a study to assess the safety and tolerability of trimetazidine in patients with amyotrophic lateral sclerosisvan Eijk, Ruben P. A., Steyn, Frederik J., Janse van Mantgem, Mark R., Schmidt, Angela, Meyjes, Myrte, Allen, Sally, Daygon, Dara V., Loeffler, Jean-Philippe, Al-Chalabi, Ammar, van den Berg, Leonard H., Henderson, Robert D. and Ngo, Shyuan T. (2025). An open-label phase 2a study to assess the safety and tolerability of trimetazidine in patients with amyotrophic lateral sclerosis. Brain Communications, 7 (1) fcaf063, fcaf063-1. doi: 10.1093/braincomms/fcaf063 |
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2024 Journal Article Generation of human induced pluripotent stem cell lines from sporadic, sporadic frontotemporal dementia, familial SOD1, and familial C9orf72 amyotrophic lateral sclerosis (ALS) patientsJiang, Leanne, Tracey, Timothy J., Gill, Melinder K., Howe, Stephanie L., Power, Dominique T., Bharti, Vanda, McCombe, Pamela A., Henderson, Robert D., Steyn, Frederik J. and Ngo, Shyuan T. (2024). Generation of human induced pluripotent stem cell lines from sporadic, sporadic frontotemporal dementia, familial SOD1, and familial C9orf72 amyotrophic lateral sclerosis (ALS) patients. Stem Cell Research, 78 103447, 1-6. doi: 10.1016/j.scr.2024.103447 |
