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2022

Journal Article

Extend mixed models to multilayer neural networks for genomic prediction including intermediate omics data

Zhao, Tianjing, Zeng, Jian and Cheng, Hao (2022). Extend mixed models to multilayer neural networks for genomic prediction including intermediate omics data. Genetics, 221 (1) iyac034. doi: 10.1093/genetics/iyac034

Extend mixed models to multilayer neural networks for genomic prediction including intermediate omics data

2022

Journal Article

Comparative analysis reveals novel changes in plasma metabolites and metabolomic networks of infants with retinopathy of prematurity

Yang, Yuhang, Yang, Qian, Luo, Sisi, Zhang, Yinsheng, Lian, Chaohui, He, Honghui, Zeng, Jian and Zhang, Guoming (2022). Comparative analysis reveals novel changes in plasma metabolites and metabolomic networks of infants with retinopathy of prematurity. Investigative Ophthalmology and Visual Science, 63 (1) 28. doi: 10.1167/iovs.63.1.28

Comparative analysis reveals novel changes in plasma metabolites and metabolomic networks of infants with retinopathy of prematurity

2021

Journal Article

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

Ni, Guiyan, Zeng, Jian, Revez, Joana A., Wang, Ying, Zheng, Zhili, Ge, Tian, Restuadi, Restuadi, Kiewa, Jacqueline, Nyholt, Dale R., Coleman, Jonathan R.I., Smoller, Jordan W., Yang, Jian, Visscher, Peter M. and Wray, Naomi R. (2021). A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts. Biological Psychiatry, 90 (9), 611-620. doi: 10.1016/j.biopsych.2021.04.018

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

2021

Journal Article

Tumor mutational burden is polygenic and genetically associated with complex traits and diseases

Sun, Xiwei, Xue, Angli, Qi, Ting, Chen, Dan, Shi, Dandan, Wu, Yang, Zheng, Zhili, Zeng, Jian and Yang, Jian (2021). Tumor mutational burden is polygenic and genetically associated with complex traits and diseases. Cancer Research, 81 (5) canres.3459.2020, 12230-1239. doi: 10.1158/0008-5472.can-20-3459

Tumor mutational burden is polygenic and genetically associated with complex traits and diseases

2021

Journal Article

Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank

Yap, Chloe X., Alvares, Gail A., Henders, Anjali K., Lin, Tian, Wallace, Leanne, Farrelly, Alaina, McLaren, Tiana, Berry, Jolene, Vinkhuyzen, Anna A. E., Trzaskowski, Maciej, Zeng, Jian, Yang, Yuanhao, Cleary, Dominique, Grove, Rachel, Hafekost, Claire, Harun, Alexis, Holdsworth, Helen, Jellett, Rachel, Khan, Feroza, Lawson, Lauren, Leslie, Jodie, Levis Frenk, Mira, Masi, Anne, Mathew, Nisha E., Muniandy, Melanie, Nothard, Michaela, Visscher, Peter M., Dawson, Paul A., Dissanayake, Cheryl ... Gratten, Jacob (2021). Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank. Molecular Autism, 12 (1) 12, 12. doi: 10.1186/s13229-020-00407-5

Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank

2021

Journal Article

Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes

Xue, Angli, Jiang, Longda, Zhu, Zhihong, Wray, Naomi R., Visscher, Peter M., Zeng, Jian and Yang, Jian (2021). Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes. Nature Communications, 12 (1) 6450, 6450. doi: 10.1038/s41467-020-20237-6

Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes

2020

Journal Article

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

Wu, Yang, Qi, Ting, Wang, Huanwei, Zhang, Futao, Zheng, Zhili, Phillips-Cremins, Jennifer E., Deary, Ian J., McRae, Allan F., Wray, Naomi R., Zeng, Jian and Yang, Jian (2020). Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data. Nature Communications, 11 (1) 2061, 1-12. doi: 10.1038/s41467-020-15587-0

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

2020

Journal Article

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

Revez, Joana A., Lin, Tian, Qiao, Zhen, Xue, Angli, Holtz, Yan, Zhu, Zhihong, Zeng, Jian, Wang, Huanwei, Sidorenko, Julia, Kemper, Kathryn E., Vinkhuyzen, Anna A. E., Frater, Julanne, Eyles, Darryl, Burne, Thomas H. J., Mitchell, Brittany, Martin, Nicholas G., Zhu, Gu, Visscher, Peter M., Yang, Jian, Wray, Naomi R. and McGrath, John J. (2020). Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration. Nature Communications, 11 (1) 1647, 1-12. doi: 10.1038/s41467-020-15421-7

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

2019

Journal Article

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

Wang, Huanwei, Zhang, Futao, Zeng, Jian, Wu, Yang, Kemper, Kathryn E., Xue, Angli, Zhang, Min, Powell, Joseph E., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2019). Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank. Science Advances, 5 (8) eaaw3538, 1-12. doi: 10.1126/sciadv.aaw3538

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

2019

Journal Article

The effect of X-linked dosage compensation on complex trait variation

Sidorenko, Julia, Kassam, Irfahan, Kemper, Kathryn E., Zeng, Jian, Lloyd-Jones, Luke R., Montgomery, Grant W., Gibson, Greg, Metspalu, Andres, Esko, Tonu, Yang, Jian, McRae, Allan F. and Visscher, Peter M. (2019). The effect of X-linked dosage compensation on complex trait variation. Nature Communications, 10 (1) 3009, 3009. doi: 10.1038/s41467-019-10598-y

The effect of X-linked dosage compensation on complex trait variation

2018

Journal Article

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

Qi, Ting, Wu, Yang, Zeng, Jian, Zhang, Futao, Xue, Angli, Jiang, Longda, Zhu, Zhihong, Kemper, Kathryn, Yengo, Loic, Zheng, Zhili, eQTLGen Consortium, Marioni, Riccardo E., Montgomery, Grant W., Deary, Ian J., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2018). Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood. Nature Communications, 9 (1) 2282, 2282. doi: 10.1038/s41467-018-04558-1

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

2018

Journal Article

Global genetic differentiation of complex traits shaped by natural selection in humans

Guo, Jing, Wu, Yang, Zhu, Zhihong, Zheng, Zhili, Trzaskowski, Maciej, Zeng, Jian, Robinson, Matthew R., Visscher, Peter M. and Yang, Jian (2018). Global genetic differentiation of complex traits shaped by natural selection in humans. Nature Communications, 9 (1) 1865, 1865. doi: 10.1038/s41467-018-04191-y

Global genetic differentiation of complex traits shaped by natural selection in humans

2018

Journal Article

A nested mixture model for genomic prediction using whole-genome SNP genotypes

Zeng, Jian, Garrick, Dorian, Dekkers, Jack and Fernando, Rohan (2018). A nested mixture model for genomic prediction using whole-genome SNP genotypes. PloS one, 13 (3) e0194683, e0194683. doi: 10.1371/journal.pone.0194683

A nested mixture model for genomic prediction using whole-genome SNP genotypes

2018

Journal Article

Genomic prediction from multiple-trait bayesian regression methods using mixture priors

Cheng, Hao, Kizilkaya, Kadir, Zeng, Jian, Garrick, Dorian and Fernando, Rohan (2018). Genomic prediction from multiple-trait bayesian regression methods using mixture priors. Genetics, 209 (1), 89-103. doi: 10.1534/genetics.118.300650

Genomic prediction from multiple-trait bayesian regression methods using mixture priors

2018

Conference Publication

Signatures of negative selection in the genetic architecture of human complex traits

Zeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, Mcrae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. 48th Annual Meeting of the Behavior-Genetics-Association (BGA), Boston MA, United States, 20-23 June 2018. New York, NY United States: Springer New York.

Signatures of negative selection in the genetic architecture of human complex traits

2017

Journal Article

Concepts, estimation and interpretation of SNP-based heritability

Yang, Jian, Zeng, Jian, Goddard, Michael E., Wray, Naomi R. and Visscher, Peter M. (2017). Concepts, estimation and interpretation of SNP-based heritability. Nature Genetics, 49 (9), 1304-1310. doi: 10.1038/ng.3941

Concepts, estimation and interpretation of SNP-based heritability

2017

Journal Article

Inference on the genetic basis of eye and skin color in an admixed population via Bayesian linear mixed models

Lloyd-Jones, Luke R., Robinson, Matthew R., Moser, Gerhard, Zeng, Jian, Beleza, Sandra, Barsh, Gregory S., Tang, Hua and Visscher, Peter M. (2017). Inference on the genetic basis of eye and skin color in an admixed population via Bayesian linear mixed models. Genetics, 206 (2), 1113-1126. doi: 10.1534/genetics.116.193383

Inference on the genetic basis of eye and skin color in an admixed population via Bayesian linear mixed models

2016

Journal Article

Impact of fitting dominance and additive effects on accuracy of genomic prediction of breeding values in layers

Heidaritabar, M., Wolc, A., Arango, J., Zeng, J., Settar, P., Fulton, J. E., O'Sullivan, N. P., Bastiaansen, J. W. M., Fernando, R. L., Garrick, D. J. and Dekkers, J. C. M. (2016). Impact of fitting dominance and additive effects on accuracy of genomic prediction of breeding values in layers. Journal of Animal Breeding and Genetics, 133 (5), 334-346. doi: 10.1111/jbg.12225

Impact of fitting dominance and additive effects on accuracy of genomic prediction of breeding values in layers

2016

Journal Article

A nested mixture model for genomic prediction using whole-genome SNP genotypes

Zeng, Jian, Garrick, Dorian J., Dekkers, Jack C. and Fernando, Rohan L (2016). A nested mixture model for genomic prediction using whole-genome SNP genotypes. Iowa State University Animal Industry Report, 13 (1). doi: 10.31274/ans_air-180814-452

A nested mixture model for genomic prediction using whole-genome SNP genotypes

2013

Journal Article

Dissecting the genetic architecture of frost tolerance in Central European winter wheat

Zhao, Yusheng, Gowda, Manje, Wuerschum, Tobias, Longin, C. Friedrich H., Korzun, Viktor, Kollers, Sonja, Schachschneider, Ralf, Zeng, Jian, Fernando, Rohan, Dubcovsky, Jorge and Reif, Jochen C. (2013). Dissecting the genetic architecture of frost tolerance in Central European winter wheat. Journal of Experimental Botany, 64 (14), 4453-4460. doi: 10.1093/jxb/ert259

Dissecting the genetic architecture of frost tolerance in Central European winter wheat