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2010 Journal Article A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general populationAntoniou, Antonis C., Wang, Xianshu, Fredericksen, Zachary S., McGuffog, Lesley, Tarrell, Robert, Sinilnikova, Olga M., Healey, Sue, Morrison, Jonathan, Kartsonaki,Christiana, Lesnick, Timothy, Ghoussaini, Maya, Barrowdale, Daniel, Peock, Susan, Cook, Margaret, Oliver, Clare, Frost, Debra, Eccles, Diana, Evans, D. Gareth, Eeles, Ros, Izatt, Louise, Chu, Carol, Douglas, Fiona, Paterson, Joan, Stoppa-Lyonnet, Dominique, Houdayer, Claude, Mazoyer, Sylvie, Giraud, Sophie, Lasset, Christine, Remenieras, Audrey ... Lakhani, Sunil (2010). A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population. Nature Genetics, 42 (10), 885-892. doi: 10.1038/ng.669 |
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2010 Journal Article Subtypes of familial breast tumours revealed by expression and copy number profilingWaddell, N, Arnold, J, Cocciardi, S, da Silva, L, Marsh, A, Riley, J, Johnstone, CN, Orloff, M, Assie, G, Eng, C, Reid, L, Keith, P, Yan, M, Fox, S, Devilee, P, Godwin, AK, Hogervorst, FBL, Couch, F, Grimmond, S, Flanagan, JM, Khanna, K, Simpson, PT, Lakhani, SR, Chenevix-Trench, G and kConFab Investigators (2010). Subtypes of familial breast tumours revealed by expression and copy number profiling. Breast Cancer Research And Treatment, 123 (3), 661-677. doi: 10.1007/s10549-009-0653-1 |
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2010 Journal Article Common genetic variants and modification of penetrance of BRCA2-associated breast cancerMia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn, Candace Guiducci, Ayellet V. Segre, Kate McGee, Lesley McGuffog, Christiana Kartsonaki, Jonathan Morrison, Sue Healey, Olga M. Sinilnikova, Dominique Stoppa-Lyonnet, Sylvie Mazoyer, Marion Gauthier-Villars, Hagay Sobol, Michel Longy, Marc Frenay, GEMO Study Collaborators, Frans B. L. Hogervorst, Matti a. Rookus, J. Margriet Collee, Nicoline Hoogerbrugge, Kees E. P. van Roozendaal, HEBON Study Collaborators, Marion Piedmonte, Wendy Rubinstein, Stacy Nerenstone ... Lakhani, Sunil (2010). Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. PLoS Genetics, 6 (10), e1001183-1-e1001183-12. doi: 10.1371/journal.pgen.1001183 |
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2010 Journal Article Gene expression profiling of formalin-fixed, paraffin-embedded familial breast tumours using the whole genome-DASL assayWaddell, Nic, Cocciardi, Sibylle, Johnson, Julie, Healey, Sue, Marsh, Anna, Riley, Joan, da Silva, Leonard, Vargas, Ana Cristina, Reid, Lynne, Simpson, Peter T., Lakhani, Sunil R. and Chenevix-Trench, Georgia (2010). Gene expression profiling of formalin-fixed, paraffin-embedded familial breast tumours using the whole genome-DASL assay. Journal of Pathology, 221 (4), 452-461. doi: 10.1002/path.2728 |
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2010 Journal Article Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriersWang, Xianshu, Pankratz, V. Shane, Fredericksen, Zachary, Tarrell, Robert, Karaus, Mary, McGuffog, Lesley, Pharaoh, Paul D.P., Ponder, Bruce A.J., Dunning, Alison M., Peock, Susan, Cook, Margaret, Oliver, Clare, Frost, Debra, EMBRACE, Sinilnikova, Olga M., Stoppa-Lyonnet, Dominique, Mazoyer, Sylvie, Houdayer, Claude, GEMO, Hogervorst, Frans B.L., Hooning, Maartje J., Ligtenberg, Marjolijn J., HEBON, Spurdle, Amanda, Chenevix-Trench, Georgia, kConFab, Schmutzler, Rita K., Wappenschmidt, Barbara, Engel, Christoph ... Lakhani, Sunil (2010). Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. Human Molecular Genetics, 19 (14), 2886-2897. doi: 10.1093/hmg/ddq174 |
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2010 Journal Article Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell linesAlexopoulou, Annika N., Leao, Maria, Caballero, Otavia L., Da Silva, Leonard, Reid, Lynne, Lakhani, Sunil R., Simpson, Andrew J., Marshall, John F., Neville, A. Munro and Jat, Parmjit S. (2010). Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines. Breast Cancer Research, 12 (4) R51, R51-1-R51-17. doi: 10.1186/bcr2610 |
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2010 Journal Article Detection of Splicing Aberrations Caused by BRCA1 and BRCA2 Sequence Variants Encoding Missense Substitutions: Implications for Prediction of PathogenicityWalker, Logan C., Whiley, Phillip J., Couch, Fergus J., Farrugia, Daniel J., Healey, Sue, Eccles, Diana M., Lin, Feng, Butler, Samantha A., Goff, Sheila A., Thompson, Bryony A., Lakhani, Sunil R., Da Silva, Leonard M., Tavtigian, Sean V., Goldgar, David E., Brown, Melissa A. and Spurdle, Amanda B. (2010). Detection of Splicing Aberrations Caused by BRCA1 and BRCA2 Sequence Variants Encoding Missense Substitutions: Implications for Prediction of Pathogenicity. Human Mutation, 31 (6), E1484-E1505. doi: 10.1002/humu.21267 |
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2010 Journal Article Incorporating tumour pathology information into breast cancer risk prediction algorithmsMavaddat, Nasim, Rebbeck, Timothy R., Lakhani, Sunil R., Easton, Douglas F. and Antoniou, Antonis C. (2010). Incorporating tumour pathology information into breast cancer risk prediction algorithms. Breast Cancer Research, 12 (3) R28, R28 - 1-R28 - 12. doi: 10.1186/bcr2576 |
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2010 Journal Article Pathology of hereditary breast cancerDa Silva, Leonard and Lakhani, Sunil R. (2010). Pathology of hereditary breast cancer. Modern Pathology, 23 (S2), S46-S51. doi: 10.1038/modpathol.2010.37 |
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2010 Conference Publication Lynch syndrome-associated breast cancers: clinicopathological characteristics of a case series from the Colon CFRRosty, Christophe, Walsh, Michael, Cummings, Margaret, Buchanan, Daniel, Arnold, Sven, McKeone, Diane, Walters, Rhiannon, Hopper, John, Jenkins, Mark, Spurdle, Amanda, McGuckin, Michael, Lakhani, Sunil and Young, Joanne (2010). Lynch syndrome-associated breast cancers: clinicopathological characteristics of a case series from the Colon CFR. AACR 101st Annual Meeting 2010, Washington, DC, United States, 17-21 April 2010. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM10-32 |
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2010 Journal Article DNA methylome of familial breast cancer identifies distinct profiles defined by mutation statusFlanagan, James M., Cocciardi, Sibylle, Waddell, Nic, Johnstone, Cameron N., Marsh, Anna, Henderson, Stephen, Simpson, Peter, da Silva, Leonard, kConFab Investigators, Khanna, Kumkum, Lakhani, Sunil, Boshoff, Chris, Chenevix-Trench, Georgia, Brown, Melissa, Cummings, Margaret and Edwards, Stacey (2010). DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status. American Journal of Human Genetics, 86 (3), 420-433. doi: 10.1016/j.ajhg.2010.02.008 |
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2010 Journal Article Bayes analysis provides evidence of pathogenicity for the BRCA1 c.135-1G>T (IVS3-1) and BRCA2 c.7977-1G>C (IVS17-1) variants displaying in vitro splicing results of equivocal clinical significance.Spurdle, Amanda B., Lakhani, Sunil R., Da Silva, Leonard M., Balleine, Rosemary L., kConFab Investigators and Goldgar, David E. (2010). Bayes analysis provides evidence of pathogenicity for the BRCA1 c.135-1G>T (IVS3-1) and BRCA2 c.7977-1G>C (IVS17-1) variants displaying in vitro splicing results of equivocal clinical significance.. Human Mutation, 31 (2), E1141-E1145. doi: 10.1002/humu.21181 |
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2010 Journal Article Breast pathology: Beyond morphologySimpson, Peter T., Reis-Filho, Jorge S. and Lakhani, Sunil R. (2010). Breast pathology: Beyond morphology. Seminars in Diagnostic Pathology, 27 (1), 91-96. doi: 10.1053/j.semdp.2009.12.001 |
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2010 Book Chapter High-risk lesions: ALH/LCIS/ADHSmart, Chanel E., Furnival, Colin M. and Lakhani, Sunil R. (2010). High-risk lesions: ALH/LCIS/ADH. Kuerer's breast surgical oncology. (pp. 179-187) edited by Henry Mark Kuerer. New York, U.S.A.: McGraw-Hill Medical. |
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2010 Book Chapter Lobular carcinoma in situ : Biology and pathologySimpson, Peter T., Reis-Filho, Jorge S. and Lakhani, Sunil R. (2010). Lobular carcinoma in situ : Biology and pathology. Diseases of the breast. (pp. 333-340) edited by Jay R. Harris, Marc E. Lippman, C. Kent Osborne and Monica Morrow. Philadelphia: Lippencott, Williams & Wilkins. |
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2010 Journal Article Breast cancer prognostic classification in the molecular era: The role of histological gradeRakha, Emad A., Reis-Filho, Jorge S., Baehner, Frederick, Dabbs, David J., Decker, Thomas, Eusebi, Vincenzo, Fox, Stephen B., Ichihara, Shu, Jacquemier, Jocelyne, Lakhani, Sunil R., Palacios, José, Richardson, Andrea L., Schnitt, Stuart J., Schmitt, Fernando C., Tan, Puay-Hoon, Tse, Gary M., Badve, Sunil and Ellis, Ian (2010). Breast cancer prognostic classification in the molecular era: The role of histological grade. Breast Cancer Research, 12 (4) 207, 1-12. doi: 10.1186/bcr2607 |
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2010 Conference Publication Shifting phenotypes in primary human mammary epithelial cultureSmart, Chanel E., Saunus, Jodi M., Keith, Patricia, Vargas, Ana Cristina, Malik, Neelam, Clarke, Catherine, Simpson, Peter T. and Lakhani, Sunil R. (2010). Shifting phenotypes in primary human mammary epithelial culture. Sixth International Conference on Hormonal Oncogenesis, Tokyo, Japan, 12-16 September 2010. |
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2010 Journal Article Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control studyMilne, Roger L., Gaudet, Mia M., Spurdle, Amanda B., Fasching, Peter A., Couch, Fergus J., Benitez, Javier, Arias Perez, Jose Ignacio, Zamora, M. Pilar, Malats, Nuria, dos Santos Silva, Isabel, Gibson, Lorna J., Fletcher, Olivia, Johnson, Nichola, Anton-Culver, Hoda, Ziogas, Argyrios, Figueroa, Jonine, Brinton, Louise, Sherman, Mark E., Lissowska, Jolanta, Hopper, John L., Dite, Gillian S., Apicella, Carmel, Southey, Melissa C., Sigurdson, Alice J., Linet, Martha S., Schonfeld, Sara J., Freedman, D. Michal, Mannermaa, Arto, Kosma, Veli-Matti ... Lakhani, Sunil (2010). Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study. Breast Cancer Research, 12 (6) R110, R110.1-R110.11. doi: 10.1186/bcr2797 |
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2010 Conference Publication Role of breast screening for characterising the heterogeneity of invasive lobular carcinomas of the breastVargas, A. C., Simpson, P., Jayanthan, J., Lane, A., Reid, L., Evans, E., Porter, A. and Lakhani, S. (2010). Role of breast screening for characterising the heterogeneity of invasive lobular carcinomas of the breast. 28th International Congress of the International-Academy-of-Pathology, Sao Paulo, Brazil, 10-15 October 2010. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. |
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2010 Journal Article HER3 and downstream pathways are involved in colonization of brain metastases from breast cancerDa Silva, Leonard, Simpson, Peter T., Smart, Chanek E., Cocciardi, Sibylle, Waddell, Nic, Lane, Annette, Morrison, Brian J., Vargas, Ana Cristina, Healey, Sue, Beesley, Jonathan, Pakkiri, Pria, Parry, Suzanne, Kurniawan, Nyoman, Reid, Lynne, Keith, Patricia, Faria, Paulo, Pereira, Emilio, Skalova, Alena, Bilous, Michael, Balleine, Rosemary L., Do, Hongdo, Dobrovic, Alexander, Fox, Stephen, Franco, Marcello, Reynolds, Brent, Khanna, Kum Kum, Cummings, Margaret, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2010). HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer. Breast Cancer Research, 12 (4) R46, R46-1-R46-11. doi: 10.1186/bcr2603 |
