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2014

Journal Article

Molecular classification of breast cancer

Vuong, Darina, Simpson, Peter T., Green, Benjamin, Cummings, Margaret C. and Lakhani, Sunil R. (2014). Molecular classification of breast cancer. Virchows Archiv, 465 (1), 1-14. doi: 10.1007/s00428-014-1593-7

Molecular classification of breast cancer

2014

Journal Article

Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

Al-Ejeh, F., Simpson, P. T., Sanus, J. M., Klein, K., Kalimutho, M., Shi, W., Miranda, M., Kutasovic, J., Raghavendra, A., Madore, J., Reid, L., Krause, L., Chenevix-Trench, G., Lakhani, S. R. and Khanna, K. K. (2014). Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer. Oncogenesis, 3 (4) e100, 1-12. doi: 10.1038/oncsis.2014.14

Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

2014

Journal Article

Processed pseudogenes acquired somatically during cancer development

Cooke, Susanna L., Shlien, Adam, Marshall, John, Pipinikas, Christodoulos P., Martincorena, Inigo, Tubio, Jose M. C., Li, Yilong, Menzies, Andrew, Mudie, Laura, Ramakrishna, Manasa, Yates, Lucy, Davies, Helen, Bolli, Niccolo, Bignell, Graham R., Tarpey, Patrick S., Behjati, Sam, Nik-Zainal, Serena, Papaemmanuil, Elli, Teixeira, Vitor H., Raine, Keiran, O'Meara, Sarah, Dodoran, Maryam S., Teague, Jon W., Butler, Adam P., Iacobuzio-Donahue, Christine, Santarius, Thomas, Grundy, Richard G., Malkin, David, Greaves, Mel ... Lakhani, Sunil R. (2014). Processed pseudogenes acquired somatically during cancer development. Nature Communications, 5 (1) 3644, 3644.1-3644.9. doi: 10.1038/ncomms4644

Processed pseudogenes acquired somatically during cancer development

2014

Journal Article

Multifactorial likelihood assessment of BRCA1 and BRCA2 missense variants confirms that BRCA1:c.122A>G(p.His41Arg) is a pathogenic mutation

Whiley, Phillip J., Parsons, Michael T., Leary, Jennifer, Tucker, Kathy, Warwick, Linda, Dopita, Belinda, Thorne, Heather, Lakhani, Sunil R., Goldgar, David E., Brown, Melissa A. and Spurdle, Amanda B. (2014). Multifactorial likelihood assessment of BRCA1 and BRCA2 missense variants confirms that BRCA1:c.122A>G(p.His41Arg) is a pathogenic mutation. PloS One, 9 (1) e86836, 1-10. doi: 10.1371/journal.pone.0086836

Multifactorial likelihood assessment of BRCA1 and BRCA2 missense variants confirms that BRCA1:c.122A>G(p.His41Arg) is a pathogenic mutation

2014

Journal Article

Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer

Al-Ejeh, Fares, Miranda, Mariska, Shi,Wei, Simpson, Peter T., Song, Sarah, Vargas, Ana Cristina, Saunus, Jodi M., Smart, Chanel E., Mariasegaram, Mythily, Wiegmans, Adrian P., Chenevix-Trench, Georgia, Lakhani, Sunil R. and Khanna, Kum Kum (2014). Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. Oncotarget, 5 (10), 3145-3158. doi: 10.18632/oncotarget.1865

Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer

2014

Journal Article

Mutations in EGFR, BRAF and RAS are rare in triple-negative and basal-like breast cancers from Caucasian women

Tilch, E., Seidens, T., Cocciardi, S., Reid, L. E., Byrne, D., Simpson, P. T., Vargas, A. C., Cummings, M. C., Fox, S. B., Lakhani, S. R. and Chenevix Trench, G. (2014). Mutations in EGFR, BRAF and RAS are rare in triple-negative and basal-like breast cancers from Caucasian women. Breast Cancer Research and Treatment, 143 (2), 385-392. doi: 10.1007/s10549-013-2798-1

Mutations in EGFR, BRAF and RAS are rare in triple-negative and basal-like breast cancers from Caucasian women

2014

Conference Publication

PMCA2 in human breast tissue with lactational change and in human breast cancer cells

Peters, Amelia A., Lee, Wei C., Dray, Eloise , Smart, Chanel E., Reid, Lynne , da Silva, Leonard , Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2014). PMCA2 in human breast tissue with lactational change and in human breast cancer cells. 13th International Meeting of the European Calcium Society, Aix-en-Provence, France, 13-17 September 2014.

PMCA2 in human breast tissue with lactational change and in human breast cancer cells

2014

Journal Article

Metastatic progression of breast cancer: Insights from 50 years of autopsies

Cummings, Margaret C., Simpson, Peter T., Reid, Lynne E., Jayanthan, Janani, Skerman, Joanna, Song, Sarah, McCart Reed, Amy E., Kutasovic, Jamie R., Morey, Adrienne L., Marquart, Louise, O'Rourke, Peter and Lakhani, Sunil R. (2014). Metastatic progression of breast cancer: Insights from 50 years of autopsies. Journal of Pathology, 232 (1), 23-31. doi: 10.1002/path.4288

Metastatic progression of breast cancer: Insights from 50 years of autopsies

2014

Journal Article

Rad51 supports triple negative breast cancer metastasis

Wiegmans, Adrian P., Al-Ejeh, Fares, Chee, Nicole, Yap, Pei-Yi, Gorski, Julia J., Da Silva, Leonard, Bolderson, Emma, Chenevix-Trench, Georgia, Anderson, Robin, Simpson, Peter T., Lakhani, Sunil R. and Khanna, Kum Kum (2014). Rad51 supports triple negative breast cancer metastasis. Oncotarget, 5 (10), 3261-3272. doi: 10.18632/oncotarget.1923

Rad51 supports triple negative breast cancer metastasis

2014

Conference Publication

Update on WHO breast classification: 2 years on

Lakhani, Sunil R. (2014). Update on WHO breast classification: 2 years on. IAP 2014: 30th Congress of the International Academy of Pathology 2014, Bangkok, Thailand, 5-10 October, 2014. London, United Kingdom: Lippincott Williams & Wilkins. doi: 10.1097/01.PAT.0000454053.47289.16

Update on WHO breast classification: 2 years on

2014

Conference Publication

Calcium efflux pump, PMCA2, in human breast tissue with lactational change and as a therapeutic target in breast cancer

Peters, Amelia A., Lee, Wei C., Dray, Eloise, Smart, Chanel E., Reid, Lynne , da Silva, Leonard , Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2014). Calcium efflux pump, PMCA2, in human breast tissue with lactational change and as a therapeutic target in breast cancer. 2nd Annual Congress of The European Society for Translational Medicine Medicine, Vienna, Austria, 22-25 September 2014.

Calcium efflux pump, PMCA2, in human breast tissue with lactational change and as a therapeutic target in breast cancer

2014

Conference Publication

Id4 Controls Mammary Stem Cells and Marks Breast Cancers with a Stem Cell Like Phenotype

Junankar, Simon, Baker, Laura, Roden, Daniel, Nair, Radhika, Elsworth, Ben, Lakhani, Sunil, Simpson, Peter, Ormandy C, Chris, O'Toole, Sandra and Swarbrick, Alexander (2014). Id4 Controls Mammary Stem Cells and Marks Breast Cancers with a Stem Cell Like Phenotype. Sydney Cancer Conference 2014, University of Sydney, NSW Australia, 26 November 2014. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12282

Id4 Controls Mammary Stem Cells and Marks Breast Cancers with a Stem Cell Like Phenotype

2014

Journal Article

Ethnicity and outcome of young breast cancer patients in the United Kingdom: the POSH study

Copson, E., Maishman, T., Gerty, S., Eccles, B., Stanton, L., Cutress, R. I., Altman, D. G., Durcan, L., Simmonds, P., Jones, L., Tapper W., Eccles, D., POSH study steering group and Lakhani, Sunil (2014). Ethnicity and outcome of young breast cancer patients in the United Kingdom: the POSH study. British Journal of Cancer, 110 (1), 230-241. doi: 10.1038/bjc.2013.650

Ethnicity and outcome of young breast cancer patients in the United Kingdom: the POSH study

2014

Book Chapter

Breast Cancer

Schnitt, Stuart J. and Lakhani, Sunil S. (2014). Breast Cancer. World Cancer Report. (pp. 362-373) edited by Bernard W. Stewart and Christopher P. Wild. Lyon, France: IARC.

Breast Cancer

2013

Journal Article

miR-139-5p is a regulator of metastatic pathways in breast cancer

Krishnan, Keerthana, Steptoe, Anita, Martin, Hilary, Pattabiraman, Diwakar R., Nones, Katia, Waddell, Nicola, Mariasegaram, Mythily, Simpson, Peter T., Lakhani, Sunil R., Vlassov, Alexander, Grimmond, Sean M. and Cloonan, Nicole (2013). miR-139-5p is a regulator of metastatic pathways in breast cancer. RNA, 19 (12), 1767-1780. doi: 10.1261/rna.042143.113

miR-139-5p is a regulator of metastatic pathways in breast cancer

2013

Journal Article

c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer

Nair, R., Roden, D. L., Teo, W. S., McFarland, A., Junankar, S., Ye, S., Nguyen, A., Yang, J., Nikolic, I., Hui, M., Morey, A., Shah, J., Pfefferle, A. D., Usary, J., Selinger, C., Baker, L. A., Armstrong, N., Cowley, M. J., Naylor, M. J., Ormandy, C. J., Lakhani, S. R., Herschkowitz, J. I., Perou, C. M., Kaplan, W., O'Toole, S. A. and Swarbrick, A. (2013). c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer. Oncogene, 33 (30), 3992-4002. doi: 10.1038/onc.2013.368

c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer

2013

Journal Article

Signatures of mutational processes in human cancer

Alexandrov, Ludmil B., Nik-Zainal, Serena, Wedge, David C., Aparicio, Samuel A. J. R., Behjati, Sam, Biankin, Andrew V., Bignell, Graham R., Bolli, Niccolo, Borg, Ake, Borresen-Dale, Anne-Lise, Boyault, Sandrine, Burkhardt, Birgit, Butler, Adam P., Caldas, Carlos, Davies, Helen R., Desmedt, Christine, Eils, Roland, Eyfjord, Jorunn Erla, Foekens, John A., Greaves, Mel, Hosoda, Fumie, Hutter, Barbara, Ilicic, Tomislav, Imbeaud, Sandrine, Imielinsk, Marcin, Jaeger, Natalie, Jones, David T. W., Jones, David, Knappskog, Stian ... Stratton, Michael R. (2013). Signatures of mutational processes in human cancer. Nature, 500 (7463), 415-421. doi: 10.1038/nature12477

Signatures of mutational processes in human cancer

2013

Journal Article

Intraoperative imprint cytology for breast cancer sentinel nodes: is it worth it?

Richards, Angela D. M., Lakhani, Sunil R., James, Daniel T. and Ung, Owen A. (2013). Intraoperative imprint cytology for breast cancer sentinel nodes: is it worth it?. ANZ Journal of Surgery, 83 (7-8), 539-544. doi: 10.1111/j.1445-2197.2012.06293.x

Intraoperative imprint cytology for breast cancer sentinel nodes: is it worth it?

2013

Journal Article

Mammographic and ultrasound features of invasive lobular carcinoma of the breast

Porter, Alan J., Evans, Elizabeth B., Foxcroft, Loani M., Simpson, Peter T. and Lakhani, Sunil R. (2013). Mammographic and ultrasound features of invasive lobular carcinoma of the breast. Journal of Medical Imaging and Radiation Oncology, 58 (1), 1-10. doi: 10.1111/1754-9485.12080

Mammographic and ultrasound features of invasive lobular carcinoma of the breast

2013

Journal Article

In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity

Smart, Chanel E., Morrison, Brian J., Saunus, Jodi M., Vargas, Ana Cristina, Keith, Patricia, Reid, Lynne, Wockner, Leesa, Amiri, Marjan Askarian, Sarkar, Debina, Simpson, Peter T., Clarke, Catherine, Schmidt, Chris W., Reynolds, Brent A., Lakhani, Sunil R. and Lopez, J. Alejandro (2013). In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PloS One, 8 (6) e64388, e64388. doi: 10.1371/journal.pone.0064388

In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity