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2026 Journal Article Therapeutic drug monitoring and the role of pharmacokinetics/pharmacodynamics in optimizing beta-lactam antibiotic dosing for deep-seated infections: a systematic reviewVale, Cassandra, Sime, Fekade B., Cotta, Menino O., Eriksson, Lars, Roberts, Jason A, Horvath, Robert and Abdul-Aziz, Mohd H. (2026). Therapeutic drug monitoring and the role of pharmacokinetics/pharmacodynamics in optimizing beta-lactam antibiotic dosing for deep-seated infections: a systematic review. Journal of Antimicrobial Chemotherapy, 81 (5) dkag142. doi: 10.1093/jac/dkag142 |
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2026 Journal Article How to perform pharmacokinetic research of antimicrobial drugs in critically ill patients undergoing continuous renal replacement therapy: a scoping review of all relevant pharmacokinetic factorsWieringa, A., Smeets, T. J. L., ter Horst, P. G. J., Hunfeld, N. G. M., Bellomo, R., Prowle, J. R., Elderman, J. H., Valkenburg, A. J., Gommers, D., Zeitlinger, M., Tängdén, T., Abdul-Aziz, M. H., Li, J., Sikma, M.A., Mangalore, R. Pai, Stocker, S.L., Endeman, H., Koch, B.C.P., Haringman, J.J., On behalf of the pharmacokinetics & pharmacodynamics anti-infective study group of the European Society of Clinical Microbiology and Infectious Diseases (EPASG), Acute Kidney Injury section of the European Society of Intensive Care Medicine (ESICM), Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) and Infections in the ICU, Sepsis, and Anti-Infective Pharmacology Working Group of International Society of Antimicrobial Chemotherapy (ISAC) (2026). How to perform pharmacokinetic research of antimicrobial drugs in critically ill patients undergoing continuous renal replacement therapy: a scoping review of all relevant pharmacokinetic factors. Clinical Microbiology and Infection, 32 (4), 560-571. doi: 10.1016/j.cmi.2025.11.033 |
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2026 Journal Article Reply to Lai and Huang, “Which beta-lactam infusion strategy is superior in ICU pneumonia? A Bayesian network meta-analysis of continuous, extended, and intermittent approaches”Li, Yixuan, Roberts, Jason A., Abdul-Aziz, Mohd H. and Sime, Fekade B. (2026). Reply to Lai and Huang, “Which beta-lactam infusion strategy is superior in ICU pneumonia? A Bayesian network meta-analysis of continuous, extended, and intermittent approaches”. Antimicrobial Agents and Chemotherapy, 70 (4) e01859-25, 1-2. doi: 10.1128/aac.01859-25 |
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2026 Journal Article Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation-an ASAP ECMO studyAbdul-Aziz, Mohd H., Cheng, Vesa, Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Kim, Hyung-Sook, Levkovich, Bianca J., Lim, Sung Yoon, Liu, Xin, McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Pellegrino, Vincent, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2026). Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation-an ASAP ECMO study. Journal of Antimicrobial Chemotherapy, 81 (4) dkag090, 1-12. doi: 10.1093/jac/dkag090 |
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2026 Journal Article The clinical spectrum and causal relationship assessment of checkpoint inhibitor-associated autoimmune diabetes mellitus (CIADM): a retrospective observational studyLi, Youjia, Qu, Kai, Yang, Qianting, Zhang, Jinming, Xu, Yitao, Wang, Haitao, Zhang, Kanghuai, Wang, Cheng, Abdul-Aziz, Mohd H and Xie, Jiao (2026). The clinical spectrum and causal relationship assessment of checkpoint inhibitor-associated autoimmune diabetes mellitus (CIADM): a retrospective observational study. Diabetic Medicine, 43 (6) e70316, 1-8. doi: 10.1111/dme.70316 |
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2025 Journal Article Antibacterial pharmacokinetics in critically ill patients receiving extracorporeal membrane oxygenation (ECMO): a systematic review of population pharmacokinetic studiesRen, Chanelle, Huang, Frank, Cheng, Vesa, Xie, Jiao, Roberts, Jason A. and Abdul-Aziz, Mohd H. (2025). Antibacterial pharmacokinetics in critically ill patients receiving extracorporeal membrane oxygenation (ECMO): a systematic review of population pharmacokinetic studies. Clinical pharmacokinetics, 65 (2) PMID 7606849, 193-215. doi: 10.1007/s40262-025-01596-z |
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2025 Journal Article The impact of an ex vivo pediatric extracorporeal membrane oxygenation circuit on sequestration of antimicrobialsCree, Michele L., Abdul-Aziz, Mohd Hafiz, Haisz, Emma, Wallis, Steven C., Won, Hayoung, Sumi, Chandra D., Marjanovic, Dusan, Ordóñez, Jenny L., Schlapbach, Luregn J. and Roberts, Jason A. (2025). The impact of an ex vivo pediatric extracorporeal membrane oxygenation circuit on sequestration of antimicrobials. Critical Care Explorations, 7 (11) e1338, e1338. doi: 10.1097/CCE.0000000000001338 |
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2025 Journal Article Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairmentSulaiman, Helmi, Rozali, Muhammad Azrai, Adiraju, Santosh K. S., Hasan, M. Shahnaz, Jamal, Janattul A., Liu, Xin, Mat-Nor, Mohd-Basri, Mazlan, Mohd Zulfakar, Othman-Jailani, Mohamad Irfan, Salmuna, Zeti Norfidiyati, Wallis, Steven C., Roberts, Jason A. and Abdul-Aziz, Mohd H. (2025). Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairment. Scientific Reports, 15 (1) 37781, 1-12. doi: 10.1038/s41598-025-20630-5 |
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2025 Journal Article Continuous or extended vs intermittent infusions of beta-lactam antibiotics in ICU patients with pneumonia: a systematic review and meta-analysis of randomized controlled trialsLi, Yixuan, Roberts, Jason A., Abdul-Aziz, Mohd H. and Sime, Fekade B. (2025). Continuous or extended vs intermittent infusions of beta-lactam antibiotics in ICU patients with pneumonia: a systematic review and meta-analysis of randomized controlled trials. Antimicrobial Agents and Chemotherapy, 69 (10) e0073225, 1-13. doi: 10.1128/aac.00732-25 |
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2025 Journal Article Pharmacological research agenda on adult extracorporeal membrane oxygenation using the Delphi method: a position article of the extracorporeal membrane oxygenation pharmacology networkMorales Castro, Diana, Al-Fares, Abdulrahman Abdullah, Paternoster, Gianluca, Lyster, Haifa, Hohlfelder, Benjamin, Arias Ortiz, Julian, Abdul-Aziz, Mohd Hafiz, Herr, Daniel, Alraish, Rawan, Ferre Contreras, Andrés, Palavecino, Marcela, Milella, Luigi, Watt, Kevin, Alkazemi, Afrah, Carini, Federico Carlos, Roberts, Jason A., Riera Del Brio, Jordi, Parra, Alba Pau, Kakar, Vivek, Dureau, Pauline, Duceppe, Marc-Alexandre, Alm, Mark, Cha, Stephanie, Shekar, Kiran, Dzierba, Amy L. and Extracorporeal Membrane Oxygenation Pharmacology Network (ECMOPharm Net) (2025). Pharmacological research agenda on adult extracorporeal membrane oxygenation using the Delphi method: a position article of the extracorporeal membrane oxygenation pharmacology network. Critical Care Medicine, 53 (11), e2246-e2260. doi: 10.1097/CCM.0000000000006806 |
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2025 Journal Article Optimizing antibiotic dosing: a prospective observational study of piperacillin/tazobactam plasma levels in critically ill patients with augmented renal clearanceNegin, Fahima, Abdul Rahim, Shahir Asraf, Mat Nor, Mohd Basri, Mohamad, Fatimah, Nordin, Nur Sazwi and Abdul-Aziz, Mohd Hafiz (2025). Optimizing antibiotic dosing: a prospective observational study of piperacillin/tazobactam plasma levels in critically ill patients with augmented renal clearance. IIUM Medical Journal Malaysia, 24 (3), 48-53. doi: 10.31436/imjm.v24i03.2607 |
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2025 Journal Article Current practices in outpatient parenteral antimicrobial therapy programmes: an international multi-centre surveyWolie, Zenaw T., Roberts, Jason A., López-Cortés, Luis Eduardo, Mirón-Rubio, Manuel, Pollard, James, Marizan Nor, Afra Nahdia, Abdul-Aziz, Mohd H., Jamieson, Conor, Seaton, R Andrew, Gilchrist, Mark and Sime, Fekade B. (2025). Current practices in outpatient parenteral antimicrobial therapy programmes: an international multi-centre survey. JAC - Antimicrobial Resistance, 7 (3) dlaf075, 1-11. doi: 10.1093/jacamr/dlaf075 |
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2025 Journal Article A Systematic Review of Pharmacokinetic Studies of Colistin and Polymyxin B in Adult PopulationsZamri, Puteri Juanita, Lim, Sazlyna Mohd Sazlly, Sime, Fekade Bruck, Roberts, Jason A. and Abdul-Aziz, Mohd Hafiz (2025). A Systematic Review of Pharmacokinetic Studies of Colistin and Polymyxin B in Adult Populations. Clinical Pharmacokinetics, 64 (5) n71, 1-35. doi: 10.1007/s40262-025-01488-2 |
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2025 Journal Article Continuous versus intermittent bolus dosing of beta-lactam antibiotics in a South African multi-disciplinary intensive care unit: a randomized controlled trialKhan, Ayesha Bibi, Abdul-Aziz, Mohd Hafiz, Hindle, Lucy, Lipman, Jeffrey, Simelela, Fetolang and Omar, Shahed (2025). Continuous versus intermittent bolus dosing of beta-lactam antibiotics in a South African multi-disciplinary intensive care unit: a randomized controlled trial. Journal of Infection, 90 (5) 106487, 1-6. doi: 10.1016/j.jinf.2025.106487 |
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2025 Journal Article Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot studyRoberts, J. A., Heffernan, A. J., Chai, M. G., Harris, P. N. A., Legg, A., Farkas, A., Laupland, K., Dhanani, J., Fourie, C., Murray, L., Abdul-Aziz, H., Ungerer, J., McWhinney, B., Lipman, J. and Cotta, M. O. (2025). Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot study. CMI Communications, 2 (1) 105051, 1-7. doi: 10.1016/j.cmicom.2024.105051 |
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2025 Journal Article Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO studyAbdul-Aziz, Mohd H., Diehl, Arne, Liu, Xin, Cheng, Vesa, Corley, Amanda, Gilder, Eileen, Levkovich, Bianca, McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Pellegrino, Vincent, Wallis, Steven C., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2025). Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study. Antimicrobial Agents and Chemotherapy, 69 (2) e0143524, 1-15. doi: 10.1128/aac.01435-24 |
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2025 Journal Article Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infectionGiuliano, Simone, Angelini, Jacopo, Campanile, Floriana, Conti, Paola, Flammini, Sarah, Pagotto, Alberto, Sbrana, Francesco, Martini, Luca, D'Elia, Denise, Abdul-Aziz, Mohd H., Cotta, Menino O., Roberts, Jason A., Bonomo, Robert A. and Tascini, Carlo (2025). Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection. Scientific Reports, 15 (1) 3519, 1-16. doi: 10.1038/s41598-025-87512-8 |
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2025 Journal Article Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenationMorales Castro, Diana, Balzani, Eleonora, Abdul-Aziz, M. Hafiz, Hernandez-Mitre, Maria Patricia, Wong, Irene, Turgeon, Julien, Tisminetzky, Manuel, Jurado-Camacho, Felipe, Morris, Idunn, Dresser, Linda, Granton, John, Uetrecht, Jack, Pang, K. Sandy, Chen, Eric, Shekar, Kiran and Fan, Eddy (2025). Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenation. Annals of the American Thoracic Society, 22 (1), 121-129. doi: 10.1513/annalsats.202407-795oc |
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2024 Journal Article Prolonged vs intermittent infusions of β-lactam antibiotics-replyRoberts, Jason A., Devaux, Anthony and Abdul-Aziz, Mohd H. (2024). Prolonged vs intermittent infusions of β-lactam antibiotics-reply. JAMA-Journal of the American Medical Association, 333 (3), 259. doi: 10.1001/jama.2024.23728 |
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2024 Journal Article Is it time to implement prolonged infusions of beta-lactam antibiotics in and beyond critical care settings?Abdul-Aziz, Mohd H., Dulhunty, Joel M., Rajbhandari, Dorrilyn, Roberts, Jason A. and Lipman, Jeffrey (2024). Is it time to implement prolonged infusions of beta-lactam antibiotics in and beyond critical care settings?. Internal Medicine Journal, 54 (12), 1931-1934. doi: 10.1111/imj.16584 |
