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2025

Journal Article

Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairment

Sulaiman, Helmi, Rozali, Muhammad Azrai, Adiraju, Santosh K. S., Hasan, M. Shahnaz, Jamal, Janattul A., Liu, Xin, Mat-Nor, Mohd-Basri, Mazlan, Mohd Zulfakar, Othman-Jailani, Mohamad Irfan, Salmuna, Zeti Norfidiyati, Wallis, Steven C., Roberts, Jason A. and Abdul-Aziz, Mohd H. (2025). Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairment. Scientific Reports, 15 (1) 37781, 1-12. doi: 10.1038/s41598-025-20630-5

Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairment

2025

Journal Article

Continuous or extended vs intermittent infusions of beta-lactam antibiotics in ICU patients with pneumonia: a systematic review and meta-analysis of randomized controlled trials

Li, Yixuan, Roberts, Jason A., Abdul-Aziz, Mohd H. and Sime, Fekade B. (2025). Continuous or extended vs intermittent infusions of beta-lactam antibiotics in ICU patients with pneumonia: a systematic review and meta-analysis of randomized controlled trials. Antimicrobial Agents and Chemotherapy, 69 (10) e0073225, 1-13. doi: 10.1128/aac.00732-25

Continuous or extended vs intermittent infusions of beta-lactam antibiotics in ICU patients with pneumonia: a systematic review and meta-analysis of randomized controlled trials

2025

Journal Article

Pharmacological research agenda on adult extracorporeal membrane oxygenation using the Delphi method: a position article of the extracorporeal membrane oxygenation pharmacology network

Morales Castro, Diana, Al-Fares, Abdulrahman Abdullah, Paternoster, Gianluca, Lyster, Haifa, Hohlfelder, Benjamin, Arias Ortiz, Julian, Abdul-Aziz, Mohd Hafiz, Herr, Daniel, Alraish, Rawan, Ferre Contreras, Andrés, Palavecino, Marcela, Milella, Luigi, Watt, Kevin, Alkazemi, Afrah, Carini, Federico Carlos, Roberts, Jason A., Riera Del Brio, Jordi, Parra, Alba Pau, Kakar, Vivek, Dureau, Pauline, Duceppe, Marc-Alexandre, Alm, Mark, Cha, Stephanie, Shekar, Kiran, Dzierba, Amy L. and Extracorporeal Membrane Oxygenation Pharmacology Network (ECMOPharm Net) (2025). Pharmacological research agenda on adult extracorporeal membrane oxygenation using the Delphi method: a position article of the extracorporeal membrane oxygenation pharmacology network. Critical Care Medicine, 53 (11), e2246-e2260. doi: 10.1097/CCM.0000000000006806

Pharmacological research agenda on adult extracorporeal membrane oxygenation using the Delphi method: a position article of the extracorporeal membrane oxygenation pharmacology network

2025

Journal Article

Optimizing antibiotic dosing: a prospective observational study of piperacillin/tazobactam plasma levels in critically ill patients with augmented renal clearance

Negin, Fahima, Abdul Rahim, Shahir Asraf, Mat Nor, Mohd Basri, Mohamad, Fatimah, Nordin, Nur Sazwi and Abdul-Aziz, Mohd Hafiz (2025). Optimizing antibiotic dosing: a prospective observational study of piperacillin/tazobactam plasma levels in critically ill patients with augmented renal clearance. IIUM Medical Journal Malaysia, 24 (3), 48-53. doi: 10.31436/imjm.v24i03.2607

Optimizing antibiotic dosing: a prospective observational study of piperacillin/tazobactam plasma levels in critically ill patients with augmented renal clearance

2025

Journal Article

Current practices in outpatient parenteral antimicrobial therapy programmes: an international multi-centre survey

Wolie, Zenaw T., Roberts, Jason A., López-Cortés, Luis Eduardo, Mirón-Rubio, Manuel, Pollard, James, Marizan Nor, Afra Nahdia, Abdul-Aziz, Mohd H., Jamieson, Conor, Seaton, R Andrew, Gilchrist, Mark and Sime, Fekade B. (2025). Current practices in outpatient parenteral antimicrobial therapy programmes: an international multi-centre survey. JAC - Antimicrobial Resistance, 7 (3) dlaf075, 1-11. doi: 10.1093/jacamr/dlaf075

Current practices in outpatient parenteral antimicrobial therapy programmes: an international multi-centre survey

2025

Journal Article

A Systematic Review of Pharmacokinetic Studies of Colistin and Polymyxin B in Adult Populations

Zamri, Puteri Juanita, Lim, Sazlyna Mohd Sazlly, Sime, Fekade Bruck, Roberts, Jason A. and Abdul-Aziz, Mohd Hafiz (2025). A Systematic Review of Pharmacokinetic Studies of Colistin and Polymyxin B in Adult Populations. Clinical Pharmacokinetics, 64 (5) n71, 1-35. doi: 10.1007/s40262-025-01488-2

A Systematic Review of Pharmacokinetic Studies of Colistin and Polymyxin B in Adult Populations

2025

Journal Article

Continuous versus intermittent bolus dosing of beta-lactam antibiotics in a South African multi-disciplinary intensive care unit: a randomized controlled trial

Khan, Ayesha Bibi, Abdul-Aziz, Mohd Hafiz, Hindle, Lucy, Lipman, Jeffrey, Simelela, Fetolang and Omar, Shahed (2025). Continuous versus intermittent bolus dosing of beta-lactam antibiotics in a South African multi-disciplinary intensive care unit: a randomized controlled trial. Journal of Infection, 90 (5) 106487, 1-6. doi: 10.1016/j.jinf.2025.106487

Continuous versus intermittent bolus dosing of beta-lactam antibiotics in a South African multi-disciplinary intensive care unit: a randomized controlled trial

2025

Journal Article

Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot study

Roberts, J. A., Heffernan, A. J., Chai, M. G., Harris, P. N. A., Legg, A., Farkas, A., Laupland, K., Dhanani, J., Fourie, C., Murray, L., Abdul-Aziz, H., Ungerer, J., McWhinney, B., Lipman, J. and Cotta, M. O. (2025). Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot study. CMI Communications, 2 (1) 105051, 1-7. doi: 10.1016/j.cmicom.2024.105051

Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot study

2025

Journal Article

Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study

Abdul-Aziz, Mohd H., Diehl, Arne, Liu, Xin, Cheng, Vesa, Corley, Amanda, Gilder, Eileen, Levkovich, Bianca, McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Pellegrino, Vincent, Wallis, Steven C., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2025). Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study. Antimicrobial Agents and Chemotherapy, 69 (2) e0143524, 1-15. doi: 10.1128/aac.01435-24

Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study

2025

Journal Article

Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection

Giuliano, Simone, Angelini, Jacopo, Campanile, Floriana, Conti, Paola, Flammini, Sarah, Pagotto, Alberto, Sbrana, Francesco, Martini, Luca, D'Elia, Denise, Abdul-Aziz, Mohd H., Cotta, Menino O., Roberts, Jason A., Bonomo, Robert A. and Tascini, Carlo (2025). Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection. Scientific Reports, 15 (1) 3519, 1-16. doi: 10.1038/s41598-025-87512-8

Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection

2025

Journal Article

Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenation

Morales Castro, Diana, Balzani, Eleonora, Abdul-Aziz, M. Hafiz, Hernandez-Mitre, Maria Patricia, Wong, Irene, Turgeon, Julien, Tisminetzky, Manuel, Jurado-Camacho, Felipe, Morris, Idunn, Dresser, Linda, Granton, John, Uetrecht, Jack, Pang, K. Sandy, Chen, Eric, Shekar, Kiran and Fan, Eddy (2025). Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenation. Annals of the American Thoracic Society, 22 (1), 121-129. doi: 10.1513/annalsats.202407-795oc

Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenation

2024

Journal Article

Prolonged vs intermittent infusions of β-lactam antibiotics-reply

Roberts, Jason A., Devaux, Anthony and Abdul-Aziz, Mohd H. (2024). Prolonged vs intermittent infusions of β-lactam antibiotics-reply. JAMA-Journal of the American Medical Association, 333 (3), 259. doi: 10.1001/jama.2024.23728

Prolonged vs intermittent infusions of β-lactam antibiotics-reply

2024

Journal Article

Is it time to implement prolonged infusions of beta-lactam antibiotics in and beyond critical care settings?

Abdul-Aziz, Mohd H., Dulhunty, Joel M., Rajbhandari, Dorrilyn, Roberts, Jason A. and Lipman, Jeffrey (2024). Is it time to implement prolonged infusions of beta-lactam antibiotics in and beyond critical care settings?. Internal Medicine Journal, 54 (12), 1931-1934. doi: 10.1111/imj.16584

Is it time to implement prolonged infusions of beta-lactam antibiotics in and beyond critical care settings?

2024

Journal Article

The impact of extracorporeal support on antimicrobial pharmacokinetics in critically ill neonatal and paediatric patients: a systematic review

Cree, Michele L., Abdul-Aziz, Mohd Hafiz, Schlapbach, Luregn J., Roberts, Jason A. and Parker, Suzanne (2024). The impact of extracorporeal support on antimicrobial pharmacokinetics in critically ill neonatal and paediatric patients: a systematic review. International Journal of Antimicrobial Agents, 64 (4) 107311, 1-16. doi: 10.1016/j.ijantimicag.2024.107311

The impact of extracorporeal support on antimicrobial pharmacokinetics in critically ill neonatal and paediatric patients: a systematic review

2024

Journal Article

COVID-19 drug treatments are prone to sequestration in extracorporeal membrane oxygenation circuits: an ex vivo extracorporeal membrane oxygenation study

Dhanani, Jayesh A., Shekar, Kiran, Parmar, Dinesh, Lipman, Jeffrey, Bristow, Debra, Wallis, Steven C., Won, Hayoung, Sumi, Chandra D., Abdul-Aziz, Mohd H. and Roberts, Jason A. (2024). COVID-19 drug treatments are prone to sequestration in extracorporeal membrane oxygenation circuits: an ex vivo extracorporeal membrane oxygenation study. ASAIO Journal, 70 (6), 546-552. doi: 10.1097/MAT.0000000000002120

COVID-19 drug treatments are prone to sequestration in extracorporeal membrane oxygenation circuits: an ex vivo extracorporeal membrane oxygenation study

2023

Journal Article

Population pharmacokinetics of fluconazole in critically ill patients receiving extracorporeal membrane oxygenation and continuous renal replacement therapy: an ASAP ECMO study

Novy, Emmanuel, Abdul-Aziz, Mohd H., Cheng, Vesa, Burrows, Fay, Buscher, Hergen, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Levkovich, Bianca J., McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Parker, Suzanne, Pellegrino, Vincent, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2023). Population pharmacokinetics of fluconazole in critically ill patients receiving extracorporeal membrane oxygenation and continuous renal replacement therapy: an ASAP ECMO study. Antimicrobial Agents and Chemotherapy, 68 (1) e0120123, e0120123. doi: 10.1128/aac.01201-23

Population pharmacokinetics of fluconazole in critically ill patients receiving extracorporeal membrane oxygenation and continuous renal replacement therapy: an ASAP ECMO study

2023

Journal Article

In silico evaluation of a beta‐lactam dosing guideline among adults with serious infections

Williams, Paul, Cotta, Menino Osbert, Abdul‐Aziz, Mohd H., Wilks, Kathryn, Farkas, Andras and Roberts, Jason A. (2023). In silico evaluation of a beta‐lactam dosing guideline among adults with serious infections. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 43 (11), 1121-1130. doi: 10.1002/phar.2753

In silico evaluation of a beta‐lactam dosing guideline among adults with serious infections

2023

Journal Article

In silico evaluation of a vancomycin dosing guideline among adults with serious infections

Williams, Paul, Cotta, Menino Osbert, Abdul-Aziz, Mohd H., Wilks, Kathryn, Farkas, Andras and Roberts, Jason A (2023). In silico evaluation of a vancomycin dosing guideline among adults with serious infections. Therapeutic Drug Monitoring, 45 (5), 631-636. doi: 10.1097/FTD.0000000000001102

In silico evaluation of a vancomycin dosing guideline among adults with serious infections

2023

Journal Article

Why is the implementation of beta-lactam therapeutic drug monitoring for the critically ill falling short? A multicenter mixed-methods study

Barreto, Erin F., Chitre, Pooja N., Pine, Kathleen H., Shepel, Kathryn K., Rule, Andrew D., Alshaer, Mohammad H., Abdul Aziz, Mohd Hafiz, Roberts, Jason A., Scheetz, Marc H., Ausman, Sara E., Moreland-Head, Lindsay N., Rivera, Christina G., Jannetto, Paul J., Mara, Kristin C. and Boehmer, Kasey R. (2023). Why is the implementation of beta-lactam therapeutic drug monitoring for the critically ill falling short? A multicenter mixed-methods study. Therapeutic Drug Monitoring, 45 (4), 508-518. doi: 10.1097/FTD.0000000000001059

Why is the implementation of beta-lactam therapeutic drug monitoring for the critically ill falling short? A multicenter mixed-methods study

2023

Journal Article

Dalbavancin as suppressive antibiotic therapy in patients with prosthetic infections: efficacy and safety

Ruiz-Sancho, Andrés, Núñez-Núñez, María, Castelo-Corral, Laura, Martínez-Marcos, Francisco Javier, Lois-Martínez, Nagore, Abdul-Aziz, Mohd Hafiz and Vinuesa-García, David (2023). Dalbavancin as suppressive antibiotic therapy in patients with prosthetic infections: efficacy and safety. Frontiers in Pharmacology, 14 1185602, 1185602. doi: 10.3389/fphar.2023.1185602

Dalbavancin as suppressive antibiotic therapy in patients with prosthetic infections: efficacy and safety