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2017 Journal Article Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signalingPlisson, Fabien, Hill, Timothy A., Mitchell, Justin M., Hoang, Huy N., de Araujo, Aline D., Xu, Weijun, Cotterell, Adam, Edmonds, David J., Stanton, Robert V., Derksen, David R., Loria, Paula M., Griffith, David A., Price, David A., Liras, Spiros and Fairlie, David P. (2017). Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling. European Journal of Medicinal Chemistry, 127, 703-714. doi: 10.1016/j.ejmech.2016.10.044 |
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2017 Journal Article Alpha helix nucleation by a simple cyclic tetrapeptideHoang, Huy N., Wu, Chongyang, Beyer, Renee L., Hill, Timothy A. and Fairlie, David P. (2017). Alpha helix nucleation by a simple cyclic tetrapeptide. Australian Journal of Chemistry, 70 (2), 213-219. doi: 10.1071/CH16591 |
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2017 Journal Article Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology DomainOdell, Luke R., Abdel-Hamid, Mohammed K., Hill, Timothy A., Ngoc Chau, , Young, Kelly A., Deane, Fiona M., Sakoff, Jennette A., Andersson, Sofia, Daniel, James A., Robinson, Phillip J. and McCluskey, Adam (2017). Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain. Journal of Medicinal Chemistry, 60 (1), 349-361. doi: 10.1021/acs.jmedchem.6b01422 |
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2016 Journal Article Helix nucleation by the smallest known α-helix in waterHoang, Huy N., Driver, Russell W., Beyer, Renee L., Hill, Timothy A., de Araujo, Aline D., Plisson, Fabien, Harrison, Rosemary S., Goedecke, Lena, Shepherd, Nicholas E. and Fairlie, David P. (2016). Helix nucleation by the smallest known α-helix in water. Angewandte Chemie (International Edition), 55 (29), 8275-8279. doi: 10.1002/anie.201602079 |
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2015 Journal Article Flexibility versus rigidity for orally bioavailable cyclic hexapeptidesNielsen, Daniel S., Lohman, Rink-Jan, Hoang, Huy Ngoc, Hill, Timothy A., Jones, Alun, Lucke, Andrew J. and Fairlie, David P. (2015). Flexibility versus rigidity for orally bioavailable cyclic hexapeptides. Chembiochem, 16 (16), 2289-2293. doi: 10.1002/cbic.201500441 |
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2015 Journal Article Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonistsHoang, Huy N., Song, Kun, Hill, Timothy A., Derksen, David R., Edmonds, David J., Kok, W. Mei, Limberakis, Chris, Liras, Spiros, Loria, Paula M., Mascitti, Vincent, Mathiowetz, Alan M., Mitchell, Justin M., Piotrowski, David W., Price, David A., Stanton, Robert V., Suen, Jacky Y., Withka, Jane M., Griffith, David A. and Fairlie, David P. (2015). Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists. Journal of Medicinal Chemistry, 58 (9), 4080-4085. doi: 10.1021/acs.jmedchem.5b00166 |
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2015 Conference Publication Cyclic penta- and hexa leucine peptides without N-methylation are orally absorbedKok, Woan Mei, Hill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor G., Schroeder, Christina I., Colless, Barbara, Bernhardt, Paul V., Edmonds, David, Griffith, David, Rotter, Charles, Ruggeri, Roger, Price, David, Liras, Spiros, Craik, David and Fairlie, David (2015). Cyclic penta- and hexa leucine peptides without N-methylation are orally absorbed. American Chemical Society Meeting, x, 2015. Washington, DC United States: American Chemical Society. |
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2015 Book Chapter Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociceptionLohman, Rink-Jan, Harrison, Rosemary S., Ruiz-Gomez, Gloria, Hoang, Huy Ngoc, Shepherd, Nicholas E., Chow, Shiao, Hill, Timothy A., Madala, Praveen K. and Fairlie, David P. (2015). Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociception. Nociceptin opioid. (pp. 1-55) edited by Gerald Litwack. Maryland Heights, MO, United States: Academic Press. doi: 10.1016/bs.vh.2014.10.001 |
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2014 Journal Article Improving on nature: making a cyclic heptapeptide orally bioavailableNielsen, Daniel S., Hoang, Huy N., Lohman, Rink-Jan, Hill, Timothy A., Lucke, Andrew J., Craik, David J., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros and Fairlie, David P. (2014). Improving on nature: making a cyclic heptapeptide orally bioavailable. Angewandte Chemie - International Edition, 53 (45), 12059-12063. doi: 10.1002/anie.201405364 |
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2014 Journal Article Helical cyclic pentapeptides constrain HIV-1 Rev peptide for enhanced RNA bindingHarrison, Rosemary S., Shepherd, Nicholas E., Hoang, Huy N., Beyer, Renee L., Ruiz-Gomez, Gloria, Kelso, Michael J., Mei Kok, W., Hill, Timothy A., Abbenante, Giovanni and Fairlie, David P. (2014). Helical cyclic pentapeptides constrain HIV-1 Rev peptide for enhanced RNA binding. Tetrahedron, 70 (42), 7645-7650. doi: 10.1016/j.tet.2014.07.096 |
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2014 Journal Article Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbedHill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor C. G., Kok, W. Mei, Liu, Ligong, Lucke, Andrew J., Stoermer, Martin J., Schroeder, Christina I., Chaousis, Stephanie, Colless, Barbara, Bernhardt, Paul V., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros, Craik, David J. and Fairlie, David P. (2014). Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed. ACS Medicinal Chemistry Letters, 5 (10), 1148-1151. doi: 10.1021/ml5002823 |
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2014 Journal Article Constraining cyclic peptides to mimic protein structure motifsHill, Timothy A., Shepherd, Nicholas E., Diness, Frederik and Fairlie, David P. (2014). Constraining cyclic peptides to mimic protein structure motifs. Angewandte Chemie (International Edition), 53 (48), 13020-13041. doi: 10.1002/anie.201401058 |
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2014 Journal Article Fixierung cyclischer Peptide: Mimetika von ProteinstrukturmotivenHill, Timothy A., Shepherd, Nicholas E., Diness, Frederik and Fairlie, David P. (2014). Fixierung cyclischer Peptide: Mimetika von Proteinstrukturmotiven. Angewandte Chemie, 126 (48), 13234-13257. doi: 10.1002/ange.201401058 |
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2014 Journal Article Comparative α-Helicity of Cyclic Pentapeptides in Waterde Araujo, Aline D., Hoang, Huy N., Kok, W. Mei, Diness, Frederik, Gupta, Praveer, Hill, Timothy A., Driver, Russell W., Price, David A., Liras, Spiros and Fairlie, David P. (2014). Comparative α-Helicity of Cyclic Pentapeptides in Water. Angewandte Chemie International Edition, 53 (27), 6965-6969. doi: 10.1002/anie.201310245/abstract |
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2013 Journal Article A novel class of anticancer compounds targets the actin cytoskeleton in tumor cellsStehn, Justine R., Haass, Nikolas K., Bonello, Teresa, Desouza, Melissa, Kottyan, Gregg, Treutlein, Herbert, Zeng, Jun, Nascimento, Paula R. B. B., Sequeira, Vanessa B., Butler, Tanya L., Allanson, Munif, Fath, Thomas, Hill, Timothy A., McCluskey, Adam, Schevzov, Galina, Palmer, Stephen J., Hardeman, Edna C., Winlaw, David, Reeve, Vivienne E., Dixon, Ian, Weninger, Wolfgang, Cripe, Timothy P. and Gunning, Peter W. (2013). A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells. Cancer Research, 73 (16), 5169-5182. doi: 10.1158/0008-5472.CAN-12-4501 |
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2013 Journal Article Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitorsMcGeachie, Andrew B., Odell, Luke R., Quan, Annie, Daniel, James A., Chau, Ngoc, Hill, Timothy A., Gorgani, Nick N., Keating, Damien J., Cousin, Michael A., van Dam, Ellen M., Mariana, Anna, Whiting, Ainslie, Perera, Swetha, Novelle, Aimee, Young, Kelly A., Deane, Fiona M., Gilbert, Jayne, Sakoff, Jennette A., Chircop, Megan, McCluskey, Adam and Robinson, Phillip J. (2013). Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors. ACS Chemical Biology, 8 (7), 1507-1518. doi: 10.1021/cb400137p |
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2013 Journal Article Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1Rao, Tara, Ruiz-Gomez, Gloria, Hill, Timothy A., Hoang, Huy N., Fairlie, David P. and Mason, Jody M. (2013). Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1. PLoS One, 8 (3) e59415, e59415.1-e59415.12. doi: 10.1371/journal.pone.0059415 |
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2012 Journal Article Folding pentapeptides into left and right handed alpha helicesHoang, Huy N., Abbenante, Giovanni, Hill, Timothy A., Ruiz-Gomez, Gloria and Fairlie, David P. (2012). Folding pentapeptides into left and right handed alpha helices. Tetrahedron, 68 (23), 4513-4516. doi: 10.1016/j.tet.2011.10.108 |
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2012 Conference Publication Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cellsStehn, J. R., Haass, N. K., Bonello, T., Desouza, M., Kottyan, G., Treutlein, H., Zeng, J., Nascimento, P. R., Butler, T., Allanson, M., Fath, T., Hill, T. A., McCluskey, A., Schevzov, G., Palmer, S., Hardeman, E. C., Winlaw, D., Reeve, V. E., Dixon, I., Weninger, W., Cripe, T. P. and Gunning, P. (2012). Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells. 39th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Marburg Germany, Mar 01-03, 2012. WILEY-BLACKWELL. |
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2011 Journal Article An Ugi-intramolecular Diels-Alder route to highly substituted tetrahydroepoxyisoindole carboxamidesGordon, Christopher P., Young, Kelly A., Robertson, Mark J., Hill, Timothy A. and McCluskey, Adam (2011). An Ugi-intramolecular Diels-Alder route to highly substituted tetrahydroepoxyisoindole carboxamides. Tetrahedron, 67 (2), 554-561. doi: 10.1016/j.tet.2010.10.042 |
