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2015

Journal Article

Assessing steatotic liver function after ischemia-reperfusion injury by in vivo multiphoton imaging of fluorescein disposition

Thorling C.A., Jin L., Weiss M., Crawford D., Liu X., Burczynski F.J., Liu D., Wang H. and Roberts M.S. (2015). Assessing steatotic liver function after ischemia-reperfusion injury by in vivo multiphoton imaging of fluorescein disposition. Drug Metabolism and Disposition, 43 (1), 154-162. doi: 10.1124/dmd.114.060848

Assessing steatotic liver function after ischemia-reperfusion injury by in vivo multiphoton imaging of fluorescein disposition

2014

Journal Article

Using skin for drug delivery and diagnosis in the critically ill

Liu, Xin, Kruger, Peter, Maibach, Howard, Colditz, Paul B. and Roberts, Michael S. (2014). Using skin for drug delivery and diagnosis in the critically ill. Advanced Drug Delivery Reviews, 77, 40-49. doi: 10.1016/j.addr.2014.10.004

Using skin for drug delivery and diagnosis in the critically ill

2014

Journal Article

Prediction of paraquat exposure and toxicity in clinically ill poisoned patients: a model based approach

Wunnapuk, Klintean, Mohammed, Fahim, Gawarammana, Indika, Liu, Xin, Verbeeck, Roger K., Buckley, Nicholas A., Roberts, Michael S. and Musuamba, Flora T. (2014). Prediction of paraquat exposure and toxicity in clinically ill poisoned patients: a model based approach. British Journal of Clinical Pharmacology, 78 (4), 855-866. doi: 10.1111/bcp.12389

Prediction of paraquat exposure and toxicity in clinically ill poisoned patients: a model based approach

2014

Journal Article

Multiphoton microscopy in defining liver function

Thorling, Camilla A., Crawford, Darrell, Burczynski, Frank J., Liu, Xin, Liau, Ian and Roberts, Michael S. (2014). Multiphoton microscopy in defining liver function. Journal of Biomedical Optics, 19 (9) 090901, 90901-090901. doi: 10.1117/1.JBO.19.9.090901

Multiphoton microscopy in defining liver function

2014

Journal Article

Effects of long-term hepatic ischemia-reperfusion injury on the function of P-glycoprotein in vivo in rats

Thorling, Camilla A., Roberts, Michael S., Liu, Xin, Fletcher, Linda M., Crawford, Darrell and Burczynski, Frank J. (2014). Effects of long-term hepatic ischemia-reperfusion injury on the function of P-glycoprotein in vivo in rats. Journal of Pharmacy and Pharmaceutical Sciences, 17 (1), 121-135. doi: 10.18433/J33C7B

Effects of long-term hepatic ischemia-reperfusion injury on the function of P-glycoprotein in vivo in rats

2014

Journal Article

Kidney biomarkers in MCPA-induced acute kidney injury in rats: reduced clearance enhances early biomarker performance

Wunnapuk, Klintean, Liu, Xin, Gobe, Glenda C., Endre, Zoltan H., Peake, Philip W., Grice, Jeffrey E., Roberts, Michael S. and Buckley, Nicholas A. (2014). Kidney biomarkers in MCPA-induced acute kidney injury in rats: reduced clearance enhances early biomarker performance. Toxicology Letters, 225 (3), 467-478. doi: 10.1016/j.toxlet.2014.01.018

Kidney biomarkers in MCPA-induced acute kidney injury in rats: reduced clearance enhances early biomarker performance

2014

Journal Article

Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers

Wunnapuk, Klintean, Gobe, Glenda, Endre, Zoltan, Peake, Philip, Grice, Jeffrey E., Roberts, Michael S., Buckley, Nicholas A. and Liu, Xin (2014). Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers. Toxicology Letters, 225 (1), 192-200. doi: 10.1016/j.toxlet.2013.12.009

Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers

2014

Journal Article

Compound Astragalus and Salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and PAI-1 mRNA transcription

Rui, Wenjuan, Xie, Lei, Liu, Xin, He, Shufang, Wu, Chao, Zhang, Xiaoxiang, Zhang, Linjie and Yang, Yan (2014). Compound Astragalus and Salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and PAI-1 mRNA transcription. Journal of Ethnopharmacology, 151 (1), 198-209. doi: 10.1016/j.jep.2013.10.022

Compound Astragalus and Salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and PAI-1 mRNA transcription

2014

Journal Article

Intravital multiphoton imaging of the selective uptake of water-dispersible quantum dots into sinusoidal liver cells

Liang X., Grice J.E., Zhu Y., Liu D., Sanchez W.Y., Li Z., Crawford D.H.G., Le Couteur D.G., Cogger V.C., Liu X., Xu Z.P. and Roberts M.S. (2014). Intravital multiphoton imaging of the selective uptake of water-dispersible quantum dots into sinusoidal liver cells. Small, 11 (14), 1711-1720. doi: 10.1002/smll.201402698

Intravital multiphoton imaging of the selective uptake of water-dispersible quantum dots into sinusoidal liver cells

2013

Journal Article

Penetration of Nanoparticles into Human Skin

Liang, Xiao Wen, Xu, Zhi Ping, Grice, Jeffrey, Zvyagin, Andrei V., Roberts, Michael S. and Liu, Xin (2013). Penetration of Nanoparticles into Human Skin. Current Pharmaceutical Design, 19 (35), 6353-6366. doi: 10.2174/1381612811319350011

Penetration of Nanoparticles into Human Skin

2013

Journal Article

Renal biomarkers predict nephrotoxicity after paraquat

Wunnapuk, Klintean, Liu, Xin, Peake, Philip, Gobe, Glenda, Endre, Zoltan, Grice, Jeffrey E., Roberts, Michael S. and Buckley, Nicholas A. (2013). Renal biomarkers predict nephrotoxicity after paraquat. Toxicology Letters, 222 (3), 280-288. doi: 10.1016/j.toxlet.2013.08.003

Renal biomarkers predict nephrotoxicity after paraquat

2013

Journal Article

Functional characterization of hepatic transporters using intravital microscopy

Weiss, Michael, Liu, Xin, Thorling, Camilla A. and Roberts, Michael S. (2013). Functional characterization of hepatic transporters using intravital microscopy. European Journal of Pharmaceutical Sciences, 49 (5), 845-849. doi: 10.1016/j.ejps.2013.06.006

Functional characterization of hepatic transporters using intravital microscopy

2013

Journal Article

Simultaneous quantification of tafetinib (SIM010603), a novel potent inhibitor of receptor tyrosine kinase, and its major metabolite in dog plasma by HPLC-ESI/MS/MS and its application to a pharmacokinetic study

Shao, Feng, Zhu, Tian, Tang, Feng and Liu, Xin (2013). Simultaneous quantification of tafetinib (SIM010603), a novel potent inhibitor of receptor tyrosine kinase, and its major metabolite in dog plasma by HPLC-ESI/MS/MS and its application to a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis, 81-82, 50-55. doi: 10.1016/j.jpba.2013.02.041

Simultaneous quantification of tafetinib (SIM010603), a novel potent inhibitor of receptor tyrosine kinase, and its major metabolite in dog plasma by HPLC-ESI/MS/MS and its application to a pharmacokinetic study

2013

Journal Article

The development of models for the evaluation of pulmonary drug disposition

Liu, Xin, Jin, Lu, Upham, John W. and Roberts, Michael S. (2013). The development of models for the evaluation of pulmonary drug disposition. Expert Opinion On Drug Metabolism & Toxicology, 9 (4), 487-505. doi: 10.1517/17425255.2013.754009

The development of models for the evaluation of pulmonary drug disposition

2013

Journal Article

Intravital multiphoton microscopy can model uptake and excretion of fluorescein in hepatic ischemia-reperfusion injury

Thorling, Camilla A., Liu, Xin, Burczynski, Frank J., Fletcher, Linda M., Roberts, Michael S. and Sanchez, Washington Y. (2013). Intravital multiphoton microscopy can model uptake and excretion of fluorescein in hepatic ischemia-reperfusion injury. Journal of Biomedical Optics, 18 (10) 101306, 1-12. doi: 10.1117/1.JBO.18.10.101306

Intravital multiphoton microscopy can model uptake and excretion of fluorescein in hepatic ischemia-reperfusion injury

2012

Journal Article

The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis

Liu, Xin, Kruger, Peter S., Weiss, Michael and Roberts, Michael S. (2012). The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis. British Journal of Clinical Pharmacology, 73 (5), 741-749. doi: 10.1111/j.1365-2125.2011.04149.x

The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis

2012

Journal Article

Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: A multicentre pharmacokinetic study

Roberts, Darren M., Roberts, Jason A., Roberts, Michael S., Liu, Xin, Nair, Priya, Cole, Louise, Lipman, Jeffrey, Bellomo, Rinaldo and on behalf of the RENAL Replacement Therapy Study Investigators (2012). Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: A multicentre pharmacokinetic study. Critical Care Medicine, 40 (5), 1523-1528. doi: 10.1097/CCM.0b013e318241e553

Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: A multicentre pharmacokinetic study

2012

Journal Article

Determination of trovafloxacin and marbofloxacin in sheep plasma samples by HPLC using UV detection

Mahmood, Adnan H., Medley, Gregory A., Grice, Jeffrey E., Liu, Xin and Roberts, Michael S. (2012). Determination of trovafloxacin and marbofloxacin in sheep plasma samples by HPLC using UV detection. Journal of Pharmaceutical and Biomedical Analysis, 62, 220-223. doi: 10.1016/j.jpba.2012.01.007

Determination of trovafloxacin and marbofloxacin in sheep plasma samples by HPLC using UV detection

2012

Journal Article

Compound Astragalus and Salvia miltiorrhiza extract inhibits cell proliferation, invasion and collagen synthesis in keloid fibroblasts by mediating transforming growth factor-beta/Smad pathway

He, S., Yang, Y., Liu, X., Huang, W., Zhang, X., Yang, S. and Zhang, X. (2012). Compound Astragalus and Salvia miltiorrhiza extract inhibits cell proliferation, invasion and collagen synthesis in keloid fibroblasts by mediating transforming growth factor-beta/Smad pathway. British Journal of Dermatology, 166 (3), 564-574. doi: 10.1111/j.1365-2133.2011.10674.x

Compound Astragalus and Salvia miltiorrhiza extract inhibits cell proliferation, invasion and collagen synthesis in keloid fibroblasts by mediating transforming growth factor-beta/Smad pathway

2011

Journal Article

Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics

Jayaraman, Ramesh, Reddy, Venkatesh P., Pasha, Mohammed Khalid, Wang, Haishan, Sangthongpitag, Kanda, Yeo, Pauline, Hu, Chang Yong, Wu, Xiaofeng, Xin, Liu, Goh, Evelyn, New, Lee Sun and Ethirajulu, Kantharaj (2011). Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics. Drug Metabolism and Disposition, 39 (12), 2219-2232. doi: 10.1124/dmd.111.041558

Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics