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2026 Journal Article Optimising tazobactam dosing in critically ill adult patients without renal replacement therapy: a population pharmacokinetic analysis of individual patient data pooled from multiple clinical studiesAssefa, Getnet M, Roberts, Jason A., Pea, Federico, Cojutti, Pier Giorgio, Breilh, Dominique, Carrie, Cedric, Zeitlinger, Markus, Isla, Arantxa, Tamme, Kadri, Wolie, Zenaw T., Walker, Robert J., Ulldemolins, Marta, Abdul-Aziz, Mohd H., Liu, Xin and Sime, Fekade B. (2026). Optimising tazobactam dosing in critically ill adult patients without renal replacement therapy: a population pharmacokinetic analysis of individual patient data pooled from multiple clinical studies. Critical Care. doi: 10.1186/s13054-026-06321-1 |
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2026 Journal Article Population pharmacokinetics of piperacillin/tazobactam in critically ill pediatric patientsDorofaeff, Tavey, Hernández-Mitre, María Patricia, Liu, Xin, Guerra Valero, Yarmarly C., Coulthard, Mark G., Lipman, Jeffrey, Wallis, Steven C., Maresco-Pennisi, Diane L., Parker, Suzane L. and Roberts, Jason A. (2026). Population pharmacokinetics of piperacillin/tazobactam in critically ill pediatric patients. Antimicrobial Agents and Chemotherapy e00272-26, e0027226. doi: 10.1128/aac.00272-26 |
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2026 Journal Article Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapyUlldemolins, Marta, Lipman, Jeffrey, Liu, Xin, Abdul-Aziz, Mohd-Hafiz, Baptista, João P., Bilgrami, Irma, Bitker, Laurent, Boidin, Clement, Brinkmann, Alexander, Cheng, Vesa, Choi, Gordon, Cole, C. Louise, De Waele, Jan J., Deans, Renae, Eastwood, Glenn M., Escobar, Leslie, Frey, Otto R., Garreau, Romain, Goutelle, Sylvain, Gresham, Rebecca, Hernandez-Mitre, Maria Patricia, Jamal, Janattul Ain, Joynt, Gavin M., Kanji, Salmaan, Kielstein, Jan T., Kluge, Stefan, König, Christina, Koulouras, Vasilios P., Lassig-Smith, Melissa ... and the ESCMID PK/PD of Anti-Infectives Study Group (EPASG) (2026). Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy. Critical Care, 30 (1) 466, 1-12. doi: 10.1186/s13054-026-06226-z |
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2026 Journal Article Mesenchymal stem cell-derived liver-on-a-chip reconstitutes human liver structure and functionBrooks, Anastasia, Yang, Haotian, Barkauskas, Deborah S., Ranaweera, Supun, Zou, Da, Goh, Sally, Ruan, Qi, Bridle, Kim, Crawford, Darrell H.G., Liu, Xin, Roberts, Michael S., Doran, Michael R., Liang, Xiaowen, Zhao, Chun-Xia and Wang, Haolu (2026). Mesenchymal stem cell-derived liver-on-a-chip reconstitutes human liver structure and function. Cell Reports Methods 101545, 101545-101545. doi: 10.1016/j.crmeth.2026.101545 |
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2026 Journal Article Population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill hospitalised adult patientsSetiawan, Eko, Gonzalez, Alvaro, Wölky, Saskia A., Cotta, Menino Osbert, Liu, Xin, Sosilya, Hernycane, Maresco-Pennisi, Diane, Novy, Emmanuel, Ordonez, Jenny, Lukas, Dwi Lily, Wallis, Steven C., Xie, Jiao, Roberts, Jason A. and Abdul-Aziz, Mohd H. (2026). Population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill hospitalised adult patients. International Journal of Antimicrobial Agents, 67 (8) 107817, 1-11. doi: 10.1016/j.ijantimicag.2026.107817 |
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2026 Journal Article Flucloxacillin plasma and urinary concentrations with and without probenecid and urinary biomarker profiles in healthy volunteersLegg, Amy, Boast, Alison, Piera, Kim, Liu, Xin, Wallis, Steven C., McCarthy, James, Davis, Joshua S., Tong, Steven Y. C., Gwee, Amanda and Roberts, Jason A. (2026). Flucloxacillin plasma and urinary concentrations with and without probenecid and urinary biomarker profiles in healthy volunteers. British Journal of Clinical Pharmacology bcp.70663. doi: 10.1002/bcp.70663 |
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2026 Journal Article A multicentre evaluation of pharmacokinetic/pharmacodynamic target attainment of piperacillin and tazobactam and the association with clinical outcomes in critically ill patients with sepsis and septic shockSulaiman, Helmi, Wölky, Saskia A., Rozali, Muhammad Azrai, Adiraju, Santosh K. S., Hasan, M. Shahnaz, Hernandez-Mitre, Maria Patricia, Liu, Xin, Mat-Nor, Mohd-Basri, Mazlan, Mohd Zulfakar, Salmuna, Zeti Norfidiyati, Wallis, Steven C., Xie, Jiao, Roberts, Jason A. and Abdul-Aziz, Mohd H. (2026). A multicentre evaluation of pharmacokinetic/pharmacodynamic target attainment of piperacillin and tazobactam and the association with clinical outcomes in critically ill patients with sepsis and septic shock. The Journal of Antimicrobial Chemotherapy, 81 (7) dkag199. doi: 10.1093/jac/dkag199 |
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2026 Journal Article Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infectionsZamri, Puteri Juanita, Wölky, Saskia A., Hernandez-Mitre, Maria P., Liu, Xin, Hasan, M. Shahnaz, Shariff, Izyani Md, Sulaiman, Helmi, Wallis, Steven C., Sumi, Chandra Datta, Parker, Suzanne L., Sime, Fekade Bruck, Roberts, Jason A. and Abdul-Aziz, Mohd Hafiz (2026). Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infections. International Journal of Antimicrobial Agents, 67 (7) 107816, 1-11. doi: 10.1016/j.ijantimicag.2026.107816 |
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2026 Journal Article Optimising therapeutic target attainment in vancomycin therapy for patients requiring intermittent haemodialysisTsai, Danny, Hernández-Mitre, María Patricia, Legg, Amy, Martin, Jacqueline, Sajiv, Cherian, Kodgire, Sachin, Naughton, William, Janson, Sonja, Hughes, Jaquelyne T., Liu, Xin and Roberts, Jason A. (2026). Optimising Therapeutic Target Attainment in Vancomycin Therapy for Patients Requiring Intermittent Haemodialysis. Nephrology, 31 (7) e70239, e70239-e70239. doi: 10.1111/nep.70239 |
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2026 Journal Article A novel meropenem dosing strategy for Outpatient Parenteral Antimicrobial Therapy (OPAT): a pilot pharmacokinetic/pharmacodynamic study in non-critically ill patientsBriquet, Caroline, Ngougni Pokem, Perrin, Liu, Xin, Wijnant, Gert-Jan, Cornu, Olivier, Yildiz, Halil, Verroken, Alexia, Roberts, Jason A., Yombi, Jean Cyr and Van Bambeke, Françoise (2026). A novel meropenem dosing strategy for Outpatient Parenteral Antimicrobial Therapy (OPAT): a pilot pharmacokinetic/pharmacodynamic study in non-critically ill patients. Antimicrobial Agents and Chemotherapy, 70 (7) e00372-26, 1-14. doi: 10.1128/aac.00372-26 |
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2026 Journal Article Plasma levels and postpartum breastmilk concentrations of sugammadex: a pharmacokinetic study in women undergoing general anaesthesia for caesarean deliveryHodge, A. T., Tognolini, A. R., Liu, X., Won, H., Roberts, J. A., Wallis, S. C., Woods, C. A. and Eley, V. A. (2026). Plasma levels and postpartum breastmilk concentrations of sugammadex: a pharmacokinetic study in women undergoing general anaesthesia for caesarean delivery. International Journal of Obstetric Anesthesia, 66 104874, 1-7. doi: 10.1016/j.ijoa.2026.104874 |
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2026 Journal Article Population pharmacokinetics of cefazolin administered as prophylaxis in paediatric patients undergoing cardiac surgeryCheng, Vesa, Suna, Jessica, Liu, Xin, Moloney, Gregory, Marathe, Supreet P., Parker, Suzanne, Ungerer, Jacobus P. J., McWhinney, Brett, Venugopal, Prem, Alphonso, Nelson and Roberts, Jason A. (2026). Population pharmacokinetics of cefazolin administered as prophylaxis in paediatric patients undergoing cardiac surgery. Anaesthesia, Critical Care and Pain Medicine, 45 (3) 101653, 1-8. doi: 10.1016/j.accpm.2025.101653 |
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2026 Journal Article A pharmacokinetic/pharmacodynamic analysis of intravenous tranexamic acid in adult patients undergoing elective total hip arthroplasty (ORACLE)Gurunathan, Usha, Medcalf, Robert L., Chiang, Lily, Liu, Zikou, Liu, Xin, Keragala, Charithani B., Hernandez-Mitre, Maria Patricia, Brady, Paul, Wallis, Steven C., Roberts, Jason A., Mullany, Daniel, Nandurkar, Harshal, Eley, Victoria and Parker, Suzanne L. (2026). A pharmacokinetic/pharmacodynamic analysis of intravenous tranexamic acid in adult patients undergoing elective total hip arthroplasty (ORACLE). British Journal of Anaesthesia, 136 (4), 1157-1165. doi: 10.1016/j.bja.2024.12.004 |
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2026 Journal Article Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation-an ASAP ECMO studyAbdul-Aziz, Mohd H., Cheng, Vesa, Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Kim, Hyung-Sook, Levkovich, Bianca J., Lim, Sung Yoon, Liu, Xin, McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Pellegrino, Vincent, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2026). Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation-an ASAP ECMO study. Journal of Antimicrobial Chemotherapy, 81 (4) dkag090, 1-12. doi: 10.1093/jac/dkag090 |
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2025 Journal Article A pharmacokinetic analysis of intravenous fluconazole in adult patients undergoing mechanical circulatory support device implantationCairns, Kelly A., Hernandez-Mitre, Maria Patricia, Peel, Trisha N., Abbott, Iain J., Kaye, David M., Marasco, Silvana, Daly, David, Warner, Victoria, Coldham, Anna, Pope, Jeffrey D., Schneider, Hans G, Dooley, Michael J., Liu, Xin, Roberts, Jason A. and Udy, Andrew A. (2025). A pharmacokinetic analysis of intravenous fluconazole in adult patients undergoing mechanical circulatory support device implantation. Clinical Pharmacokinetics, 65 (3), 395-404. doi: 10.1007/s40262-025-01607-z |
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2025 Journal Article Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairmentSulaiman, Helmi, Rozali, Muhammad Azrai, Adiraju, Santosh K. S., Hasan, M. Shahnaz, Jamal, Janattul A., Liu, Xin, Mat-Nor, Mohd-Basri, Mazlan, Mohd Zulfakar, Othman-Jailani, Mohamad Irfan, Salmuna, Zeti Norfidiyati, Wallis, Steven C., Roberts, Jason A. and Abdul-Aziz, Mohd H. (2025). Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairment. Scientific Reports, 15 (1) 37781, 1-12. doi: 10.1038/s41598-025-20630-5 |
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2025 Journal Article Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapyRoberts, Jason A., Ulldemolins, Marta, Liu, Xin, Baptista, João P., Bilgrami, Irma, Boidin, Clement, Brinkmann, Alexander, Castro, Pedro, Choi, Gordon, Cole, Louise, De Waele, Jan J., Deans, Renae, Donnellan, Sine, Eastwood, Glenn M., Frey, Otto R., Goutelle, Sylvain, Gresham, Rebecca, Jamal, Janattul Ain, Joynt, Gavin M., Kanji, Salmaan, Kluge, Stefan, König, Christina, Koulouras, Vasilios P., Lassig-Smith, Melissa, Laterre, Pierre-Francois, Lee, Anna, Lefrant, Jean-Yves, Lei, Katie, Leung, Patricia ... Young, Helen (2025). Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy. Intensive Care Medicine, 51 (9), 1628-1640. doi: 10.1007/s00134-025-08067-w |
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2025 Journal Article Dosing optimisation of intravenous lidocaine in patients with class 1–3 obesity by population pharmacokinetic analysisTognolini, Angela R., Liu, Xin, Pandey, Saurabh, Roberts, Jason A., Wallis, Steven C., Jackson, Dwane and Eley, Victoria A. (2025). Dosing optimisation of intravenous lidocaine in patients with class 1–3 obesity by population pharmacokinetic analysis. Anaesthesia, 80 (5), 511-521. doi: 10.1111/anae.16531 |
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2025 Journal Article Ceftriaxone population pharmacokinetics in plasma and cerebrospinal fluid of neurocritical care patientsKumta, Nilesh, Heffernan, Aaron J., Liu, Xin, Parker, Suzanne L., Cotta, Menino Osbert, Wallis, Steven C., Livermore, Amelia, Starr, Therese, Wai, Wong Tat, Joynt, Gavin M., Lipman, Jeffrey and Roberts, Jason A. (2025). Ceftriaxone population pharmacokinetics in plasma and cerebrospinal fluid of neurocritical care patients. International Journal of Antimicrobial Agents, 65 (5) 107461, 107461. doi: 10.1016/j.ijantimicag.2025.107461 |
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2025 Journal Article Population pharmacokinetic modelling of remdesivir and its metabolite GS-441524 in hospitalised patients with COVID-19Roberts, Darren M., Liu, Xin, Parker, Suzanne L., Burke, Andrew, Peek, Jenny, Carland, Jane E., Murnion, Bridin, Seah, Vincent, Wallis, Steven C., Sumi, Chandra D., Pandey, Saurabh, Buscher, Hergen, Byrne, Anthony, Sandaradura, Indy, Bowen, David, Holz, Simon, Stewart, Adam G., Hajkowicz, Krispin M. and Roberts, Jason A. (2025). Population pharmacokinetic modelling of remdesivir and its metabolite GS-441524 in hospitalised patients with COVID-19. Clinical Pharmacokinetics, 64 (5) e0022222, 743-756. doi: 10.1007/s40262-025-01496-2 |
