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2016 Journal Article A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotypeQuek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016). A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype. Human Molecular Genetics, 26 (1), 109-123. doi: 10.1093/hmg/ddw371 |
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2016 Journal Article Antagonizing STAT5B dimerization with an osmium complexLiu, Li-Juan, Wang, Wanhe, Kang, Tian-Shu, Liang, Jia-Xin, Liu, Chenfu, Kwong, Daniel W. J., Wong, Vincent Kam Wai, Ma, Dik-Lung and Leung, Chung-Hang (2016). Antagonizing STAT5B dimerization with an osmium complex. Scientific Reports, 6 36044. doi: 10.1038/srep36044 |
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2016 Journal Article Profiling ribonucleotide and deoxyribonucleotide pools perturbed by gemcitabine in human non-small cell lung cancer cellsGuo, Jian-Ru, Chen, Qian-Qian, Lam, Christopher Wai Kei, Wang, Cai-Yun, Wong, Vincent Kam Wai, Chang, Zee-Fen and Zhang, Wei (2016). Profiling ribonucleotide and deoxyribonucleotide pools perturbed by gemcitabine in human non-small cell lung cancer cells. Scientific Reports, 6 (1) 37250. doi: 10.1038/srep37250 |
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2016 Journal Article Corrigendum: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesisTakasato, Minoru, Er, Pei X., Chiu, Han S., Maier, Barbara, Baillie, Gregory J., Ferguson, Charles, Parton, Robert G., Wolvetang, Ernst J., Roost, Matthias S., Lopes, Susana M. Chuva de Sousa and Little, Melissa H. (2016). Corrigendum: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature, 536 (7615), 238-238. doi: 10.1038/nature17982 |
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2016 Journal Article AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulationCullen, Jason K., Murad, Norazian Abdul, Yeo, Abrey, McKenzie, Matthew, Ward, Micheal, Chong, Kok Leong, Schieber, Nicole L., Parton, Robert G., Lim, Yi Chieh, Wolvetang, Ernst, Maghzal, Ghassan J., Stocker, Roland and Lavin, Martin F. (2016). AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation. Plos One, 11 (7) e0160162, e0160162. doi: 10.1371/journal.pone.0160162 |
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2016 Journal Article Induction of human iPSC-derived cardiomyocyte proliferation revealed by combinatorial screening in high density microbioreactor arraysTitmarsh, Drew M., Glass, Nick R., Mills, Richard J., Hidalgo, Alejandro, Wolvetang, Ernst J., Porrello, Enzo R., Hudson, James E. and Cooper-White, Justin J. (2016). Induction of human iPSC-derived cardiomyocyte proliferation revealed by combinatorial screening in high density microbioreactor arrays. Scientific Reports, 6 (1) 24637, 24637. doi: 10.1038/srep24637 |
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2016 Journal Article AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulationCullen, Jason K., Murad, Norazian Abdul, Yeo, Abrey, McKenzie, Matthew, Ward, Micheal, Chong, Kok Leong, Schieber, Nicole L., Parton, Robert G., Lim, Yi Chieh, Wolvetang, Ernst, Maghzal, Ghassan J., Stocker, Roland and Lavin, Martin F. (2016). AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation. PLoS One, 11 (2) e0148213, e0148213. doi: 10.1371/journal.pone.0148213 |
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2016 Journal Article Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Klionsky, Daniel J., et al., Wolvetang, Ernst and Walker, Mark J. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12 (1), 1-222. doi: 10.1080/15548627.2015.1100356 |
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2016 Journal Article Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cellsKlawitter, Sabine, Fuchs,Nina V., Upton, Kyle R., Munoz-Lopez, Martin, Shukla, Ruchi, Wang, Jichang, Garcia-Canadas, Marta, Lopez-Ruiz, Cesar, Gerhardt, Daniel J., Sebe, Attila, Grabundzija, Ivana, Merkert, Sylvia, Gerdes, Patricia, Pulgarin, J. Andres, Bock, Anja, Held, Ulrike, Witthuhn, Anett, Haase, Alexandra, Sarkadi, Balazs, Lower, Johannes, Wolvetang, Ernst J., Martin, Ulrich, Ivics, Zoltan, Izsvak, Zsuzsanna, Garcia-Perez, Jose L., Faulkner, Geoffrey J. and Schumann, Gerald G. (2016). Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells. Nature Communications, 7 (1) 10286, 1-14. doi: 10.1038/ncomms10286 |
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2016 Journal Article Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition) (vol 12, pg 1, 2015)Kliosnky, D., Ernst Wolvetang and Mark J. Walker (2016). Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition) (vol 12, pg 1, 2015). Autophagy, 12 (2), 443-443. doi: 10.1080/15548627.2016.1147886 |
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2015 Journal Article The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosomeHurst, Laurence D., Ghanbarian, Avazeh T., Forrest, Alistair R. R., Huminiecki, Lukasz, Rehli, Michael, Baillie, J. Kenneth, de Hoon, Michiel J. L., Haberle, Vanja, Lassmann, Timo, Kulakovskiy, Ivan V., Lizio, Marina, Itoh, Masayoshi, Andersson, Robin, Mungall, Christopher J., Meehan, Terrence F., Schmeier, Sebastian, Bertin, Nicolas, Jorgensen, Mette, Dimont, Emmanuel, Arner, Erik, Schmidl, Christian, Schaefer, Ulf, Medvedeva, Yulia A., Plessy, Charles, Vitezic, Morana, Severin, Jessica, Semple, Colin A., Ishizu, Yuri, Young, Robert S. ... Hayashizaki, Yoshihide (2015). The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome. PLoS Biology, 13 (12) e1002315, e1002315. doi: 10.1371/journal.pbio.1002315 |
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2015 Journal Article Generation of footprint-free induced pluripotent stem cells from human fibroblasts using episomal plasmid vectorsOvchinnikov, Dmitry A., Sun, Jane and Wolvetang, Ernst J. (2015). Generation of footprint-free induced pluripotent stem cells from human fibroblasts using episomal plasmid vectors. Methods in Molecular Biology, 1330, 37-45. doi: 10.1007/978-1-4939-2848-4_4 |
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2015 Journal Article Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolutionBriggs, James A., Wolvetang, Ernst J., Mattick, John S., Rinn, John L. and Barry, Guy (2015). Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution. Neuron, 88 (5), 861-877. doi: 10.1016/j.neuron.2015.09.045 |
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2015 Journal Article Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesisTakasato, Minoru, Er, Pei X., Chiu, Han S., Maier, Barbara, Baillie, Gregory J., Ferguson, Charles, Parton, Robert G., Wolvetang, Ernst J., Roost, Matthias S., de Sousa Lopes, Susana M. Chuva and Little, Melissa H. (2015). Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature, 526 (7574), 564-568. doi: 10.1038/nature15695 |
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2015 Journal Article A protocol for the identification and validation of novel genetic causes of kidney diseaseMallett, Andrew, Patel, Chirag, Maier, Barbara, McGaughran, Julie, Gabbett, Michael, Takasato, Minoru, Cameron, Anne, Trnka, Peter, Alexander, Stephen I., Rangan, Gopala, Tchan, Michel C., Caruana, Georgina, John, George, Quinlan, Cathy, McCarthy, Hugh J., Hyland, Valentine, Hoy, Wedy E., Wolvetang, Ernst, Taft, Ryan, Simons, Cas, Healy H. and Little, Melissa (2015). A protocol for the identification and validation of novel genetic causes of kidney disease. BMC Nephrology, 16 (152) 148, 152. doi: 10.1186/s12882-015-0148-8 |
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2015 Journal Article Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic DevelopmentHasegawa, Yu., Taylor, Deanne., Ovchinnikov, Dmitry A., Wolvetang, Ernst J., de Torrente, Laurence. and Mar, Jessica C. (2015). Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development. PLoS Genetics, 11 (8) e1005428, e1005428. doi: 10.1371/journal.pgen.1005428 |
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2015 Journal Article A new model to study neurodegeneration in ataxia oculomotor apraxia type 2Becherel, Olivier J., Sun, Jane, Yeo, Abrey J., Nayler, Sam, Fogel, Brent L., Gao, Fuying, Coppola, Giovanni, Criscuolo, Chiara, De Michele, Giuseppe, Wolvetang, Ernst and Lavin, Martin F. (2015). A new model to study neurodegeneration in ataxia oculomotor apraxia type 2. Human Molecular Genetics, 24 (20), 5759-5774. doi: 10.1093/hmg/ddv296 |
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2015 Journal Article Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cellsArner, Erik, Daub, Carsten O., Vitting-Seerup, Kristoffer, Andersson, Robin, Lilje, Berit, Drabløs, Finn, Lennartsson, Andreas, Rönnerblad, Michelle, Hrydziuszko, Olga, Vitezic, Morana, Freeman, Tom C., Alhendi, Ahmad M. N., Arner, Peter, Axton, Richard, Baillie, J. Kenneth, Beckhouse, Anthony, Bodega, Beatrice, Briggs, James, Brombacher, Frank, Davis, Margaret, Detmar, Michael, Ehrlund, Anna, Endoh, Mitsuhiro, Eslami, Afsaneh, Fagiolini, Michela, Fairbairn, Lynsey, Faulkner, Geoffrey J., Ferrai, Carmelo, Fisher, Malcolm E. ... Hayashizaki, Yoshihide (2015). Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science, 347 (6225), 1010-1014. doi: 10.1126/science.1259418 |
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2015 Journal Article High-throughput, deterministic single cell trapping and long-term clonal cell culture in microfluidic devicesChen, Huaying, Sun, Jane, Wolvetang, Ernst and Cooper-White, Justin (2015). High-throughput, deterministic single cell trapping and long-term clonal cell culture in microfluidic devices. Lab on a Chip, 15 (4), 1072-1083. doi: 10.1039/C4LC01176G |
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2015 Journal Article TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.Thakar, Nilay Y., Ovchinnikov, Dmitry A., Hastie, Marcus L., Kobe, Bostjan, Gorman, Jeffrey J. and Wolvetang, Ernst J. (2015). TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.. Molecular Biology of the Cell, 26 (5), 993-1006. doi: 10.1091/mbc.E14-08-1290 |
