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2019 Other Outputs An epigenome-wide association study of sex-specific chronological ageingMcCartney, Daniel L., Hillary, Robert F., Zhang, Qian, Stevenson, Anna J., Walker, Rosie M., Bermingham, Mairead L., Morris, Stewart W., Campbell, Archie, Murray, Alison D., Whalley, Heather C., Porteous, David J., Evans, Kathryn L., Chandra, Tamir, Deary, Ian J., McIntosh, Andrew M., Visscher, Peter M., McRae, Allan F. and Marioni, Riccardo E. (2019). An epigenome-wide association study of sex-specific chronological ageing. doi: 10.1101/606020 |
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2019 Other Outputs Childhood intelligence attenuates the association between biological ageing and health outcomes in laterStevenson, Anna J., McCartney, Daniel L., Hillary, Robert F., Redmond, Paul, Taylor, Adele M., Zhang, Qian, McRae, Allan F., Spires-Jones, Tara L., McIntosh, Andrew M., Deary, Ian J. and Marioni, Riccardo E. (2019). Childhood intelligence attenuates the association between biological ageing and health outcomes in later. doi: 10.1101/588293 |
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2019 Journal Article Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseasesMortlock, Sally, Restuadi, Restuadi, Levien, Rupert, Girling, Jane E., Holdsworth-Carson, Sarah J., Healey, Martin, Zhu, Zhihong, Qi, Ting, Wu, Yang, Lukowski, Samuel W., Rogers, Peter A. W., Yang, Jian, McRae, Allan F., Fung, Jenny N. and Montgomery, Grant W. (2019). Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases. Clinical Epigenetics, 11 (1) 49, 49. doi: 10.1186/s13148-019-0648-7 |
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2019 Journal Article An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth CohortHamilton, Olivia K. L., Zhang, Qian, McRae, Allan F., Walker, Rosie M., Morris, Stewart W., Redmond, Paul, Campbell, Archie, Murray, Alison D., Porteous, David J., Evans, Kathryn L., McIntosh, Andrew M., Deary, Ian J. and Marioni, Riccardo E. (2019). An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort. International Journal of Obesity, 43 (9), 1795-1802. doi: 10.1038/s41366-018-0262-3 |
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2019 Other Outputs Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936Hillary, Robert F., McCartney, Daniel L., Harris, Sarah E., Stevenson, Anna J., Seeboth, Anne, Zhang, Qian, Liewald, David C., Evans, Kathryn L., Ritchie, Craig W., Tucker-Drob, Elliot M., Wray, Naomi R., McRae, Allan F., Visscher, Peter M., Deary, Ian J. and Marioni, Riccardo E. (2019). Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936. doi: 10.1101/558940 |
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2019 Conference Publication Common genetic variation explains a high proportion of the elevated risk of psychiatric disorders in children of younger mothersGratten, Jacob, Yang, Yuanhao, Trzaskowski, Maciej, Kemper, Kathryn, Yengo, Loic, Zheng, Zhili, Zhang, Futao, Zhu, Zhihong, Mcrae, Allan, Yang, Jian, Wray, Naomi and Visscher, Peter (2019). Common genetic variation explains a high proportion of the elevated risk of psychiatric disorders in children of younger mothers. 26th World Congress of Psychiatric Genetics (WCPG), Glasgow, Scotland, 11-15 October, 2018. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.euroneuro.2018.08.167 |
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2019 Book Chapter A Cache-based data movement infrastructure for on-demand scientific cloud computingAbramson, David, Carroll, Jake, Jin, Chao, Mallon, Michael, van Iperen, Zane, Nguyen, Hoang, McRae, Allan and Ming, Liang (2019). A Cache-based data movement infrastructure for on-demand scientific cloud computing. Supercomputing frontiers. (pp. 38-56) Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-030-18645-6_3 |
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2019 Conference Publication Identifying Target Genes for Endometriosis through Integration of Genetic Effects on Transcription and Methylation in Human EndometriumMortlock, Sally, Fung, Jenny N., Girling, Jane E., Holdsworth-Carson, Sarah J., Healey, Martin, Lukowski, Samuel W., McKinnon, Brett D., Yang, Jian, McRae, Allan, Rogers, Peter A. W. and Montgomery, Grant W. (2019). Identifying Target Genes for Endometriosis through Integration of Genetic Effects on Transcription and Methylation in Human Endometrium. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, 12-16 March 2019. Thousand Oaks, CA, United States: Sage. |
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2018 Journal Article Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageingStevenson, Anna J., McCartney, Daniel L., Harris, Sarah E., Taylor, Adele M., Redmond, Paul, Starr, John M., Zhang, Qian, McRae, Allan F., Wray, Naomi R., Spires-Jones, Tara L., McColl, Barry W., McIntosh, Andrew M., Deary, Ian J. and Marioni, Riccardo E. (2018). Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing. Clinical Epigenetics, 10 (1) 159, 159. doi: 10.1186/s13148-018-0585-x |
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2018 Journal Article Identification of 55,000 replicated DNA methylation QTLMcRae, Allan F., Marioni, Riccardo E., Shah, Sonia, Yang, Jian, Powell, Joseph E., Harris, Sarah E., Gibson, Jude, Henders, Anjali K., Bowdler, Lisa, Painter, Jodie N., Murphy, Lee, Martin, Nicholas G., Starr, John M., Wray, Naomi R., Deary, Ian J., Visscher, Peter M. and Montgomery, Grant W. (2018). Identification of 55,000 replicated DNA methylation QTL. Scientific Reports, 8 (1) 17605, 17605. doi: 10.1038/s41598-018-35871-w |
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2018 Journal Article Genotype effects contribute to variation in longitudinal methylome patterns in older peopleZhang, Qian, Marioni, Riccardo E., Robinson, Matthew R., Higham, Jon, Sproul, Duncan, Wray, Naomi R., Deary, Ian J., McRae, Allan F. and Visscher, Peter M. (2018). Genotype effects contribute to variation in longitudinal methylome patterns in older people. Genome Medicine, 10 (1) 75, 75. doi: 10.1186/s13073-018-0585-7 |
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2018 Journal Article Epigenetic prediction of complex traits and deathMcCartney, Daniel L., Hillary, Robert F., Stevenson, Anna J., Ritchie, Stuart J., Walker, Rosie M., Zhang, Qian, Morris, Stewart W., Bermingham, Mairead L., Campbell, Archie, Murray, Alison D., Whalley, Heather C., Gale, Catharine R., Porteous, David J., Haley, Chris S., McRae, Allan F., Wray, Naomi R., Visscher, Peter M., McIntosh, Andrew M., Evans, Kathryn L., Deary, Ian J. and Marioni, Riccardo E. (2018). Epigenetic prediction of complex traits and death. Genome Biology, 19 (1) 136, 136. doi: 10.1186/s13059-018-1514-1 |
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2018 Other Outputs Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageingStevenson, Anna J, McCartney, Daniel L, Harris, Sarah E, Taylor, Adele M, Redmond, Paul, Starr, John M, Zhang, Qian, McRae, Allan F, Wray, Naomi R, Spires-Jones, Tara L, McColl, Barry W, McIntosh, Andrew M, Deary, Ian J and Marioni, Riccardo E (2018). Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing. doi: 10.1101/397877 |
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2018 Journal Article Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndromeFung, Jenny N., Mortlock, Sally, Girling, Jane E., Holdsworth-Carson, Sarah J., Teh, Wan Tinn, Zhu, Zhihong, Lukowski, Samuel W., McKinnon, Brett D., McRae, Allan, Yang, Jian, Healey, Martin, Powell, Joseph E., Rogers, Peter A. W. and Montgomery, Grant W (2018). Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome. Scientific Reports, 8 (1) 11424, 11424. doi: 10.1038/s41598-018-29462-y |
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2018 Journal Article Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetesXue, Angli, Wu, Yang, Zhu, Zhihong, Zhang, Futao, Kemper, Kathryn E., Zheng, Zhili, Yengo, Loic, Lloyd-Jones, Luke R., Sidorenko, Julia, Wu, Yeda, eQTLGen Consortium, McRae, Allan F., Visscher, Peter M., Zeng, Jian and Yang, Jian (2018). Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nature Communications, 9 (1) 2941, 2941. doi: 10.1038/s41467-018-04951-w |
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2018 Journal Article DNA methylation signatures of depressive symptoms in middle-aged and elderly persons: meta-analysis of multiethnic epigenome-wide studiesStory Jovanova, Olivera, Nedeljkovic, Ivana, Derek, Spieler, Walker, Rosie M., Liu, Chunyu, Luciano, Michelle, Bressler, Jan, Brody, Jennifer, Drake, Amanda J., Evans, Kathryn L., Gondalia, Rahul, Kunze, Sonja, Kuhnel, Brigitte, Lahti, Jari, Lemaitre, Rozenn N., Marioni, Riccardo E., Swenson, Brenton, Himali, Jayandra Jung, Wu, Hongsheng, Li, Yun, McRae, Allan F., Russ, Tom C., Stewart, James, Wang, Zhiying, Zhang, Guosheng, Ladwig, Karl-Heinz, Uitterlinden, Andre G., Guo, Xiuqing, Peters, Annette ... Amin, Najaf (2018). DNA methylation signatures of depressive symptoms in middle-aged and elderly persons: meta-analysis of multiethnic epigenome-wide studies. JAMA Psychiatry, 75 (9), 949-959. doi: 10.1001/jamapsychiatry.2018.1725 |
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2018 Journal Article Identifying gene targets for brain-related traits using transcriptomic and methylomic data from bloodQi, Ting, Wu, Yang, Zeng, Jian, Zhang, Futao, Xue, Angli, Jiang, Longda, Zhu, Zhihong, Kemper, Kathryn, Yengo, Loic, Zheng, Zhili, eQTLGen Consortium, Marioni, Riccardo E., Montgomery, Grant W., Deary, Ian J., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2018). Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood. Nature Communications, 9 (1) 2282, 2282. doi: 10.1038/s41467-018-04558-1 |
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2018 Journal Article Genome-wide survey of parent-of-origin effects on DNA methylation identifies candidate imprinted loci in humansCuellar Partida, Gabriel, Laurin, Charles, Ring, Susan M., Gaunt, Tom R., McRae, Allan, Visscher, Peter M., Montgomery, Grant W., Martin, Nicholas G., Hemani, Gibran, Suderman, Matthew, Relton, Caroline L., Davey Smith, George and Evans, David M. (2018). Genome-wide survey of parent-of-origin effects on DNA methylation identifies candidate imprinted loci in humans. Human Molecular Genetics, 27 (16), 2927-2939. doi: 10.1093/hmg/ddy206 |
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2018 Journal Article GWAS on family history of Alzheimer's diseaseMarioni, Riccardo E., Harris, Sarah E., Zhang, Qian, McRae, Allan F., Hagenaars, Saskia P., Hill, W. David, Davies, Gail, Ritchie, Craig W., Gale, Catharine R., Starr, John M., Goate, Alison M., Porteous, David J., Yang, Jian, Evans, Kathryn L., Deary, Ian J., Wray, Naomi R. and Visscher, Peter M. (2018). GWAS on family history of Alzheimer's disease. Translational Psychiatry, 8 (1) 99, 99. doi: 10.1038/s41398-018-0150-6 |
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Featured 2018 Journal Article Signatures of negative selection in the genetic architecture of human complex traitsZeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, McRae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. Nature Genetics, 50 (5), 746-753. doi: 10.1038/s41588-018-0101-4 |
