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2022

Conference Publication

High-throughput bioassays applied to phylogenetic and envenomation studies of spider and snake venoms

Cardoso, Fernanda C. (2022). High-throughput bioassays applied to phylogenetic and envenomation studies of spider and snake venoms. Venom Week VIII, Scottsdale, AZ, United States, 18-21 July 2022.

High-throughput bioassays applied to phylogenetic and envenomation studies of spider and snake venoms

2022

Conference Publication

The unexplored pharmacopeia of Australian spider venoms: learning from the experts

Wirth, Hayden and Cardoso, Fernanda C. (2022). The unexplored pharmacopeia of Australian spider venoms: learning from the experts. Pathogens and Natural Toxins e-Conference section Venomous Animals, Brisbane, Australia, 1 July - 31 August 2022.

The unexplored pharmacopeia of Australian spider venoms: learning from the experts

2022

Conference Publication

Idiosyncratic treatment of motor neuron disease: selective inhibition of voltage-gated sodium channels using spider venom peptide (ProTX-III) to treat motor neuron disease

Kotapati, Charan , Bellingham, Mark C. and Cardoso, Fernanda C. (2022). Idiosyncratic treatment of motor neuron disease: selective inhibition of voltage-gated sodium channels using spider venom peptide (ProTX-III) to treat motor neuron disease. Pathogens and Natural Toxins e-Conference section Diagnostics and Therapeutics From Natural Toxins, Brisbane, Australia, 1 July - 31 August 2022.

Idiosyncratic treatment of motor neuron disease: selective inhibition of voltage-gated sodium channels using spider venom peptide (ProTX-III) to treat motor neuron disease

2022

Conference Publication

Structure, function, and evolution of nettle caterpillar venom toxins

Goudarzi, Mohaddeseh H., Robinson, Samuel D., Cardoso, Fernanda C., Lawrence, Nicole, Chin, Yanni, King, Glenn F. and Walker, Andrew A. (2022). Structure, function, and evolution of nettle caterpillar venom toxins. Pathogens and Natural Toxins e-Conference, Brisbane, QLD Australia, 1 July - 31 August 2022.

Structure, function, and evolution of nettle caterpillar venom toxins

2022

Journal Article

Venom peptides: a rich combinatorial library for drug development

Cardoso, Fernanda C., Servent, Denis and de Lima, Maria Elena (2022). Venom peptides: a rich combinatorial library for drug development. Frontiers in Molecular Biosciences, 9 924023, 924023. doi: 10.3389/fmolb.2022.924023

Venom peptides: a rich combinatorial library for drug development

2022

Journal Article

Inhibition of N-type calcium ion channels by tricyclic antidepressants – experimental and theoretical justification for their use for neuropathic pain

Cardoso, Fernanda C., Schmit, Matthieu, Kuiper, Michael J., Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2022). Inhibition of N-type calcium ion channels by tricyclic antidepressants – experimental and theoretical justification for their use for neuropathic pain. RSC Medicinal Chemistry, 13 (2), 183-195. doi: 10.1039/d1md00331c

Inhibition of N-type calcium ion channels by tricyclic antidepressants – experimental and theoretical justification for their use for neuropathic pain

2021

Journal Article

Voltage-gated sodium channel modulation by a new spider toxin Ssp1a isolated from an Australian theraphosid

Dongol, Yashad, Choi, Phil M., Wilson, David T., Daly, Norelle L., Cardoso, Fernanda C. and Lewis, Richard J. (2021). Voltage-gated sodium channel modulation by a new spider toxin Ssp1a isolated from an Australian theraphosid. Frontiers in Pharmacology, 12 795455, 795455. doi: 10.3389/fphar.2021.795455

Voltage-gated sodium channel modulation by a new spider toxin Ssp1a isolated from an Australian theraphosid

2021

Journal Article

Engineering of a spider peptide via conserved structure-function traits optimizes sodium channel inhibition in vitro and anti-nociception in vivo

Hu, Huiyu, Mawlawi, Saja, Zhao, Tianjiao, Jami, Sina, Deuis, Jennifer R., Vetter, Irina, Lewis, Richard J. and Cardoso, Fernanda C. (2021). Engineering of a spider peptide via conserved structure-function traits optimizes sodium channel inhibition in vitro and anti-nociception in vivo. Frontiers in Molecular Biosciences, 8 742457, 742457. doi: 10.3389/fmolb.2021.742457

Engineering of a spider peptide via conserved structure-function traits optimizes sodium channel inhibition in vitro and anti-nociception in vivo

2021

Journal Article

Pharmacological Inhibition of the Voltage-Gated Sodium Channel Nav1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome

Jiang, Yan, Castro, Joel, Blomster, Linda V., Agwa, Akello J., Maddern, Jessica, Schober, Gudrun, Herzig, Volker, Chow, Chun Yuen, Cardoso, Fernanda C., Demétrio De Souza França, Paula, Gonzales, Junior, Schroeder, Christina I., Esche, Steffen, Reiner, Thomas, Brierley, Stuart M. and King, Glenn F. (2021). Pharmacological Inhibition of the Voltage-Gated Sodium Channel Nav1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome. ACS Pharmacology & Translational Science, 4 (4) acsptsci.1c00072, 1362-1378. doi: 10.1021/acsptsci.1c00072

Pharmacological Inhibition of the Voltage-Gated Sodium Channel Nav1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome

2021

Conference Publication

Rapid optimization of spider peptides using conserved structure-function traits

Cardoso, Fernanda C. (2021). Rapid optimization of spider peptides using conserved structure-function traits. Venom to Drugs Conference, Daydream Island, QLD Australia, 15-19 March 2021.

Rapid optimization of spider peptides using conserved structure-function traits

2021

Journal Article

Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain

Hasan, Md. Mahadhi, Ragnarsson, Lotten, Cardoso, Fernanda C. and Lewis, Richard J. (2021). Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain. PLOS ONE, 16 (3) e0243645, e0243645. doi: 10.1371/journal.pone.0243645

Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain

2021

Conference Publication

Subcutaneous analgesic actions and mode of action of binding of ω-conotoxins at Cav2.2

Hasan, Mahadhi, Abraham, Nikita, Cardoso, Fernanda C., Ragnarsson, Lotten, Starobova, Hana, Mueller, Alexander, Vetter, Irina and Lewis, Richard J. (2021). Subcutaneous analgesic actions and mode of action of binding of ω-conotoxins at Cav2.2. Venom to Drugs, Daydream Island, QLD Australia, 15 - 19 March 2021.

Subcutaneous analgesic actions and mode of action of binding of ω-conotoxins at Cav2.2

2021

Conference Publication

Structure-function of the spider peptide ProTx-III

Zhao, Tianjiao, Rosengren, Johan K., Cardoso, Fernanda C. and Lewis, Richard J. (2021). Structure-function of the spider peptide ProTx-III. Venom to Drugs, Daydream Island, QLD Australia, 15-19 March 2021.

Structure-function of the spider peptide ProTx-III

2021

Conference Publication

Characterization and structure-function of a novel spider-venom toxin Phlo3a at hNav1.2, 1.3 and 1.7

Dongol, Yashad, Cardoso, Fernanda C. and Lewis, Richard J. (2021). Characterization and structure-function of a novel spider-venom toxin Phlo3a at hNav1.2, 1.3 and 1.7. Venom to Drugs, Daydream Island, QLD, Australia, 15-19 March 2021.

Characterization and structure-function of a novel spider-venom toxin Phlo3a at hNav1.2, 1.3 and 1.7

2021

Journal Article

A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome

Cardoso, Fernanda C., Castro, Joel, Grundy, Luke, Schober, Gudrun, Garcia-Caraballo, Sonia, Zhao, Tianjiao, Herzig, Volker, King, Glenn F., Brierley, Stuart M. and Lewis, Richard J. (2021). A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain, 162 (2), 569-581. doi: 10.1097/j.pain.0000000000002041

A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome

2020

Conference Publication

Rationally Designed Analogues of the Novel Spider-venom Peptide Phlo3a Shifts the Potency and Subtype Selectivity at Therapeutic Nav Channel Targets for Pain and Epilepsy

Dongol, Y., Choi, P., Wilson, D., Cardoso, F. C. and Lewis, R. J. (2020). Rationally Designed Analogues of the Novel Spider-venom Peptide Phlo3a Shifts the Potency and Subtype Selectivity at Therapeutic Nav Channel Targets for Pain and Epilepsy. SBMS Postgraduate Symposium in Biomedical Sciences, Brisbane, QLD Australia, 24 November 2020.

Rationally Designed Analogues of the Novel Spider-venom Peptide Phlo3a Shifts the Potency and Subtype Selectivity at Therapeutic Nav Channel Targets for Pain and Epilepsy

2020

Journal Article

Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency

Peschel, Alicia, Cardoso, Fernanda C., Walker, Andrew A., Durek, Thomas, Stone, M Rhia L., Braga Emidio, Nayara, Dawson, Philip E., Muttenthaler, Markus and King, Glenn F. (2020). Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency. Journal of Medicinal Chemistry, 63 (21), 12773-12785. doi: 10.1021/acs.jmedchem.0c01107

Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency

2020

Journal Article

The neuronal calcium ion channel activity of constrained analogues of MONIRO-1

Cardoso, Fernanda C., Marliac, Marie-Adeline, Geoffroy, Chloe, Schmit, Matthieu, Bispat, Anjie, Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2020). The neuronal calcium ion channel activity of constrained analogues of MONIRO-1. Bioorganic and Medicinal Chemistry, 28 (18) 115655, 115655. doi: 10.1016/j.bmc.2020.115655

The neuronal calcium ion channel activity of constrained analogues of MONIRO-1

2020

Journal Article

Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulator

Wang, Dan, Himaya, S.W.A., Giacomotto, Jean, Hasan, Md. Mahadhi, Cardoso, Fernanda C., Ragnarsson, Lotten and Lewis, Richard J. (2020). Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulator. Marine Drugs, 18 (7) 343, 1-13. doi: 10.3390/md18070343

Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulator

2020

Journal Article

Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases

Cardoso, Fernanda C (2020). Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases. Biochemical Pharmacology, 181 114107, 114107. doi: 10.1016/j.bcp.2020.114107

Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases