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2021 Journal Article A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndromeCardoso, Fernanda C., Castro, Joel, Grundy, Luke, Schober, Gudrun, Garcia-Caraballo, Sonia, Zhao, Tianjiao, Herzig, Volker, King, Glenn F., Brierley, Stuart M. and Lewis, Richard J. (2021). A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain, 162 (2), 569-581. doi: 10.1097/j.pain.0000000000002041 |
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2020 Conference Publication Rationally Designed Analogues of the Novel Spider-venom Peptide Phlo3a Shifts the Potency and Subtype Selectivity at Therapeutic Nav Channel Targets for Pain and EpilepsyDongol, Y., Choi, P., Wilson, D., Cardoso, F. C. and Lewis, R. J. (2020). Rationally Designed Analogues of the Novel Spider-venom Peptide Phlo3a Shifts the Potency and Subtype Selectivity at Therapeutic Nav Channel Targets for Pain and Epilepsy. SBMS Postgraduate Symposium in Biomedical Sciences, Brisbane, QLD Australia, 24 November 2020. |
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2020 Journal Article Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otencyPeschel, Alicia, Cardoso, Fernanda C., Walker, Andrew A., Durek, Thomas, Stone, M Rhia L., Braga Emidio, Nayara, Dawson, Philip E., Muttenthaler, Markus and King, Glenn F. (2020). Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency. Journal of Medicinal Chemistry, 63 (21), 12773-12785. doi: 10.1021/acs.jmedchem.0c01107 |
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2020 Journal Article The neuronal calcium ion channel activity of constrained analogues of MONIRO-1Cardoso, Fernanda C., Marliac, Marie-Adeline, Geoffroy, Chloe, Schmit, Matthieu, Bispat, Anjie, Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2020). The neuronal calcium ion channel activity of constrained analogues of MONIRO-1. Bioorganic and Medicinal Chemistry, 28 (18) 115655, 115655. doi: 10.1016/j.bmc.2020.115655 |
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2020 Journal Article Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulatorWang, Dan, Himaya, S.W.A., Giacomotto, Jean, Hasan, Md. Mahadhi, Cardoso, Fernanda C., Ragnarsson, Lotten and Lewis, Richard J. (2020). Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulator. Marine Drugs, 18 (7) 343, 1-13. doi: 10.3390/md18070343 |
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2020 Journal Article Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseasesCardoso, Fernanda C (2020). Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases. Biochemical Pharmacology, 181 114107, 114107. doi: 10.1016/j.bcp.2020.114107 |
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2020 Conference Publication Harnessing multifunctional spider-venom peptides to modulate pain pathwaysCardoso, Fernanda (2020). Harnessing multifunctional spider-venom peptides to modulate pain pathways. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier . doi: 10.1016/j.toxicon.2019.10.082 |
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2019 Journal Article Spider knottin pharmacology at voltage-gated sodium channels and their potential to modulate pain pathwaysDongol, Yashad, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Spider knottin pharmacology at voltage-gated sodium channels and their potential to modulate pain pathways. Toxins, 11 (11) 10.3390/toxins11110626, 626. doi: 10.3390/toxins11110626 |
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2019 Journal Article Venomic, transcriptomic, and bioactivity analyses of Pamphobeteus verdolaga venom reveal complex disulfide-rich peptides that modulate calcium channelsEstrada-Gomez, Sebastian, Cardoso,Fernanda Caldas, Vargas-Muñoz, Leidy Johana, Quintana-Castillo, Juan Carlos, Gómez, Claudia Marcela Arenas, Pineda, Sandy Steffany and Saldarriaga-Cordoba, Monica Maria (2019). Venomic, transcriptomic, and bioactivity analyses of Pamphobeteus verdolaga venom reveal complex disulfide-rich peptides that modulate calcium channels. Toxins, 11 (9) 496, 496. doi: 10.3390/toxins11090496 |
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2019 Journal Article Multifunctional toxins in snake venoms and therapeutic implications: From pain to hemorrhage and necrosisFerraz, Camila R., Arrahman, Arif, Xie, Chunfang, Casewell, Nicholas R., Lewis, Richard J., Kool, Jeroen and Cardoso, Fernanda C. (2019). Multifunctional toxins in snake venoms and therapeutic implications: From pain to hemorrhage and necrosis. Frontiers in Ecology and Evolution, 7 (JUN) 218. doi: 10.3389/fevo.2019.00218 |
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2019 Journal Article Structure–function and therapeutic potential of spider venom-derived cysteine knot peptides targeting sodium channelsCardoso, Fernanda C. and Lewis, Richard J. (2019). Structure–function and therapeutic potential of spider venom-derived cysteine knot peptides targeting sodium channels. Frontiers in Pharmacology, 10 (APR) 366, 366. doi: 10.3389/fphar.2019.00366 |
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2019 Journal Article ‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET PotencyZiegman, Rebekah , Brust, Andreas , Jha, Prerna , Cardoso, Fernanda C. , Lewis, Richard J. and Alewood, Paul F. (2019). ‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency. Marine Drugs, 17 (3) 165, 165. doi: 10.3390/md17030165 |
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2019 Conference Publication Harnessing multifunctional spider peptides to modulate pain pathwaysCardoso, Fernanda C. (2019). Harnessing multifunctional spider peptides to modulate pain pathways. International Society for Toxinology World Conference 2019, Buenos Aires, Argentina, 8-13 September 2019. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. |
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2019 Conference Publication Rational design of spider knottin Phlo3a to strategically modulate multiple noxious NaV channelsDongol, Yashad, Choi, Phil, Wilson, David, Cardoso, Fernanda C. and Lewis, Richards J. (2019). Rational design of spider knottin Phlo3a to strategically modulate multiple noxious NaV channels. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD, Australia, 29 November 2019. |
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2019 Conference Publication Characterization of δ-conotoxin Tx-VIA as selective T-type modulatorWang, Dan, Himaya, S. W. A., Giacomotto, Jean, Hasan, Mahadhi, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Characterization of δ-conotoxin Tx-VIA as selective T-type modulator. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD, Australia, 29 November 2019. |
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2019 Conference Publication Disclosing the bioactive surface of the potent NaV channel inhibitor ProTx-III [μ-TRTX-Tp1a]Zhao, Tianjiao, Rosengren, K. Johan, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Disclosing the bioactive surface of the potent NaV channel inhibitor ProTx-III [μ-TRTX-Tp1a]. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD Australia, 29 November 2019. |
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2019 Conference Publication Cooperative interactions of loops 1, 4 and C-terminal of the ICK spider peptide Tap1a engender NaV inhibitory propertiesMawlawi, Saja E., Zhao, Thianjiao, Lewis, Richard J. and Cardoso, Fernanda C. (2019). Cooperative interactions of loops 1, 4 and C-terminal of the ICK spider peptide Tap1a engender NaV inhibitory properties. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD Australia, 29 November 2019. |
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2019 Conference Publication Molecular interactions between spider toxins and the sodium channel Nav1.1Hu, Huyiu, Lewis, Richard J. and Cardoso, Fernanda C. (2019). Molecular interactions between spider toxins and the sodium channel Nav1.1. Pain Retreat 2019, Stradbroke Island, QLD Australia, 27-29 May 2019. |
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2019 Conference Publication Structure-function relationships of spider venom neurotoxins: what are we learning from it?Cardoso, Fernadna C. (2019). Structure-function relationships of spider venom neurotoxins: what are we learning from it?. Pain Retreat 2019, Stradbroke Island, QLD, Australia, 27-29 May 2019. |
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2019 Conference Publication Discovery of novel cav and nav modulators in spider venoms and applications in the development of drugs to treat chronic painCardoso, Fernanda C., King, Glenn F. and Lewis, R. J. (2019). Discovery of novel cav and nav modulators in spider venoms and applications in the development of drugs to treat chronic pain. 19th World Congress of the International Society on Toxinology, Haikou City, Hainan Province, China, 24-31 October 2017. Oxford, United Kingdom: Elsevier. |
