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2013 Journal Article Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control studyTalmud, Philippa J., Shah, Sonia, Whittall, Ros, Futema, Marta, Howard, Philip, Cooper, Jackie A., Harrison, Seamus C., Li, KaWah, Drenos, Fotios, Karpe, Frederik, Neil, H. Andrew W., Descamps, Olivier S., Langenberg, Claudia, Lench, Nicholas, Kivimaki, Mika, Whittaker, John, Hingorani, Aroon D., Kumari, Meena and Humphries, Steve E. (2013). Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study. Lancet, 381 (9874), 1293-1301. doi: 10.1016/S0140-6736(12)62127-8 |
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2013 Journal Article Loci influencing blood pressure identified using a cardiovascular gene-centric arrayGanesh, S.K., Tragante, V., Guo, W., Guo, Y., Lanktree, M.B., Smith, E.N., Johnson, T., Castillo, B.A., Barnard, J., Baumert, J., Chang, Y.-P.C., Elbers, C.C., Farrall, M., Fischer, M.E., Franceschini, N., Gaunt, T.R., Gho, J.M.I.H., Gieger, C., Gong, Y., Isaacs, A., Kleber, M.E., Leach, I.M., McDonough, C.W., Meijs, M.F., Mellander, O., Molony, C.M., Nolte, I.M., Padmanabhan, S., Price, T.S. ... Asselbergs, F.W. (2013). Loci influencing blood pressure identified using a cardiovascular gene-centric array. Human Molecular Genetics, 22 (8), 1663-1678. doi: 10.1093/hmg/dds555 |
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2013 Journal Article Causal relevance of blood lipid fractions in the development of carotid atherosclerosis mendelian randomization analysisShah S., Casas J.-P., Drenos F., Whittaker J., Deanfield J., Swerdlow D.I., Holmes M.V., Kivimaki M., Langenberg C., Wareham N., Gertow K., Sennblad B., Strawbridge R.J., Baldassarre D., Veglia F., Tremoli E., Gigante B., De Faire U., Kumari M., Talmud P.J., Hamsten A., Humphries S.E. and Hingorani A.D. (2013). Causal relevance of blood lipid fractions in the development of carotid atherosclerosis mendelian randomization analysis. Circulation: Cardiovascular Genetics, 6 (1), 63-72. doi: 10.1161/CIRCGENETICS.112.963140 |
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2013 Journal Article A gene-centric study of common carotid artery remodellingHarrison S.C., Zabaneh D., Asselbergs F.W., Drenos F., Jones G.T., Shah S., Gertow K., Sennblad B., Strawbridge R.J., Gigante B., Holewijn S., De Graaf J., Vermeulen S., Folkersen L., van Rij A.M., Baldassarre D., Veglia F., Talmud P.J., Deanfield J.E., Agu O., Kivimaki M., Kumari M., Bown M.J., Nyyssonen K., Rauramaa R., Smit A.J., Franco-Cereceda A., Giral P., Mannarino E. ... Humphries S.E. (2013). A gene-centric study of common carotid artery remodelling. Atherosclerosis, 226 (2), 440-446. doi: 10.1016/j.atherosclerosis.2012.11.002 |
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2012 Journal Article Integration of genetics into a systems model of electrocardiographic traits using humancvd beadchipGaunt, Tom R, Shah, Sonia, Nelson, Christopher P, Drenos, Fotios, Braund, Peter S., Adeniran, Ismail, Folkersen, Lasse, Lawlor, Debbie A., Casas, Juan-Pablo, Amuzu, Antoinette, Kivimaki, Mika, Whittaker, John, Eriksson, Per, Zhang, Henggui, Hancox, Jules C., Tomaszewski, Maciej, Burton, Paul R., Tobin, Martin D., Humphries, Steve E., Talmud, Philippa J., Macfarlane, Peter W., Hingorani, Aroon D., Samani, Nilesh J., Kumari, Meena and Day, Ian N.M. (2012). Integration of genetics into a systems model of electrocardiographic traits using humancvd beadchip. Circulation: Cardiovascular Genetics, 5 (6), 630-638. doi: 10.1161/CIRCGENETICS.112.962852 |
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2012 Journal Article Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetesMorris, Andrew P., Voight, Benjamin F., Teslovich, Tanya M., Ferreira, Teresa, Segre, Ayellet V., Steinthorsdottir, Valgerdur, Strawbridge, Rona J., Khan, Hassan, Grallert, Harald, Mahajan, Anubha, Prokopenko, Inga, Kang, Hyun Min, Dina, Christian, Esko, Tonu, Fraser, Ross M., Kanoni, Stavroula, Kumar, Ashish, Lagou, Vasiliki, Langenberg, Claudia, Luan, Jian'an, Lindgren, Cecilia M., Mueller-Nurasyid, Martina, Pechlivanis, Sonali, Rayner, N. William, Scott, Laura J., Wiltshire, Steven, Yengo, Loic, Kinnunen, Leena, Rossin, Elizabeth J. ... Shah, Sonia (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 44 (9), 981-990. doi: 10.1038/ng.2383 |
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2012 Journal Article Erratum: Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height ((The American Journal of Human Genetics (2010) 88 (6-18))Lanktree, Matthew B., Guo, Yiran, Murtaza, Muhammed, Glessner, Joseph T., Bailey, Swneke D., Onland-Moret, N. Charlotte, Lettre, Guillaume, Ongen, Halit, Rajagopalan, Ramakrishnan, Johnson, Toby, Shen, Haiqing, Nelson, Christopher P., Klopp, Norman, Baumert, Jens, Padmanabhan, Sandosh, Pankratz, Nathan, Pankow, James S., Shah, Sonia, Taylor, Kira, Barnard, John, Peters, Bas J., Maloney, Cliona M., Lobmeyer, Maximilian T., Stanton, Alice, Zafarmand, M. Hadi, Romaine, Simon P.R., Mehta, Amar, Van Iperen, Erik P.A., Gong, Yan ... Keating, Brendan J. (2012). Erratum: Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height ((The American Journal of Human Genetics (2010) 88 (6-18)). American Journal of Human Genetics, 90 (6), 1116-1117. doi: 10.1016/j.ajhg.2012.05.017 |
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2012 Journal Article Erratum: Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci (American Journal of Human Genetics (2012) 90 (410-425))Saxena, Richa, Elbers, Clara C., Guo, Yiran, Peter, Inga, Gaunt, Tom R., Mega, Jessica L., Lanktree, Matthew B., Tare, Archana, Castillo, Berta Almoguera, Li, Yun R., Johnson, Toby, Bruinenberg, Marcel, Gilbert-Diamond, Diane, Rajagopalan, Ramakrishnan, Voight, Benjamin F., Balasubramanyam, Ashok, Barnard, John, Bauer, Florianne, Baumert, Jens, Bhangale, Tushar, Boehm, Bernhard O., Braund, Peter S., Burton, Paul R., Chandrupatla, Hareesh R., Clarke, Robert, Cooper-DeHoff, Rhonda M., Crook, Errol D., Davey-Smith, George, Day, Ian N. ... Keating, Brendan J. (2012). Erratum: Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci (American Journal of Human Genetics (2012) 90 (410-425)). American Journal of Human Genetics, 90 (4), 753-753. doi: 10.1016/j.ajhg.2012.03.001 |
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2012 Journal Article Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes lociSaxena, Richa, Elbers, Clara C., Guo, Yiran, Peter, Inga, Gaunt, Tom R., Mega, Jessica L., Lanktree, Matthew B., Tare, Archana, Castillo, Berta A., Li, Yun R., Johnson, Toby, Bruinenberg, Marcel, Gilbert-Diamond, Diane, Rajagopalan, Ramakrishnan, Voight, Benjamin F., Balasubramanyam, Ashok, Barnard, John, Bauer, Florianne, Baumert, Jens, Bhangale, Tushar, Bohm, Bernhard O., Braund, Peter S., Burton, Paul R., Chandrupatla, Hareesh R., Clarke, Robert, Cooper-Dehoff, Rhonda M., Crook, Errol D., Davey-Smith, George, Day, Ian N. ... Keating, Brendan J. (2012). Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. American Journal of Human Genetics, 90 (3), 410-425. doi: 10.1016/j.ajhg.2011.12.022 |
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2012 Journal Article Cholesteryl ester transfer protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular riskPapp, Audrey C., Pinsonneault, Julia K., Wang, Danxin, Newman, Leslie C., Gong, Yan, Johnson, Julie A., Pepine, Carl J., Kumari, Meena, Hingorani, Aroon D., Talmud, Philippa J., Shah, Sonia, Humphries, Steve E. and Sadee, Wolfgang (2012). Cholesteryl ester transfer protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk. PLoS ONE, 7 (3) e31930, e31930.1-e31930.9. doi: 10.1371/journal.pone.0031930 |
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2012 Journal Article Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease riskGertow, Karl, Sennblad, Bengt, Strawbridge, Rona J., Ohrvik, John, Zabaneh, Delilah, Shah, Sonia, Veglia, Fabrizio, Fava, Cristiano, Kavousi, Maryam, McLachlan, Stela, Kivimaki, Mika, Bolton, Jennifer L., Folkersen, Lasse, Gigante, Bruna, Leander, Karin, Vikstrom, Max, Larsson, Malin, Silveira, Angela, Deanfield, John, Voight, Benjamin F., Fontanillas, Pierre, Sabater-Lleal, Maria, Colombo, Gualtiero I., Kumari, Meena, Langenberg, Claudia, Wareham, Nick J., Uitterlinden, André G., Gabrielsen, Anders, Hedin, Ulf ... Hamsten, Anders (2012). Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk. Circulation: Cardiovascular Genetics, 5 (6), 656-665. doi: 10.1161/CIRCGENETICS.112.963660 |
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2012 Journal Article Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathwaysScott, Robert A., Lagou, Vasiliki, Welch, Ryan P., Wheeler, Eleanor, Montasser, May E., Luan, Jian’an, Mägi, Reedik, Strawbridge, Rona J., Rehnberg, Emil, Gustafsson, Stefan, Kanoni, Stavroula, Rasmussen-Torvik, Laura J., Yengo, Loïc, Lecoeur, Cecile, Shungin, Dmitry, Sanna, Serena, Sidore, Carlo, Johnson, Paul C. D., Jukema, J. Wouter, Johnson, Toby, Mahajan, Anubha, Verweij, Niek, Thorleifsson, Gudmar, Hottenga, Jouke-Jan, Shah, Sonia, Smith, Albert V., Sennblad, Bengt, Gieger, Christian, Salo, Perttu ... Barroso, Inês (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics, 44 (9), 991-1005. doi: 10.1038/ng.2385 |
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2012 Journal Article Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics CollaborationAngelakopoulou, Aspasia, Shah, Tina, Sofat, Reecha, Shah, Sonia, Berry, Diane J., Cooper, Jackie, Palmen, Jutta, Tzoulaki, Ioanna, Wong, Andrew, Jefferis, Barbara J., Maniatis, Nikolas, Drenos, Fotios, Gigante, Bruna, Hardy, Rebecca, Laxton, Ross C., Leander, Karin, Motterle, Anna, Simpson, Iain A., Smeeth, Liam, Thomson, Andy, Verzilli, Claudio, Kuh, Diana, Ireland, Helen, Deanfield, John, Caulfield, Mark, Wallace, Chris, Samani, Nilesh, Munroe, Patricia B., Lathrop, Mark ... Hingorani, Aroon D. (2012). Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. European Heart Journal, 33 (3), 393-407. doi: 10.1093/eurheartj/ehr225 |
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2012 Journal Article IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes riskYiannakouris, N., Cooper, J. A., Shah, S., Drenos, F., Ireland, H. A., Stephens, J. W., Li, K.-W., Elkeles, R., Godsland, I. F., Kivimaki, M., Hingorani, A. D., Kumari, M., Talmud, P. J. and Humphries, S. E. (2012). IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk. Nutrition, Metabolism and Cardiovascular Diseases, 22 (12), 1024-1030. doi: 10.1016/j.numecd.2011.05.009 |
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2012 Journal Article Use of Allele-Specific FAIRE to Determine Functional Regulatory Polymorphism Using Large-Scale Genotyping ArraysSmith, Andrew J. P., Howard, Philip, Shah, Sonia, Eriksson, Per, Stender, Stefan, Giambartolomei, Claudia, Folkersen, Lasse, Tybjaerg-Hansen, Anne, Kumari, Meena, Palmen, Jutta, Hingorani, Aroon D., Talmud, Philippa J. and Humphries, Steve E. (2012). Use of Allele-Specific FAIRE to Determine Functional Regulatory Polymorphism Using Large-Scale Genotyping Arrays. PLoS Genetics, 8 (8) e1002908, e1002908.1-e1002908.10. doi: 10.1371/journal.pgen.1002908 |
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2011 Journal Article Transcriptomic analyses of murine resolution-phase macrophagesStables, Melanie J., Shah, Sonia, Camon, Evelyn B., Lovering, Ruth C., Newson, Justine, Bystrom, Jonas, Farrow, Stuart and Gilroy, Derek W. (2011). Transcriptomic analyses of murine resolution-phase macrophages. Blood, 118 (26), e192-e208. doi: 10.1182/blood-2011-04-345330 |
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2011 Journal Article Blood pressure loci identified with a gene-centric arrayJohnson, Toby, Gaunt, Tom R., Newhouse, Stephen J., Padmanabhan, Sandosh, Tomaszewski, Marciej, Kumari, Meena, Morris, Richard W., Tzoulaki, Ioanna, O'Brien, Eoin T., Poulter, Neil R., Sever, Peter, Shields, Denis C., Thom, Simon, Wannamethee, Sasiwarang G., Whincup, Peter H., Brown, Morris J., Connell, John M., Dobson, Richard J., Howard, Philip J., Mein, Charles A., Onipinla, Abiodun, Shaw-Hawkins, Sue, Zhang, Yun, Smith, George Davey, Day, Ian N. M., Lawlor, Debbie A., Goodall, Alison H.., Fowkes, F. Gerald, Abecasis, Goncalo R. ... Munroe, Patricia B. (2011). Blood pressure loci identified with a gene-centric array. American Journal of Human Genetics, 89 (6), 688-700. doi: 10.1016/j.ajhg.2011.10.013 |
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2011 Journal Article Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with HeightLanktree, Matthew B., Guo, Yiran, Murtaza, Muhammed, Glessner, Joseph T., Bailey, Swneke D., Onland-Moret, N. Charlotte, Lettre, Guillaume, Ongen, Halit, Rajagopalan, Ramakrishnan, Johnson, Toby, Shen, Haiqing, Nelson, Christopher P., Klopp, Norman, Baumert, Jens, Padmanabhan, Sandosh, Pankratz, Nathan, Pankow, James S., Shah, Sonia, Taylor, Kira, Barnard, John, Peters, Bas J., Maloney, Cliona M., Lobmeyer, Maximilian T., Stanton, Alice, Zafarmand, M. Hadi, Romaine, Simon P. R., Mehta, Amar, van Iperen, Erik P. A., Gong, Yan ... Keating, Brendan J. (2011). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 88 (1), 6-18. doi: 10.1016/j.ajhg.2010.11.007 |
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2011 Journal Article Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophyShah, Sonia, Nelson, Christopher P., Gaunt, Tom R., van der Harst, Pim, Barnes, Timothy, Braund, Peter S., Lawlor, Debbie A., Casas, Juan-Pablo, Padmanabhan, Sandosh, Drenos, Fotios, Kivimaki, Mika, Talmud, Philippa J., Humphries, Steve E., Whittaker, John, Morris, Richard W., Whincup, Peter H., Dominiczak, Anna, Munroe, Patricia B., Johnson, Toby, Goodall, Alison H., Cambien, Francois, Diemert, Patrick, Hengstenberg, Christian, Ouwehand, Willem H., Felix, Janine F., Glazer, Nicole L., Tomaszewski, Maciej, Burton, Paul R., Tobin, Martin D. ... Samani, Nilesh J. (2011). Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy. Circulation: Cardiovascular Genetics, 4 (6), 626-635. doi: 10.1161/CIRCGENETICS.111.960203 |
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2011 Journal Article Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohortsZabaneh, Delilah, Kumari, , Meena, Sandhu, Manj, Wareham, Nick, Wainwright, Nick, Papamarkou, Theodore, Hopewell, Jemma, Clarke, Robert, Li, KaWah, Palmen, Jutta, Talmud, Philippa J., Kronenberg, Florian, Lamina, Claudia, Summerer, Monika, Paulweber, Bernhard, Price, Jackie, Fowkes, Gerry, Stewart, Marlene, Drenos, Fotios, Shah, Sonia, Shah, Tina, Casas, Juan-Pablo, Kivimaki, Mika, Whittaker, John, Hingorani, Aroon D. and Humphries, Steve E. (2011). Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts. Atherosclerosis, 217 (2), 447-451. doi: 10.1016/j.atherosclerosis.2011.04.015 |
