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2013 Journal Article Mouse models uncap novel roles of SSBsBain, Amanda L., Shi, Wei and Khanna, Kum Kum (2013). Mouse models uncap novel roles of SSBs. Cell Research, 23 (6), 744-745. doi: 10.1038/cr.2013.63 |
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2013 Journal Article Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitorAl-Ejeh, Fares, Shi, Wei, Miranda, Mariska, Simpson, Peter T., Vargas, Ana Cristina, Song, Sarah, Wiegmans, Adrian P., Swarbrick, Alex, Welm, Alana L., Brown, Michael P., Chenevix-Trench, Georgia, Lakhani, Sunil R. and Khanna, Kum Kum (2013). Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor. Journal of Nuclear Medicine, 54 (6), 913-921. doi: 10.2967/jnumed.112.111534 |
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2013 Journal Article Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitmentJeffery, Jessie M., Grigoriev, Ilya, Poser, Ina, van der Horst, Armando, Hamilton, Nicholas, Waterhouse, Nigel, Bleier, Jonathan, Subramaniam, V. Nathan, Maly, Ivan V., Akhmanova, Anna and Khanna, Kum Kum (2013). Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment. Cell Cycle, 12 (6), 899-906. doi: 10.4161/cc.23879 |
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2013 Journal Article Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrestSingh, Mayank, Hunt, Clayton, Pandita, Raj K., Kumar, Rakesh, Yang, Chin-Rang, Horikoshi, Nobuo, Bachoo, Robert, Serag, Sara, Story, Michael D., Shay, Jerry W., Powell, Simon N., Gupta, Arun, Jeffery, Jessie, Pandita, Shruti, Chen, Benjamin P.C., Deckbar, Dorothee, Löbrich, Markus, Yang, Qin, Khanna, Kum Kum, Worman, Howard J. and Panditaa, Tej K. (2013). Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest. Molecular and Cellular Biology, 33 (6), 1210-1222. doi: 10.1128/MCB.01676-12 |
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2013 Journal Article Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2Shi, Wei, Bain, Amanda L., Schwer, Bjoern, Al-Ejeh, Fares, Smith, Corey, Wong, Lee, Chai, Hua, Miranda, Mariska S., Ho, Uda, Kawaguchi, Makoto, Miura, Yutaka, Finnie, John W., Wall, Meaghan, Heierhorst, Jorg, Wicking, Carol, Spring, Kevin J., Alt, Frederick W. and Khanna, Kum Kum (2013). Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genetics, 9 (2) e1003298, e1003298.1-e1003298.19. doi: 10.1371/journal.pgen.1003298 |
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2013 Journal Article EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma MultiformeDay, Bryan W., Stringer, Brett W., Al-Ejeh, Fares, Ting, Michael J., Wilson, John, Ensbey, Kathleen S., Jamieson, Paul R., Bruce, Zara C., Lim, Yi Chieh, Offenhauser, Carolin, Charmsaz, Sara, Cooper, Leanne T., Ellacott, Jennifer K., Harding, Angus, Leveque, Lucie, Inglis, Po, Allan, Suzanne, Walker, David G., Lackmann, Martin, Osborne, Geoffrey, Khanna, Kum Kum, Reynolds, Brent A., Lickliter, Jason D. and Boyd, Andrew W. (2013). EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme. Cancer Cell, 23 (2), 238-248. doi: 10.1016/j.ccr.2013.01.007 |
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2012 Journal Article Inactivation of ATM/ATR DNA Damage Checkpoint Promotes Androgen Induced Chromosomal Instability in Prostate Epithelial CellsChiu, Yung-Tuen, Liu, Ji, Tang, Kaidun, Wong, Yong-Chuan, Khanna, Kum Kum and Ling, Ming-Tat (2012). Inactivation of ATM/ATR DNA Damage Checkpoint Promotes Androgen Induced Chromosomal Instability in Prostate Epithelial Cells. Plos One, 7 (12) e51108. doi: 10.1371/journal.pone.0051108 |
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2012 Journal Article Kruppel-associated Box (KRAB)-associated Co-repressor (KAP-1) Ser-473 Phosphorylation Regulates Heterochromatin Protein 1β (HP1-β) Mobilization and DNA Repair in HeterochromatinBolderson, Emma, Savage, Kienan I., Mahen, Robert, Pisupati, Venkat, Graham, Mark E., Richard, Derek J., Robinson, Phillip J., Venkitaraman, Ashok R. and Khanna, Kum Kum (2012). Kruppel-associated Box (KRAB)-associated Co-repressor (KAP-1) Ser-473 Phosphorylation Regulates Heterochromatin Protein 1β (HP1-β) Mobilization and DNA Repair in Heterochromatin. Journal of Biological Chemistry, 287 (33), 28122-28131. doi: 10.1074/jbc.M112.368381 |
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2012 Journal Article Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11Noll, J. E., Jeffery, J., Al-Ejeh, F., Kumar, R., Khanna, K. K., Callen, D. F. and Neilsen, P. M. (2012). Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11. Oncogene, 31 (23), 2836-2848. doi: 10.1038/onc.2011.456 |
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2012 Journal Article A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structureLuijsterburg, Martijn S., Acs, Klara, Ackermann, Leena, Wiegant, Wouter W., Bekker-Jensen, Simon, Larsen, Dorthe H., Khanna, Kum Kum, van Attikum, Haico, Mailand, Niels and Dantuma, Nico P. (2012). A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure. Embo Journal, 31 (11), 2511-2527. doi: 10.1038/emboj.2012.104 |
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2012 Journal Article Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1Wu, Juan, Zhang, Xian, Zhang, Ling, Wu, Ching-Yuan, Rezaeian, Abdol Hossein, Chan, Chia-Hsin, Li, Ju-Mei, Wang, Jing, Gao, Yuan, Han, Fei, Jeong, Yun Seong, Yuan, Xiandao, Khanna, Kum Kum, Jin, Jianping, Zeng, Yi-Xin and Lin, Hui-Kuan (2012). Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1. Molecular Cell, 46 (3), 351-361. doi: 10.1016/j.molcel.2012.02.018 |
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2012 Journal Article INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cellsMorris, Christelle, Tomimatsu, Nozomi, Richard, Derek J., Cluet, David, Burma, Sandeep, Khanna, Kum Kum and Jalinot, Pierre (2012). INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells. Cancer Research, 72 (8), 2006-2016. doi: 10.1158/0008-5472.CAN-11-2562 |
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2012 Journal Article Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisionsTomimatsu, Nozomi, Mukherjee, Bipasha, Deland, Katherine, Kurimasa, Akihiro, Bolderson, Emma, Khanna, Kum Kum and Burma, Sandeep (2012). Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair, 11 (4), 441-448. doi: 10.1016/j.dnarep.2012.01.006 |
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2012 Journal Article Tocotrienol as a potential anticancer agentLing, Ming T., Luk, Sze U., Al-Ejeh, Fares and Khanna, Kum K. (2012). Tocotrienol as a potential anticancer agent. Carcinogenesis, 33 (2), 233-239. doi: 10.1093/carcin/bgr261 |
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2012 Journal Article Potential roles for prions and protein-only inheritance in cancerAntony, H., Wiegmans, A. P., Wei, M. Q., Chernoff, Y. O., Khanna, K. K. and Munn, A. L. (2012). Potential roles for prions and protein-only inheritance in cancer. Cancer metastasis reviews, 31 (1-2), 1-19. doi: 10.1007/s10555-011-9325-9 |
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2011 Journal Article ATM protein kinase: The linchpin of cellular defenses to stressBhatti, Shahzad, Kozlov, Sergei, Farooqi, Ammad Ahmad, Naqi, Ali, Lavin, Martin and Khanna, Kum Kum (2011). ATM protein kinase: The linchpin of cellular defenses to stress. Cellular and Molecular Life Sciences, 68 (18), 2977-3006. doi: 10.1007/s00018-011-0683-9 |
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2011 Journal Article Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neuronsJung, Cha-Gyun, Uhm, Kyung-Ok, Miura, Yutaka, Hosono, Takashi, Horike, Hirofumi, Khanna, Kum Kum, Kim, Mi-Jeong and Michikawa, Makoto (2011). Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons. Molecular Neurodegeneration, 6 (47) 47, 1-14. doi: 10.1186/1750-1326-6-47 |
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2011 Journal Article Rare variants in the ATM gene and risk of breast cancerGoldgar, David E., Healey, Sue, Dowty, James G., Da Silva, Leonard, Chen, Xiaoqing, Spurdle, Amanda B., Terry, Mary B., Daly, Mary J., Buys, Saundra M., Southey, Melissa C., Andrulis, Irene, John, Esther M., Breast Cancer Family Registry, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Khanna, Kum K., Hopper, John L., Oefner, Peter J., Lakhani, Sunil and Chenevix-Trench, Georgia (2011). Rare variants in the ATM gene and risk of breast cancer. Breast Cancer Research, 13 (4) R73, R73-1-R73-9. doi: 10.1186/bcr2919 |
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2011 Journal Article hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activityRichard, Derek J., Cubeddu, Liza, Urquhart, Aaron J., Bain, Amanda, Bolderson, Emma, Menon, Dinoop, White, Malcolm F. and Khanna, Kum Kum (2011). hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity. Nucleic Acids Research, 39 (9), 3643-3651. doi: 10.1093/nar/gkq1340 |
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2011 Journal Article Breast cancer stem cells: Treatment resistance and therapeutic opportunitiesAL-Ejeh, Fares, Smart, Chanel E., Morrison, Brian J., Chenevix-Trench, Georgia, Lopez, J. Alejandro, Lakhani, Sunil R., Brown, Michael P. and Khanna, Kum Kum (2011). Breast cancer stem cells: Treatment resistance and therapeutic opportunities. Carcinogenesis, 32 (5), 650-658. doi: 10.1093/carcin/bgr028 |
