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2011 Journal Article A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in miceYoungson, N. A., Vickaryous, N., van der Horst, A., Epp, T., Harten, S., Fleming, J. S., Khanna, K. K., de Kretser, D. M. and Whitelaw, Emma (2011). A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice. Mammalian Genome, 22 (3-4), 235-248. doi: 10.1007/s00335-011-9317-7 |
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2011 Journal Article hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complexRichard, Derek J., Savage, Kienan, Bolderson, Emma, Cubeddu, Liza, So, Sairei, Ghita, Mihaela, Chen, David J., White, Malcolm F., Richard, Kerry, Prise, Kevin M., Schettino, Giuseppe and Khanna, Kum Kum (2011). hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex. Nucleic Acids Research, 39 (5), 1692-1702. doi: 10.1093/nar/gkq1098 |
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2011 Journal Article Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challengesSimpson, Peter T., Vargas, Ana Christina, Al-Ejeh, Fares, Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2011). Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challenges. Human Pathology, 42 (2), 153-165. doi: 10.1016/j.humpath.2010.07.008 |
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2011 Journal Article Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer familiesJohnson, Julie, Healey, Sue, Khanna, Kum Kum, kConFab and Chenevix-Trench, Georgia (2011). Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families. Breast Cancer Research and Treatment, 129 (1), 255-263. doi: 10.1007/s10549-011-1539-6 |
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2010 Journal Article Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humansSchoenmakers, Erik, Agostini, Maura, Mitchell, Catherine, Schoenmakers, Nadia, Papp, Laura, Rajanayagam, Odelia, Padidela, Raja, Ceron-Gutierrez, Lourdes, Doffinger, Rainer, Prevosto, Claudia, Luan, Jian'an, Montano, Sergio, Lu, Jun, Castanet, Mireille, Clemons, Nick, Groeneveld, Matthijs, Castets, Perrine, Karbaschi, Mahsa, Aitken, Sri, Dixon, Adrian, Williams, Jane, Campi, Irene, Blount, Margaret, Burton, Hannah, Muntoni, Francesco, O'Donovan, Dominic, Dean, Andrew, Warren, Anne, Brierley, Charlotte ... Chatterjee, Krishna (2010). Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. Journal of Clinical Investigation, 120 (12), 4220-4235. doi: 10.1172/JCI43653 |
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2010 Journal Article Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomesAl-Ejeh, F., Kumar, R., Wiegmans, A., Lakhani, S.R., Brown, M.P. and Khanna, K.K. (2010). Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes. Oncogene, 29 (46), 6085-6098. doi: 10.1038/onc.2010.407 |
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2010 Journal Article The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stressKim, TS, Kawaguchi, M, Suzuki, M, Jung, CG, Asai, K, Shibamoto, Y, Lavin, MF, Khanna, KK and Miura, Y (2010). The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. DMM Disease Models and Mechanisms, 3 (11-12), 752-762. doi: 10.1242/dmm.004689 |
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2010 Journal Article A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activationHinz, Michael, Stilmann, Michael, Arslan, Seda Çöl, Khanna, Kum Kum, Dittmar, Gunnar and Scheidereit, Claus (2010). A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. Molecular Cell, 40 (1), 63-74. doi: 10.1016/j.molcel.2010.09.008 |
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2010 Journal Article Subtypes of familial breast tumours revealed by expression and copy number profilingWaddell, N, Arnold, J, Cocciardi, S, da Silva, L, Marsh, A, Riley, J, Johnstone, CN, Orloff, M, Assie, G, Eng, C, Reid, L, Keith, P, Yan, M, Fox, S, Devilee, P, Godwin, AK, Hogervorst, FBL, Couch, F, Grimmond, S, Flanagan, JM, Khanna, K, Simpson, PT, Lakhani, SR, Chenevix-Trench, G and kConFab Investigators (2010). Subtypes of familial breast tumours revealed by expression and copy number profiling. Breast Cancer Research And Treatment, 123 (3), 661-677. doi: 10.1007/s10549-009-0653-1 |
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2010 Journal Article Novel single stranded DNA binding proteins crucial for the DNA damage responseCubeddu, L., Richard, D. J., White, M. F. and Khanna, K. K. (2010). Novel single stranded DNA binding proteins crucial for the DNA damage response. The FEBS Journal, 277 (Supp. 1), 193-193. doi: 10.1111/j.1742-4658.2010.07680.x |
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2010 Journal Article Centrobin regulates the assembly of functional mitotic spindlesJeffery, J. M., Urquhart, A. J., Subramaniam, V. N., Parton, R.G. and Khanna, K.K. (2010). Centrobin regulates the assembly of functional mitotic spindles. Oncogene, 29 (18), 2649-2658. doi: 10.1038/onc.2010.37 |
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2010 Journal Article Selenium and selenoproteins in health and diseasePapp, Laura V., Holmgren, Arne and Khanna, Kum Kum (2010). Selenium and selenoproteins in health and disease. Antioxidants and Redox Signaling, 12 (7), 793-795. doi: 10.1089/ars.2009.2973 |
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2010 Journal Article SECIS-binding protein 2 promotes cell survival by protecting against oxidative stressPapp, Laura V., Lu, Jun, Bolderson, Emma, Boucher, Didier, Singh, Ravindra, Holmgren, Arne and Khanna, Kum Kum (2010). SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress. Antioxidants and Redox Signaling, 12 (7), 797-808. doi: 10.1089/ars.2009.2913 |
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2010 Journal Article Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaksBolderson, Emma, Tomimatsu, Nozomi, Richard, Derek J., Boucher, Didier, Kumar, Rakesh, Pandita, Tej K., Burma, Sandeep and Khanna, Kum Kum (2010). Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Research, 38 (6) gkp1164, 1821-1831. doi: 10.1093/nar/gkp1164 |
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2010 Journal Article DNA methylome of familial breast cancer identifies distinct profiles defined by mutation statusFlanagan, James M., Cocciardi, Sibylle, Waddell, Nic, Johnstone, Cameron N., Marsh, Anna, Henderson, Stephen, Simpson, Peter, da Silva, Leonard, kConFab Investigators, Khanna, Kumkum, Lakhani, Sunil, Boshoff, Chris, Chenevix-Trench, Georgia, Brown, Melissa, Cummings, Margaret and Edwards, Stacey (2010). DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status. American Journal of Human Genetics, 86 (3), 420-433. doi: 10.1016/j.ajhg.2010.02.008 |
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2010 Journal Article Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?Lakhani, Sunil R., Khanna, Kum K. and Chenevix-Trench, Georgia (2010). Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?. Breast Cancer Research, 12 (2) 104, 104-1-104-2. doi: 10.1186/bcr2483 |
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2010 Journal Article HER3 and downstream pathways are involved in colonization of brain metastases from breast cancerDa Silva, Leonard, Simpson, Peter T., Smart, Chanek E., Cocciardi, Sibylle, Waddell, Nic, Lane, Annette, Morrison, Brian J., Vargas, Ana Cristina, Healey, Sue, Beesley, Jonathan, Pakkiri, Pria, Parry, Suzanne, Kurniawan, Nyoman, Reid, Lynne, Keith, Patricia, Faria, Paulo, Pereira, Emilio, Skalova, Alena, Bilous, Michael, Balleine, Rosemary L., Do, Hongdo, Dobrovic, Alexander, Fox, Stephen, Franco, Marcello, Reynolds, Brent, Khanna, Kum Kum, Cummings, Margaret, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2010). HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer. Breast Cancer Research, 12 (4) R46, R46-1-R46-11. doi: 10.1186/bcr2603 |
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2009 Journal Article Cep55 stabilization is required for normal execution of cytokinesisArmando van der Horst, Jacinta Simmons and Kum Kum Khanna (2009). Cep55 stabilization is required for normal execution of cytokinesis. Cell Cycle, 8 (22), 3742-3749. doi: 10.4161/cc.8.22.10047 |
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2009 Journal Article Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break RepairEmma Bolderson, Derek J. Richard, Bin-Bing S. Zhou and Kum Kum Khanna (2009). Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair. Clinical Cancer Research, 15 (20), 6314-6320. doi: 10.1158/1078-0432.CCR-09-0096 |
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2009 Journal Article Clinical and Molecular Characterization of a Novel Selenocysteine Insertion Sequence-Binding Protein 2 (SBP2) Gene Mutation (R128X)Caterina Di Cosmo, Neil McLellan, Xiao-Hui Liao, Kum Kum Khanna, Roy E. Weiss, Laura Papp and Samuel Refetoff (2009). Clinical and Molecular Characterization of a Novel Selenocysteine Insertion Sequence-Binding Protein 2 (SBP2) Gene Mutation (R128X). Journal of Clinical Endocrinology and Metabolism, 94 (10), 4003-4009. doi: 10.1210/jc.2009-0686 |
