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2020 Journal Article Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibitionRaninga, Prahlad, Lee, Andy, Sinha, Debottam, Dong, Lan-feng, Datta, Keshava, Lu, Xue, Kalita-de Croft, Priyakshi, Dutt, Mriga, Hill, Michelle M., Pouliot, Normand M., Gowda, Harsha, Kalimutho, Murugan, Neuzil, Jiri and Khanna, Kum Kum (2020). Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition. Theranostics, 10 (12), 5259-5275. doi: 10.7150/thno.42705 |
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2020 Journal Article Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancerRaninga, Prahlad V., Lee, Andy C., Sinha, Debottam, Shih, Yu-Yin, Mittal, Deepak, Makhale, Ashwini, Bain, Amanda L., Nanayakarra, Devathri, Tonissen, Kathryn F., Kalimutho, Murugan and Khanna, Kum Kum (2020). Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancer. International Journal of Cancer, 146 (1), 123-136. doi: 10.1002/ijc.32410 |
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2019 Journal Article LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer (vol 8, 73, 2018)Boulding, T., McCuaig, R. D., Tan, A., Hardy, K., Wu, F., Dunn, J., Kalimutho, M., Sutton, C. R., Forwood, J. K., Bert, A. G., Goodall, G. J., Malik, L., Yip, D., Dahlstrom, J. E., Zafar, A., Khanna, K. K. and Rao, S. (2019). LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer (vol 8, 73, 2018). Scientific Reports, 9 18771. doi: 10.1038/s41598-019-55020-1 |
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2019 Conference Publication Synergistic anti-cancer activity of auranofin with anti-PD-L1 therapy in triple negative breast cancerRaninga, P., Lee, A., Sinha, D., Shin, Y-Y., Mittal, D., Kalimutho, M. and Khanna, K. K. (2019). Synergistic anti-cancer activity of auranofin with anti-PD-L1 therapy in triple negative breast cancer. 44th Congress of the European-Society-for-Medical-Oncology (ESMO), Barcelona, Spain, 27 September - 1 October 2019. Oxford, United Kingdom: Oxford University Press. |
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2019 Journal Article First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylationZhou, Chenxi, Hancock, Janelle L., Khanna, Kum Kum and Homer, Hayden A. (2019). First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation. Journal of Cell Science, 132 (18) jcs233379, jcs233379. doi: 10.1242/jcs.233379 |
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2019 Journal Article GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell SurvivalCabrera, Elisa, Raninga, Prahlad, Khanna, Kum Kum and Freire, Raimundo (2019). GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival. Cancers, 11 (8), 1073. doi: 10.3390/cancers11081073 |
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2019 Journal Article Mechanisms of genomic instability in breast cancerDuijf, Pascal H.G., Nanayakkara, Devathri, Nones, K., Srihari, Sriganesh, Kalimutho, Murugan and Khanna, Kum Kum (2019). Mechanisms of genomic instability in breast cancer. Trends in Molecular Medicine, 25 (7), 595-611. doi: 10.1016/j.molmed.2019.04.004 |
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2019 Journal Article Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancersNones, K., Johnson, J., Newell, F., Patch, A. M., Thorne, H., Kazakoff, S. H., de Luca, X. M., Parsons, M. T., Ferguson, K., Reid, L. E., McCart Reed, A. E., Srihari, S., Lakis, V., Davidson, A. L., Mukhopadhyay, P., Holmes, O., Xu, Q., Wood, S., Leonard, C., The Kathleen Cuningham Foundation Consortium for Research into Familial Aspects of Breast Cancer (kConFab), The Australian Breast Cancer Tissue Bank (ABCTB), The Brisbane Breast Bank (BBB), Beesley, J., Harris, J. M., Barnes, D., Degasperi, A., Ragan, M. A., Spurdle, A. B., Khanna, K. K. ... Simpson, P. T. (2019). Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers. Annals of Oncology, 30 (7) mdz132, 1071-1079. doi: 10.1093/annonc/mdz132 |
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2019 Other Outputs Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian CancerSanij, Elaine, Hannan, Katherine M., Yan, Shunfei, Xuan, Jiachen, Ahern, Jessica E., Chan, Keefe T., Son, Jinbae, Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Trigos, Anna S., Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M.J.J., Hannan, Ross D, Scott, Clare L., Sheppard, Karen E and Pearson, Richard B (2019). Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer. doi: 10.1101/621623 |
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2019 Journal Article Patterns of genomic instability in breast cancerKalimutho, Murugan, Nones, Katia, Srihari, Sriganesh, Duijf, Pascal H.G., Waddell, Nicola and Khanna, Kum Kum (2019). Patterns of genomic instability in breast cancer. Trends in Pharmacological Sciences, 40 (3), 198-211. doi: 10.1016/j.tips.2019.01.005 |
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2019 Journal Article Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancerKalimutho, Murugan, Sinha, Debottam, Mittal, Deepak, Srihari, Sriganesh, Nanayakkara, Devathri, Shafique, Shagufta, Raninga, Prahlad, Nag, Purba, Parsons, Kate and Khanna, Kum Kum (2019). Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer. Journal of Experimental and Clinical Cancer Research, 38 (1) 85, 1-18. doi: 10.1186/s13046-019-1075-5 |
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2018 Journal Article RNA interference to enhance radiation therapy: targeting the DNA damage responseRatnayake, G., Bain, A. L., Fletcher, N., Howard, C. B., Khanna, K. K. and Thurecht, K. J. (2018). RNA interference to enhance radiation therapy: targeting the DNA damage response. Cancer Letters, 439, 14-23. doi: 10.1016/j.canlet.2018.09.011 |
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2018 Journal Article RAD51 paralogs promote genomic integrity and chemoresistance in cancer by facilitating homologous recombinationHarris, Janelle Louise, Rabellino, Andrea and Khanna, Kum Kum (2018). RAD51 paralogs promote genomic integrity and chemoresistance in cancer by facilitating homologous recombination. Annals of Translational Medicine, 6 S122. doi: 10.21037/atm.2018.12.30 |
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2018 Journal Article Optimizing poly (ADP-ribose) polymerase inhibition through combined epigenetic and immunotherapyPrasanna, Thiru, Wu, Fan, Khanna, Kum Kum, Yip, Desmond, Malik, Laeeq, Dahlstrom, Jane E. and Rao, Sudha (2018). Optimizing poly (ADP-ribose) polymerase inhibition through combined epigenetic and immunotherapy. Cancer Science, 109 (11), 3383-3392. doi: 10.1111/cas.13799 |
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2018 Journal Article CEP55 is a determinant of cell fate during perturbed mitosis in breast cancerKalimutho, Murugan, Sinha, Debottam, Jeffery, Jessie, Nones, Katia, Srihari, Sriganesh, Fernando, Winnie C., Duijf, Pascal H. G., Vennin, Claire, Raninga, Prahlad, Nanayakkara, Devathri, Mittal, Deepak, Saunus, Jodi M., Lakhani, Sunil R., López, J Alejandro, Spring, Kevin J., Timpson, Paul, Gabrielli, Brian, Waddell, Nicola and Khanna, Kum Kum (2018). CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO Molecular Medicine, 10 (9) e8566. doi: 10.15252/emmm.201708566 |
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2018 Conference Publication CEP55 over-expression causes genomic instability to initiate spontaneous tumour formation in vivoSinha, D., Kalimutho, M., Bain, A.L. and Khanna, K.K. (2018). CEP55 over-expression causes genomic instability to initiate spontaneous tumour formation in vivo. 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, Netherlands, 30 June – 3 July 2018. London, United Kingdom: Elsevier. doi: 10.1136/esmoopen-2018-eacr25.730 |
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2018 Journal Article The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated traffickingHarris, Janelle L., Dave, Keyur, Gorman, Jeffrey and Khanna, Kum Kum (2018). The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking. International Journal of Biochemistry & Cell Biology, 99, 28-37. doi: 10.1016/j.biocel.2018.03.002 |
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2018 Journal Article Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signalingSinha, Debottam, Kalimutho, Murugan, Bowles, Josephine, Chan, Ai-Leen, Merriner, D. Jo, Bain, Amanda L., Simmons, Jacinta L., Freire, Raimundo, Lopez, J Alejandro, Hobbs, Robin M., O'Bryan, Moira K. and Khanna, Kum Kum (2018). Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling. The FASEB Journal, 32 (9), 4984-4999. doi: 10.1096/fj.201701096RR |
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2018 Journal Article Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patientJohnson, Julie, Bessette, Darrell C., Saunus, Jodi M., Smart, Chanel E., Song, Sarah, Johnston, Rebecca L., Cocciardi, Sibylle, Rozali, Esdy N., Johnstone, Cameron N., Vargas, Ana Christina, Kazakoff, Stephen H., BioBank, Victorian Cancer, Khanna, Kum Kum, Lakhani, Sunil R., Chenevix-Trench, Georgia, Simpson, Peter T., Nones, Katia, Waddell, Nicola and Al-Ejeh, Fares (2018). Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient. Breast Cancer Research and Treatment, 170 (1), 179-188. doi: 10.1007/s10549-018-4719-9 |
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2018 Journal Article LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancerBoulding, T., McCuaig, R. D., Tan, A., Hardy, K., Wu, F., Dunn, J., Kalimutho, M., Sutton, C. R., Forwood, J. K., Bert, A. G., Goodall, G. J., Malik, L., Yip, D., Dahlstrom, J. E., Zafar, A., Khanna, K. K. and Rao, S. (2018). LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer. Scientific Reports, 8 (1) 73. doi: 10.1038/s41598-017-17913-x |
