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2024

Journal Article

Severe acute liver disease in adults: Contemporary role of histopathology

Clouston, Andrew D, Gouw, Annette S H, Tiniakos, Dina, Bedossa, Pierre, Brunt, Elizabeth M, Callea, Francesco, Dienes, Hans-Peter, Goodman, Zachary D, Hubscher, Stefan G, Kakar, Sanjay, Kleiner, David E, Lackner, Carolin, Park, Young N, Roberts, Eve A, Schirmacher, Peter, Terracciano, Luigi, Torbenson, Michael, Wanless, Ian R, Zen, Yoh and Burt, Alastair D (2024). Severe acute liver disease in adults: Contemporary role of histopathology. Histopathology, 85 (4), 549-561. doi: 10.1111/his.15212

Severe acute liver disease in adults: Contemporary role of histopathology

2024

Journal Article

Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD

Wang, Yewei, Ullah, Md Ashik, Waltner, Olivia G., Bhise, Shruti S., Ensbey, Kathleen S., Schmidt, Christine R., Legg, Samuel R.W., Sekiguchi, Tomoko, Nelson, Ethan L., Kuns, Rachel D., Nemychenkov, Nicole S., Atilla, Erden, Yeh, Albert C., Takahashi, Shuichiro, Boiko, Julie R., Varelias, Antiopi, Blazar, Bruce R., Koyama, Motoko, Minnie, Simone A., Clouston, Andrew D., Furlan, Scott N., Zhang, Ping and Hill, Geoffrey R. (2024). Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD. Journal of Clinical Investigation, 134 (11) e170125, 19-19. doi: 10.1172/jci170125

Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD

2024

Journal Article

Steatohepatitic hepatocellular Carcinoma:A new approach to classifying morphological subtypes of hepatocellular carcinoma

Soon, Gwyneth S.T., Callea, Francesco, Burt, Alastair D., Cook, Sam, Terracciano, Luigi, Ercan, Caner, Dienes, Hans-Peter, Goodman, Zachary D., Roberts, Eve A., Clouston, Andrew D., Gouw, Annette S.H., Kleiner, David E., Park, Young Nyun, Chung, Taek, Schirmacher, Peter, Tiniakos, Dina, Dimopoulou, Konstantina, Weber, Achim, Endhardt, Katharina and Torbenson, Michael (2024). Steatohepatitic hepatocellular Carcinoma:A new approach to classifying morphological subtypes of hepatocellular carcinoma. Human Pathology, 149, 55-65. doi: 10.1016/j.humpath.2024.06.007

Steatohepatitic hepatocellular Carcinoma:A new approach to classifying morphological subtypes of hepatocellular carcinoma

2024

Conference Publication

qBallooning: AI-based ballooned hepatocyte detection and quantification by second harmonic generation/two photon excitation microscopy

Kleiner, David E., Clouston, Andrew D., Goodman, Zachary, Guy, Cynthia D., Brunt, Elizabeth M., Lackner, Carolin, Tiniakos, Dina G., Wee, Aileen, Yeh, Matthew, Leow, Wei Qiang, Chng, Elaine, Ren, Yayun, Goh, George Boon Bee, Powell, Elizabeth E., Rinella, Mary E., Sanyal, Arun J, Neuschwander-Tetri, Brent A., Younossi, Zobair, Charlton, Michael, Ratziu, Vlad, Harrison, Stephen A., Tai, Dean and Anstee, Quentin M. (2024). qBallooning: AI-based ballooned hepatocyte detection and quantification by second harmonic generation/two photon excitation microscopy. EASL Congress 2024, Milan, Italy, 5-8 June 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/s0168-8278(24)01444-2

qBallooning: AI-based ballooned hepatocyte detection and quantification by second harmonic generation/two photon excitation microscopy

2024

Journal Article

IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation

Zhang, Ping, Fleming, Peter, Andoniou, Christopher E., Waltner, Olivia G., Bhise, Shruti S., Martins, Jose Paulo, McEnroe, Benjamin A., Voigt, Valentina, Daly, Sheridan, Kuns, Rachel D., Ekwe, Adaeze P., Henden, Andrea S., Saldan, Alda, Olver, Stuart, Varelias, Antiopi, Smith, Corey, Schmidt, Christine R., Ensbey, Kathleen S., Legg, Samuel R.W., Sekiguchi, Tomoko, Minnie, Simone A., Gradwell, Mark, Wagenaar, Irma, Clouston, Andrew D., Koyama, Motoko, Furlan, Scott N., Kennedy, Glen A., Ward, E Sally, Degli-Esposti, Mariapia A. ... Tey, Siok-Keen (2024). IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation. Journal of Clinical Investigation, 134 (7) e174184. doi: 10.1172/jci174184

IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation

2024

Book Chapter

Transplantation Pathology

Clouston, Andrew D. and Hübscher, Stefan G. (2024). Transplantation Pathology. MacSween's Pathology of the Liver, Eighth Edition. (pp. 947-1038) Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-7020-8228-3.00014-4

Transplantation Pathology

2023

Journal Article

Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity

Koyama, Motoko, Hippe, Daniel S., Srinivasan, Sujatha, Proll, Sean C., Miltiadous, Oriana, Li, Naisi, Zhang, Ping, Ensbey, Kathleen S., Hoffman, Noah G., Schmidt, Christine R., Yeh, Albert C., Minnie, Simone A., Strenk, Susan M., Fiedler, Tina L., Hattangady, Namita, Kowalsky, Jacob, Grady, Willian M., Degli-Esposti, Mariapia A., Varelias, Antiopi, Clouston, Andrew D., van den Brink, Marcel R.M., Dey, Neelendu, Randolph, Timothy W., Markey, Kate A., Fredricks, David N. and Hill, Geoffrey R. (2023). Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity. Immunity, 56 (8), 1876-1893.e8. doi: 10.1016/j.immuni.2023.06.024

Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity

2023

Journal Article

Placental hepatic nodule with molecular subtyping

Young, Vanessa, Clouston, Andrew, Corbett-Burns, Sophie and Russell, Peter (2023). Placental hepatic nodule with molecular subtyping. International Journal of Surgical Pathology, 31 (5), 582-584. doi: 10.1177/10668969221117241

Placental hepatic nodule with molecular subtyping

2023

Journal Article

Patient-Reported Bowel, Urinary, and Sexual Outcomes After Laparoscopic-Assisted Resection or Open Resection for Rectal Cancer: The Australasian Laparoscopic Cancer of the Rectum Randomized Clinical Trial (ALaCart)

Mercieca-Bebber, Rebecca, Eggins, Renee, Brown, Kilian, Gebski, Val J., Brewer, Kate, Lai, Lenna, Bailey, Lisa, Solomon, Michael J., Lumley, John W., Hewett, Peter, Clouston, Andrew D., Wilson, Kate, Hague, Wendy, Hayes, Julian, White, Stephen, Morgan, Matt, Simes, R. John and Stevenson, Andrew R. L. (2023). Patient-Reported Bowel, Urinary, and Sexual Outcomes After Laparoscopic-Assisted Resection or Open Resection for Rectal Cancer: The Australasian Laparoscopic Cancer of the Rectum Randomized Clinical Trial (ALaCart). Annals of Surgery, 277 (3), 449-455. doi: 10.1097/SLA.0000000000005412

Patient-Reported Bowel, Urinary, and Sexual Outcomes After Laparoscopic-Assisted Resection or Open Resection for Rectal Cancer: The Australasian Laparoscopic Cancer of the Rectum Randomized Clinical Trial (ALaCart)

2023

Journal Article

Lithium attenuates graft-versus-host disease via effects on the intestinal stem cell niche

Koyama, Motoko, Samson, Luke, Ensbey, Kathleen S., Takahashi, Shuichiro, Clouston, Andrew D., Martin, Paul J. and Hill, Geoffrey R. (2023). Lithium attenuates graft-versus-host disease via effects on the intestinal stem cell niche. Blood, 141 (3), 315-319. doi: 10.1182/blood.2022015808

Lithium attenuates graft-versus-host disease via effects on the intestinal stem cell niche

2023

Journal Article

Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors

Lemech, Charlotte, Dredge, Keith, Bampton, Darryn, Hammond, Edward, Clouston, Andrew, Waterhouse, Nigel J, Stanley, Amanda C, Leveque-El Mouttie, Lucie, Chojnowski, Grace M, Haydon, Andrew, Pavlakis, Nick, Burge, Matthew, Brown, Michael P and Goldstein, David (2023). Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors. Journal for ImmunoTherapy of Cancer, 11 (1) e006136, e006136. doi: 10.1136/jitc-2022-006136

Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors

2022

Journal Article

Reliability of histologic assessment for NAFLD and development of an expanded NAFLD activity score

Pai, Rish K., Jairath, Vipul, Hogan, Malcolm, Zou, Guangyong, Adeyi, Oyedele A., Anstee, Quentin M., Aqel, Bashar A., Behling, Cynthia, Carey, Elizabeth J., Clouston, Andrew D., Corey, Kathleen, Feagan, Brian G., Kleiner, David E., Ma, Christopher, McFarlane, Stefanie C., Noureddin, Mazen, Ratziu, Vlad, Valasek, Mark A., Younossi, Zobair M., Harrison, Stephen A. and Loomba, Rohit (2022). Reliability of histologic assessment for NAFLD and development of an expanded NAFLD activity score. Hepatology, 76 (4), 1150-1163. doi: 10.1002/hep.32475

Reliability of histologic assessment for NAFLD and development of an expanded NAFLD activity score

2022

Journal Article

Complexity of ballooned hepatocyte feature recognition: defining a training atlas for artificial intelligence-based imaging in NAFLD

Brunt, Elizabeth M., Clouston, Andrew D., Goodman, Zachary, Guy, Cynthia, Kleiner, David E., Lackner, Carolin, Tiniakos, Dina G., Wee, Aileen, Yeh, Matthew, Leow, Wei Qiang, Chng, Elaine, Ren, Yayun, Boon Bee, George Goh, Powell, Elizabeth E., Rinella, Mary, Sanyal, Arun J., Neuschwander-Tetri, Brent, Younossi, Zobair, Charlton, Michael, Ratziu, Vlad, Harrison, Stephen A., Tai, Dean and Anstee, Quentin M. (2022). Complexity of ballooned hepatocyte feature recognition: defining a training atlas for artificial intelligence-based imaging in NAFLD. Journal of Hepatology, 76 (5), 1030-1041. doi: 10.1016/j.jhep.2022.01.011

Complexity of ballooned hepatocyte feature recognition: defining a training atlas for artificial intelligence-based imaging in NAFLD

2022

Journal Article

Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group: results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology

Lohse, Ansgar W., Sebode, Marcial, Bhathal, Prithi S., Clouston, Andrew D., Dienes, Hans P., Jain, Dhanpat, Gouw, Annette S. H., Guindi, Maha, Kakar, Sanjay, Kleiner, David E., Krech, Till, Lackner, Carolin, Longerich, Thomas, Saxena, Romil, Terracciano, Luigi, Washington, Kay, Weidemann, Sören, Hübscher, Stefan G. and Tiniakos, Dina (2022). Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group: results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology. Liver International, 42 (5), 1058-1069. doi: 10.1111/liv.15217

Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group: results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology

2022

Journal Article

Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease

Keshvari, Sahar, Genz, Berit, Teakle, Ngari, Caruso, Melanie, Cestari, Michelle F., Patkar, Omkar L., Tse, Brian W. C., Sokolowski, Kamil A., Ebersbach, Hilmar, Jascur, Julia, MacDonald, Kelli P. A., Miller, Gregory, Ramm, Grant A., Pettit, Allison R., Clouston, Andrew D., Powell, Elizabeth E., Hume, David A. and Irvine, Katharine M. (2022). Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Disease Models and Mechanisms, 15 (4) dmm049387, 1-15. doi: 10.1242/dmm.049387

Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease

2022

Journal Article

ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis

Nalkurthi, Christina, Schroder, Wayne A., Melino, Michelle, Irvine, Katharine M., Nyuydzefe, Melanie, Chen, Wei, Liu, Jing, Teng, Michele WL., Hill, Geoffrey R., Bertolino, Patrick, Blazar, Bruce R., Miller, Gregory C., Clouston, Andrew D., Zanin-Zhorov, Alexandra and MacDonald, Kelli PA. (2022). ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis. JHEP Reports, 4 (1) 100386, 1-14. doi: 10.1016/j.jhepr.2021.100386

ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis

2021

Journal Article

Bone marrow regulatory T cells are a unique population, supported by niche-specific cytokines and plasmacytoid dendritic cells, and required for chronic graft-versus-host disease control

Nicholls, Jemma, Cao, Benjamin, Le Texier, Laetitia, Xiong, Laura Yan, Hunter, Christopher R., Llanes, Genesis, Aguliar, Ethan G., Schroder, Wayne A., Phipps, Simon, Lynch, Jason P., Cao, Huimin, Heazlewood, Shen Y., Williams, Brenda, Clouston, Andrew D., Nefzger, Christian M., Polo, Jose M., Nilsson, Susan K., Blazar, Bruce R. and MacDonald, Kelli P. A. (2021). Bone marrow regulatory T cells are a unique population, supported by niche-specific cytokines and plasmacytoid dendritic cells, and required for chronic graft-versus-host disease control. Frontiers in Cell and Developmental Biology, 9 737880, 737880. doi: 10.3389/fcell.2021.737880

Bone marrow regulatory T cells are a unique population, supported by niche-specific cytokines and plasmacytoid dendritic cells, and required for chronic graft-versus-host disease control

2021

Journal Article

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

Henden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey R. (2021). IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease. Blood, 138 (8), 722-737. doi: 10.1182/blood.2020006375

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

2021

Conference Publication

Interferon Lambda Protects Gastrointestinal Stem Cells from Acute Gvhd

Henden, Andrea S., Robb, Renee, Forero, Adriana, Kuns, Rachel D., Ensbey, Kathleen S., Chang, Karshing, Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nic, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey (2021). Interferon Lambda Protects Gastrointestinal Stem Cells from Acute Gvhd. 2021 TCT Meetings of ASTCT and CIBMTR, Online, 8-12 February 2021. Amsterdam, Netherlands: Elsevier. doi: 10.1016/s2666-6367(21)00107-x

Interferon Lambda Protects Gastrointestinal Stem Cells from Acute Gvhd

2020

Journal Article

Randomized, placebo controlled trial of experimental hookworm infection for improving gluten tolerance in celiac disease

Croese, John, Miller, Gregory C., Marquart, Louise, Llewellyn, Stacey, Gupta, Rohit, Becker, Luke, Clouston, Andrew D., Welch, Christine, Sidorenko, Julia, Wallace, Leanne, Visscher, Peter M., Remedios, Matthew L., McCarthy, James S., OʼRourke, Peter, Radford-Smith, Graham, Loukas, Alex, Norrie, Mark, Masson, John W., Gearry, Richard B., Rahman, Tony and Giacomin, Paul R. (2020). Randomized, placebo controlled trial of experimental hookworm infection for improving gluten tolerance in celiac disease. Clinical and Translational Gastroenterology, 11 (12) e00274, 1-11. doi: 10.14309/ctg.0000000000000274

Randomized, placebo controlled trial of experimental hookworm infection for improving gluten tolerance in celiac disease