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2025

Journal Article

Genome of venomous caterpillar Doratifera vulnerans reveals recruitment of immune peptides and their adaptation as pain-inducing toxins

Goudarzi, Mohaddeseh H., Robinson, Samuel D., Cardoso, Fernanda C., Suryamohan, Kushal, Lawrence, Nicole, Eagles, David A., Hoang, Huy N., Vetter, Irina, Fairlie, David P., Seshagiri, Somasekar, King, Glenn F. and Walker, Andrew A. (2025). Genome of venomous caterpillar Doratifera vulnerans reveals recruitment of immune peptides and their adaptation as pain-inducing toxins. Proceedings of the National Academy of Sciences, 122 (49) e2513640122, 1-11. doi: 10.1073/pnas.2513640122

Genome of venomous caterpillar Doratifera vulnerans reveals recruitment of immune peptides and their adaptation as pain-inducing toxins

2025

Journal Article

Venom peptides across Asian and American tarantulas utilize dual pharmacology to target activation and fast inactivation of voltage-gated sodium channels

Nashikwala, Amatulla S., Kotapati, Charan, Eagles, David A., Lewis, Richard J. and Cardoso, Fernanda C. (2025). Venom peptides across Asian and American tarantulas utilize dual pharmacology to target activation and fast inactivation of voltage-gated sodium channels. Toxins, 17 (11) 561, 561. doi: 10.3390/toxins17110561

Venom peptides across Asian and American tarantulas utilize dual pharmacology to target activation and fast inactivation of voltage-gated sodium channels

2024

Journal Article

Secondary structure propensities of the Ebola delta peptide E40 in solution and model membrane environments

Li, Jiayu, Eagles, David A., Tucker, Isaac J., Pereira Schmidt, Anneka C. and Deplazes, Evelyne (2024). Secondary structure propensities of the Ebola delta peptide E40 in solution and model membrane environments. Biophysical Chemistry, 314 107318, 1-9. doi: 10.1016/j.bpc.2024.107318

Secondary structure propensities of the Ebola delta peptide E40 in solution and model membrane environments

2023

Journal Article

Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae)

Walker, Andrew A., Robinson, Samuel D., Merritt, David J., Cardoso, Fernanda C., Goudarzi, Mohaddeseh Hedayati, Mercedes, Raine S., Eagles, David A., Cooper, Paul, Zdenek, Christina N., Fry, Bryan G., Hall, Donald W., Vetter, Irina and King, Glenn F. (2023). Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae). Proceedings of the National Academy of Sciences, 120 (29) e2305871120, e2305871120. doi: 10.1073/pnas.2305871120

Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae)

2023

Journal Article

Venom composition and bioactive RF-amide peptide toxins of the saddleback caterpillar, Acharia stimulea (Lepidoptera: Limacodidae)

Goudarzi, Mohaddeseh H., Eagles, David A., Lim, Junxian, Biggs, Kimberley A., Kotze, Andrew C., Ruffell, Angela P., Fairlie, David P., King, Glenn F. and Walker, Andrew A. (2023). Venom composition and bioactive RF-amide peptide toxins of the saddleback caterpillar, Acharia stimulea (Lepidoptera: Limacodidae). Biochemical Pharmacology, 213 115598, 1-11. doi: 10.1016/j.bcp.2023.115598

Venom composition and bioactive RF-amide peptide toxins of the saddleback caterpillar, Acharia stimulea (Lepidoptera: Limacodidae)

2023

Journal Article

The β3‐subunit modulates the effect of venom peptides ProTx‐II and OD1 on NaV 1.7 gating

Salvage, Samantha C., Rahman, Taufiq, Eagles, David A., Rees, Johanna S., King, Glenn F., Huang, Christopher L‐H. and Jackson, Antony P. (2023). The β3‐subunit modulates the effect of venom peptides ProTx‐II and OD1 on NaV 1.7 gating. Journal of Cellular Physiology, 238 (6), 1354-1367. doi: 10.1002/jcp.31018

The β3‐subunit modulates the effect of venom peptides ProTx‐II and OD1 on NaV 1.7 gating

2022

Journal Article

Cysteine-rich α-conotoxin SII displays novel interactions at the muscle nicotinic acetylcholine receptor

Wilhelm, Patrick, Luna-Ramirez, Karen, Chin, Yanni K.-Y., Dekan, Zoltan, Abraham, Nikita, Tae, Han-Shen, Chow, Chun Yuen, Eagles, David A., King, Glenn F., Lewis, Richard J., Adams, David J. and Alewood, Paul F. (2022). Cysteine-rich α-conotoxin SII displays novel interactions at the muscle nicotinic acetylcholine receptor. ACS Chemical Neuroscience, 13 (8), 1245-1250. doi: 10.1021/acschemneuro.1c00857

Cysteine-rich α-conotoxin SII displays novel interactions at the muscle nicotinic acetylcholine receptor

2022

Journal Article

A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals

Eagles, David A., Saez, Natalie J., Krishnarjuna, Bankala, Bradford, Julia J., Chin, Yanni K.-Y., Starobova, Hana, Mueller, Alexander, Reichelt, Melissa E., Undheim, Eivind A. B., Norton, Raymond S., Thomas, Walter G., Vetter, Irina, King, Glenn F. and Robinson, Samuel D. (2022). A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals. Proceedings of the National Academy of Sciences, 119 (7) e2112630119. doi: 10.1073/pnas.2112630119

A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals

2020

Journal Article

Fifteen years of NaV1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?

Eagles, David A., Chow, Chun Yuen and King, Glenn F. (2020). Fifteen years of NaV1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?. British Journal of Pharmacology, 179 (14) bph.15327, 3592-3611. doi: 10.1111/bph.15327

Fifteen years of NaV1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?