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2025 Journal Article Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulationAntón-Plágaro, Carlos, Chen, Kai-en, Guo, Qian, Liu, Meihan, Evans, Ashley J., Lewis, Philip A., Heesom, Kate J., Wilkinson, Kevin A., Collins, Brett M. and Cullen, Peter J. (2025). Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation. Nature Communications, 16 (1) 6990, 1-23. doi: 10.1038/s41467-025-61802-1 |
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2025 Journal Article Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibitionDaly, James L., Chen, Kai-en, Butkovič, Rebeka, Guo, Qian, Healy, Michael D., Pennink, Eva, Gamble-Strutt, Georgia, Higham, Zara, Moody, Edmund R. R., Lewis, Philip A., Heesom, Kate J., Williams, Tom A., McMillan, Kirsty J., Collins, Brett M. and Cullen, Peter J. (2025). Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibition. Proceedings of the National Academy of Sciences, 122 (27) e2501111122, e2501111122-27. doi: 10.1073/pnas.2501111122 |
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2025 Journal Article Cavin1 binding nanobodies reveal structural flexibility and regulated interactions of the N-terminal coiled-coil domainGao, Ya, Tillu, Vikas A., Wu, Yeping, Rae, James, Hall, Thomas E., Chen, Kai-en, Weeratunga, Saroja, Guo, Qian, Livingstone, Emma, Tham, Wai-Hong, Parton, Robert G. and Collins, Brett M. (2025). Cavin1 binding nanobodies reveal structural flexibility and regulated interactions of the N-terminal coiled-coil domain. Journal of Cell Science, 138 (8) 263756. doi: 10.1242/jcs.263756 |
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2025 Journal Article Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with RetromerChen, Kai-En, Tillu, Vikas A., Gopaldass, Navin, Chowdhury, Sudeshna Roy, Leneva, Natalya, Kovtun, Oleksiy, Ruan, Juanfang, Guo, Qian, Ariotti, Nicholas, Mayer, Andreas and Collins, Brett M. (2025). Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer. Nature Communications, 16 (1) 3568, 3568. doi: 10.1038/s41467-025-58846-8 |
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2024 Journal Article Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27–Retromer complexGuo, Qian, Chen, Kai-en, Gimenez-Andres, Manuel, Jellett, Adam P., Gao, Ya, Simonetti, Boris, Liu, Meihan, Danson, Chris M., Heesom, Kate J., Cullen, Peter J. and Collins, Brett M. (2024). Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27–Retromer complex. Proceedings of the National Academy of Sciences, 121 (33) e2405041121, 1-12. doi: 10.1073/pnas.2405041121 |
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2022 Journal Article SNX27–Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recyclingSimonetti, Boris, Guo, Qian, Giménez-Andrés, Manuel, Chen, Kai-En, Moody, Edmund R. R., Evans, Ashley J., Chandra, Mintu, Danson, Chris M., Williams, Tom A., Collins, Brett M. and Cullen, Peter J. (2022). SNX27–Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling. PLoS Biology, 20 (4) e3001601, e3001601. doi: 10.1371/journal.pbio.3001601 |
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2021 Journal Article De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complexChen, Kai-En, Guo, Qian, Hill, Timothy A., Cui, Yi, Kendall, Amy K., Yang, Zhe, Hall, Ryan J., Healy, Michael D., Sacharz, Joanna, Norwood, Suzanne J., Fonseka, Sachini, Xie, Boyang, Reid, Robert C., Leneva, Natalya, Parton, Robert G., Ghai, Rajesh, Stroud, David A., Fairlie, David P, Suga, Hiroaki, Jackson, Lauren P., Teasdale, Rohan D., Passioura, Toby and Collins, Brett M. (2021). De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex. Science Advances, 7 (49) eabg4007, eabg4007. doi: 10.1126/sciadv.abg4007 |
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2021 Journal Article Community-wide experimental evaluation of the PROSS stability-design methodPeleg, Yoav, Vincentelli, Renaud, Collins, Brett M., Chen, Kai-En, Livingstone, Emma K., Weeratunga, Saroja, Leneva, Natalya, Guo, Qian, Remans, Kim, Perez, Kathryn, Bjerga, Gro E K, Larsen, Øivind, Vaněk, Ondřej, Skořepa, Ondřej, Jacquemin, Sophie, Poterszman, Arnaud, Kjær, Svend, Christodoulou, Evangelos, Albeck, Shira, Dym, Orly, Ainbinder, Elena, Unger, Tamar, Schuetz, Anja, Matthes, Susann, Bader, Michael, de Marco, Ario, Storici, Paola, Semrau, Marta S., Stolt-Bergner, Peggy ... Fleishman, Sarel J. (2021). Community-wide experimental evaluation of the PROSS stability-design method. Journal of Molecular Biology, 433 (13) 166964, 166964. doi: 10.1016/j.jmb.2021.166964 |
