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2025 Journal Article Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulationAntón-Plágaro, Carlos, Chen, Kai-en, Guo, Qian, Liu, Meihan, Evans, Ashley J., Lewis, Philip A., Heesom, Kate J., Wilkinson, Kevin A., Collins, Brett M. and Cullen, Peter J. (2025). Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation. Nature Communications, 16 (1) 6990, 1-23. doi: 10.1038/s41467-025-61802-1 |
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2025 Journal Article Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibitionDaly, James L., Chen, Kai-en, Butkovič, Rebeka, Guo, Qian, Healy, Michael D., Pennink, Eva, Gamble-Strutt, Georgia, Higham, Zara, Moody, Edmund R. R., Lewis, Philip A., Heesom, Kate J., Williams, Tom A., McMillan, Kirsty J., Collins, Brett M. and Cullen, Peter J. (2025). Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibition. Proceedings of the National Academy of Sciences, 122 (27) e2501111122, e2501111122-27. doi: 10.1073/pnas.2501111122 |
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2025 Journal Article Cavin1 binding nanobodies reveal structural flexibility and regulated interactions of the N-terminal coiled-coil domainGao, Ya, Tillu, Vikas A., Wu, Yeping, Rae, James, Hall, Thomas E., Chen, Kai-en, Weeratunga, Saroja, Guo, Qian, Livingstone, Emma, Tham, Wai-Hong, Parton, Robert G. and Collins, Brett M. (2025). Cavin1 binding nanobodies reveal structural flexibility and regulated interactions of the N-terminal coiled-coil domain. Journal of Cell Science, 138 (8) 263756. doi: 10.1242/jcs.263756 |
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2025 Journal Article Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with RetromerChen, Kai-En, Tillu, Vikas A., Gopaldass, Navin, Chowdhury, Sudeshna Roy, Leneva, Natalya, Kovtun, Oleksiy, Ruan, Juanfang, Guo, Qian, Ariotti, Nicholas, Mayer, Andreas and Collins, Brett M. (2025). Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer. Nature Communications, 16 (1) 3568, 3568. doi: 10.1038/s41467-025-58846-8 |
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2024 Journal Article Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27–Retromer complexGuo, Qian, Chen, Kai-en, Gimenez-Andres, Manuel, Jellett, Adam P., Gao, Ya, Simonetti, Boris, Liu, Meihan, Danson, Chris M., Heesom, Kate J., Cullen, Peter J. and Collins, Brett M. (2024). Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27–Retromer complex. Proceedings of the National Academy of Sciences, 121 (33) e2405041121, 1-12. doi: 10.1073/pnas.2405041121 |
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2023 Other Outputs Structural characterisation of endosomal trafficking protein sorting nexin 27Guo, Qian (2023). Structural characterisation of endosomal trafficking protein sorting nexin 27. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/f0f0d72 |
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2023 Conference Publication Discovery and structural characterization of novel nanobodies targeting the Cavin1 complex essential for forming caveola membrane vesiclesGao, Ya, Tillu, Vikas A., Wu, Yeping, Rae, James, Hall, Thomas E., Chen, Kai-En, Weeratunga, Saroja, Guo, Qian, Parton, Robert G. and Collins, Brett M. (2023). Discovery and structural characterization of novel nanobodies targeting the Cavin1 complex essential for forming caveola membrane vesicles. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323086825 |
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2023 Conference Publication Structural basis for coupling of the WASH subunit Fam21 with the SNX27–retromer endosomal trafficking complexGuo, Qian, Chen, Kai-En, Simonetti, Boris, Gimenez-Andres, Manuel, Cullen, Peter J. and Collins, Brett M. (2023). Structural basis for coupling of the WASH subunit Fam21 with the SNX27–retromer endosomal trafficking complex. XXVI IUCr Congress, Melbourne, VIC, Australia, 22-29 August 2023. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1107/s2053273323086837 |
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2023 Conference Publication Discovery and structural characterization of novel nanobodies targeting the Cavin1 complex essential for forming caveola membrane vesiclesGao, Ya, Tillu, Vikas A., Wu, Yeping, Rae, James, Hall, Thomas E., Chen, Kai-en, Weeratunga, Saroja, Guo, Qian, Parton, Robert G. and Collins, Brett M. (2023). Discovery and structural characterization of novel nanobodies targeting the Cavin1 complex essential for forming caveola membrane vesicles. XXVI IUCr Congress, Melbourne, VIC, Australia, 22-29 August 2023. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1107/S2053273323086825 |
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2022 Journal Article SNX27–Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recyclingSimonetti, Boris, Guo, Qian, Giménez-Andrés, Manuel, Chen, Kai-En, Moody, Edmund R. R., Evans, Ashley J., Chandra, Mintu, Danson, Chris M., Williams, Tom A., Collins, Brett M. and Cullen, Peter J. (2022). SNX27–Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling. PLoS Biology, 20 (4) e3001601, e3001601. doi: 10.1371/journal.pbio.3001601 |
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2021 Journal Article De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complexChen, Kai-En, Guo, Qian, Hill, Timothy A., Cui, Yi, Kendall, Amy K., Yang, Zhe, Hall, Ryan J., Healy, Michael D., Sacharz, Joanna, Norwood, Suzanne J., Fonseka, Sachini, Xie, Boyang, Reid, Robert C., Leneva, Natalya, Parton, Robert G., Ghai, Rajesh, Stroud, David A., Fairlie, David P, Suga, Hiroaki, Jackson, Lauren P., Teasdale, Rohan D., Passioura, Toby and Collins, Brett M. (2021). De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex. Science Advances, 7 (49) eabg4007, eabg4007. doi: 10.1126/sciadv.abg4007 |
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2021 Journal Article Community-wide experimental evaluation of the PROSS stability-design methodPeleg, Yoav, Vincentelli, Renaud, Collins, Brett M., Chen, Kai-En, Livingstone, Emma K., Weeratunga, Saroja, Leneva, Natalya, Guo, Qian, Remans, Kim, Perez, Kathryn, Bjerga, Gro E K, Larsen, Øivind, Vaněk, Ondřej, Skořepa, Ondřej, Jacquemin, Sophie, Poterszman, Arnaud, Kjær, Svend, Christodoulou, Evangelos, Albeck, Shira, Dym, Orly, Ainbinder, Elena, Unger, Tamar, Schuetz, Anja, Matthes, Susann, Bader, Michael, de Marco, Ario, Storici, Paola, Semrau, Marta S., Stolt-Bergner, Peggy ... Fleishman, Sarel J. (2021). Community-wide experimental evaluation of the PROSS stability-design method. Journal of Molecular Biology, 433 (13) 166964, 166964. doi: 10.1016/j.jmb.2021.166964 |
