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2022 Journal Article Synthesis of obtusifoliol and analogues as CYP51 substratesChurchman, Luke R., Salisbury, Lauren J. and De Voss, James J. (2022). Synthesis of obtusifoliol and analogues as CYP51 substrates. Organic and Biomolecular Chemistry, 20 (36), 7316-7324. doi: 10.1039/d2ob01307j |
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2022 Journal Article The structures of the steroid binding CYP142 cytochrome P450 enzymes from Mycobacterium ulcerans and Mycobacterium marinumGhith, Amna, Doherty, Daniel Z., Bruning, John B., Russell, Robert A., De Voss, James J. and Bell, Stephen G. (2022). The structures of the steroid binding CYP142 cytochrome P450 enzymes from Mycobacterium ulcerans and Mycobacterium marinum. ACS Infectious Diseases, 8 (8), 1606-1617. doi: 10.1021/acsinfecdis.2c00215 |
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2022 Journal Article The cytochrome P450 OxyA from the kistamicin biosynthesis cyclization cascade is highly sensitive to oxidative damageGreule, Anja, Izoré, Thierry, Machell, Daniel, Hansen, Mathias H., Schoppet, Melanie, De Voss, James J., Charkoudian, Louise K., Schittenhelm, Ralf B., Harmer, Jeffrey R. and Cryle, Max J. (2022). The cytochrome P450 OxyA from the kistamicin biosynthesis cyclization cascade is highly sensitive to oxidative damage. Frontiers in Chemistry, 10 868240, 868240. doi: 10.3389/fchem.2022.868240 |
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2022 Journal Article Different geometric requirements for cytochrome P450-catalyzed aliphatic versus aromatic hydroxylation results in chemoselective oxidationColeman, Tom, Kirk, Alicia M., Lee, Joel H. Z., Doherty, Daniel Z., Bruning, John B., Krenske, Elizabeth H., De Voss, James J. and Bell, Stephen G. (2022). Different geometric requirements for cytochrome P450-catalyzed aliphatic versus aromatic hydroxylation results in chemoselective oxidation. ACS Catalysis, 12 (2), 1258-1267. doi: 10.1021/acscatal.1c05483 |
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2022 Journal Article To be, or not to be, an inhibitor: a comparison of Azole interactions with and oxidation by a cytochrome P450 enzymePodgorski, Matthew N., Coleman, Tom, Giang, Peter D., Wang, C. Ruth, Bruning, John B., Bernhardt, Paul V., De Voss, James J. and Bell, Stephen G. (2022). To be, or not to be, an inhibitor: a comparison of Azole interactions with and oxidation by a cytochrome P450 enzyme. Inorganic Chemistry, 61 (1) acs.inorgchem.1c02786, 236-245. doi: 10.1021/acs.inorgchem.1c02786 |
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2021 Journal Article The stereoselective oxidation of para-substituted benzenes by a cytochrome P450 biocatalystChao, Rebecca R., Lau, Ian C.-K., Coleman, Tom, Churchman, Luke R., Child, Stella A., Lee, Joel H. Z., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2021). The stereoselective oxidation of para-substituted benzenes by a cytochrome P450 biocatalyst. Chemistry - A European Journal, 27 (59), 14765-14777. doi: 10.1002/chem.202102757 |
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2021 Journal Article The inactivation by curcumin-mediated photosensitization of Botrytis cinerea apores isolated from strawberry fruitsHuang, Li, Yong, Ken W. L., Fernando, W. Chrishanthi, Carpinelli de Jesus, Matheus, De Voss, James J., Sultanbawa, Yasmina and Fletcher, Mary T. (2021). The inactivation by curcumin-mediated photosensitization of Botrytis cinerea apores isolated from strawberry fruits. Toxins, 13 (3) 196, 196. doi: 10.3390/toxins13030196 |
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2021 Journal Article Understanding the mechanistic requirements for efficient and stereoselective alkene epoxidation by a cytochrome P450 enzymeColeman, Tom, Kirk, Alicia M., Chao, Rebecca R., Podgorski, Matthew N., Harbort, Joshua S., Churchman, Luke R., Bruning, John B., Bernhardt, Paul V., Harmer, Jeffrey R., Krenske, Elizabeth H., De Voss, James J. and Bell, Stephen G. (2021). Understanding the mechanistic requirements for efficient and stereoselective alkene epoxidation by a cytochrome P450 enzyme. ACS Catalysis, 11 (4), 1995-2010. doi: 10.1021/acscatal.0c04872 |
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2020 Journal Article Caco-2 cell permeability of flavonoids and saponins from Gynostemma pentaphyllum: the immortal herbAhmed, Iftekhar, Leach, David N., Wohlmuth, Hans, De Voss, James J. and Blanchfield, Joanne T. (2020). Caco-2 cell permeability of flavonoids and saponins from Gynostemma pentaphyllum: the immortal herb. ACS Omega, 5 (34) acsomega.0c02180, 21561-21569. doi: 10.1021/acsomega.0c02180 |
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2020 Journal Article A chemoenzymatic approach to the synthesis of glycopeptide antibiotic analoguesTailhades, Julien, Zhao, Yongwei, Ho, Y. T. Candace, Greule, Anja, Ahmed, Iftekhar, Schoppet, Melanie, Kulkarni, Ketav, Goode, Rob J. A., Schittenhelm, Ralf B., De Voss, James J. and Cryle, Max J. (2020). A chemoenzymatic approach to the synthesis of glycopeptide antibiotic analogues. Angewandte Chemie, 132 (27), 10991-10995. doi: 10.1002/ange.202003726 |
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2020 Journal Article Oxygen surrogate systems for supporting human drug-metabolizing cytochrome P450 enzymesStrohmaier, Silja J., De Voss, James J., Jurva, Ulrik, Andersson, Shalini and Gillam, Elizabeth M. J. (2020). Oxygen surrogate systems for supporting human drug-metabolizing cytochrome P450 enzymes. Drug Metabolism and Disposition , 48 (6), 432-437. doi: 10.1124/dmd.120.090555 |
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2020 Journal Article A chemoenzymatic approach to the synthesis of glycopeptide antibiotic analoguesTailhades, Julien, Zhao, Yongwei, Ho, Y. T. Candace, Greule, Anja, Ahmed, Iftekhar, Schoppet, Melanie, Kulkarni, Ketav, Goode, Rob J. A., Schittenhelm, Ralf B., De Voss, James J. and Cryle, Max J. (2020). A chemoenzymatic approach to the synthesis of glycopeptide antibiotic analogues. Angewandte Chemie International Edition, 59 (27) anie.202003726, 10899-10903. doi: 10.1002/anie.202003726 |
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2020 Journal Article Structural insights into the role of the acid-alcohol pair of residues required for dioxygen activation in cytochrome P450 enzymesColeman, Tom, Stok, Jeanette E., Podgorski, Matthew N., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2020). Structural insights into the role of the acid-alcohol pair of residues required for dioxygen activation in cytochrome P450 enzymes. JBIC Journal of Biological Inorganic Chemistry, 25 (4), 583-596. doi: 10.1007/s00775-020-01781-4 |
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2020 Journal Article Biophysical techniques for distinguishing ligand binding modes in cytochrome P450 monooxygenasesPodgorski, Matthew N., Harbort, Joshua S., Coleman, Tom, Stok, Jeanette E., Yorke, Jake A., Wong, Luet-Lok, Bruning, John B., Bernhardt, Paul V., De Voss, James J., Harmer, Jeffrey R. and Bell, Stephen G. (2020). Biophysical techniques for distinguishing ligand binding modes in cytochrome P450 monooxygenases. Biochemistry, 59 (9) acs.biochem.0c00027, 1038-1050. doi: 10.1021/acs.biochem.0c00027 |
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2020 Journal Article An inexpensive, efficient alternative to NADPH to support catalysis by thermostable cytochrome P450 enzymesStrohmaier, Silja J., Baek, Jong Min, De Voss, James J., Jurva, Ulrik, Andersson, Shalini and Gillam, Elizabeth M. J. (2020). An inexpensive, efficient alternative to NADPH to support catalysis by thermostable cytochrome P450 enzymes. ChemCatChem, 12 (6) cctc.201902235, 1750-1761. doi: 10.1002/cctc.201902235 |
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2020 Journal Article Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactionsPodgorski, Matthew N., Coleman, Tom, Chao, Rebecca R., De Voss, James J., Bruning, John B. and Bell, Stephen G. (2020). Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions. Journal of Inorganic Biochemistry, 203 110913, 1-13. doi: 10.1016/j.jinorgbio.2019.110913 |
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2019 Journal Article Rearrangement-free hydroxylation of methylcubanes by a cytochrome P450: the case for dynamical coupling of C–H abstraction and reboundSarkar, Md. Raihan, Houston, Sevan D., Savage, G. Paul, Williams, Craig M., Krenske, Elizabeth H., Bell, Stephen G. and De Voss, James J. (2019). Rearrangement-free hydroxylation of methylcubanes by a cytochrome P450: the case for dynamical coupling of C–H abstraction and rebound. Journal of the American Chemical Society, 141 (50) jacs.9b08064, 19688-19699. doi: 10.1021/jacs.9b08064 |
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2019 Journal Article Exploring the substrate specificity of cytochrome P450cinStok, Jeanette E., Giang, Peter D., Wong, Siew Hoon and De Voss, James J. (2019). Exploring the substrate specificity of cytochrome P450cin. Archives of Biochemistry and Biophysics, 672 108060, 108060. doi: 10.1016/j.abb.2019.07.025 |
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2019 Journal Article The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complementHouston, Sevan D., Fahrenhorst-Jones, Tyler, Xing, Hui, Chalmers, Benjamin A., Sykes, Melissa L., Stok, Jeanette E., Farfan Soto, Clementina, Burns, Jed M., Bernhardt, Paul V., De Voss, James J., Boyle, Glen M., Smith, Maree T., Tsanaktsidis, John, Savage, G. Paul, Avery, Vicky M. and Williams, Craig M. (2019). The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement. Organic and Biomolecular Chemistry, 17 (28), 6790-6798. doi: 10.1039/c9ob01238a |
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2019 Journal Article Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibioticsGreule, Anja, Izoré, Thierry, Iftime, Dumitrita, Tailhades, Julien, Schoppet, Melanie, Zhao, Yongwei, Peschke, Madeleine, Ahmed, Iftekhar, Kulik, Andreas, Adamek, Martina, Goode, Robert J. A., Schittenhelm, Ralf B., Kaczmarski, Joe A., Jackson, Colin J., Ziemert, Nadine, Krenske, Elizabeth H., De Voss, James J., Stegmann, Evi and Cryle, Max J. (2019). Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics. Nature Communications, 10 (1) 2613, 2613. doi: 10.1038/s41467-019-10384-w |
