|
2024 Journal Article Synthesis of steroidal inhibitors for Mycobacterium tuberculosisChurchman, Luke R., Beckett, James R., Tan, Lendl, Woods, Kyra, Doherty, Daniel Z., Ghith, Amna, Bernhardt, Paul V., Bell, Stephen G., West, Nicholas P. and De Voss, James J. (2024). Synthesis of steroidal inhibitors for Mycobacterium tuberculosis. The Journal of Steroid Biochemistry and Molecular Biology, 239 106479, 1-16. doi: 10.1016/j.jsbmb.2024.106479 |
|
2024 Journal Article Engineering peroxygenase activity into cytochrome P450 monooxygenases through modification of the oxygen binding regionPodgorski, Matthew N., Akter, Jinia, Churchman, Luke R., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2024). Engineering peroxygenase activity into cytochrome P450 monooxygenases through modification of the oxygen binding region. ACS Catalysis, 14 (10), 7426-7443. doi: 10.1021/acscatal.4c01326 |
|
2024 Journal Article An engineered biarylitide cross-linking P450 from RiPP biosynthesis generates alternative cyclic peptidesTreisman, Maxine, Coe, Laura, Zhao, Yongwei, Sasi, Vishnu Mini, Gullick, Jemma, Hansen, Mathias H., Ly, Aviva, Leichthammer, Victor, Hess, Caroline, Machell, Daniel L., Schittenhelm, Ralf B., Hooper, Joel, Jackson, Colin J., Tailhades, Julien, De Voss, James J. and Cryle, Max J. (2024). An engineered biarylitide cross-linking P450 from RiPP biosynthesis generates alternative cyclic peptides. Organic Letters, 26 (9), 1828-1833. doi: 10.1021/acs.orglett.3c04366 |
|
2024 Journal Article CYP108N14: a monoterpene monooxygenase from Rhodococcus globerulusGiang, Peter D., Churchman, Luke R., Buczynski, Julia B., Bell, Stephen G., Stok, Jeanette E. and De Voss, James J. (2024). CYP108N14: a monoterpene monooxygenase from Rhodococcus globerulus. Archives of Biochemistry and Biophysics, 752 109852, 1-8. doi: 10.1016/j.abb.2023.109852 |
|
2024 Journal Article Structural insights into a side chain cross-linking Biarylitide P450 from RiPP biosynthesisHansen, Mathias H., Keto, Angus, Treisman, Maxine, Sasi, Vishnu Mini, Coe, Laura, Zhao, Yongwei, Padva, Leo, Hess, Caroline, Leichthammer, Victor, Machell, Daniel L., Schittenhelm, Ralf B., Jackson, Colin J., Tailhades, Julien, Crüsemann, Max, De Voss, James J., Krenske, Elizabeth H. and Cryle, Max J. (2024). Structural insights into a side chain cross-linking Biarylitide P450 from RiPP biosynthesis. ACS Catalysis, 14 (2), 812-826. doi: 10.1021/acscatal.3c05417 |
|
2023 Journal Article Synthesis of substituted norcaranes for use as probes of enzyme mechanismsChurchman, Luke R., Giang, Peter D., Buczynski, Julia B., Stok, Jeanette E., Bell, Stephen G. and De Voss, James J. (2023). Synthesis of substituted norcaranes for use as probes of enzyme mechanisms. Organic and Biomolecular Chemistry, 21 (48), 9647-9658. doi: 10.1039/d3ob01571h |
|
2023 Journal Article Differentiating dyes: A Spectroscopic investigation into the composition of scarlet bloodroot (Haemodorum coccineum R.Br.) rhizomeCarpinelli de Jesus, Matheus, Church, Taylah, Wapling, Johanna A., Collins, Raelene, Leach, Gregory J., Leach, David, De Voss, James J. and Blanchfield, Joanne T. (2023). Differentiating dyes: A Spectroscopic investigation into the composition of scarlet bloodroot (Haemodorum coccineum R.Br.) rhizome. Molecules, 28 (21) 7422, 1-14. doi: 10.3390/molecules28217422 |
|
2023 Journal Article Efficient biocatalytic C–H bond oxidation: an engineered heme-thiolate peroxygenase from a thermostable cytochrome P450Gee, Alecia R., Stone, Isobella S. J., Stockdale, Tegan P., Pukala, Tara L., De Voss, James J. and Bell, Stephen G. (2023). Efficient biocatalytic C–H bond oxidation: an engineered heme-thiolate peroxygenase from a thermostable cytochrome P450. Chemical Communications, 59 (90), 13486-13489. doi: 10.1039/d3cc04626e |
|
2023 Journal Article The oxidation of oxygen and sulfur‐containing heterocycles by cytochrome P450 enzymesPodgorski, Matthew N, Keto, Angus B, Coleman, Tom, Bruning, John B, De Voss, James J, Krenske, Elizabeth H and Bell, Stephen Graham (2023). The oxidation of oxygen and sulfur‐containing heterocycles by cytochrome P450 enzymes. Chemistry – A European Journal, 29 (50) e202301371, e202301371. doi: 10.1002/chem.202301371 |
|
2023 Journal Article Cytochrome P450-catalyzed oxidation of halogen-containing substratesColeman, Tom, Podgorski, Matthew N., Doyle, Maya L., Scaffidi-Muta, Jarred M., Campbell, Eleanor C., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2023). Cytochrome P450-catalyzed oxidation of halogen-containing substrates. Journal of Inorganic Biochemistry, 244 112234, 1-12. doi: 10.1016/j.jinorgbio.2023.112234 |
|
2023 Journal Article Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenaseAkter, Jinia, Stockdale, Tegan P., Child, Stella A., Lee, Joel H. Z., De Voss, James J. and Bell, Stephen G. (2023). Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenase. Journal of Inorganic Biochemistry, 244 112209, 1-9. doi: 10.1016/j.jinorgbio.2023.112209 |
|
2023 Journal Article The bacterial cytochrome P450 (CYP) CYP125 enzymes can competitively oxidise sitosterol in the presence of cholesterolDoherty, Daniel Z., Ghith, Amna, Ho, Ava, De Voss, James J. and Bell, Stephen G. (2023). The bacterial cytochrome P450 (CYP) CYP125 enzymes can competitively oxidise sitosterol in the presence of cholesterol. Chemical Communications, 59 (61), 9392-9395. doi: 10.1039/d3cc02312e |
|
2023 Journal Article Characterization of the cholesterol biosynthetic pathway in Dioscorea transversaSalisbury, Lauren J., Fletcher, Stephen J., Stok, Jeanette E., Churchman, Luke R., Blanchfield, Joanne T. and De Voss, James J. (2023). Characterization of the cholesterol biosynthetic pathway in Dioscorea transversa. Journal of Biological Chemistry, 299 (6) 104768, 1-16. doi: 10.1016/j.jbc.2023.104768 |
|
2023 Journal Article Engineering C–C bond cleavage activity into a P450 monooxygenase enzymeMiller, Justin C., Lee, Joel H. Z., Mclean, Mark A., Chao, Rebecca R., Stone, Isobella S. J., Pukala, Tara L., Bruning, John B., De Voss, James J., Schuler, Mary A., Sligar, Stephen G. and Bell, Stephen G. (2023). Engineering C–C bond cleavage activity into a P450 monooxygenase enzyme. Journal of the American Chemical Society, 145 (16), 9207-9222. doi: 10.1021/jacs.3c01456 |
|
2023 Journal Article Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteriaMu, Andre, Klare, William P., Baines, Sarah L., Ignatius Pang, C. N., Guérillot, Romain, Harbison-Price, Nichaela, Keller, Nadia, Wilksch, Jonathan, Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Keller, Bernhard, Nijagal, Brunda, Tull, Dedreia, Dayalan, Saravanan, Chua, Hwa Huat Charlie, Skoneczny, Dominik, Koval, Jason, Hachani, Abderrahman, Shah, Anup D., Neha, Nitika, Jadhav, Snehal, Partridge, Sally R., Cork, Amanda J., Peters, Kate, Bertolla, Olivia, Brouwer, Stephan, Hancock, Steven J., Álvarez-Fraga, Laura, De Oliveira, David M. P. ... Walker, Mark J. (2023). Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nature Communications, 14 (1) 1530, 1-21. doi: 10.1038/s41467-023-37200-w |
|
2023 Journal Article Cymredoxin, a [2Fe–2S] ferredoxin, supports catalytic activity of the p-cymene oxidising P450 enzyme CYP108N12Giang, Peter D., Churchman, Luke R., Stok, Jeanette E., Bell, Stephen G. and De Voss, James J. (2023). Cymredoxin, a [2Fe–2S] ferredoxin, supports catalytic activity of the p-cymene oxidising P450 enzyme CYP108N12. Archives of Biochemistry and Biophysics, 737 109549, 109549. doi: 10.1016/j.abb.2023.109549 |
|
2022 Journal Article Investigating the active oxidants involved in cytochrome P450 catalyzed sulfoxidation reactionsPodgorski, Matthew N., Coleman, Tom, Churchman, Luke R., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2022). Investigating the active oxidants involved in cytochrome P450 catalyzed sulfoxidation reactions. Chemistry: A European Journal, 28 (72) e202202428, 1-12. doi: 10.1002/chem.202202428 |
|
2022 Journal Article Exploring the factors which result in cytochrome P450 catalyzed desaturation versus hydroxylationColeman, Tom, Doherty, Daniel Z., Zhang, Ting, Podgorski, Matthew N., Qiao, Ruihong, Lee, Joel H. Z., Bruning, John B., De Voss, James J., Zhou, Weihong and Bell, Stephen G. (2022). Exploring the factors which result in cytochrome P450 catalyzed desaturation versus hydroxylation. Chemistry - An Asian Journal, 17 (24) e202200986, 1-14. doi: 10.1002/asia.202200986 |
|
2022 Journal Article Enabling aromatic hydroxylation in a cytochrome P450 monooxygenase rnzyme through protein engineeringColeman, Tom, Lee, Joel, Kirk, Alicia M, Doherty, Daniel Z, Podgorski, Matthew N, Pinidiya, Dilshi K, Bruning, John B, De Voss, James J, Krenske, Elizabeth H and Bell, Stephen Graham (2022). Enabling aromatic hydroxylation in a cytochrome P450 monooxygenase rnzyme through protein engineering. Chemistry: A European Journal, 28 (67) e202201895, 1-14. doi: 10.1002/chem.202201895 |
|
2022 Journal Article CYP108N12 initiates p-cymene biodegradation in Rhodococcus globerulusGiang, Peter D., Churchman, Luke R., Stok, Jeanette E., Soo, Rochelle M. and De Voss, James J. (2022). CYP108N12 initiates p-cymene biodegradation in Rhodococcus globerulus. Archives of Biochemistry and Biophysics, 730 109410, 109410. doi: 10.1016/j.abb.2022.109410 |
