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2013 Journal Article Acetohydroxyacid synthase: A target for antimicrobial drug discoveryPue, Nason and Guddat, Luke W. (2013). Acetohydroxyacid synthase: A target for antimicrobial drug discovery. Current Pharmaceutical Design, 19 (5), 1-17. doi: 10.2174/13816128113199990009 |
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2013 Journal Article Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activityKeough, Dianne T., Špaček, Petr, Hocková, Dana, Tichý, Tomáš, Vrbková, Silvie, Slavětínská, Lenka, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina, Wang, Tzu-Hsuan, de Jersey, John and Guddat, Luke W. (2013). Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. Journal of Medicinal Chemistry, 56 (6), 2513-2526. doi: 10.1021/jm301893b |
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2013 Journal Article Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthaseLee, Yu-Ting, Cui, Chang-Jun, Chow, Eve W. L., Pue, Nason, Lonhienne, Thierry, Wang, Jian-Guo, Fraser, James A. and Guddat, Luke W. (2013). Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. Journal of Medicinal Chemistry, 56 (1), 210-219. doi: 10.1021/jm301501k |
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2013 Journal Article The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snakeMillers, Emma-Karin I., Johnson, Lambro A., Birrell, Geoff W., Masci, Paul P., Lavin, Martin F., de Jersey, John and Guddat, Luke W. (2013). The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake. PLoS One, 8 (1) e54104, e54104.1-e54104.12. doi: 10.1371/journal.pone.0054104 |
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2012 Journal Article Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeuticsFeder, Daniel, Hussein, Waleed M., Clayton, Daniel J., Kan, Meng-Wei, Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke W. (2012). Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chemical Biology and Drug Design, 80 (5), 665-674. doi: 10.1111/cbdd.12001 |
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2012 Journal Article Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycleWong, Sze-Ho, Lonhienne, Thierry G. A., Winzor, Donald J., Schenk, Gerhard and Guddat, Luke W. (2012). Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. Journal of Molecular Biology, 424 (3-4), 168-179. doi: 10.1016/j.jmb.2012.09.018 |
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2012 Journal Article Binuclear metallohydrolases: Complex mechanistic strategies for a simple chemical reactionSchenk, Gerhard, Mitić, Nataša, Gahan, Lawrence R., Ollis, David L., McGeary, Ross P. and Guddat, Luke W. (2012). Binuclear metallohydrolases: Complex mechanistic strategies for a simple chemical reaction. Accounts of Chemical Research, 45 (9), 1593-1603. doi: 10.1021/ar300067g |
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2012 Journal Article A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factorsLiu, Ligong, Li, Caiping, Cochran, Siska, Feder, Daniel, Guddat, Luke W. and Ferro, Vito (2012). A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors. Bioorganic & Medicinal Chemistry Letters, 22 (19), 6190-6194. doi: 10.1016/j.bmcl.2012.08.001 |
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2012 Journal Article Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, plasmodium falciparum and plasmodium vivax 6-oxopurine phosphoribosyltransferasesHockova, Dana, Keough, Dianne T., Janeba, Zlatko, Wang, Tzu-Hsuan, de Jersey, John and Guddat, Luke W. (2012). Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, plasmodium falciparum and plasmodium vivax 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry, 55 (13), 6209-6223. doi: 10.1021/jm300662d |
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2012 Journal Article Penicillin inhibitors of purple acid phosphataseFaridoon, Hussein, Waleed M., Islam, Nazar Ul, Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2012). Penicillin inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 22 (7), 2555-2559. doi: 10.1016/j.bmcl.2012.01.123 |
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2012 Journal Article The structure-activity relationship in herbicidal monosubstituted sulfonylureasLi, Zheng-Ming, Ma, Yi, Guddat, Luke, Cheng, Pei-Quan, Wang, Jian-Guo, Pangi, Siew S., Dong, Yu-Hui, Lai, Cheng-Ming, Wang, Ling-Xiu, Jia, Guo-Feng, Li, Yong-Hong, Wang, Su-Hua, Liu, Jie, Zhao, Wei-Guang and Wang, Bao Lei (2012). The structure-activity relationship in herbicidal monosubstituted sulfonylureas. Pest Management Science, 68 (4), 618-628. doi: 10.1002/ps.2305 |
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2012 Journal Article Synthesis of purine N-9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agentsKrecmerova, Marcela, Dracinsky, Martin, Hockova, Dana, Holy, Antonín, Keough, Dianne T. and Guddat, Luke W. (2012). Synthesis of purine N-9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. Bioorganic and Medicinal Chemistry, 20 (3), 1222-1230. doi: 10.1016/j.bmc.2011.12.034 |
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2012 Journal Article Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacterEly, Fernanda, Pedroso, Marcelo M., Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2012). Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter. Journal of Inorganic Biochemistry, 106 (1), 19-22. doi: 10.1016/j.jinorgbio.2011.09.015 |
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2011 Journal Article Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferasesCesnek, Michael, Hockova, Dana, Holy, Antonín, Dracinsky, Martin, Baszczynski, Ondřej, de Jersey, John, Keough, Dianne T. and Guddat, Luke W. (2011). Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorganic and Medicinal Chemistry, 20 (2), 1076-1089. doi: 10.1016/j.bmc.2011.11.034 |
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2011 Journal Article Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivativesWang, Jianguo, Tan, Haizhong, Li, Yonghong, Ma, Yi, Li, Zhengming and Guddat, Luke W. (2011). Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives. Journal of Agricultural and Food Chemistry, 59 (18), 9892-9900. doi: 10.1021/jf2021607 |
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2011 Journal Article 6-Oxopurine phosphoribosyltransferase: A target for the development of antimalarial drugsde Jersey, John, Holý, Antonín, Hocková, Dana, Naesens, Lieve, Keough, Dianne T. and Guddat, Luke W. (2011). 6-Oxopurine phosphoribosyltransferase: A target for the development of antimalarial drugs. Current Topics in Medicinal Chemistry, 11 (16), 2085-2102. doi: 10.2174/156802611796575911 |
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2011 Journal Article Drug targets for the treatment of protozoan parasitic diseasesGuddat, L (2011). Drug targets for the treatment of protozoan parasitic diseases. Current Topics in Medicinal Chemistry, 11 (16), 2010-2011. doi: 10.2174/156802611796575920 |
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2010 Journal Article Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapyKeough, Dianne T., Hockova, Daná, Krečmerová, Marcela, Česnek, Michal, Holý, Antonín, Naesens, Lieve, Brereton, Ian M., Winzor, Donald J., de Jersey, John and Guddat, Luke W. (2010). Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy. Molecular and Biochemical Parasitology, 173 (2), 165-169. doi: 10.1016/j.molbiopara.2010.05.018 |
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2010 Journal Article The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysisEly, Fernanda, Hadler, Kieran S., Gahan, Lawrence R., Guddat, Luke W., Ollis, David L. and Schenk, Gerhard (2010). The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis. Biochemical Journal, 432 (3), 565-573. doi: 10.1042/BJ20101054 |
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2009 Journal Article Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferaseHockova, Dana, Holy, Antonín, Masojidkova, Milena, Keough, Dianne T., de Jersey, John and Guddat, Luke W. (2009). Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorganic & Medicinal Chemistry, 17 (17), 6218-6232. doi: 10.1016/j.bmc.2009.07.044 |
