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2024 Journal Article Structure, dynamics and evolution of the Candida albicans multi-drug resistance ABC transporter CDR1Shin, Jeeeun, Jin, Ruitao, Gall, Barnabas, Jobichen, Chacko, Jackson, Colin, Rug, Melanie, Corry, Ben and Brock, Joseph (2024). Structure, dynamics and evolution of the Candida albicans multi-drug resistance ABC transporter CDR1. doi: 10.1101/2024.10.28.620768 |
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2024 Journal Article Structural transitions in kinesin minus-end directed microtubule motilityShibata, Satoki, Wang, Matthew Y., Imasaki, Tsuyoshi, Shigematsu, Hideki, Wei, Yuanyuan, Jobichen, Chacko, Hagio, Hajime, Sivaraman, J., Endow, Sharyn A. and Nitta, Ryo (2024). Structural transitions in kinesin minus-end directed microtubule motility. |
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2024 Journal Article Sensing for survival: specialised regulatory mechanisms of Type III secretion systems in Gram-negative pathogensManisha, Yadav, Srinivasan, Mahalashmi, Jobichen, Chacko, Rosenshine, Ilan and Sivaraman, J. (2024). Sensing for survival: specialised regulatory mechanisms of Type III secretion systems in Gram-negative pathogens. Biological Reviews, 99 (3), 837-863. doi: 10.1111/brv.13047 |
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2023 Journal Article Bacterioferritin nanocage structures uncover the biomineralization process in ferritinsJobichen, Chacko, Chong, Tan Ying, Rattinam, Rajesh, Basak, Sandip, Srinivasan, Mahalashmi, Choong, Yeu Khai, Pandey, Kannu Priya, Tran Bich Ngoc,, Shi, Jian, Angayarkanni, Jayaraman and Sivaraman, J. (2023). Bacterioferritin nanocage structures uncover the biomineralization process in ferritins. PNAS Nexus, 2 (7) pgad235, pgad235. doi: 10.1093/pnasnexus/pgad235 |
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2023 Journal Article Structural understanding of fungal terpene synthases for the formation of linear or cyclic terpene productsRehka, T., Sharma, Deepti, Lin, Fu, Choong, Yeu Khai, Lim, Chinchin, Jobichen, Chacko and Zhang, Congqiang (2023). Structural understanding of fungal terpene synthases for the formation of linear or cyclic terpene products. ACS Catalysis, 13 (7), 4949-4959. doi: 10.1021/acscatal.2c05598 |
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2023 Journal Article Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavageLi, Jianwei, Jobichen, Chacko, Machida, Satoru, Meng, Sun, Read, Randy J., Chen, Hongying, Jian, Shi, Yuan, Yuren Adam and Sivaraman, J. (2023). Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage. Plos Biology, 21 (3) e3002023, e3002023. doi: 10.1371/journal.pbio.3002023 |
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2022 Journal Article A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminaseShankar, Srihari, Ramachandran, Sarath, Tulsian, Nikhil, Radhakrishnan, Sridhar, Jobichen, Chacko and Sivaraman, J. (2022). A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminase. The FEBS Journal, 290 (9), 2437-2448. doi: 10.1111/febs.16658 |
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2022 Book Chapter Proteases as therapeutic targets: a structural biology perspectiveChoong, Yeu Khai, Srinivasan, Mahalashmi and Jobichen, Chacko (2022). Proteases as therapeutic targets: a structural biology perspective. Therapeutic protein targets for drug discovery and clinical evaluation: bio-crystallography and drug design. (pp. 103-121) edited by Velmurugan, D, Bhattacharjee, Atanu and Gayath, D. Singapore: World Scientific Publishing Co.. doi: 10.1142/9789811254796_0005 |
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2022 Journal Article Structural and functional insights into fungal glutaminase using a computational approachAmobonye, Ayodeji, Singh, Samayaditya, Mukherjee, Koel, Jobichen, Chacko, Qureshi, Insaf Ahmed and Pillai, Santhosh (2022). Structural and functional insights into fungal glutaminase using a computational approach. Process Biochemistry, 117, 76-89. doi: 10.1016/j.procbio.2022.03.019 |
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2022 Journal Article Bacterial antagonism of Chromobacterium haemolyticum and characterization of its putative type VI secretion systemZwe, Ye Htut, Yadav, Manisha, Ten, Michelle Mei Zhen, Srinivasan, Mahalashmi, Jobichen, Chacko, Sivaraman, J. and Li, Dan (2022). Bacterial antagonism of Chromobacterium haemolyticum and characterization of its putative type VI secretion system. Research in Microbiology, 173 (3) 103918, 103918. doi: 10.1016/j.resmic.2021.103918 |
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2021 Journal Article Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanismGavor, Edem, Choong, Yeu Khai, Jobichen, Chacko, Mok, Yu Keung, Kini, R. Manjunatha and Sivaraman, J. (2021). Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism. Protein Science, 30 (12), 2445-2456. doi: 10.1002/pro.4212 |
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2021 Journal Article Crystal structure of Aedes aegypti trypsin inhibitor in complex with μ-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitorWalvekar, Varsha Ashok, Ramesh, Karthik, Jobichen, Chacko, Kannan, Muthu, Sivaraman, J., Kini, R. Manjunatha and Mok, Yu Keung (2021). Crystal structure of Aedes aegypti trypsin inhibitor in complex with μ-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor. Protein Science, 31 (2), 470-484. doi: 10.1002/pro.4245 |
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2021 Journal Article Structural and mechanistic insight into stem-loop RNA processing by yeast Pichia stipitis DicerChan, JingRu, Qinqin, Fu, Jianwei, Li, Ying, Chen, Machida, Satoru, Wei, Chen, Yuan, Yuren Adam and Jobichen, Chacko (2021). Structural and mechanistic insight into stem-loop RNA processing by yeast Pichia stipitis Dicer. Protein Science, 30 (6), 1210-1220. doi: 10.1002/pro.4086 |
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2021 Journal Article Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivationChichili, Vishnu Priyanka Reddy, Chew, Ti Weng, Shankar, Srihari, Er, Shi Yin, Chin, Cheen Fei, Jobichen, Chacko, Pan, Catherine Qiurong, Zhou, Yiting, Yeong, Foong May, Low, Boon Chuan and Sivaraman, J. (2021). Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation. National Academy of Sciences. Proceedings, 118 (21) e2014242118, 1-12. doi: 10.1073/pnas.2014242118 |
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2021 Journal Article The autocatalytic cleavage domain is not required for the activity of scpc, a virulence protease from streptococcus pyogenes: a structural insightJobichen, Chacko, Chong, Tan Ying, Ling, Tai Hui and Sivaraman, J. (2021). The autocatalytic cleavage domain is not required for the activity of scpc, a virulence protease from streptococcus pyogenes: a structural insight. Biochemistry, 60 (19), 1564-1568. doi: 10.1021/acs.biochem.1c00185 |
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2020 Journal Article Unusual quaternary structure of a homodimeric synergistic-type toxin from mamba snake venom defines its molecular evolutionAoki-Shioi, Narumi, Jobichen, Chacko, Sivaraman, J. and Kini, R. Manjunatha (2020). Unusual quaternary structure of a homodimeric synergistic-type toxin from mamba snake venom defines its molecular evolution. Biochemical Journal, 477 (20), 3951-3962. doi: 10.1042/BCJ20200529 |
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2020 Journal Article Structural basis for the inhibition mechanism of ecotin against neutrophil elastase by targeting the active site and secondary binding siteJobichen, Chacko, Prabhakar, Mahalakshmi Tirumuru, Loh, Su Ning and Sivaraman, J. (2020). Structural basis for the inhibition mechanism of ecotin against neutrophil elastase by targeting the active site and secondary binding site. Biochemistry, 59 (30), 2788-2795. doi: 10.1021/acs.biochem.0c00493 |
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2020 Journal Article SYNCRIP, a new player in pri-let-7a processingChen, Ying, Chan, Jingru, Chen, Wei, Li, Jianwei, Sun, Meng, Kannan, Gayathiri Sathyamoorthy, Mok, Yu-Keung, Yuan, Yuren Adam and Jobichen, Chacko (2020). SYNCRIP, a new player in pri-let-7a processing. RNA, 26 (3), 290-305. doi: 10.1261/rna.072959.119 |
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2020 Journal Article AtFKBP53: a chimeric histone chaperone with functional nucleoplasmin and PPIase domainsSingh, Ajit Kumar, Datta, Aritreyee, Jobichen, Chacko, Luan, Sheng and Vasudevan, Dileep (2020). AtFKBP53: a chimeric histone chaperone with functional nucleoplasmin and PPIase domains. Nucleic Acids Research, 48 (3), 1531-1550. doi: 10.1093/nar/gkz1153 |
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2020 Journal Article Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptorsFoo, Chun Shin, Jobichen, Chacko, Hassan-Puttaswamy, Varuna, Dekan, Zoltan, Tae, Han-Shen, Bertrand, Daniel, Adams, David J., Alewood, Paul F., Sivaraman, J., Nirthanan, Selvanayagam and Kini, R. Manjunatha (2020). Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors. British Journal of Pharmacology, 177 (8), 1822-1840. doi: 10.1111/bph.14954 |
