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2021 Journal Article The autocatalytic cleavage domain is not required for the activity of scpc, a virulence protease from streptococcus pyogenes: a structural insightJobichen, Chacko, Chong, Tan Ying, Ling, Tai Hui and Sivaraman, J. (2021). The autocatalytic cleavage domain is not required for the activity of scpc, a virulence protease from streptococcus pyogenes: a structural insight. Biochemistry, 60 (19), 1564-1568. doi: 10.1021/acs.biochem.1c00185 |
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2020 Journal Article Unusual quaternary structure of a homodimeric synergistic-type toxin from mamba snake venom defines its molecular evolutionAoki-Shioi, Narumi, Jobichen, Chacko, Sivaraman, J. and Kini, R. Manjunatha (2020). Unusual quaternary structure of a homodimeric synergistic-type toxin from mamba snake venom defines its molecular evolution. Biochemical Journal, 477 (20), 3951-3962. doi: 10.1042/BCJ20200529 |
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2020 Journal Article Structural basis for the inhibition mechanism of ecotin against neutrophil elastase by targeting the active site and secondary binding siteJobichen, Chacko, Prabhakar, Mahalakshmi Tirumuru, Loh, Su Ning and Sivaraman, J. (2020). Structural basis for the inhibition mechanism of ecotin against neutrophil elastase by targeting the active site and secondary binding site. Biochemistry, 59 (30), 2788-2795. doi: 10.1021/acs.biochem.0c00493 |
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2020 Journal Article SYNCRIP, a new player in pri-let-7a processingChen, Ying, Chan, Jingru, Chen, Wei, Li, Jianwei, Sun, Meng, Kannan, Gayathiri Sathyamoorthy, Mok, Yu-Keung, Yuan, Yuren Adam and Jobichen, Chacko (2020). SYNCRIP, a new player in pri-let-7a processing. RNA, 26 (3), 290-305. doi: 10.1261/rna.072959.119 |
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2020 Journal Article AtFKBP53: a chimeric histone chaperone with functional nucleoplasmin and PPIase domainsSingh, Ajit Kumar, Datta, Aritreyee, Jobichen, Chacko, Luan, Sheng and Vasudevan, Dileep (2020). AtFKBP53: a chimeric histone chaperone with functional nucleoplasmin and PPIase domains. Nucleic Acids Research, 48 (3), 1531-1550. doi: 10.1093/nar/gkz1153 |
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2020 Journal Article Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptorsFoo, Chun Shin, Jobichen, Chacko, Hassan-Puttaswamy, Varuna, Dekan, Zoltan, Tae, Han-Shen, Bertrand, Daniel, Adams, David J., Alewood, Paul F., Sivaraman, J., Nirthanan, Selvanayagam and Kini, R. Manjunatha (2020). Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors. British Journal of Pharmacology, 177 (8), 1822-1840. doi: 10.1111/bph.14954 |
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2019 Journal Article Identification of a α-helical molten globule intermediate and structural characterization of β-cardiotoxin, an all β-sheet protein isolated from the venom of Ophiophagus hannah (king cobra)Roy, Amrita, Sun Qingxiang,, Alex, Chapeaurouge, Rajagopalan, Nandhakishore, Jobichen, Chacko, Sivaraman, J. and Kini, R. Manjunatha (2019). Identification of a α-helical molten globule intermediate and structural characterization of β-cardiotoxin, an all β-sheet protein isolated from the venom of Ophiophagus hannah (king cobra). Protein Science, 28 (5), 952-963. doi: 10.1002/pro.3605 |
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2019 Book Chapter Role of plant volatiles, pest-resistant varieties and transgenics in tri-trophic interactionsJobichen, Chacko and Selvanarayanan, V. (2019). Role of plant volatiles, pest-resistant varieties and transgenics in tri-trophic interactions. Experimental techniques in host-plant resistance. (pp. 245-252) edited by Akshay Kumar Chakravarthy and Venkatesan Selvanarayanan. Singapore: Springer. doi: 10.1007/978-981-13-2652-3_25 |
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2018 Journal Article Structural basis for the pathogenesis of Campylobacter jejuni Hcp1, a structural and effector protein of the Type VI Secretion SystemNoreen, Zobia, Jobichen, Chacko, Abbasi, Rashda, Seetharaman, Jayaraman, Sivaraman, J. and Bokhari, Habib (2018). Structural basis for the pathogenesis of Campylobacter jejuni Hcp1, a structural and effector protein of the Type VI Secretion System. FEBS Journal, 285 (21), 4060-4070. doi: 10.1111/febs.14650 |
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2018 Journal Article Structure of ScpC, a virulence protease from Streptococcus pyogenes, reveals the functional domains and maturation mechanismJobichen, Chacko, Tan, Ying Chong, Prabhakar, Mahalakshmi Tirumuru, Nayak, Digant, Biswas, Debabrata, Pannu, Navraj S., Hanski, Emanuel and Sivaraman, J. (2018). Structure of ScpC, a virulence protease from Streptococcus pyogenes, reveals the functional domains and maturation mechanism. Biochemical Journal, 475 (17), 2847-2860. doi: 10.1042/bcj20180145 |
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2018 Journal Article Proteobacterial origin of protein arginine methylation and regulation of complex I assembly by MidAHameed, Umar F. Shahul, Sanislav, Oana, Lay, Sui T., Annesley, Sarah J., Jobichen, Chacko, Fisher, Paul R., Swaminathan, Kunchithapadam and Arold, Stefan T. (2018). Proteobacterial origin of protein arginine methylation and regulation of complex I assembly by MidA. Cell Reports, 24 (8), 1996-2004. doi: 10.1016/j.celrep.2018.07.075 |
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2018 Journal Article Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptideLiu, Bee Hui, Jobichen, Chacko, Chia, C. S. Brian, Chan, Tim Hon Man, Tang, Jing Ping, Chung, Theodora X. Y., Li, Jia, Poulsen, Anders, Hung, Alvin W., Koh-Stenta, Xiaoying, Tan, Yaw Sing, Verma, Chandra S., Tan, Hong Kee, Wu, Chan-Shuo, Li, Feng, Hill, Jeffrey, Joy, Joma, Yang, Henry, Chai, Li, Sivaraman, J. and Tenen, Daniel G. (2018). Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide. National Academy of Sciences. Proceedings, 115 (30), E7119-E7128. doi: 10.1073/pnas.1801253115 |
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2018 Journal Article Biophysical studies and modelling indicate the binding preference of TAZ WW domain for LATS1 PPxY motifVerma, Apoorva, Lin, Fu, Tan, Ying Chong, Hidayat, Muhammad Nur, Jobichen, Chacko, Fan, Hao and Sivaraman, J. (2018). Biophysical studies and modelling indicate the binding preference of TAZ WW domain for LATS1 PPxY motif. Biochemical and Biophysical Research Communications, 502 (3), 307-312. doi: 10.1016/j.bbrc.2018.05.127 |
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2017 Journal Article Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatumIyer, Janaki Krishnamoorthy, Koh, Cho Yeow, Kazimirova, Maria, Roller, Ladislav, Jobichen, Chacko, Swaminathan, Kunchithapadam, Mizuguchi, Jun, Iwanaga, Sadaaki, Nuttall, Patricia A., Chan, Mark Y. and Kini, R. Manjunatha (2017). Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum. The FASEB Journal, 31 (7), 2981-2995. doi: 10.1096/fj.201601216R |
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2016 Journal Article Ringhalexin from Hemachatus haemachatus: A novel inhibitor of extrinsic tenase complexBarnwal, Bhaskar, Jobichen, Chacko, Girish, Vallerinteavide Mavelli, Foo, Chun Shin, Sivaraman, J. and Kini, R. Manjunatha (2016). Ringhalexin from Hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex. Scientific Reports, 6 25935, 1-13. doi: 10.1038/srep25935 |
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2015 Journal Article Structural basis of mapping the spontaneous mutations with 5-flurouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosisGhode, Pramila, Jobichen, Chacko, Ramachandran, Sarath, Bifani, Pablo and Sivaraman, J. (2015). Structural basis of mapping the spontaneous mutations with 5-flurouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosis. Biochemical and Biophysical Research Communications, 467 (3), 577-582. doi: 10.1016/j.bbrc.2015.09.133 |
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2015 Journal Article Structural basis for a unique ATP synthase core complex from Nanoarcheaum equitansMohanty, Soumya, Jobichen, Chacko, Chichili, Vishnu Priyanka Reddy, Velazquez-Campoy, Adrian, Low, Boon Chuan, Hogue, Christopher W. V. and Sivaraman, J. (2015). Structural basis for a unique ATP synthase core complex from Nanoarcheaum equitans. Journal of Biological Chemistry, 290 (45), 27280-27296. doi: 10.1074/jbc.M115.677492 |
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2015 Journal Article Structure of AcrH-AopB chaperone-translocator complex reveals a role for membrane hairpins in type III secretion system translocon assemblyNguyen, Van Sang, Jobichen, Chacko, Tan, Kang Wei, Tan, Yih Wan, Chan, Siew Leong, Ramesh, Karthik, Yuan, Yongming, Hong, Yunhan, Seetharaman, Jayaraman, Leung, Ka Yin, Sivaraman, J. and Mok, Yu Keung (2015). Structure of AcrH-AopB chaperone-translocator complex reveals a role for membrane hairpins in type III secretion system translocon assembly. Structure, 23 (11), 2022-2031. doi: 10.1016/j.str.2015.08.014 |
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2015 Journal Article Extended loop region of Hcp1 is critical for the assembly and function of type VI secretion system in Burkholderia pseudomalleiLim, Yan Ting, Jobichen, Chacko, Wong, Jocelyn, Limmathurotsakul, Direk, Li, Shaowei, Chen, Yahua, Raida, Manfred, Srinivasan, Nalini, MacAry, Paul Anthony, Sivaraman, J. and Gan, Yunn-Hwen (2015). Extended loop region of Hcp1 is critical for the assembly and function of type VI secretion system in Burkholderia pseudomallei. Scientific Reports, 5 8235, 1-10. doi: 10.1038/srep08235 |
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2014 Journal Article Molecular replacement with a large number of molecules in the asymmetric unitJobichen, Chacko and Swaminathan, Kunchithapadam (2014). Molecular replacement with a large number of molecules in the asymmetric unit. Acta Crystallographica Section F-Structural Biology Communications, 70 (9), 1296-1302. doi: 10.1107/S2053230X14014381 |
