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2025 Journal Article Autoimmune origin for immune checkpoint inhibitor-diabetes revealed by deep immune phenotyping of the pancreasQuandt, Zoe, Young, Arabella, Barlow, Graham Larson, Smith, Jennifer A, Kusmartseva, Irina, Dong, Shen, Shapiro, Melanie R, Kang, Jee Hye, Felton, Jamie L, Nguyen, Vinh Q, Szot, Greg, Hassoun, Assad A, Perdigoto, Ana Luisa, Herold, Kevan C, Nolan, Garry, Bollyky, Paul L, Brusko, Todd M, Nakayama, Maki, Cooper, Stewart and Anderson, Mark S (2025). Autoimmune origin for immune checkpoint inhibitor-diabetes revealed by deep immune phenotyping of the pancreas. Journal for immunotherapy of cancer, 13 (8) e011818, 1-9. doi: 10.1136/jitc-2025-011818 |
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2024 Journal Article Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clonesSmith, Jennifer A., Yuen, Benjamin T. K., Purtha, Whitney, Balolong, Jared M., Phipps, Jonah D., Crawford, Frances, Bluestone, Jeffrey A., Kappler, John W. and Anderson, Mark S. (2024). Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones. Proceedings of the National Academy of Sciences of the United States of America, 121 (20) e2320268121, 1-10. doi: 10.1073/pnas.2320268121 |
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2024 Journal Article Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse modelYin, Mianmian, Smith, Jennifer A, Chou, Marissa, Chan, Jackie, Jittayasothorn, Yingyos, Gould, Douglas B, Caspi, Rachel R, Anderson, Mark S and DeFranco, Anthony L (2024). Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model. Proceedings of the National Academy of Sciences of the United States of America, 121 (5) e2311487121, 1-12. doi: 10.1073/pnas.2311487121 |
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2022 Journal Article Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protectionVanDyke, Derek, Iglesias, Marcos, Tomala, Jakub, Young, Arabella, Smith, Jennifer, Perry, Joseph A., Gebara, Edward, Cross, Amy R., Cheung, Laurene S., Dykema, Arbor G., Orcutt-Jahns, Brian T., Henclova, Tereza, Golias, Jaroslav, Balolong, Jared, Tomasovic, Luke M., Funda, David, Meyer, Aaron S., Pardoll, Drew M., Hester, Joanna, Issa, Fadi, Hunter, Christopher A., Anderson, Mark S., Bluestone, Jeffrey A., Raimondi, Giorgio and Spangler, Jamie B. (2022). Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection. Cell Reports, 41 (3) 111478, 111478. doi: 10.1016/j.celrep.2022.111478 |
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2021 Journal Article A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell toleranceWarshauer, Jeremy T, Belk, Julia A, Chan, Alice Y, Wang, Jiaxi, Gupta, Alexander R, Shi, Quanming, Skartsis, Nikolaos, Peng, Yani, Phipps, Jonah D, Acenas, Dante, Smith, Jennifer A, Tamaki, Stanley J, Tang, Qizhi, Gardner, James M, Satpathy, Ansuman T and Anderson, Mark S (2021). A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance. The Journal of Experimental Medicine, 218 (8) e20210759, 1-18. doi: 10.1084/jem.20210759 |
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2021 Journal Article Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal treeHendley, Audrey M, Rao, Arjun A, Leonhardt, Laura, Ashe, Sudipta, Smith, Jennifer A, Giacometti, Simone, Peng, Xianlu L, Jiang, Honglin, Berrios, David I, Pawlak, Mathias, Li, Lucia Y, Lee, Jonghyun, Collisson, Eric A, Anderson, Mark S, Fragiadakis, Gabriela K, Yeh, Jen Jen, Ye, Chun Jimmie, Kim, Grace E, Weaver, Valerie M and Hebrok, Matthias (2021). Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree. eLife, 10 e67776, 1-29. doi: 10.7554/eLife.67776 |
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2020 Journal Article Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasisLee, James C., Mehdizadeh, Sadaf, Smith, Jennifer, Young, Arabella, Mufazalov, Ilgiz A., Mowery, Cody T., Daud, Adil and Bluestone, Jeffrey A. (2020). Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis. Science Immunology, 5 (52) eaba0759, 1-14. doi: 10.1126/sciimmunol.aba0759 |
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2020 Journal Article Evaluation of SARS-CoV-2 serology assays reveals a range of test performanceWhitman, Jeffrey D., Hiatt, Joseph, Mowery, Cody T., Shy, Brian R., Yu, Ruby, Yamamoto, Tori N., Rathore, Ujjwal, Goldgof, Gregory M., Whitty, Caroline, Woo, Jonathan M., Gallman, Antonia E., Miller, Tyler E., Levine, Andrew G., Nguyen, David N., Bapat, Sagar P., Balcerek, Joanna, Bylsma, Sophia A., Lyons, Ana M., Li, Stacy, Wong, Allison Wai-yi, Gillis-Buck, Eva Mae, Steinhart, Zachary B., Lee, Youjin, Apathy, Ryan, Lipke, Mitchell J., Smith, Jennifer Anne, Zheng, Tina, Boothby, Ian C., Isaza, Erin ... Marson, Alexander (2020). Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Nature Biotechnology, 38 (10), 1174-1183. doi: 10.1038/s41587-020-0659-0 |
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2019 Journal Article Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stageTuong, Zewen, Lewandowski, Andrew, Bridge, Jennifer, Gonzalez-Cruz, Jazmina, Yamada, Miko, Lambie, Duncan, Lewandowski, Richard, Steptoe, Raymond, Leggatt, Graham, Simpson, Fiona, Frazer, Ian, Soyer, Peter and Wells, James W. (2019). Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage. Scientific Reports, 9 (1) 17754, 17754. doi: 10.1038/s41598-019-54435-0 |
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2018 Journal Article Cytokines, chemokines, and other biomarkers of response for checkpoint inhibitor therapy in skin cancerBridge, Jennifer A., Lee, James C., Daud, Adil, Wells, James W. and Bluestone, Jeffrey A. (2018). Cytokines, chemokines, and other biomarkers of response for checkpoint inhibitor therapy in skin cancer. Frontiers in Medicine, 5 (DEC) 351, 351. doi: 10.3389/fmed.2018.00351 |
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2017 Journal Article CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skinOvergaard, Nana H., Cruz, Jazmina L., Bridge, Jennifer A., Nel, Hendrik J., Frazer, Ian H., La Gruta, Nicole K., Blumenthal, Antje, Steptoe, Raymond J. and Wells, James W. (2017). CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin. Journal of Leukocyte Biology, 102 (3), 837-844. doi: 10.1189/jlb.1AB0217-065R |
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2017 Journal Article Sirolimus increases T-cell abundance in the sun exposed skin of kidney transplant recipientsBurke, Michael Thomas, Sambira Nahum, Lauren C., Isbel, Nicole M., Carroll, Robert P., Soyer, Hans Peter, Francis, Ross, Bridge, Jennifer Anne, Hawley, Carmel, Oliver, Kimberly, Staatz, Christine E. and Wells, James William (2017). Sirolimus increases T-cell abundance in the sun exposed skin of kidney transplant recipients. Transplantation Direct, 3 (7), e171. doi: 10.1097/TXD.0000000000000694 |
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2016 Journal Article Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejectionColeman, Miranda A., Jessup, Claire F., Bridge, Jennifer A., Overgaard, Nana H., Penko, Daniella, Walters, Stacey, Borg, Danielle J., Galea, Ryan, Forbes, Josephine M., Thomas, Ranjeny, Coates, Patrick T. C., Grey, Shane T., Wells, James W. and Steptoe, Raymond J. (2016). Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection. Diabetes, 65 (5), 1328-1340. doi: 10.2337/db15-1418 |
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2016 Journal Article MicroRNA-206 is differentially expressed in Brca1-deficient mice and regulates epithelial and stromal cell compartments of the mouse mammary glandWronski, A., Sandhu, G. K., Milevskiy, M. J., Brewster, B. L., Bridge, J. A., Shewan, A. M., Edwards, S. L., French, J. D. and Brown, M. A. (2016). MicroRNA-206 is differentially expressed in Brca1-deficient mice and regulates epithelial and stromal cell compartments of the mouse mammary gland. Oncogenesis, 5 (4) e218, e218.1-e218.9. doi: 10.1038/oncsis.2016.27 |
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2014 Journal Article Comparative Immune Phenotypic Analysis of Cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in Immune-Competent Individuals: Proportional Representation of CD8+ T-Cells but Not FoxP3+ Regulatory T-Cells Is Associated with Disease StageFreeman, Andrew, Bridge, Jennifer A., Maruthayanar, Pirashanthini, Overgaard, Nana H., Jung, Ji-Won, Simpson, Fiona, Prow, Tarl W., Soyer, H. Peter, Frazer, Ian H., Freeman, Michael and Wells, James W. (2014). Comparative Immune Phenotypic Analysis of Cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in Immune-Competent Individuals: Proportional Representation of CD8+ T-Cells but Not FoxP3+ Regulatory T-Cells Is Associated with Disease Stage. PLoS One, 9 (10) e110928, e110928.1-e110928.9. doi: 10.1371/journal.pone.0110928 |
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2014 Journal Article IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasiaGosmann, Christina, Mattarollo, Stephen R., Bridge, Jennifer A., Frazer, Ian H. and Blumenthal, Antje (2014). IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia. Journal of Immunology, 193 (5), 2248-2257. doi: 10.4049/jimmunol.1400216 |
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2013 Journal Article Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacyColeman, Miranda A., Bridge, Jennifer A., Lane, Steven W., Dixon, Chantelle M., Hill, Geoffrey R., Wells, James W., Thomas, Ranjeny and Steptoe, Raymond J. (2013). Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy. Blood, 121 (6), 1049-1058. doi: 10.1182/blood-2012-06-434100 |
